Clinical trials: High-risk Medications
Describe Typical Gray Scale/Color Doppler Ultrasound Features of Gestational Trophoblastic Neoplasia at the US Examination, To Assess if There Are Differences at the Baseline US Scan Between Low-risk and High-risk Patients
Gestional Trophoblastic Neoplasia Ultrasound Assessment: Titanium Study
Gestational trophoblast diseases are characterized by abnormal proliferation of trophoblastic tissue, which can occur consequent to any pregnancy event.
- Conditions
- Describe Typical Gray Scale/Color Doppler Ultrasound Features of Gestational Trophoblastic Neoplasia at the US Examination, To Assess if There Are Differences at the Baseline US Scan Between Low-risk and High-risk Patients, To Identify Ultrasound Predictors of Resistance to First-line Single Drug Chemotherapy in Low-risk GTN Patients, To Investigate if Machine Learning (ML) Algorithms (Radiomics, Deep Neural Networks (DNN), and Other Machine Learning Algorithms
- Trial name
- TITANIUM (NCT06284980)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Advanced Colorectal Carcinoma, Recurrent Colorectal Carcinoma
Molecular Study and Precision Medicine for Colorectal Cancer
Researchers collect specimens from advanced or recurrent colorectal cancer (CRC) patients to conduct molecular profiling and establish tumor organoids (PDOs)/ patient-derived xenografts (PDXs).
- Trial name
- MSPM (NCT05883683)
- Testing
- Molecular Profiling & drug testing in tumor organoids and PDXs
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Coronary Artery Disease, Dyslipidemias
Comparative Study of Rosuvastatin/Ezetimib 20/10 mg and Atovastatin/Ezetimib 40/10 mg (TOLERANT Trial)
the investigators would like to compare the differences between roschvastin and atovastatin in patients who require high-dose statin/ejetimib to undergo a new generation of drug elution stent implantation for cardiovascular…
- Trial name
- NCT05910476
- Testing
- a high dose of statin/ezetimib
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Fluorosis, Dental, Fluorosis
Design of a Multicomponent Intervention to Reduce the Risk of Exposure Fluorine
Introduction Systemic exposure to fluoride is a significant challenge for global public health; this is because although fluoride prevents dental caries, prolonged exposure to high concentrations can cause adverse effects on…
- Trial name
- NCT07232888
- Testing
- multicomponent intervention, Conventional intervention
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio Nariño
PICU, Nurses
Smart Mind Maps in Promoting Safe Administration of High-Alert Medications
In PICU setting, drug administration, monitoring, and prescribing errors made up most cases (54%) of MEs . Emphasizes these issues requires a multifaceted approach, including staff training, creation of innovative cognitive…
- Trial name
- HAMs- PICU (NCT07320196)
- Testing
- smart mind mapsde
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Hypertension
Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension
This trial is aimed to assess the efficacy and safety of a fixed-dose combination therapy with Valsartan and Chlorthalidone, Vs Valsartan or Chlorthalidone alone for treatment of adult patients with diagnosis of arterial…
- Trial name
- NCT01850160
- Testing
- GROUP A: Valsartan plus Chlorthalidone, GROUP B: Valsartan, GROUP C: Chlorthalidone
- Where
- 8 sites in Colombia, Ecuador
- Volunteers
- 124 people
- Sponsor
- Farma de Colombia SA
Delirium
PROfylactic Haloperidol in Patients Defined as High Risk for DElirium With Delirium Risk mOdel
The hospital pharmacy at the Zuyderland Medical Centre developed the DElirium MOdel (DEMO) to predict which patients are at risk of developing a delirium in patients aged 60 or older.
- Trial name
- PRODEO (NCT03199950)
- Testing
- Haloperidol
- Where
- Netherlands
- Volunteers
- 1,366 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Substance Use, Stress
Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School
Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e.…
- Conditions
- Substance Use, Stress, Relation, Interpersonal, Bullying
- Trial name
- PeerLearning (NCT04478240)
- Testing
- PeerLearning.net
- Where
- United States
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Hypertension
A Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension
The purpose of this study is to determine the long term safety and tolerability of azilsartan medoxomil, once daily (QD), in participants with Essential Hypertension.
- Trial name
- NCT00696384
- Testing
- Azilsartan medoxomil, Azilsartan medoxomil, with or without chlorthalidone and other non-angiotensin II receptor blocker antihypertensive medications.
- Where
- 45 sites in United States, Argentina and 1 more
- Volunteers
- 418 people
- Sponsor
- Takeda
Drug Resistant Epilepsy
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy
Evaluation of the role of estimation of serum level of miRNAs223 and HMGB1in detection of patient with drug resistant epilepsy. Early detection of the prognosis might help in guiding patients for proper management and treatment…
- Trial name
- NCT05555537
- Testing
- MiRNA223 and High mobility group box1(HMGB1)
- Volunteers
- 90 people
- Sponsor
- Assiut University
Overweight, Childhood, Obesity Prevention
High Five! - School-based Prevention of Overweight and Obesity Among 6 to 9 Year Olds
The goal of this interventional study is to assess the effectiveness of the school-based "High Five!" program in reducing overweight, obesity and high blood pressure in children aged 7-9 years old.
- Conditions
- Overweight, Childhood, Obesity Prevention, Blood Pressure
- Trial name
- DINO-PL (NCT07357857)
- Testing
- High Five
- Where
- Poland
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Obesity, Elevated High-sensitivity C-reactive Protein (hsCRP)
A Study to See How Safe a New Medicine (NNC6022-0004) is in Healthy People and People Living With Obesity
This study is being done to look at the efficacy single and multiple ascending dose study investigating safety, tolerability, pharmacokinetics, food effect and target engagement in healthy adults including a single cohort in…
- Trial name
- NCT07693868
- Testing
- NNC6022-0004
- Where
- Netherlands
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Solid Cancer
A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
This study will evaluate the safety and efficacy of R-DXd therapy in participants with ovarian, peritoneal, or fallopian tube cancer.
- Trial name
- NCT06161025
- Testing
- R-DXd, Paclitaxel, Topotecan
- Where
- 167 sites in United States, Australia and 17 more
- Volunteers
- 860 people
- Sponsor
- Daiichi Sankyo
Transfusion-associated Circulatory Overload
Transfusion-Associated Circulatory Overload Best Eliminated With Lasix
This is a pilot double-blinded placebo-controlled randomized controlled trial (RCT) to evaluate the feasibility of conducting a multicenter, randomized, placebo-controlled trial to assess the efficacy of pre-transfusion…
- Trial name
- NCT02802696
- Testing
- Furosemide, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Muscle-Invasive Bladder Cancer (MIBC)
EV + Toripalimab vs GC as Neoadjuvant Therapy in Locally Advanced/High-Risk MIBC
The purpose of this Phase II, open-label, multicenter, randomized controlled study is to evaluate the efficacy and safety of Enfortumab Vedotin in combination with Toripalimab compared to Gemcitabine plus Cisplatin.
- Trial name
- NCT07647289
- Testing
- enfortumab vedotin (EV), Toripalimab, Gemcitabine (Chemotherapy)
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Peking University Third Hospital
Risk Behavior, HIV/AIDS
Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs
This study will evaluate the efficacy and cost-effectiveness of CHRP-BB - an integrated bio-behavioral approach that incorporates the use of PrEP - with an evidence-based behavioral approach aimed at enhancing PrEP adherence and…
- Conditions
- Risk Behavior, HIV/AIDS, Medication Adherence, Substance Abuse
- Trial name
- CHRP-BB (NCT03282890)
- Testing
- CHRP-BB
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Connecticut
Disasters, Disaster Preparedness
Effectiveness of an Audiovisual Disaster-Education Intervention on Disaster Risk Perception and Preparedness Belief Among Senior High-School Adolescents
This cluster-randomized controlled trial tests whether a short, standardized disaster-education video improves two psychological precursors of disaster preparedness among senior high-school students in a hazard-prone district of…
- Conditions
- Disasters, Disaster Preparedness, Health Behavior, Risk Perception
- Trial name
- DERAP (NCT07781527)
- Testing
- Audiovisual disaster-education module, Attention-matched general-health video
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Tanjungpura University
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones
This phase I trial tests the safety, side effects and best dose of tin (Sn)-177m-diethylenetriaminepentaacetic acid (DTPA) and how well it works in treating prostate, breast or non-small cell lung cancer that has spread from…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Bone
- Trial name
- NCT06982222
- Testing
- Biospecimen Collection, Bone Scan, Computed Tomography
- Sponsor
- National Cancer Institute (NCI)
Heartburn
Esomeprazole And Symptomatic Response In Patients With Or Without An Elevated Risk For Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated GI Damage
The purpose of this study is to compare the treatment effect in patients with upper gastro-intestinal complaints with an elevated risk for NSAID-associated GI-damage to those without an elevated risk for NSAID-associated damage…
- Trial name
- Synchronise (NCT00524329)
- Volunteers
- 1,220 people
- Sponsor
- AstraZeneca
Meningitis, Neurological Infections
Pharmacological Study of High Doses of Ceftriaxone in Meningitidis
The aim of the study is to describe the concentrations of Ceftriaxone at the steady state, in patients treated for meningitis, to determine pharmacokinetic parameters at high dose in this population.
- Trial name
- NCT01745679
- Testing
- Ceftriaxone treatment
- Where
- 7 sites in France
- Volunteers
- 198 people
- Sponsor
- Nantes University Hospital