Clinical trials: High-risk Patient
Glioma, Glioma, Malignant
Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery
This retrospective study aims to assess the utility of 2D non-navigated intraoperative ultrasound (ioUS) as a cost-effective alternative for guiding the surgical resection of gliomas and for detecting residual tumor.
- Conditions
- Glioma, Glioma, Malignant, Low-grade Glioma, High-grade Glioma
- Trial name
- 2D-ioUS-Glio (NCT05873946)
- Testing
- intraoperative ultrasound
- Where
- Spain
- Volunteers
- 99 people
- Sponsor
- Hospital del Rio Hortega
Respiratory Disease (Clinically Stable Individuals - Patients Recovered From Respiratory Disease)
The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing
The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are: 1.
- Trial name
- NCT07066566
- Testing
- Asymmetric nasal cannula - DUET, Conventional nasal high flow cannula
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Larissa University Hospital
Chronic Obstructive Pulmonary Disease
Nasal High Flow to Maintain the Benefits of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients
Chronic obstructive pulmonary disease (COPD) is a major cause of disability and mortality worldwide. This systemic disease progressively leads to dyspnea and exercise capacity impairment.
- Trial name
- PPR-NHF (NCT03882372)
- Testing
- Nasal high flow
- Where
- France
- Volunteers
- 2 people
- Sponsor
- ADIR Association
Hematopoietic and Lymphatic System Neoplasm, Acute Lymphobkastic Leukemia
A Study to Determine Number of Patients Who Develop High Ammonia Levels After Receiving Recombinant Erwinia Asparaginase
This study evaluates the incidence of symptomatic hyperammonemia (high ammonia levels) in patients being treated with recombinant Erwinia asparaginase.
- Trial name
- NCT06600659
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Acute Myocardial Infarction (AMI)
Coronary and Myocardial Evaluation by Cardiac CT for Acute Myocardial Infarction
Acute myocardial infarction (AMI) remains a major cause of mortality and morbidity worldwide. Although percutaneous coronary intervention (PCI) combined with guideline-directed medical therapy has substantially improved survival…
- Trial name
- COMET-AMI (NCT07537296)
- Testing
- Cardiac CT Follow-up and Echocardiographic Follow-up
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Contrast-Induced Nephropathy
High Dose Atorvastatin for Preventing Contrast-induced Nephropathy
The aim of this study is to determine the efficacy of atorvastatin in the prevention of contrast-induced nephropathy in patients undergoing computed tomography coronary angiography.
- Trial name
- NCT02114346
- Testing
- Atorvastatin, 0.9% sodium chloride
- Where
- Iran
- Volunteers
- 250 people
- Sponsor
- Isfahan University of Medical Sciences
Infectious Disease of Digestive Tract
The Use of Probiotics to Evaluate Colonization With Antimicrobial Resistant Bacteria
The purpose of this study is to evaluate the effectiveness of bacteria called Lactobacillus GG, a Probiotic, in preventing the growth of resistant bacteria in the digestive tract in patients on a ventilator.
- Trial name
- NCT01551186
- Testing
- Lactobacillus rhamnosus GG
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus
Inter-Device Concordance of Plantar Thermal Asymmetry Measurement (HIK-DM-2026)
This cross-sectional observational study measures the inter-device concordance between two infrared thermographic cameras, a low-cost model (HIKMICRO Mini2 V2) and a high-resolution model (HIKMICRO M60), when measuring plantar…
- Trial name
- NCT07463456
- Testing
- HIKMICRO® Mini2 V2, HIKMICRO® M60
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Eduardo Luis Martín Javier
Hypertension
Telmisartan and Hydrochlorothiazide Antihypertensive Treatment Study in High Sodium Intake Population
In this research, the investigators aim to compare the antihypertensive efficacy and safety of monotherapy of routine dose angiotensin receptor antagonist telmisartan (ARB) and diuretic Hydrochlorothiazide (HCTZ) in high sodium…
- Trial name
- NCT02255253
- Testing
- Telmisartan, Hydrochlorothiazide
- Where
- 14 sites in China
- Volunteers
- 1,410 people
- Sponsor
- The George Institute for Global Health, China
MDS, AML
Non-interventional Study With Azacitidin (Vidaza®)
The purpose of this non-interventional study is to collect data on the efficiency and safety of Azacitidin in the routine application.
- Conditions
- MDS, AML, CMMOL
- Trial name
- Piaza (NCT01192945)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- iOMEDICO AG
Bronchiectasis
Study of the Effect of FLUTTER® VRP1 (PEP and Oscillating High Frequency).
The research sought to assess the effects of Flutter ® VRP1 in patients with bronchiectasis.
- Trial name
- FLUTTER®VRP1 (NCT01209546)
- Testing
- control group, Flutter group, PEP group
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Prostate Cancer, Oligometastasis
Comparison of Intermittent Androgen Deprivation Therapy With or Without Irradiation Recovery in Prostate Cancer Patients
Metastatic prostate cancer has traditionally been regarded as an incurable dissemination of disease, and treatment is focused on delaying progression rather than eliminating all tumor burden.
- Trial name
- OLIGOPELVIS2 (NCT03630666)
- Testing
- IADT, IADT + radiotherapy
- Where
- 16 sites in France
- Volunteers
- 256 people
- Sponsor
- Institut Cancerologie de l'Ouest
Hypoxemia During Surgery, Atelectasis
Usage of High Flow Nasal Cannula in Preventing Desaturations in Elderly Patients Going for Lower Limb Surgeries
To study the effect of high flow nasal cannula in comparisons with nasoprong used intraoperatively in patients oxygenation status
- Trial name
- NCT06054022
- Testing
- high flow nasal cannula, nasoprong oxyen 2Litres per minute
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Non Hodgkin's Lymphoma
Phase I Trial of Clofarabine in Combo w/ HD Etoposide & Cyclophosphamide and APBSCT for Pts w/ High-Risk or Refractory NHL
This is a phase I trial to determine the maximum tolerated dose (MTD) of clofarabine in a combination with high-dose etoposide and cyclophosphamide.
- Trial name
- NCT00477945
- Testing
- clofarabine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Indiana University
Colon Cancer Stage Iv
The Effectiveness of High-dose Intravenous Vitamin c With Very Low Carbohydrate Diet for Terminal Colon Cancer Patients
The purpose is to evaluate the effectiveness of high dose intravenous vitamin C (IVC) therapy plus very low carbohydrate diet (VLCD) for stage IV colon cancer (with KRAS and BRAF mutation ) with or without chemotherapy.
- Trial name
- NCT04035096
- Testing
- Ascorbic Acid, Control group
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
General Surgery, Disease Outbreaks
Short-term Outcome of Covid-19 Surgical Patients: Case-series of a High-risk Area Community Hospital
The investigators retrospectively evaluated all the patients operated in a high-risk community hospital from the first Italian case of Covid-19 (February 21st) to the April 10th (in order to have at least a 30-days follow-up).
- Trial name
- NCT04430062
- Testing
- Surgical procedures performed under general anesthesia
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
Lymphoma, Relapsed Lymphoma
Study to Assess the Safety, Tolerability and Pharmacokinetics of Fimepinostat (CUDC-907) in Patients With Lymphoma
This is a phase 1, open-label, dose-escalation study of fimepinostat (CUDC-907) in patients with relapsed and/or refractory diffuse large B-cell lymphoma (DLBCL), or high-grade B-cell lymphoma (HGBL) with or without MYC and BCL2…
- Conditions
- Lymphoma, Relapsed Lymphoma, Refractory Lymphoma, Relapsed and/or Refractory Lymphoma
- Trial name
- NCT01742988
- Testing
- fimepinostat, Rituximab, venetoclax
- Where
- 11 sites in United States
- Volunteers
- 106 people
- Sponsor
- Curis, Inc.
Bladder Cancer
Role of ERBT Plus Intravesical BCG in Intermediate-Risk or High-Risk NMBC
This is a prospective, multi-centre randomised trial comparing between cTURBT plus 1-year BCG therapy, and ERBT plus 1-year BCG therapy, in patients with intermediate-risk or high-risk NMIBC.
- Trial name
- NCT07724886
- Testing
- Conventional Transurethral Resection of Bladder Tumour, Transurethral En Bloc Resection of Bladder Tumour
- Where
- 2 sites in Hong Kong
- Volunteers
- 732 people
- Sponsor
- Chinese University of Hong Kong
Brain Tumor, Anaplastic Astrocytoma
Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma
RATIONALE: Ritonavir and lopinavir may stop the growth of gliomas by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Conditions
- Brain Tumor, Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Oligodendroglioma
- Trial name
- NCT01095094
- Testing
- ritonavir, lopinavir
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Case Comprehensive Cancer Center
Myelofibrosis
A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment
The purpose of the study is to evaluate the overall survival of participants treated with imetelstat compared to best available therapy with intermediate-2 or high-risk Myelofibrosis (MF) who are relapsed/refractory (R/R) to…
- Trial name
- NCT04576156
- Testing
- Imetelstat, Best Available Therapy (BAT)
- Where
- 144 sites in United States, Argentina and 24 more
- Volunteers
- 327 people
- Sponsor
- Geron Corporation