Clinical trials: High-risk Pregnancy
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Type 1 Diabetes, Pregnancy, High Risk
Commercial or Open Source Closed Loop Impact on Pregnancy Study
The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems.
- Conditions
- Type 1 Diabetes, Pregnancy, High Risk, Insulin Dependent Diabetes, Pregnancy Related
- Trial name
- COSCLIP (NCT06654713)
- Testing
- Commercial AID system, Open source AID system
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, San Francisco
Endometrial Cancer
A Safety and Efficacy of CCRT With Paclitaxel as Adjuvant Therapy to Post-Operative Advanced Endometrial Cancer Patients
The purpose of this study is to determine whether post-operative concurrent chemoradiation with paclitaxel is effective and safe in the treatment of high risk postoperative endometrial cancer patients.
- Trial name
- NCT00373620
- Testing
- paclitaxel
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Korean Gynecologic Oncology Group
Cervical Cancers
Serplulimab With Chemoradiotherapy for Postoperative Cervical Cancer With Risk Factors
A Phase II Study of Serplulimab Plus Chemoradiotherapy as Adjuvant Treatment for Postoperative Cervical Cancer with Multiple Risk Factors
- Trial name
- NCT06727617
- Testing
- Serplulimab, Chemotherapy, radiotherapy
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Renal Stone
Enhanced Versus Extended Preoperative Antibiotic Prophylaxis Regimens for Retrograde Intrarenal Surgery in High Infectious Risk Patients
In the available literature, there is a lack the risk categorization of infectious complications after RIRS with subsequent recommendation as regard to AP in different risk patients.
- Trial name
- NCT05384197
- Testing
- Enhanced regimen, Extended regimen
- Where
- Egypt
- Volunteers
- 280 people
- Sponsor
- Mansoura University
Ovarian Cancer, Ovarian Neoplasms
A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα)
This study, ELU- FRα-1, was focused on adult subjects who have advanced, recurrent or refractory folate receptor alpha (FRα) overexpressing tumors considered to be topoisomerase 1 inhibitor-sensitive based on scientific…
- Conditions
- Ovarian Cancer, Ovarian Neoplasms, Ovarian Carcinoma, Endometrial Cancer
- Trial name
- NCT05001282
- Testing
- ELU001
- Where
- 18 sites in United States
- Volunteers
- 79 people
- Sponsor
- Elucida Oncology
Stress Urinary Incontinence
Effects of High Intensity Focused Electromagnetic Therapy With Pelvic Floor Muscle Training on Urine Leakage and Quality of Life in Primipara or Multipara Women With Stress Urinary Incontinence
This study aimed to evaluate the impact of High-Intensity Focused Electromagnetic Therapy (HIFEM) combined with Pelvic Floor Muscle Training (PFMT) versus PFMT alone on urine leakage and quality of life in primiparous and…
- Trial name
- NCT06638489
- Testing
- High-Intensity-Focused-Electromagnetic-Therapy (HIFEM), Pelvic-Floor-Muscle-Training (PFMT)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Non Muscle Invasive Bladder Cancer, High-grade Ta/ T1 Papillary Disease Bladder Cancer
Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin
This is a Phase 3, open-label, single arm trial designed to evaluate Cretostimogene patients with NMIBC who have failed prior BCG therapy.
- Trial name
- BOND-003 (NCT04452591)
- Testing
- Cretostimogene Grenadenorepvec, n-dodecyl-B-D-maltoside
- Where
- 86 sites in United States, Australia and 4 more
- Volunteers
- 190 people
- Sponsor
- CG Oncology, Inc.
Nephrotic Syndrome
Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome
A multicenter, randomized, study will be performed to evaluate the efficacy of low dose steroid combined with mycophenolic acid (MyforticR) versus high dose steroid in inducing remission in adults with minimal change nephrotic…
- Trial name
- MSN (NCT01197040)
- Testing
- Prednisone, acid mycophenolic (Myfortic)
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bladder Cancer
High Resolution Imaging for Early and Better Detection of Bladder Cancer
The goal of this study is to develop, optimize, and validate a High Resolution Imaging System in the bladder that displays images in real-time, providing automated diagnostic criteria for bladder cancer screening.
- Trial name
- HRME_Bladder (NCT02340650)
- Testing
- Standard High Resolution Microendoscope and/or Line-Scanning Confocal High Resolution Microendoscope
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- The University of Texas Health Science Center, Houston
Maternal Anxiety Level, Non Stress Test (NST)
Effects of Virtual Reality and Relaxation During Non-Stress Testing
Aim: This randomized controlled trial aimed to compare the effectiveness of virtual reality and progressive muscle relaxation exercise in reducing anxiety during the non-stress test (NST) and to evaluate their effects on maternal…
- Conditions
- Maternal Anxiety Level, Non Stress Test (NST), High Risk Pregnancy, Virtual Reality
- Trial name
- NCT07669090
- Testing
- Virtual reality glasses, Progressive muscle relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Istanbul University - Cerrahpasa
Cervical Cancer
Trial of Postoperative Chemoradiotherapy With or Without Consolidation Chemotherapy for Cervical Cancer Patients
The purpose of this study is to determine the efficacy and safety of consolidation chemotherapy with paclitaxel plus cisplatin (2 cycles per 3 weeks) following radical hysterectomy and adjuvant chemoradiation (2 cycles per 4…
- Trial name
- NCT01755845
- Testing
- paclitaxel, cisplatin, radiotherapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- xie congying
Preterm Birth, Premature Birth
Prevention of sPTB With Early Cervical Pessary Treatment in Women at High Risk for PTB
Prevention of preterm birth (PTB) is a key factor for a positive short-term and long-term outcome of the newborn children as mortality and morbidity are inversely related to gestational age at delivery.
- Trial name
- Prometheus (NCT03418012)
- Testing
- cervical pessary, Control-Group
- Where
- 9 sites in Australia, Germany and 2 more
- Volunteers
- 310 people
- Sponsor
- Bürgerhospital Frankfurt
High Grade Serous Ovarian Cancer, Folate Receptor Alpha Positive
Folate Receptor Alpha (FRα) Expression and Heterogeneity in Epithelial Ovarian Cancer
This is a single-country, retrospective, observational biomarker study conducted in Greece to evaluate Folate Receptor Alpha (FRα) expression in patients with high-grade serous ovarian, fallopian tube, and primary peritoneal…
- Trial name
- FRONTIER (NCT07889843)
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Hellenic Cooperative Oncology Group
Sexual Dysfunctions, Psychological, High Risk Pregnancy
Sexual Function Changes in High-Risk Pregnancies
Sexual Function Changes in High-Risk Pregnancies
- Conditions
- Sexual Dysfunctions, Psychological, High Risk Pregnancy, Sexual Behavior
- Trial name
- NCT05093647
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Diabetes Type 2, Diabetic Nephropathy
Ramipril and Clopidogrel in Oxidative Stress, Vascular Inflammation and Endothelial Dysfunction in Type 2 Diabetes and Diabetic Nephropathy
The purpose of this study is to determine whether the combination with ramipril and clopidogrel leads to further improvement of endothelial function, reduction of oxidative stress and reduction of vascular inflammation, compared…
- Conditions
- Diabetes Type 2, Diabetic Nephropathy, Vascular Disease
- Trial name
- NCT01743014
- Testing
- Ramipril, Clopidogrel
- Where
- 2 sites in Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
High Grade Serous Ovarian Cancer
Unravelling Tumour Biology In Ovarian Cancer With Precision Imaging
The objective of this study is to explore the integration of in vivo and ex vivo of MRI with histology and molecular assessments to advance non-invasive characterization of tumor heterogeneity in high-grade serous ovarian cance
- Trial name
- MR-O-MICS (NCT06084195)
- Testing
- Blood sample and tissue sample
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Preeclampsia
Comparison of High- Versus Low-Dose Aspirin for Pregnancy Outcomes in Women at High Risk of Preeclampsia
The goal of this randomized clinical trial is to compare the effects of two doses of aspirin, 75 mg and 150 mg, in pregnant women who are at high risk of developing preeclampsia. The main question the study aims to answer is: 1.
- Trial name
- NCT07779057
- Testing
- Aspirin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Medicare Hospital (Pvt) Limited
Clear Cell Renal Cell Carcinoma
Neoadjuvant PD-L1 Inhibitor Plus Anlotinib for Kidney Preservation in Complex Renal Cell Carcinoma
This is a prospective, multicenter, single-arm phase II study evaluating the efficacy and safety of neoadjuvant PD-L1 inhibitor TQB2450 in combination with anlotinib in patients with locally advanced, high-complexity (RENAL score…
- Trial name
- NCT07602101
- Testing
- TQB2450 + Anlotinib
- Volunteers
- 33 people
- Sponsor
- RenJi Hospital
Pain, Postoperative, Ureter Stone
Local Anaesthetic and Steroid in the Ureter
Précis: Randomised control trial to evaluate safety and efficacy of intraluminal injection of high pH-high concentration of a long-acting local anesthetic and long-acting glucocorticoid in the ureter after ureteroscopy.
- Trial name
- LASTE (NCT03296189)
- Testing
- Levobupivacaine, Dexamethasone Sodium Phosphate
- Where
- Ireland
- Volunteers
- 150 people
- Sponsor
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
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