Clinical trials: High-risk Pregnancy
Neuroblastoma, Sarcoma
A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
This study will expand the types of pediatric cancers being evaluated for response to cabozantinib. The current COG study is restricted to Ewing sarcoma, osteosarcoma, rhabdomyosarcoma, Wilms tumor, and a handful of uncommon…
- Trial name
- NCT05135975
- Testing
- Cabozantinib
- Where
- 6 sites in United States
- Volunteers
- 86 people
- Sponsor
- Nationwide Children's Hospital
Postpartum Hemorrhage
Carbetocin Versus Misoprostol in High Risk Patients for Postpartum Hemorrhage After C.S.
We will compare between Carbitocin and Misoprostol in prevention of postpartum hemorrhage in high risk patients after C.S.
- Trial name
- PPH (NCT02277067)
- Testing
- Carbetocin, Misoprostol
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Endometrial Cancer
Pilot Study Using a PET Gamma Probe to Evaluate Lymph Nodes in Endometrial Cancer
The surgical management of high-risk endometrial cancer often involves an extensive operation to remove lymph nodes as sites of possible cancer spread.
- Trial name
- NCT01467219
- Testing
- lymphadenectomy, therapeutic conventional therapy, Positron Emission Tomography/ Computed Tomography
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Women's Health: Cervical Neoplasm
Mobile Outreach Screening of High-Risk Human Papillomavirus Infection in Women with Limited Access to Health Services in Seine-Saint-Denis (greater Paris Area, France)
The study is a prospective cervical cancer screening intervention in the nonclinical setting of a mobile testing unit in a vehicle, using point-of-care HPV PCR tests with self-collected vaginal swabs.
- Trial name
- PAPMOBILE (NCT06656611)
- Testing
- HPV self sampling
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Fallopian Tube Carcinosarcoma, Primary Peritoneal Carcinosarcoma
Vaccine Therapy Plus Pembrolizumab in Treating Advanced Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer
This phase I/II trial tests the safety, side effects, best dose, and effectiveness of multi-epitope folate receptor alpha-loaded dendritic cell vaccine (FRalphaDC) with pembrolizumab in treating patients with ovarian, fallopian…
- Conditions
- Fallopian Tube Carcinosarcoma, Primary Peritoneal Carcinosarcoma, Recurrent Fallopian Tube Carcinoma, Recurrent Fallopian Tube Clear Cell Adenocarcinoma
- Trial name
- FRAPPE (NCT05920798)
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Ovarian Hyperstimulation Syndrome
Comparative Study Between Calcium Gluconate With Diosmin, Cabergoline and Cabergoline With Diosmin
Ovarian hyperstimulation syndrome is a potentially fatal iatrogenic condition. This syndrome is characterized by a sudden increase of the vascular permeability which results in the development of a massive extravascular exudate…
- Trial name
- NCT06333691
- Testing
- Calcium Gluconate
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Minia University
End-Stage Renal Disease, Kidney Transplantation
A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant
The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney transplants.
- Trial name
- NCT00005113
- Testing
- Cyclosporine, Sirolimus, Tacrolimus
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Boston Children's Hospital
PCOS (Polycystic Ovary Syndrome)
Feasibility Effects of a Low-GI, High-fibre Diet in PCOS: a Prospective Cohort Study in Remote Yunnan
This study aims to observe the effects of a 6-month, culturally-adapted low glycemic index-high fiber (LGI-HF) dietary on IR, androgen levels, and menstrual regularity among women with PCOS in remote areas of Yunnan Province.
- Trial name
- NCT07426146
- Testing
- low glycemic index-high fiber
- Where
- 2 sites in China
- Volunteers
- 56 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Renal Failure, Protein-Energy Malnutrition
Examining the Impact of High-protein Oral Supplement on Protein Status of Adults on Peritoneal Dialysis
This is a 6-month prospective interventional clinical trial designed to evaluate the impact of whey protein isolate oral supplement on protein status.
- Trial name
- NCT06154161
- Testing
- Whey protein supplement
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Pregnancy Complications, Pregnancy, High Risk
Defining, Recognising and Escalating Maternal Early Deterioration (DREaMED)
Every year more than 700,000 women give birth in the United Kingdom. Of these at least 8700 nearly die - called a "near-miss", and 70 die. Many more women suffer harm, often with effects lasting for life.
- Trial name
- DREaMED (NCT06560931)
- Where
- United Kingdom
- Volunteers
- 459,160 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Acute Kidney Injury
Efficacy and Safety of RMC-035 in Subjects at High Risk for Acute Kidney Injury Following Open-Chest Cardiac Surgery
This study evaluates RMC-035 compared to placebo for the prevention of acute kidney injury (AKI) in subjects who are at high risk for AKI following cardiac surgery.
- Trial name
- AKITA (NCT05126303)
- Testing
- RMC-035
- Where
- 29 sites in United States, Canada and 3 more
- Volunteers
- 177 people
- Sponsor
- Guard Therapeutics AB
Pre-eclampsia, Pregnancy, High Risk
Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia
The primary aim is to establish the effectiveness of plasma PlGF measurement in reducing maternal morbidity (with assessment of perinatal safety in parallel) in women presenting with suspected pre-eclampsia prior to 37 weeks'…
- Conditions
- Pre-eclampsia, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- PARROT (NCT02881073)
- Testing
- Maternal plasma PlGF quantification
- Where
- 7 sites in Ireland
- Volunteers
- 2,313 people
- Sponsor
- Irish Centre for Fetal and Neonatal Translational Research
Recurrent Bladder Cancer, Transitional Cell Carcinoma of the Bladder
Sunitinib Malate in Treating Patients With Recurrent Transitional Cell Bladder Cancer
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor.
- Trial name
- NCT01118351
- Testing
- sunitinib malate, immunohistochemistry staining method, TdT-mediated dUTP nick end labeling assay
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Case Comprehensive Cancer Center
Smoking Cessation, Cervical Cancer
Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)
The goal of this research study is to compare the efficacy of a treatment approach that comprises both Motivation And Problem-Solving (MAPS)-based telephone counseling and a personally-tailored SMS-delivered text-based approach…
- Conditions
- Smoking Cessation, Cervical Cancer, High Grade Cervical Dysplasia
- Trial name
- NCT05645146
- Testing
- Smoking Cessation treatment delivered by Tobacco Free Florida Quitline, Nicotine patch, Nicotine Lozenge
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Kidney Diseases
Designing and Implementing a Safety Net Surveillance Program for High Risk CKD
The objective of this initiative is to develop and evaluate a risk-based, provincial public health screening program for chronic kidney disease (CKD) that provides proactive care for adults at high-risk of kidney failure who have…
- Trial name
- CKD Safety-Net (NCT07724288)
- Testing
- Letter to participants
- Where
- Canada
- Volunteers
- 972 people
- Sponsor
- University of Manitoba
Acute Myeloid Leukemia, Anatomic Stage III Breast Cancer AJCC v8
National Cancer Institute "Cancer Moonshot Biobank"
This trial collects multiple tissue and blood samples, along with medical information, from cancer patients. The "Cancer Moonshot Biobank" is a longitudinal study.
- Conditions
- Acute Myeloid Leukemia, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
- Trial name
- NCT04314401
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- 150 sites in United States, Puerto Rico
- Volunteers
- 1,600 people
- Sponsor
- National Cancer Institute (NCI)
End Stage Renal Disease
Safety and Efficacy Study of Thymoglobulin Versus IL2 Receptor Antagonists
The purpose of this study is to evaluate the safety and efficacy of induction therapy with Thymoglobulin in comparison with IL2 receptor antagonists (daclizumab or basiliximab).
- Trial name
- NCT00859131
- Testing
- Rabbit Antithymocyte globulin, Daclizumab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Medical University of South Carolina
Cervical Cancer
Use of High-Resolution Microendoscopy (HRME) in Patients With Cervical Dysplasia
The goal of this clinical research study is to compare a type of imaging called high-resolution microendoscopy (HRME) for detecting abnormal tissue in the cervix to the standard of care, which is visual inspection with acetic…
- Trial name
- NCT02420665
- Testing
- Proflavine, HRME Imaging, Phone Call
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Fetal Growth Retardation
Prediction of Placental Fetal Growth Restriction in High Risk Population (PoPFGR)
This study intends to prospectively enroll high-risk pregnant women to establish a multicenter cohort. By combining maternal basic characteristics, medical history, early pregnancy ultrasound, and biological markers, we aim to…
- Trial name
- NCT06096805
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Urolithiasis
High Supracostal Versus Subcostal Puncture in Adult PCNL
as the supra eleventh puncture PCNL is not well investigated in the literature we will conduct that randomised trial in comparison to the subcostal one
- Trial name
- NCT06350045
- Testing
- PCNL
- Where
- Egypt
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Assiut University
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