Clinical trials: High-risk Pregnancy
Pregnancy Related, Cardiac Output, High
Non-invasive Haemodynamic Monitoring in Pregnancy
This prospective and observational trial over 55 pregnant women (third trimester) compares non invasive haemodynamic monitoring using Nexfin technology and ultrasonography technic
- Conditions
- Pregnancy Related, Cardiac Output, High, Haemodynamic Instability
- Trial name
- NCT03046784
- Testing
- haemodynamic evaluation
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hospital Nord
Pregnancy, High Risk
Motor Imagery in High-Risk Pregnants
The aim of this study is to determine the acute effects of motor imagery exercises on fetal heart rate, uterine contractions, maternal heart rate, blood pressure, oxygen saturation and well-being in high-risk pregnant women.
- Trial name
- NCT05946252
- Testing
- Motor imagery, Diaphragmatic breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Izmir University of Economics
Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), CKD Stage 3
Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in…
- Conditions
- Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), CKD Stage 3, CKD Stage 4, CKD Stage 5
- Trial name
- PLAFOND (NCT05514184)
- Testing
- PLAFOND diet
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Endometrial Neoplasms
The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma
This randomized trial is studying the efficacy and safety of the chemotherapy compared with radiation therapy alone as adjuvant treatment after operation in Patients with high risk and Stage I endometrial carcinoma.
- Trial name
- EC-01 (NCT01820858)
- Testing
- Paclitaxel, Paraplatin (Carboplatin Injection), Pelvic Radiation
- Where
- 3 sites in China
- Volunteers
- 300 people
- Sponsor
- Ding Ma
Chronic Kidney Disease
Inspiratory Muscle Training in Chronic Kidney Disease
Chronic kidney disease is a renal injury and progressive and irreversible loss of kidney function and in its most advanced stage is called chronic renal failure.
- Trial name
- NCT03082404
- Testing
- Inspiratory muscle training
- Volunteers
- 25 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Cardiac Surgery, Aortocoronary Bypass
Remote Ischemic Preconditioning After Cardiac Surgery
Acute kidney injury (AKI) is a well-recognized complication after cardiac surgery with cardiopulmonary bypass (CPB). The aim of this study is to reduce the incidence of AKI by implementing remote ischemic preconditioning and to…
- Trial name
- RIPCRenal (NCT02997748)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University Hospital Muenster
Motor Disorders, Neurodevelopmental Disorders
Neuromotor Development and Motor Related Health Care in Children with a High Risk Neonatal Period
The overall aim of the study is to evaluate the prevalence of motor- and neurological disorders (cerebral pares and other less severe motor disorders) in Swedish infants with a high-risk neonatal period and to elucidate whether…
- Conditions
- Motor Disorders, Neurodevelopmental Disorders, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT06645717
- Volunteers
- 2,900 people
- Sponsor
- Karolinska Institutet
Prostate Cancer, Prostatic Neoplasm
Evaluation of Diagnostic Accuracy of [68Ga]Ga-PSMA-11 PET/CT in Primary Staging of Intermediate and High Risk Prostatic Cancer in Men Newly Diagnosed
This is a diagnostic accuracy prospective, single-centre, open-label, single group assignment interventional study. Its aim is to evaluate the diagnostic accuracy of [68Ga]Ga-PSMA-11 PET/CT in detection of primary tumour and…
- Conditions
- Prostate Cancer, Prostatic Neoplasm, Urogenital Neoplasms, Prostatic Disease
- Trial name
- PSMA-PROSTAPET (NCT04462926)
- Testing
- [68Ga]Ga-PSMA-11 PET/CT
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Obstetric Anesthesia Problems, High-Risk Pregnancy
Effect of Intra-abdominal Pressure to the Level of the Sensory Block at Caesarean Section Under Spinal Anesthesia
It is known that an increase in intra-abdominal pressure (IAP) causes a decrease in the volume of cerebrospinal fluid in the lumbar and lower thoracic region, which may contribute to the development of more high spinal block.
- Trial name
- IAPSB (NCT02237092)
- Testing
- Measurement of IAP
- Where
- Russia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Tver Regional Perinatal Center
Acute Kidney Failure
Clinical Trial of Sodium Bicarbonate to Prevent Contrast-Induced Nephropathy
The purpose of this study is to determine whether sodium bicarbonate is effective in the prevention of sodium-induced nephropathy
- Trial name
- NCT00424320
- Testing
- Sodium bicarbonate
- Where
- 2 sites in Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Respiratory Syncytial Virus Infections
A Study on the Safety and Immune Response to an Unadjuvanted RSV Maternal Vaccine, in High Risk Pregnant Women Aged 15 to 49 Years and Infants Born to the Vaccinated Mothers
The purpose of this study was to evaluate the safety, reactogenicity and immune response of a single intramuscular dose of the respiratory syncytial virus (RSV) maternal vaccine compared to placebo, when administered in the…
- Trial name
- NCT04980391
- Testing
- RSV MAT
- Where
- 35 sites in United States, Brazil and 7 more
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gestational Diabetes Mellitus in Pregnancy
Shear Wave Elastography in Gestational Diabetes Mellitus
Our aim was to investigate and compare placental elasticity by using Shear wave elastography (SWE) in patients with gestational diabetes mellitus (GDM) with and without insulin to non-diabetic controls.
- Trial name
- NCT04455880
- Testing
- SWE is a novel noninvasive dynamic ultrasound technique which refers to measurement for quantitative analysis of tissue elasticity
- Where
- Turkey (Türkiye)
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Gulsum Uysal
Chronic Kidney Disease (CKD), Elderly
Sertraline and the Risk of Serious Adverse Events
The goal of this population-based cohort study is to assess the safety of initiating a new outpatient prescription of 50 mg/day of Sertraline, a higher dose, compared to 25 mg/day, a lower dose, in adults aged 65+ with low kidney…
- Conditions
- Chronic Kidney Disease (CKD), Elderly, Outpatient
- Trial name
- NCT07387120
- Testing
- Sertraline 50 mg, Sertraline 25 mg
- Where
- Canada
- Volunteers
- 6,893 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
High Risk Pregnancy, Cesarean Section
Education of Pregnant Women With a Prenatal Indication for Cesarean Section Through Periodic Short Message Service (SMS) and Interactive Voice Response System (IVR) in Uganda
Women with antenatally identified indications for planned pre-labor cesarean delivery in low-resource settings frequently present in labor before their scheduled delivery, resulting in emergency cesarean delivery and increased…
- Trial name
- NCT07696325
- Testing
- SMS and Interactive Voice Response (IVR) Educational Intervention
- Where
- Uganda
- Volunteers
- 71 people
- Sponsor
- Massachusetts General Hospital
Gestational Diabetes Mellitus, Dietary Habits
A Study of the Intervention of Time-restricted Eating in High-risk Populations of GDM
This is a randomized controlled trial, aiming to investigate whether a time-restricted eating (TRE) can reduce the incidence of gestational diabetes mellitus (GDM) in high-risk pregnant women.
- Conditions
- Gestational Diabetes Mellitus, Dietary Habits, Lifestyle Intervention, Randomized Controlled Study
- Trial name
- NCT06431997
- Testing
- Time-limited eating
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Fudan University
Endometrial Cancer, Stage III Endometrial Cancer
A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer
The purpose of this study is to find out whether short-course radiation therapy (1 week instead of the usual 5 weeks) with chemotherapy (carboplatin and paclitaxel) is practical (feasible), meaning that most participants are able…
- Conditions
- Endometrial Cancer, Stage III Endometrial Cancer, Stage III Endometrial Carcinoma, Endometrial Carcinoma
- Trial name
- NCT05691010
- Testing
- Intensity-modulated radiation therapy, Carboplatin, Paclitaxel
- Where
- 7 sites in United States
- Volunteers
- 28 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
HIV Infections, Herpes Genitalis
HIV and Genital Herpes Among High-Risk Men Who Have Sex With Men (MSM) in Lima, Peru
The purpose of this study is to provide biomedical and behavioral information that is necessary for planning and starting HIV prevention trials in Lima, Peru.
- Conditions
- HIV Infections, Herpes Genitalis, HIV Seronegativity, Syphilis
- Trial name
- NCT00023582
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non Muscle Invasive Bladder Cancer
Study of CG0070 Given in Combination With Pembrolizumab, in Non-Muscle Invasive Bladder Cancer, Unresponsive to Bacillus Calmette-Guerin
To evaluate the activity of intravesical administration of CG0070 and intravenous administration of Pembrolizumab in patients with tissue pathology-confirmed non-muscle invasive bladder cancer (NMIBC) who have…
- Trial name
- CORE-001 (NCT04387461)
- Testing
- CG0070, Pembrolizumab Injection, n-dodecyl-B-D-maltoside
- Where
- 19 sites in United States, South Korea
- Volunteers
- 35 people
- Sponsor
- CG Oncology, Inc.
Cancer Harboring BRAF Alterations, HGG
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with BRAF altered (BRAF V600E or BRAF fusions) locally advanced or metastatic solid tumors, or recurrent or progressive…
- Conditions
- Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors
- Trial name
- NCT05503797
- Testing
- Plixorafenib
- Where
- 70 sites in United States, Australia and 10 more
- Volunteers
- 254 people
- Sponsor
- Fore Biotherapeutics
Asthma, Pulmonary Function
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring.
- Conditions
- Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
- Trial name
- VCSIP (NCT06106646)
- Testing
- No active intervention in this protocol (previously randomized to Vitamin C)
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- Oregon Health and Science University
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