Clinical trials: High-risk Pregnancy
Infant, Premature, Premature Birth
Comparing IM vs. Vaginal Progesterone for Pre-term Birth
This is a randomized controlled trial comparing weekly intramuscular injection of 17 alpha hydroxylprogesterone caproate with daily vaginal progesterone in women with singleton pregnancies and history of prior spontaneous preterm…
- Trial name
- NCT00579553
- Testing
- Intramuscular Progesterone, Vaginal Progesterone
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Fetal Growth Restriction, Perinatal Outcome
Relationship of DV Doppler Parameters to Perinatal Outcomes in IUGR vs Non-IUGR
This observational study investigates whether blood flow in the ductus venosus, a small fetal vein measured by Doppler ultrasound, is related to pregnancy outcomes.
- Conditions
- Fetal Growth Restriction, Perinatal Outcome, Pregnancy, High Risk
- Trial name
- DV-FGR (NCT07190157)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Izmir City Hospital
Family, Pregnancy, High Risk
The Effectiveness of MInding the Baby in a Danish Community Sample
Minding the Baby is an intensive and preventive home-visiting programme that helps vulnerable or high risk mothers. MTB is delivered by an interdisciplinary team.
- Trial name
- MTB (NCT03495895)
- Testing
- Minding the Baby, Usual Care
- Where
- Denmark
- Volunteers
- 256 people
- Sponsor
- VIVE - The Danish Center for Social Science Research
Pregnancy Related, Pregnancy Complications
MYFEMBREE®: A Retrospective Cohort Study Using an Administrative Healthcare Database to Assess Pregnancy Outcomes in Women Treated With Relugolix Combination Therapy
This is a retrospective cohort study that will be conducted using secondary de-identified electronic healthcare data (EHD) that originally were collected for the purposes of health insurance billing and/or routine patient care…
- Conditions
- Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk
- Trial name
- NCT05739136
- Testing
- Relugolix + Estradiol + Norethindrone Acetate
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Female Infertility, Ovarian Insufficiency
Efficacy Study Comparing the Effect of Clomiphencitrate to an Antagonist Protocol
The aim of this study is to assess the oocyte yield of infertile women with suspected or known poor ovarian reserve (POR) undergoing a GnRH antagonist protocol for IVF with Merional® starting either with a low (150 IU) or a high…
- Trial name
- CANTAPOR (NCT01577472)
- Testing
- High Dose Clomiphencitrat, Low Dose Clomiphencitrat
- Where
- Switzerland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
AKI (Acute Kidney Injury) Due to Trauma
Single-Center Prospective Study to Investigate the Difference in the Incidence of Contrast-Induced Nephropathy in High-Risk Patients With the Use of the Dye-Vert Plus System
Coronary angiography (CAG) for diagnostic or therapeutic purposes such as percutaneous coronary intervention (PCI) is one of the common procedures which require the use of intravenous contrast media.
- Trial name
- Dye-Vert Plus (NCT04279457)
- Testing
- DyeVert Plus System, Standardized hydration protocol
- Where
- United States
- Volunteers
- 1,802 people
- Sponsor
- CAMC Health System
Premature Birth, Respiratory Distress Syndrome, Newborn
High-Flow Nasal Cannula Versus Nasal CPAP as Primary Support in Preterm Respiratory Distress Syndrome
This single-center randomized controlled trial compared heated humidified high-flow nasal cannula (HHHFNC) with nasal continuous positive airway pressure (nCPAP) as primary noninvasive respiratory support in preterm infants…
- Trial name
- NCT07693530
- Testing
- Group 1 Heated humidified high-flow nasal cannula (HHHFNC), Group 2 Nasal continuous positive airway pressure (nCPAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Kayseri City Hospital
Abortion, Spontaneous
High Molecular Weight Hyaluronic Acid, α-lipoic Acid, Magnesium, Vitamin B6 and Vitamin D, in the Prevention of Spontaneous Abortion
The study aims to verify if the association of high molecular weight hyaluronic acid, α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D, reduces the risk of miscarriage in patients at risk.
- Trial name
- NCT05449171
- Testing
- high molecular weight hyaluronic acid, α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
High Risk Pregnancy
Antenatal High-Risk Pregnancy Intervention Bundle in Rural Nepal
The proposed study will assess and implement a comprehensive antenatal HRP screening and telehealth follow-up program in rural Nepal. The main questions it aims to answer are: 1.
- Trial name
- NCT07717619
- Testing
- High Risk Pregnancy Bundle
- Where
- Nepal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute Coronary Syndrome
Protective Effect of Early High Dose stATins On Cardiovascular and Renal Events in Acute Coronary Syndrome
Registration of all ACS patients (STEMI and NSTEMI) admitted to the cardiology ward and scheduled for early invasive strategy. The aim is to evaluate the protective effects of early (on admission) high-dose high-potency statin…
- Trial name
- PRATO-ACS (NCT04087200)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Centro Cardiopatici Toscani
Chronic Kidney Disease Stage 5, Mineral Metabolism Disorder
Acute Changes in the Mineral Metabolism After a High Phosphorous Containing Meal in Dialysis Patients
The purpose of the study is to investigate whether a high phosphorous containing meal causes acute changes in p-phosphate levels in patients with dialysis-dependent kidney failure.
- Trial name
- NCT03868371
- Testing
- High phosphorous containing meal, Low phosphorous containing meal
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Herlev Hospital
Hypertension, Coronary Disease
Analyzing How Genetics May Affect Response to High Blood Pressure Medications
High blood pressure is one of the most common health problems in the United States. There are many medications to treat high blood pressure, but there is a large variance in how people respond to these medications.
- Conditions
- Hypertension, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00563901
- Where
- 2 sites in United States
- Volunteers
- 37,939 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
NMIBC
SHR-1501 Combined With SHR-2005 for High-Risk Non-Muscle Invasive Bladder Cancer Which is Not Completely Resectable by TURBt
This is a single-center, single-arm, phase Ib/II study, aimed at assessing the safety and efficacy of SHR-1501 in combination with SHR-2005 as treatment for patients with high-risk non-muscle invasive bladder cancer (HR NMIBC)…
- Trial name
- NCT06588179
- Testing
- SHR-1501+SHR-2005
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Fudan University
Infant, Very Low Birth Weight
Liquid Preterm Formula Versus Powdered Human Milk Fortifier in VLBW Infants
This study aims to compare the short-term effects on growth and feeding tolerance of a liquid high calorie formula added to human milk versus powdered human milk fortifier in small preterm infants.
- Trial name
- NCT00760942
- Testing
- Similac special care 30, Similac human milk fortifier
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Oklahoma
Renal Carcinoma, Renal Mass
Robot-Assisted Ultrasound for Thermal Ablative Therapy in Treating Patients With Small Kidney Masses Undergoing Surgery
This clinical trial studies a type of ultrasound called robot-assisted laparoscopic high-intensity focused ultrasound for performing thermal ablative therapy, or sound wave therapy, in treating patients with small kidney masses…
- Trial name
- NCT02370342
- Testing
- Robot-Assisted Laparoscopic Surgery, High-Intensity Focused Ultrasound Ablation, Therapeutic Laparoscopic Surgery
- Where
- 2 sites in United States
- Sponsor
- University of Southern California
Chronic Kidney Diseases
Designing and Implementing a Safety Net Surveillance Program for High Risk CKD
The objective of this initiative is to develop and evaluate a risk-based, provincial public health screening program for chronic kidney disease (CKD) that provides proactive care for adults at high-risk of kidney failure who have…
- Trial name
- CKD Safety-Net (NCT07724288)
- Testing
- Letter to participants
- Where
- Canada
- Volunteers
- 972 people
- Sponsor
- University of Manitoba
Epithelial Ovarian Cancer
A Trial Using Novel Markers to Predict Malignancy in Elevated-Risk Women
The Novel Markers Trial will compare the safety, feasibility and effectiveness of two different epithelial ovarian cancer screening strategies that use CA125 and add HE4 as either a first or second line screen.
- Trial name
- NCT01121640
- Testing
- CA125 assay on Abbott Architect i1000SR platform, HE4 assay on Architect i1000SR platform, Transvaginal Ultrasound
- Where
- 5 sites in United States
- Volunteers
- 854 people
- Sponsor
- Fred Hutchinson Cancer Center
Dystocia
Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation
Oxytocin is a medication that is often used to strengthen contractions to overcome delayed labor progress. The primary aim of this study is to determine whether receiving a higher dose of oxytocin lowers the chance of needing a…
- Trial name
- NCT02487797
- Testing
- Oxytocin, Sodium Chloride 0.9%
- Where
- United States
- Volunteers
- 1,003 people
- Sponsor
- Northwestern University
Non-muscle Invasive Bladder Cancer
A Study to Evaluate Eciskafusp Alfa in Combination With Bacillus Calmette-guerin (BCG) in Participants With BCG-unresponsive High-risk Non-muscle Invasive Bladder Cancer (NMIBC)
The study aims to establish the safety, tolerability, pharmacokinetics (PK), relevant biomarkers, pharmacodynamics (PD) and preliminary anti-tumor activity of the intravesical administration of eciskafusp alfa in combination with…
- Trial name
- NCT06816017
- Testing
- Eciskafusp Alfa, BCG Medac Strain
- Where
- 9 sites in Australia, Italy and 4 more
- Sponsor
- Hoffmann-La Roche
Pregnancy Related, Thyroid Stimulating; Hormone, C
Correlation Between Levothyroxine and Blood Th17/Treg in Pregnant Women With Normal-high TSH and Positive TPOAb
The purpose of this clinical trial is to understand the impact of different doses of levothyroxine on the immune inflammatory response in pregnant women with normal-high TSH and positive TPOAb in the first half of pregnancy.
- Trial name
- NCT06527859
- Testing
- Levothyroxin
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital of Zhengzhou University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.