Clinical trials: Hip Replacement, Total
Blood Loss
Comparison of Topical and Intravenous Tranexamic Acid in Total Hip Arthroplasty
Recently, there has been interest in applying tranexamic acid topically before the closure of surgical wounds in total hip replacement.
- Trial name
- NCT02312440
- Testing
- 0.9% sodium chloride, tranexamic acid
- Where
- China
- Volunteers
- 173 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Complications; Arthroplasty, Infection or Inflammation, Wound Complication
Improvement in Wound Healing With Negative Pressure Wound Therapy for Postoperative Total Hip Arthroplasty
For the target population of adult patients following primary total hip arthroplasty, the randomized clinical trial will be used to evaluate the efficacy of the use of a mobile negative pressure wound therapy(NPWT) device…
- Trial name
- NCT02355691
- Testing
- PREVENA
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis of the Hip
A Prospective, Randomized Trial Comparing Same Day Discharge and Overnight Hospital Stay Among Total Hip Arthroplasties Done by the Direct Anterior Approach
The purpose of this study is to identify differences in satisfaction, pain and length of stay between patients undergoing hip replacement who are discharged from the hospital on the day of surgery compared to patients who stay…
- Trial name
- NCT02230657
- Testing
- Same day discharge, Next day discharge
- Where
- 2 sites in United States
- Sponsor
- Rothman Institute Orthopaedics
Total Hip Arthroplasty (THA) or Total Knee Arthroplasty (TKA), Preoperative Adductor Canal Block (ACB)
The Impact of Regional Motor-sparing Blocks on Early Rehabilitation Following Primary Hip or Knee Arthroplasty
The purpose of this study is to determine whether a single nerve block given before surgery can help patients regain independence and mobility more quickly after planned hip or knee replacement surgery for osteoarthritis.
- Conditions
- Total Hip Arthroplasty (THA) or Total Knee Arthroplasty (TKA), Preoperative Adductor Canal Block (ACB), Preoperative Pericapsular Nerve Group (PENG)
- Trial name
- NCT07834619
- Testing
- PENG Block with Ropivacaine, Adductor Canal Block with Ropivacaine, Subarachnoid anesthesia
- Where
- Poland
- Volunteers
- 220 people
- Sponsor
- Poznan University of Physical Education
Osteoarthritis, Degenerative Joint Disease
Postoperative Hip Precautions After Total Hip Arthroplasty Via the Posterior Approach: A Prospective Randomized Trial
The purpose of this study is to determine if hip precautions, which are instructions that limit functional use of a hip replacement after surgery, affect the rate of dislocation in the first six weeks after primary total hip…
- Trial name
- NCT02686528
- Testing
- Hip Precautions, No Hip Precautions
- Where
- United States
- Volunteers
- 1,133 people
- Sponsor
- Rush University Medical Center
Pain, Postoperative
Parecoxib for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty
Evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.
- Trial name
- NCT02272660
- Testing
- Parecoxib sodium, Normal saline injection
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Peking Union Medical College Hospital
Hip Fractures
Hemiarthroplasty Versus Total Hip Replacement for Intracapsular Hip Fractures
In England each year over 9,000 people fracture their hip. Most of these are elderly females with the fracture occurring after a fall.
- Trial name
- NCT02998359
- Testing
- Hemiarthroplasty, Total hip arthroplasty
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Peterborough and Stamford Hospitals NHS Foundation Trust
Venous Thromboembolism
Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Hip Replacement Surgery
The purpose of this study is to examine the superiority of YM150 to the placebo and to evaluate the dose-dependent response of YM150 in patients undergoing elective total hip replacement surgery.
- Trial name
- NCT00913120
- Testing
- YM150, Enoxaparin
- Where
- 16 sites in Japan, South Korea and 2 more
- Volunteers
- 610 people
- Sponsor
- Astellas Pharma Inc
Osteonecrosis, Osteoarthritis
A Short Metaphyseal Fitting Total Hip Arthroplasty in Young and Elderly Patients
The investigators determined whether 1. new short, metaphyseal-fitting cementless anatomical femoral stem provides major functional improvements 2. radiographically secure implant fixation is achieved with this new stem 3.
- Trial name
- NCT01345097
- Testing
- Total Hip Arthroplasty
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Ewha Womans University
Displaced Fracture Neck Femur, Total Hip Arthroplasty (THA)
Total Hip Arthroplasty Versus Bipolar Hemiarthroplasty for Treatment of Intracapsular Displaced Fracture Neck Femur in Elderly Active Patients
Femoral neck fracture (FNF) is a worldwide health problem that can cause significant morbidity and mortality. Most femoral neck fractures are associated with a fall, and the risk factors include osteoporosis, chronic medication…
- Conditions
- Displaced Fracture Neck Femur, Total Hip Arthroplasty (THA), Bipolar Hemiarthroplasty, Elderly Active Patients
- Trial name
- NCT07409909
- Testing
- Total Hip Arthroplasty, Bipolar Hemiarthroplasty
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Total Hip Replacement
Study of the Wear of a Highly Cross-linked Polyethylene Acetabular Doped With Vitamin E and Coated With Titanium in Total Hip Replacement
The total hip replacement, with over 120,000 cases per year in France, provides short term, excellent functional results and a significant improvement in quality of life, in almost all cases.
- Trial name
- POLYTITAN (NCT02524587)
- Testing
- standard polyethylene acetabular irradiated at 3 Mrad, radio stereometric analysis (RSA) of the acetabular, acetabular polyethylene vitamys®
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Caen
Arthropathy of Hip
A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty
A single preoperative dose of tranexamic acid (TXA) reduces blood loss and red blood cell transfusion in primary hip arthroplasty. Numerous regimens have been tested, ranging from 10mg/kg up to 3g.
- Trial name
- PRADO (NCT03822793)
- Testing
- Group 1: perfusion of 300 mg Exacyl, Group 2: perfusion of 500 mg Exacyl, Group 3: perfusion of 1000 mg Exacyl
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Osteoarthritis
"Score Infectivity" During Reoperation on Total Hip or Knee Prosthesis
The hip or knee is a validated treatment of end-stage osteoarthritis, and these interventions commonly make a significant improvement in the quality of life of patients. Infection can occur in 1-5% of cases.
- Trial name
- NCT02467764
- Testing
- Retrospective study
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Osteoarthritis
A Trial Comparing Mini-posterior Approach and Direct Anterior Approach
The purpose is to determine if differences exist in the attainment of functional milestones that reflect activities of daily living between mini-posterior and direct anterior approach total hip arthroplasty (THA).
- Trial name
- NCT01024309
- Testing
- Mini-Posterior surgical approach for total hip arthroplasty, Direct Anterior surgical approach for total hip arthroplasty
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Postoperative Pain, Total Hip Arthroplasty (THA)
Safety and Efficacy of Dexamethasone Versus Dexmedetomidine as Adjuvants in PENG Block in Hip Surgeries for Postoperative Pain Management
This study evaluates and compares the analgesic efficacy and safety of adding dexamethasone versus dexmedetomidine to bupivacaine in an ultrasound-guided pericapsular nerve group (PENG) block combined with a lateral femoral…
- Trial name
- NCT07847047
- Testing
- Bupivacaine 0.25%, Dexamethasone, Dexmedetomidine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Total Hip Replacement
Digital Healthcare App After Total Hip Arthroplasty
This study examines the effectiveness of rehabilitation after hip replacement surgery using a specialised app called Akina Cloud. Medical professionals at the Schulthess Clinic will provide detailed information about the study.
- Trial name
- NCT06409312
- Testing
- Akina Cloud
- Volunteers
- 20 people
- Sponsor
- Schulthess Klinik
Osteoarthritis
Inpatient vs Outpatient Total Hip Replacement
This study is a pragmatic randomized clinical trial comparing standard inpatient total hip arthroplasty with same day discharge.
- Trial name
- NCT03026764
- Testing
- Outpatient, Inpatient
- Where
- Canada
- Volunteers
- 558 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Total Knee Replacement, Total Hip Replacement
Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)
The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee and hip arthroplasty could be observed with the substitution of Intravenous meloxicam for ketorolac in the…
- Trial name
- NCT05291598
- Testing
- IV meloxicam, Ketorolac
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- University of Miami
Delirium, Hip Arthroplasty
Delirium, Intraoperative Cerebral Perfusion and EEG Abnormalities After Total Hip Arthroplasty
The overall objective of this study is to test for perturbations in intraoperative electroencephalogram (EEG) , cerebral blood flow (CBF), cerebral metabolic rate of oxygen consumption (CMRO2), oxygen extraction fraction (OEF)…
- Conditions
- Delirium, Hip Arthroplasty, Elderly
- Trial name
- NCT02818764
- Testing
- Blood Draw, Cerebral Spinal Fluid collection, Electroencephalogram
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Pennsylvania
Quadratus Lumborum Block
Transmuscular Quadratus Lumborum Block on Post-Operative Analgesia After Total Hip Arthroplasty
The aim of this study is to compare between the post-operative analgesic effect of two approaches of transmuscular quadratus lumborum block (transverse versus paraspinous sagittal transmuscular QLB) in total hip replacement…
- Trial name
- NCT05465967
- Testing
- Quadratus lumborum Block
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tanta University
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