Clinical trials: Hip Replacement Arthroplasty
Osteoarthritis, Hip Infection
Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement
Infection remains one of the most difficult-to-treat complications of total hip arthroplasty. The gold standard treatment is two-stage removal of the prosthesis with later replacement of permanent implants.The first stage…
- Conditions
- Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation
- Trial name
- SPACERHIP (NCT01373099)
- Testing
- Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rush University Medical Center
Drainage
Evaluating the Effectiveness of 2 Surgical Skin Preparation Methods in Reducing Surgical Wound Drainage After Total Hip or Knee Replacement
Surgical skin complications can be costly and could contribute to extended in-patient stay following total joint replacement or even the need for re-admission.
- Trial name
- NCT01097135
- Testing
- Duraprep Surgical Solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Rothman Institute Orthopaedics
Avascular Necrosis of Hip
THRA_hematologic Variables
Total hip replacement arthroplasty is a surgery having intra- and postoperative substantial blood loss. The investigators will investigate the relationship between the various hematologic variables and postoperative bleeding…
- Trial name
- NCT01521858
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Bundang Hospital
Surgery, Cholecystectomy, Laparoscopic
Benefits of 'Repeat Back' Protocols Within A Computer-Based Informed Consent Program
This is a VA Merit Review Study involving 7 VA medical centers participating in a parallel group randomized trial comparing "repeat back" versus standard electronic consent for 4 common elective surgical procedures (total hip…
- Conditions
- Surgery, Cholecystectomy, Laparoscopic, Prostatectomy, Arthroplasty, Replacement, Hip
- Trial name
- NCT00288899
- Testing
- Enhanced surgical iMedConsent process (with "repeat back"), standard surgical iMedConsent process
- Where
- 7 sites in United States
- Volunteers
- 575 people
- Sponsor
- VA Office of Research and Development
Pain, Postoperative, Opioid Overdose
Ultrasound-guided PENG Block in Total Hip Replacement
This randomized controlled study will be carried out on 60 adult patients undergoing primary total hip replacement in Tanta University Hospitals.
- Trial name
- NCT04984109
- Testing
- Real PENG block
- Where
- Egypt
- Volunteers
- 71 people
- Sponsor
- Tanta University
Delirium
Effect of Nasal Spray Dexmedetomidine on Emergence Delirium Prevention in Total Hip Replacement
Emergence Delirium (ED) is a common postoperative complication refers to an acute brain dysfunction that occurs during the recovery from general anesthesia, which is mainly characterized by sudden attention and consciousness…
- Trial name
- NCT06579001
- Testing
- Nasal spray dexmedetomidine
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Osteoarthritis, Knee, Osteoarthritis, Hip
Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)
The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total joint arthroplasty, as compared to standard of care analgesia.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
- Trial name
- NCT02197273
- Testing
- Liposomal bupivacaine, Standard of care analgesia
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- OhioHealth
Surgical, Anxiety
Virtual Reality Therapy to Improve Arthroplasty Outcomes
Virtual reality (VR) has recently emerged as a non-medication-based method to manage anxiety. The patient wears a VR headset and is offered an immersive environment with hypnotic components with sound and imagery in a 3D…
- Conditions
- Surgical, Anxiety, Pain Management, Joint (Knee or Hip Replacement)
- Trial name
- VROOM (NCT07872670)
- Testing
- Virtual Reality Headset, Blood Samples, Questionnaires
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- NHS Highland Research, Development and Innovation Organisation
Pain, Postoperative, Arthroplasty Complications
Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty
Prospective randomized double blinded, placebo controlled study that will evaluate the effect of intra-operative ketamine administration on post-operative analgesic requirements and self-reported pain in patients undergoing total…
- Trial name
- NCT04437888
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hip Arthroplasty Replacement
Follow up Study of Patients Undergoing Total Hip Arthroplasty CERAFIT® Grafted With Poly Sodium Styrene Sulfonate
The risk of infection after primary Total Hip Arthroplasties (THA)is generally estimated to be less than 1% but remains a severe and costly complication, source of morbidity and even mortality.
- Trial name
- NCT01454271
- Testing
- Total Hip Arthroplasty Replacement
- Where
- France
- Sponsor
- Societe ACTIVBIOMAT
Hip Replacement Arthroplasty
Stimulating Catheter for Lumbar Plexus Block: Better Postoperative Analgesia?
Stimulating catheters have been introduced to reduce the incidence of secondary failure after continuous peripheral nerve blocks, but they effectiveness over traditional nonstimulating catheters is still controversial.
- Trial name
- NCT02162121
- Testing
- Continuous lumbar plexus: stimulating catheter, Spinal Anesthesia, Local anesthetic infusion
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- ASST Gaetano Pini-CTO
Cement Syndrome, Hypotension and Shock
Role of Inferior Vena Cava Dispensability Index in Predicting Hypotension of Cement Syndrome in Hip Replacement Surgery Under General Anaesthesia
The aim of the study is to evaluate ICV distensibility index for predicting the incidence of hypotension following cementation in orthopedic hip replacement surgery in patient undergoing general anaesthesia
- Trial name
- NCT07669376
- Testing
- Ultrasound measurement of IVC
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Rehabilitation, Analgesia
Observational Prospective Study of Opiate-free Anesthesia for Anterior Total Hip Replacement
Opioid-free anesthesia (ATO) is a multimodal anaesthesia combining different analgesic and anesthetic modalities thus excluding opiates as an intraoperative.
- Conditions
- Rehabilitation, Analgesia, Anesthesia
- Trial name
- ASOPHA (NCT04112277)
- Testing
- Cumulative morphine consumption
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hôpital Privé Sévigné
Knee Pain Chronic, Knee Pain Swelling
Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant to Medical Treatment. A Prospective Randomized Controlled Trial
The goal of this clinical investigation is to evaluate the effectiveness on pain of arterial occlusion (embolization) of neovessels by microparticle in a double-blind sham controlled randomised trial in patients with persistent…
- Trial name
- EPROGE (NCT06466330)
- Testing
- microparticles, embolization
- Where
- 11 sites in France
- Volunteers
- 112 people
- Sponsor
- Societe Francaise de Rhumatologie
Hip Replacement
Quadratus Lumborum Block Versus Fascia Iliaca Nerve Block for Patients Undergoing Total Hip Replacement
Investigators hypothesise that for patients undergoing elective total hip replacements, a single injection Transmuscular Quadratus Lumborum (TQL) block, when compared to a single injection Fascia Iliaca Block (FIB), will provide…
- Trial name
- NCT03551860
- Testing
- TQL, FIB
- Where
- Ireland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
Arthroplasty, Replacement, Hip, Anesthesia, Spinal
Goal Directed Fluid Therapy Versus Liberal Fluid Regimen in Primary Elective Hip Artrhoplasty
Patients undergoing elective primary total hip replacement and spinal anesthesia may encounter significant hemodynamic instability.
- Conditions
- Arthroplasty, Replacement, Hip, Anesthesia, Spinal, Hemodynamic Monitoring, Crystalloid Solutions
- Trial name
- NCT04996420
- Testing
- Clearsight non invasive hemodynamic monitoring
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Femoral Neck Fractures
Direct Anterior Approach for Femoral Neck Fractures
The primary objective is to examine if in patients with a dislocated femoral neck fracture who receive a total hip arthroplasty, direct anterior approach will give a better result in terms of mobilization, function and pain in…
- Trial name
- NCT03695497
- Testing
- Direct anterior approach, Direct Lateral Approach
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- Helse Møre og Romsdal HF
Arthroplasty, Hip Replacement, Arthroplasty, Knee Replacement
Early Perioperative Quality Of Recovery After Hip and Knee Arthroplasty: a Retrospective Comparative Cohort Study
Hip and knee replacements are indicated to improve long-term quality of life and pain. These long-term results may depend on the quality of the initial postoperative recovery.
- Trial name
- EARLY-QoR (NCT06107296)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Strasbourg, France
Post-operative Pain, Total Hip Arthroplasty (THA)
Ultrasound Guided Lumbar Erector Spinae Block Using Bupivacaine - Magnesium Sulphate Versus Bupivacaine - Dexamethasone in Total Hip Replacement Surgery
The current study was done to evaluate the effect of adding dexamethasone and magnesium sulfate to bupivacaine as adjuvants in an ultrasound-guided erector spinae block for patients undergoing total hip arthroplasty (THA), and to…
- Conditions
- Post-operative Pain, Total Hip Arthroplasty (THA), Erector Spinae Plane Block
- Trial name
- NCT07418671
- Testing
- Bupivacaine-Magnesium Sulphate, Bupivacaine-Dexamethasone, Bupivacaine-Saline
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Arthroplasty, Replacement, Hip
Longjohn Amgen Study - Effect of Denosumab...
The overall objective of the proposed study is to quantify bone loss around non-cemented total hip replacement femoral and acetabular components using DEXA analysis in patients receiving Prolia (denosumab) in the first year of…
- Trial name
- EDRPBLFHR (NCT02444585)
- Testing
- Denosumab
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California