Clinical trials: Hip Replacement Arthroplasty
Primary Osteoarthritis, Secondary Osteoarthritis
Anthology Hip Replacement System - Orthopaedic Data Evolution Panel (ODEP) Surveillance Study
This clinical study will verify the clinical and radiographic performance of the prosthesis when used in human subjects over a period of 10 years. All complications will be documented.
- Conditions
- Primary Osteoarthritis, Secondary Osteoarthritis, Avascular Necrosis, Primary Total Hip Replacement (THR)
- Trial name
- NCT04425603
- Testing
- Anthology Hip Replacement System
- Where
- 4 sites in United Kingdom
- Volunteers
- 270 people
- Sponsor
- Smith & Nephew Orthopaedics AG
Hip Pain
Metal Ion Levels in Stryker Trident II Tritanium System with Modular Dual Mobility (MDM) Liner, Ceramic Head, and SecurFit Advanced Stems
Metal Ions levels of cobalt, chromium, and titanium in 40 patients preoperatively and at least 1 year status post total hip replacement with the Trident II Tritatnium system using an MDM liner and ceramic head.
- Trial name
- NCT03433742
- Testing
- Blood levels drawn
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Pain, Postoperative
Safety and Efficacy Study of KAI-1678 to Treat Subjects With Postoperative Pain
The purpose of this study is to determine whether KAI-1678 is effective in the treatment of postoperative pain following total hip or total knee replacement.
- Trial name
- NCT01015235
- Testing
- KAI-1678, Ketorolac Tromethamine
- Where
- New Zealand
- Volunteers
- 90 people
- Sponsor
- KAI Pharmaceuticals
Pain, Total Knee Replacement
Predicting, Understanding and Speeding Recovery After TKA
The objective of this research study is to better understand patterns of recovery after Total Knee Arthroplasty (TKA) amd Total Hip Replacement (THA).
- Conditions
- Pain, Total Knee Replacement, Total Hip Replacement
- Trial name
- NCT02685735
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain, Total Hip Replacement
Morphine COnsumption in Joint Replacement Patients, With and Without GaBapentin Treatment, a RandomIzed ControlLEd Study
Total hip arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain in these patients.
- Trial name
- MOBILE (NCT00889148)
- Testing
- Gabapentin
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- McMaster University
Knee Replacement, Hip Replacement
Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement
The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
- Conditions
- Knee Replacement, Hip Replacement, Hyperglycemia
- Trial name
- HyTe-1 (NCT01021826)
- Where
- Finland
- Volunteers
- 193 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Hip Injuries, Surgery
Benefit of 3-D Planning in Total Hip Replacement. A Prospective Randomized Study
In this prospective randomized four-armed study the investigators aim to compare wheter 3-D planning, which necessitates preoperative CT acquisition and sophisticated planning together with engineers, results in measurable…
- Conditions
- Hip Injuries, Surgery, Prosthesis User
- Trial name
- NCT05120063
- Testing
- SPS monoblock stem, Symbios, Quadra-H, Medacta, 3D planning of THR
- Volunteers
- 133 people
- Sponsor
- Balgrist University Hospital
Total Hip Arthroplasty, Total Knee Arthroplasty
Autologous Blood Transfusion After Local Infiltration
Total knee and hip arthroplasty for osteoarthritis is performed on still broader indications even in elderly patients with previous or current medical conditions.
- Trial name
- NCT01576263
- Testing
- Autologous blood transfusion with ropivacaine
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Arthroplasty, Osteoarthritis
Efficacy of Preoperative Muscle Training on Postoperative Orthopaedic Surgery Recovery
The purpose of this study is to assess the effectiveness of a preoperative muscle training program on hip or knee TJA (Total Joint Arthroplasty).
- Trial name
- NCT03483519
- Testing
- Rehabilitation, Standard of Care
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thromboembolism
Xarelto Regulatory Post-Marketing Surveillance
This study is to identify the following problems and questions with respect to the safety and effectiveness of Xarelto in comparison with other pharmacologic agents in the prophylaxis of venous thromboembolism (VTE) in a large…
- Trial name
- NCT01029743
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Pharmacologic agents (e.g. LMWH/VKA/Fondaparinux/Aspirin and etc.)
- Where
- South Korea
- Volunteers
- 3,388 people
- Sponsor
- Bayer
Primary Total Hip Replacement
A DEXA Clinical Study to Evaluate the Osteointegrative Potential of Trabecular Titanium™
The purpose of this clinical trial is to evaluate the osteointegrative potential of the Trabecular TitaniumTM and to measure the pattern of changing in bone mineral density (BMD) around an uncemented acetabular cup, manufactured…
- Trial name
- NCT02635581
- Testing
- Delta TT acetabular cup
- Where
- 4 sites in Italy
- Volunteers
- 84 people
- Sponsor
- Limacorporate S.p.a
Arthroplasty
Efficacy and Safety Study of 4975 in Patients Undergoing Total Hip Replacement
Evaluate the efficacy, safety and tolerability of a single intraoperative dose of 4975 in patients undergoing total hip replacement
- Trial name
- NCT00683267
- Testing
- 4975, highly purified capsaicin
- Where
- 10 sites in United States
- Volunteers
- 118 people
- Sponsor
- Anesiva, Inc.
Pain, Postoperative
PAracetamol and NSAID in Combination: A Randomised, Blinded, Parallel, 4-group Clinical Trial
Trial name: PAracetamol and NSAID in combination: A randomised, blinded, parallel, 4-group clinical trial Trial acronym: PANSAID Background: Effective postoperative pain management is essential for the well-being and…
- Trial name
- PANSAID (NCT02571361)
- Testing
- Paracetamol (1g x 4), Ibuprofen (400 mg x 4), Paracetamol (0,5 g x 4)
- Where
- 6 sites in Denmark
- Volunteers
- 556 people
- Sponsor
- Daniel Hägi-Pedersen
Pain, Postoperative
Oxycodone vs. Fentanyl in Early Postoperative Pain After Total Hip Replacement
Oxycodone is one of the most widely used opioids for pain treatment. Many studies demonstrated good efficacy of oxycodone on postoperative pain.
- Trial name
- NCT03019562
- Testing
- Oxycodone, Fentanyl
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Kyunghee University Medical Center
Patients Requiring Hip Replacement
MASTER SL Clinical Study
The purpose of this study is: to generate data to evaluate Orthopaedic Data Evaluation Panel (ODEP) rating to support existing short-term clinical results and CE documentation; to assess the clinical performance of the MASTER SL…
- Trial name
- NCT02126345
- Testing
- MASTER SL femoral stem and DELTA TT acetabular cup
- Where
- 4 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- Limacorporate S.p.a
Postoperative Pain
Comparison of the Efficacy of PENG Block in Combination With LFCN Block and Wound Infiltration
The ultrasound-guided approach for the blockade of articular branches of femoral and obturator nerves, pericapsular nerve group (PENG) block, is an effective method for postoperative analgesia in hip surgeries.
- Trial name
- NCT04681222
- Testing
- LFCN, Wound infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Derince Training and Research Hospital
Total Hip Replacement, Wound Complication
Hip DAA Closure Techniques
This study aims to analyze the difference in rates of wound complications using two different closure techniques in Direct anterior approach for primary total hip replacement.
- Trial name
- NCT06006572
- Testing
- wound closure subcuticular running stitch using 3-0 monocryl suture without skin adhesive, wound closure subcuticular running stitch using 3-0 monocryl suture with two layers of skin adhesive
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthritis, Hip, Total Hip Arthroplasty
Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA
Aim: To compare the effect of one single dose versus multiple doses of prophylactic antibiotics administered within 24 hours, on the development of PJI in patients with osteoarthritis undergoing primary THA.
- Conditions
- Osteoarthritis, Hip, Total Hip Arthroplasty, Prosthetic-joint Infection
- Trial name
- ProHipQ-OA (NCT05530551)
- Testing
- Antibiotic dosage practice
- Where
- 36 sites in Denmark
- Volunteers
- 20,000 people
- Sponsor
- Soren Overgaard
Arthroplasty, Replacement, Hip, Osteoarthritis, Hip
Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement.
Total hip replacement is the most successful treatment modern healthcare can offer patients to regain quality of life. Periprosthetic joint infection (PJI) is the most common and devastating complication after total hip…
- Conditions
- Arthroplasty, Replacement, Hip, Osteoarthritis, Hip, Antibiotic Resistant Infection, Prosthetic Joint Infection
- Trial name
- ABOGRAFT (NCT05169229)
- Testing
- Vancomycin + Tobramycin, Saline
- Where
- Sweden
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Linkoeping
Pain, Postoperative
Analgesic Efficacy, Safety and Tolerability of Two Paracetamol-Containing Solutions in Post-Surgical Hip Replacement Pain
The aim of the study is to evaluate the therapeutic efficacy, safety and local tolerability of two different paracetamol-containing solutions in postoperative total hip replacement.
- Trial name
- NCT00508495
- Testing
- Paracetamol (acetaminophen), Paracetamol 1% solution, 0.9% sodium chloride solution
- Where
- 8 sites in Hungary
- Volunteers
- 148 people
- Sponsor
- Baxter Healthcare Corporation