Clinical trials: Hip or Knee Surgery
Osteoarthritis
Pain Expectations in Subjects With Osteoarthritis
The purpose of this research study is to test whether or not researchers can alter or change expectations on pain. The researchers will test whether there is an effect on the size of the pupil and responses to thermal heat…
- Trial name
- NCT02155257
- Testing
- Modafinil, Gabapentin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Total Knee Replacement, Total Hip Replacement
New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery
LY517717 (a capsule given by mouth) is a blood thinner that may prevent blood clots from forming in the legs and may prevent those blood clots from traveling to the lungs.
- Trial name
- NCT00074828
- Testing
- LY517717, enoxaparin
- Where
- 8 sites in Australia, Austria and 6 more
- Volunteers
- 511 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis (OA), Osteoarthritis (OA) of the Hip
Evaluation of Choose to Move Replacement Ready (CTM-RR)
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada.
- Conditions
- Osteoarthritis (OA), Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Total Knee Anthroplasty
- Trial name
- CTM-RR (NCT07696650)
- Testing
- Choose to Move Replacement Ready
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
Osteoarthritis, Depression
Psychological, Sexually and Social Consequences of Osteoarthritis Treatment With THA or TKA and Joint Preserving Surgery
The project runs as a Ph.d. project at the Faculty of Health Sciences- University of Copenhagen. In Denmark the investigators operate around 16.000 artificial hips and knees yearly, mainly due to osteoarthritis.
- Conditions
- Osteoarthritis, Depression, Hip Dysplasia
- Trial name
- NCT01305759
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Hvidovre University Hospital
Linear or Emi-linear Incisions, Total Hip Arthroplasty
Prevena™ Incision Management System Over Primarily Closed Hip and Knee Incisions in Patients Immediately Post Total Hip and Knee Arthroplasty
The intent of this study is to evaluate the Prevena ™ 125 Unit and dressing system, when applied to either the hip or knee area over a surgical cut for the time you are hospitalized.
- Conditions
- Linear or Emi-linear Incisions, Total Hip Arthroplasty, Total Knee Arthroplasty
- Trial name
- Prevena2009-45 (NCT01380665)
- Testing
- Prevena Incisional Management System
- Sponsor
- KCI USA, Inc
Arthroplasty, Replacement, Thromboembolism
Pradaxa (Dabigatran Etexilate 220 mg/q.d. in the General Population After Hip or Knee Replacement Surgery
An observational cohort study on safety and efficacy of the 220 mg dose Pradaxa to generate additional data in predefined sub populations of patients at increased risk of bleeding or VTE
- Trial name
- NCT00846807
- Where
- 112 sites in Austria, France and 7 more
- Volunteers
- 5,476 people
- Sponsor
- Boehringer Ingelheim
Old Age, Knee Replacement Surgery
Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality
Sleep disturbances are prevalent in older patients with osteoarthrosis or fracture who are scheduled for knee or hip replacement surgery.
- Conditions
- Old Age, Knee Replacement Surgery, Hip Replacement Surgery, Dexmedetomidine
- Trial name
- NCT05950646
- Testing
- Dexmedetomidine, Esketamine, Normal saline
- Where
- 2 sites in China
- Volunteers
- 154 people
- Sponsor
- Peking University First Hospital
Prophylaxis, Thromboembolism, Venous, Total Knee Replacement
Study to Observe Safety of Xarelto in VTE Prophlylaxis After Elective TKR (Total Knee Replacement) or THR (Total Hip Replacement)
The primary objective of this study is to evaluate the safety of Xarelto in the prophylaxis of VTE in Indian patients undergoing elective TKR/THR
- Conditions
- Prophylaxis, Thromboembolism, Venous, Total Knee Replacement, Total Hip Replacement
- Trial name
- XYRIS (NCT01523418)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Sponsor
- Bayer
Osteoarthritis, Pain
Study of Safety, Efficacy of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3007
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as adjunctive therapy compared with placebo in participants with signs and symptoms of osteoarthritis of the hip or knee that are…
- Trial name
- NCT02301234
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg, Celecoxib 100 mg
- Where
- 64 sites in United States, Australia and 9 more
- Volunteers
- 111 people
- Sponsor
- Janssen Research & Development, LLC
Pain, Anxiety State
App Delivered Brief Mindfulness Intervention for Surgical Patients
This will be a single-site, five-arm, parallel group randomized control trial involving patients undergoing knee or hip replacement surgery.
- Conditions
- Pain, Anxiety State, Depressive State
- Trial name
- NCT05433389
- Testing
- Breath Counting, Body Scan, Mindful Breathing
- Where
- United States
- Volunteers
- 823 people
- Sponsor
- University of Utah
Arthritis, Osteoarthritis, Knee
Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement
The study will describe the short-term effects the study drug, rivaroxaban, has on the body when a patient is switched from enoxaparin injection (by needle) to oral rivaroxaban (by mouth) for the prevention of blood clotting in…
- Conditions
- Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
- Trial name
- NCT01094886
- Testing
- Rivaroxaban
- Where
- 5 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Total Knee Arthroplasty, Total Hip Arthroplasty Revision
Interventional Study Exploring the Occurrence of Surgical Site Infections.
Interventional study exploring surgical site complication occurrences in high-risk revision patients undergoing TKA or THA using NPWT.
- Conditions
- Total Knee Arthroplasty, Total Hip Arthroplasty Revision, Total Knee Arthroplasty Revision
- Trial name
- NCT06661473
- Testing
- Avance Solo Negative Pressure Wound Therapy
- Where
- 8 sites in United States
- Volunteers
- 104 people
- Sponsor
- Molnlycke Health Care AB
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Effects of Preoperative Education, and Follow-up Sessions of Patients With Total Hip and Knee Arthroplasty (ESIPPES)
The shortening of the length of stay implies rethinking the perioperative management (around the operative period), which precedes and immediately follows the operation, in order to ensure a good preparation of the patient and an…
- Trial name
- ESIPPES (NCT05452161)
- Testing
- Control group, Intervention group A, Intervention group B
- Where
- Switzerland
- Volunteers
- 163 people
- Sponsor
- Haute Ecole de Santé Vaud
Anesthesia
Audiovisual Distraction for Patients Undergoing Total Knee or Hip Replacement Surgery
The primary purpose of this study is to investigate whether audiovisual distraction can lead to a reduction in standard of care administered intraoperative propofol consumption compared to those who receive propofol sedation…
- Trial name
- NCT03191838
- Testing
- Audiovisual Distraction
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Opioid Use, Pain, Post Operative
A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery
Opioid addiction in post-operative patients is recognized but not fully understood; therefore, in order to address this growing crisis, it is essential to explore alternative approaches to managing pain and apply them to the…
- Trial name
- NCT05252858
- Testing
- nCAP Signal Relief Patch, Standard of Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Jacques E. Chelly
Prehabilitation, Knee Osteoarthritis
Effectiveness of a Prehabilitation Program for Hip or Knee Arthroplasty Surgery.
We live in an increasingly aging society in which the incidence of osteoarticular diseases increases, among which osteoarthritis (OA) stands out.
- Conditions
- Prehabilitation, Knee Osteoarthritis, Hip Osteoarthritis, Physical Therapy Modalities
- Trial name
- Preoperative (NCT06721897)
- Testing
- Prehabilitation Program, Non prehabilitation Program
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Jaén