Clinical trials: Histological Response
Lymphoma, Follicular
Positron Emission Tomography (PET)-Scan in the Evaluation of High Tumor Burden Follicular Lymphoma
The purpose of the study is to assess in a prospective series of patients with high tumor burden follicular lymphoma treated with R-CHOP, the predictive value of [18F]-FDG PET performed over (after 4 treatments), and at the end…
- Trial name
- NCT00915096
- Where
- 22 sites in France, Italy
- Volunteers
- 121 people
- Sponsor
- Lymphoma Study Association
Breast Cancer
Histology VABB-Histology Post Surgery Pilot Project (BETTY Trial)
Pilot study on patients with invasive ductal breast cancer triple negative or receptor tyrosine-protein kinase erbB-2 (HER2) overexpressed, any axillary lymphnodes status (any cN), candidates to neoadjuvant chemotherapy.
- Trial name
- BETTY (NCT04365803)
- Testing
- vacuum-assisted breast biopsy
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- European Institute of Oncology
Mantle Cell Lymphoma
A Study of MabThera (Rituximab) Plus Standard Chemotherapy in Patients With Previously Untreated Mantle Cell Lymphoma.
This single arm study will evaluate the benefit of adding MabThera to standard induction chemotherapy in patients with newly diagnosed mantle cell lymphoma.
- Trial name
- NCT00472420
- Testing
- rituximab [MabThera/Rituxan], First line chemotherapy
- Where
- 7 sites in Hungary
- Volunteers
- 48 people
- Sponsor
- Hoffmann-La Roche
Nasopharyngeal Carcinoma (NPC)
Reduced-dose Versus Conventional-dose Intensity-modulated Radiation Therapy for Locally Advanced Nasopharyngeal Carcinoma With Remission After Induction Chemotherapy and Immunotherapy
To explore the efficacy and safety of reduced-dose radiotherapy combined with concurrent chemotherapy and immunotherapy in stage Ⅳa (AJCC 8th,) locally advanced nasopharyngeal carcinoma patients who are sensitive to induction…
- Trial name
- NCT07328841
- Testing
- Full course of PD-1blockades, Cisplatin-based induction chemotherapy, Standard-dose radiotherapy
- Where
- 12 sites in China
- Volunteers
- 456 people
- Sponsor
- Ming-Yuan Chen
Soft Tissue Sarcoma
Predictive Models of Treatment Responses and Survival Outcomes in Patients With Soft Tissue Sarcoma
The aim of this study was to developed and validated models to predict therapeutic responses and patients' survivals in patients with soft tissue sarcoma and compared these models with currently available models.
- Trial name
- NCT05171413
- Testing
- Prediction model
- Where
- China
- Volunteers
- 800 people
- Sponsor
- West China Hospital
Amyloidosis; Systemic
BCD With or Without Doxycycline in Mayo Stage II-III Light Chain Amyloidosis Patients
Survival of intermediate and high-risk primary light chain amyloidosis (pAL) remains poor due to high mortality within 3-6 months of diagnosis.
- Trial name
- NCT03401372
- Testing
- Doxycycline, Bortezomib, Cyclophosphamide
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Jian Li
Non-Small Cell Lung Cancer, Renal Cell Carcinoma (RCC)
A Pilot Study of Blood-based Biomarkers for Response to Immune Checkpoint Inhibitors
A pilot study evaluating baseline and on-treatment changes in tumor fraction (TFx) in peripheral blood in patients with NSCLC and RCC being treated with checkpoint inhibitor therapy as part of standard of care.
- Trial name
- NCT06630429
- Testing
- Biospecimen Collection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Gingival Pigmentation
The Adjunctive Role of Vitamin C on Pigment Recurrence (Randomized Clinical and Histological Trial)
The goal of this clinical trial is to determine the role of vitamin C on recurrence of gingival pigment after patients who are healthy and esthetically concerned with it received surgical removal of this pigment.
- Trial name
- NCT06312605
- Testing
- Injectable applied vitamin C, Topical applied Vitamin C, Surgical depigmentation only
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acute Myeloid Leukemia
FLT PET/CT in Measuring Response in Patients With Previously Untreated Acute Myeloid Leukemia
This phase II trial studies fluorothymidine F 18 (FLT) positron emission tomography (PET)/computed tomography (CT) in measuring response in patients with previously untreated acute myeloid leukemia.
- Trial name
- NCT02392429
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 11 sites in United States
- Volunteers
- 87 people
- Sponsor
- National Cancer Institute (NCI)
Prematurity, Histologic Chorioamnionitis
Infant Immune Response to Bacterial Infection
This study will examine the response of white blood cells to bacterial infection in blood taken from the umbilical cords of newly delivered infants.
- Trial name
- NCT00546195
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Glioblastoma
FDG PET/CT in Monitoring Very Early Therapy Response in Patients With Glioblastoma
This pilot clinical trial studies fluordeoxyglucose (fludeoxyglucose) F-18 (FDG) positron emission tomography (PET)/computed tomography (CT) in monitoring very early therapy response in patients with glioblastoma.
- Trial name
- NCT02902757
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Positron Emission Tomography
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Biliary Tract Cancer, Cholangiocarcinoma
Biomarker Discovery in Patients With Advanced Biliary Tract Cancer
Biliary tract cancer is a rare gastrointestinal malignant neoplasm and includes intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gall bladder cancer.
- Conditions
- Biliary Tract Cancer, Cholangiocarcinoma, Gallbladder Cancer
- Trial name
- NCT04871321
- Testing
- nab-paclitaxel plus gemcitabine-cisplatin
- Where
- South Korea
- Volunteers
- 119 people
- Sponsor
- CHA University
Acute Myeloid Leukemia, in Relapse
A Prospective, Interventional Study Assessing Response to Cytarabine, Daunorubicin and Etoposide (ADE) for First Relapse of Paediatric Acute Myeloid Leukemia
One-third to one-half of patients with AML relapse and in general relapsed AML patients have a poor prognosis. The treatment of relapsed AML consists of induction chemotherapy followed by Allogenic Stem Cell Transplant (ASCT).
- Trial name
- NCT03053206
- Testing
- ADE Protocol
- Volunteers
- 84 people
- Sponsor
- All India Institute of Medical Sciences
Hepatocellular Carcinoma (HCC), Liver Neoplasms
Validation of Blood-Based Biomarkers in TACE-Treated Hepatocellular Carcinoma
The goal of this prospective observational study is to validate the clinical utility of specific blood-based biomarkers for predicting and monitoring treatment response in patients with hepatocellular carcinoma (HCC) undergoing…
- Trial name
- BLOOD-TACE-M (NCT07414433)
- Where
- Serbia
- Volunteers
- 60 people
- Sponsor
- University of Belgrade
Oropharyngeal Squamous Cell Carcinoma
Lattice-Based Radiotherapy and Chemoimmunotherapy for Oropharyngeal Squamous Cell Carcinoma
This single-arm Phase I/II trial evaluates induction chemoimmunotherapy combined with lattice radiotherapy (LRT) in patients with non-low risk oropharyngeal squamous cell carcinoma and primary tumor ≥3 cm or primary tumor and…
- Trial name
- NCT07428148
- Testing
- Induction Chemo-Immunotherapy, Lattice Radiotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Chronic Myeloid Leukemia
Discontinuation of Imatinib Mesylate in Patients With Chronic-Phase Chronic Myeloid Leukemia Previously Treated With Interferon-Alpha
To investigate whether patients with chronic-phase chronic myeloid leukemia (CP-CML) previously treated with interferon-alpha (IFN) and presently on a tyrosine kinase inhibitor (TKI) (imatinib mesylate, dasatinib, or nilotinib)…
- Trial name
- NCT01073436
- Testing
- Discontinuation of therapy
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Michigan Rogel Cancer Center
Melanoma Stage III, Melanoma Stage IV
Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma
The purpose of this study is to determine how beta-glucan affects the immune system in subjects with melanoma.
- Trial name
- NCT04513028
- Testing
- Beta-Glucan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kelly McMasters
CML, Chronic Myelogenous Leukemia
Study of Efficacy and Safety of Asciminib in Combination With Imatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Who Have Been Previously Treated With Imatinib and Have Not Achieved Deep Molecular Response.
To evaluate efficacy, safety and pharmacokinetic profile of asciminib 40mg+imatinib or asciminib 60mg+imatinib versus continued imatinib and versus nilotinib in pre-treated patients with Chronic Myeloid Leukemia in chronic phase…
- Conditions
- CML, Chronic Myelogenous Leukemia, Leukemia, Myeloid Chronic, Hematologic Diseases
- Trial name
- NCT03578367
- Testing
- Asciminib add-on, Imatinib, Nilotinib
- Where
- 30 sites in United States, Austria and 13 more
- Volunteers
- 104 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Glioma
Study of the Anti-tumoral Immune Response
This study evaluates the frequency of the spontaneous T cells specific CD4 answers of tumoral antigens breast cancer and glioma.
- Trial name
- ERISA (NCT02854644)
- Testing
- additional blood sample
- Where
- France
- Volunteers
- 167 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Esophageal Squamous Cell Carcinoma, Chemoradiotherapy
Oral Microbiome is Associated With the Response to Chemoradiotherapy in Initial Inoperable Patients With Esophageal Squamous Cell Cancer
Esophageal cancer accounts for more than half of the world, seriously affecting people's health in China. 95% patients are squamous cell carcinoma.
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Initial Inoperable
- Trial name
- NCT06190847
- Testing
- regular chemoradiotherapy
- Where
- China
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
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