Clinical trials: Histological Response
Relapsed/Refractory Follicular Lymphoma
Study to Evaluate the Response to Treatment With Mosunetuzumab in Relapsed/Refractory Follicular Lymphoma (FL) After at Least Two Lines of Therapy, Within the Compassionate Use Program (CUP).
Retrospective, multicenter observational study to evaluate the response to treatment with Mosunetuzumab in relapsed/refractory Follicular Lymphoma (FL) after at least three lines of therapy, within the Compassionate Use Program…
- Trial name
- MosuOSSHSR (NCT07278921)
- Testing
- Mosunetuzumab
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Andrés José Maria Ferreri
ISS Stage III Plasma Cell Myeloma, Multiple Myeloma
Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial
This phase II trial test whether combination chemotherapy works to improve blood test results in patients with high-risk multiple myeloma.
- Trial name
- NCT05497804
- Testing
- Bone Marrow Aspiration and Biopsy, Carfilzomib, Computed Tomography
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Sepsis, Acute Myeloid Leukemia
Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia
Acute leukemia is a life threatening illness that strikes people of all ages. In addition to surviving the direct effects of the disease, the treatment of leukemia generally requires chemotherapy which has its own burden.
- Trial name
- AML (NCT00806325)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University
Melanoma
T Cell Transfer With or Without Dendritic Cell Vaccination in Patients With Melanoma
The purpose of this study is to learn if dendritic cell vaccine will increase the effect of tumor infiltrating lymphocytes given with chemotherapy and interleukin-2 in patients with melanoma.
- Trial name
- NCT01946373
- Testing
- Cyclophosphamide, Fludarabine, T cells
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska University Hospital
Melanoma
IL2 Imaging in Metastatic Melanoma
T cell infiltration of tumor lesions is a known prognostic factor in several tumor types and is used as treatment mechanism in some of these tumor types.
- Trial name
- NCT02922283
- Testing
- IL2-PET scan, Tumor biopsy, CT scan
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- University Medical Center Groningen
Melanoma (Skin)
Immunological Functionnal Test Validation to Predict Melanoma Metastatic Patient Response to Checkpoint Inhibitors
Checkpoint inhibitor such as anti-CTLA-4 and anti-PD-1 are known to block inhibitory signals and increase the immune antimutoral response.
- Trial name
- mela-quantif (NCT05649683)
- Testing
- Evaluation of cytokine production
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Advanced Solid Tumors
A First-in-human Study to Learn How Safe the Study Drug BAY2965501 is, Find the Best Dose (Single Drug & Combination), How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, How it Acts on Different Tumors in Participants With Advanced Solid Tumors
Researchers are looking for a better way to treat people who have advanced solid tumors. Advanced solid tumors are types of cancer that may have spread to nearby tissue, lymph nodes, and/or to distant parts of the body and that…
- Trial name
- NCT05614102
- Testing
- BAY2965501, Pembrolizumab, Platinum-based Chemotherapy
- Where
- 21 sites in United States, Belgium and 5 more
- Volunteers
- 284 people
- Sponsor
- Bayer
DLBCL, Multiple Myeloma
Multiparametric Cardiac MRI in Patients Under CAR T-cell Therapy
Recently chimeric antigen receptor (CAR) T-cell therapy, a new class of chemo therapy, has gained regulatory approval for the treatment of diseases such as B-cell lymphoma.
- Conditions
- DLBCL, Multiple Myeloma, Cytokine Release Syndrome, Myocarditis
- Trial name
- NCT05414162
- Testing
- Cardiac MRI
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bonn
Recurrent Nasopharyngeal Carcinoma
Examine the Prognostic Role of FLT PET/CT for Patients With LR-NPC Treated by Carbon Ion Therapy
We aim, in this study, to examine whether reduction of FLT PET derived SUV before and after carbon ion radiotherapy can predict the treatment response and survivals for patients with locoregionally recurrent nasopharyngeal…
- Trial name
- NCT03689556
- Testing
- FLT PET/CT
- Volunteers
- 40 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Squamous Cell Carcinoma of the Head and Neck
Memory Phenotype and PD-1 Inhibition Response in Oral Cancer
The purpose of this research study is collect tissue and blood samples from patients who are having surgery and use those samples in lab studies to see if there are any markers in blood and tissue that can help predict how cancer…
- Trial name
- NCT03862066
- Testing
- Blood collection, Tissue collection
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Medical University of South Carolina
Leukemia, Myelomonocytic, Chronic
A Study of HDC/IL-2 Treatment in Chronic Myelomonocytic Leukemia (CMML)
Enrolled subjects will receive histamine dihydrochloride (HDC; Ceplene®) and/or IL-2 (Proleukin®) subcutaneously (s.c.) twice daily (BID) in 3-week periods followed by 3- or 6 week rest periods.
- Trial name
- NCT03040401
- Testing
- Cohort 1, Ceplene® and Proleukin®, Cohort 2, Ceplene® and Proleukin®, Cohort 3, Ceplene® and Proleukin®
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- Vastra Gotaland Region
Sarcoma
PET Scan Combined With CT Scan in Evaluating Treatment Response in Patients Undergoing Treatment for Bone Cancer or Soft Tissue Sarcoma
RATIONALE: Diagnostic procedures, such as PET scan and CT scan, may help doctors determine the extent of cancer and predict a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00335751
- Testing
- positron emission tomography computed tomography (PET/CT)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Leukemia
Eltrombopag With or Without Hypomethylating Agent After Hypomethylating Agent Failure For Patients With Myelodysplastic Syndrome (MDS)
The goal of this clinical research study is to learn if eltrombopag can help to control MDS. The safety of this drug will also be studied.
- Trial name
- NCT01893372
- Testing
- Eltrombopag, Hypomethylating Agent (HMA)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Lymphocytic Leukemia (CLL)
Study of Oral Venetoclax Tablets in Combination With Intravenous Obinutuzumab Injection to Assess Achievement of Best Response in Adult Participants With Chronic Lymphocytic Leukemia
Chronic Lymphoid Leukemia (CLL) is the most common type of leukemia (cancer of blood cells) in adults affecting men more so than women.
- Trial name
- FIRST (NCT04655261)
- Where
- 4 sites in Russia
- Volunteers
- 5 people
- Sponsor
- AbbVie
Metastatic Adenoid Cystic Carcinoma
An Investigational Scan (Ga-68 PSMA-11 PET/CT) for the Detection of Therapy Response in Patients With Metastatic Adenoid Cystic Carcinoma
This phase II trial tests whether gallium-68 (Ga-68) prostate specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) imaging is useful for detecting therapy response in patients with…
- Trial name
- NCT06521775
- Testing
- Computed Tomography, Electronic Health Record Review, Ga-68 PSMA-11
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Malignant Melanoma
RATIONALE: Vaccines made from tumor cells may help the body build an effective immune response to kill tumor cells. PURPOSE: This phase II trial is studying vaccine therapy to see how well it works in treating patients with…
- Trial name
- NCT00128583
- Testing
- polyvalent melanoma vaccine
- Where
- 11 sites in United States, Australia
- Sponsor
- CancerVax Corporation
Gastric Adenocarcinoma, Gastric Squamous Cell Carcinoma
Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer
This phase II trial studies how well pembrolizumab and palliative radiation therapy works in treating patients with esophagus, stomach, or gastroesophageal junction cancer that has spread to other parts of the body.
- Conditions
- Gastric Adenocarcinoma, Gastric Squamous Cell Carcinoma, Gastroesophageal Junction Adenocarcinoma, Metastatic Malignant Neoplasm in the Stomach
- Trial name
- NCT02830594
- Testing
- External Beam Radiation Therapy, Laboratory Biomarker Analysis, Pembrolizumab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- City of Hope Medical Center
Melanoma Stage III or IV
Dendritic Cell Vaccination in Melanoma Patients Scheduled for Regional Lymph Node Dissection
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients, and both immunological and clinical responses have…
- Trial name
- NCT00243594
- Testing
- Peptide-pulsed dendritic cells
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Neuroendocrine Tumors, GEP-NET
Influence of Tumour and Patient's Related Factors on the Response to Medical Treatments in Well Differentiated GEP-NENs
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) represent the most common NeuroEndocrin Neoplasms (NEN) site, comprising 55-70% of all NENs, and they are extremely heterogeneous diseases in terms of clinical…
- Trial name
- FARINET (NCT06356467)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- IRCCS San Raffaele
Glioblastoma Multiforme
Evaluating Therapeutic Response to Novo-TTF
This study is to assess the utility of high resolution 3D echo planar magnetic resonance spectroscopy (3D EPSI) in monitoring Novo-TTF response in glioblastoma multiforme (GBM) patients.
- Trial name
- NCT02441322
- Testing
- Novo-TTF
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
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