Clinical trials: Histology
Acquired Immune Deficiency Syndrome, Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted
Correlation Between Cytokines and Hepatic Histology in Patients Infected by HIV-1 and the Hepatitis-C Virus
This study aims at correlating TNF-α, INF-γ, IL-2, IL-4, IL-10 and TGF-β values as dosed by ELISA and mRNA expression by real-time PCR with histopathological hepatic biopsy findings in individuals with HIV/HCV coinfection.
- Conditions
- Acquired Immune Deficiency Syndrome, Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted, HIV Infections
- Trial name
- NCT00499434
- Where
- Brazil
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Obesity
Protocol for the Assessment of Variability in Histology and Gene Expression in Bariatric Surgery Patients.
It is known that a vast majority of patients seeking a bariatric surgery weight reduction procedure have non-alcoholic fatty liver disease (NAFLD), while a smaller subset of patients within this group have a more serious liver…
- Trial name
- NCT00280527
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Northwestern University
Non-Small Cell Lung Cancer
Atezolizumab in Advanced Non-small Cell Lung Cancer With Rare Histologies (CHANCE Trial)
This study is aimed to explore the antitumor activity and the safety profile of atezolizumab in pretreated advanced NSCLC patients with rare histological subtypes.
- Trial name
- CHANCE (NCT03976518)
- Testing
- Atezolizumab
- Where
- 10 sites in Italy
- Volunteers
- 43 people
- Sponsor
- Gruppo Oncologico Italiano di Ricerca Clinica
Patients With Locally Advanced or Metastatic Non-Squamous NSCLC Requiring First-Line Treatment and no Driver Gene Alterations Confirmed by Histology or Cytology
Phase II Study to Evaluate Telisotuzumab Adizutecan in Combination With RC148 as First-Line Treatment for Patients With Non-Squamous Non-Small-Cell Lung Cancer
To Evaluate the Safety, Tolerability, and Preliminary Antitumor Efficacy of RC148 in Combination with Telisotuzumab adizutecan as First-line Treatment for Locally Advanced or Metastatic Non-Squamous Non-Small-Cell Lung Cancer
- Trial name
- NCT07874282
- Testing
- Telisotuzumab adizutecan plus RC148
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RemeGen Co., Ltd.
Bladder Carcinoma
hARnessing CAbozantinib and Durvalumab Immuno-oncology Association: ARCADIA Study"
Cabozantinib plus Durvalumab in patients with advanced and chemotherapy-treated bladder carcinoma, of urothelial and non-urothelial histology: an open-label, single-centre, phase 2, single-arm proof-of-concept trial: ARCADIA study
- Trial name
- ARCADIA (NCT03824691)
- Testing
- Cabozantinib, Durvalumab
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Liver Neoplasms
SonoVue®-Enhanced Ultrasound Versus Unenhanced US for Focal Liver Lesion Characterization
The purpose of this study is to demonstrate the superiority of SonoVue®-enhanced ultrasound versus unenhanced ultrasound for characterization of Focal Liver Lesions using final diagnosis based on histology or combined…
- Trial name
- NCT00788697
- Testing
- SonoVue-enhanced ultrasound, Unenhanced ultrasound
- Where
- United States
- Volunteers
- 349 people
- Sponsor
- Bracco Diagnostics, Inc
Skeletal Muscle Changes After Crt
Effect of Cardiac Resynchronization Therapy (CRT) on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response
Heart failure patients with left bundle branch block have a poor prognosis. Biventricular pacing which synchronize the heart pump action is associated with improved functional capacity.
- Trial name
- NCT01019915
- Testing
- CRT
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Helse Stavanger HF
Colorectal Polyp
Polyp Histology Prediction by Artificial Intelligence
We have been developing artificial intelligence based polyp histology prediction (AIPHP) method to classify Narrow Band Imaging(NBI) colonoscopy images to predict the hyperplastic or neoplastic histology of polyps.
- Trial name
- NCT05545189
- Testing
- colonoscopy,polypectomy
- Volunteers
- 1,200 people
- Sponsor
- Petz Aladar County Teaching Hospital
Latent Tuberculosis Bacteriology and Histology Unknown, Latent Tuberculosis
A Phase I/IIa AERAS-456 in HIV-Negative Adults With & Without Latent Tuberculosis Infection (C-035-456)
This is a Phase I/IIa, double-blind, randomized, placebo-controlled, dose- and regimen-finding study in healthy adults with and without LTBI, who are BCG-vaccinated, HIV negative, and have no history or evidence of TB disease.
- Trial name
- NCT01865487
- Testing
- H56ug/IC31nmol
- Where
- 2 sites in South Africa
- Volunteers
- 98 people
- Sponsor
- Aeras
Dense Breasts, Breast Cancer
Histology of Functional Density in Premenopausal Breast
The investigators hypothesize that knowledge of the functional behavior of areas of mammographic density will enable more specific identification of dense tissue at-risk for breast cancer, ultimately providing predictive…
- Trial name
- NCT01588834
- Testing
- breast biopsy
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Solid Tumor, Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations
Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors
The objective of this study is to determine the safety, pharmacokinetics, maximum tolerated dose/recommended Phase 2 dose, and efficacy of PLX7486.
- Conditions
- Solid Tumor, Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations, Tenosynovial Giant Cell Tumor
- Trial name
- NCT01804530
- Testing
- PLX7486 TsOH
- Where
- 4 sites in United States
- Volunteers
- 59 people
- Sponsor
- Plexxikon
Nonpolypoid Colorectal Neoplasms(NP-CRN)
Prevalence and Characteristics of Nonpolypoid Colorectal Neoplasms - A Chinese Cohort Study
The nonpolypoid colorectal neoplasms (NP-CRNs) are relatively common in patients with gastrointestinal alarm systoms. The depressed lesions have a greater risk of having cancer than flat and polypoid lesions.
- Trial name
- NCT01533311
- Volunteers
- 1,342 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Resistance Exercise, Muscle Hypertrophy
Muscle Adaptations in Children and Adults Following Twelve Weeks of Flywheel or Weight Stack Resistance Exercise
The goal of this trial is to compare resistance exercise using traditional techniques and flywheel training to controls in healthy children ages nine to 13 and adults ages 18 to 50.
- Conditions
- Resistance Exercise, Muscle Hypertrophy, Skeletal Muscle, EMG
- Trial name
- KidREx (NCT06698055)
- Testing
- Flywheel Resistance Exercise, Weight Stack Resistance Exercise
- Where
- Sweden
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Björn Alkner
Lymphoma
Rituximab and Interleukin-2 in Treating Patients With Relapsed or Refractory Intermediate- or High-Grade Non-Hodgkin's Lymphoma
RATIONALE: Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Trial name
- NCT00059904
- Testing
- aldesleukin, rituximab
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
End-Stage Renal Disease
Artificial Intelligence-based Techniques to Characterize KIdney Microstructure on Histological ImagEs
The primary aim of this observational exploratory study will be to use fully anonymized histological images of kidney human tissue from patients with any kidney disease and normal kidney tissue to develop novel deep…
- Trial name
- AI-TIME (NCT06690190)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Colo-rectal Cancer
Piecemeal Resection and Advanced Histology Independently Predict Local Recurrence After Colorectal Snare-based Endoscopic Resection: a Time-to-event Cohort Study
The objective of this retrospective cohort observational study is to identify variables related to the recurrence of colorectal lesions after snare polypectomy resection in colonoscopies.
- Trial name
- NCT07445178
- Where
- Brazil
- Volunteers
- 255 people
- Sponsor
- University of Sao Paulo
Carcinoma, Squamous Cell
STUDY OBSERVATIONAL OF ERLOTINIB AS SECOND LINE TREATMENT IN PATIENTS WITH SQUAMOUS NSCLC AND EGFR NATIVE
OBJECTIVE study the effectiveness of the administration of Erlotinib 150 mg/Day v.o. in second-line treatment in patients with lung cancer advanced non-small of histology predominantly flaky by assessing the survival free of…
- Trial name
- GGCP 055/12 (NCT02328391)
- Where
- Spain
- Volunteers
- 51 people
- Sponsor
- Grupo Gallego de Cancer de Pulmon
Atrophy, Jaw, Edentulous, Partially
Comparative Results of Six Biomaterials Used in Two-stage Maxillary Sinus
Objectives: The aim of the study was to compare histological and histomorphometric results of six bone substitute materials used as graft in two-stage maxillary sinus augmentation model, after 6-month-healing.
- Conditions
- Atrophy, Jaw, Edentulous, Partially, Sinus Floor Augmentation, Bone Substitutes
- Trial name
- NCT03496688
- Testing
- Sinus floor augmentation
- Volunteers
- 6 people
- Sponsor
- University of Roma La Sapienza
Carcinoma, Large Cell, Carcinoma, Non-Small-Cell Lung
Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer
The objective of this study is to test a clinical benefit of the addition of CP 751,871 to erlotinib therapy in patients with advanced NSCLC of non adenocarcinoma histology. The primary endpoint is Overall Survival (OS).
- Conditions
- Carcinoma, Large Cell, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Carcinoma, Adenosquamous Cell
- Trial name
- NSCLC (NCT00673049)
- Testing
- CP 751,871 (Figitumumab), Erlotinib
- Where
- 175 sites in United States, Belgium and 25 more
- Volunteers
- 583 people
- Sponsor
- Pfizer
Non-Small Cell Lung Cancer
A Non-interventional Survey on the EGFR (Epidermal Growth Factor Receptor) Mutation Status in Completely Resected Chinese Non-Small Cell Lung Cancer (NSCLC) Patients With Adenocarcinoma Histology
This is a descriptive observational study. The primary objective is to explore the EGFR gene mutation status in early stage NSCLC with adenocarcinoma histology after complete resection.
- Trial name
- ICAN (NCT01106781)
- Where
- 13 sites in China
- Volunteers
- 591 people
- Sponsor
- AstraZeneca