Clinical trials: History of Cancer
Coats Disease
Coats Plus Syndrome and LCC Syndrome: Series of 10 Pediatric Cases. Review of Literature and Natural History
Coats plus syndrome is a very rare and serious disease, caused by premature telomere shortening. It is a pediatric, multi-systemic disease, the main features of which are retinal vasculopathy and neurological disorders…
- Trial name
- COATS+ (NCT04089995)
- Testing
- data collection
- Where
- 6 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Limoges
Breast Cancer
National Screening in Denmark With MR Versus Mammography and Ultrasound of Women With BRCA1 or BRCA2 Mutations
The purpose of the study is to determine whether MR of the breast is a better screening tool than mammography combined with ultrasound of the breast in women with BRCA1 or BRCA2 gene mutations.
- Trial name
- MR BRCA (NCT00413491)
- Testing
- MR mammography, MR
- Where
- 4 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Precancerous Conditions, Leukoplakia
Natural History of Oro-pharyngeal Cancer Precursors
Oro-pharyngeal cancers can develop from squamous dysplastic precursor lesions, which occur in a subset of common white (leukoplakia), red (erythroplasia), or mixed oro-pharyngeal plaques.
- Conditions
- Precancerous Conditions, Leukoplakia, Erythroplasia, Oral Papillomas
- Trial name
- NCT00179361
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Albert Einstein College of Medicine
Head and Neck Neoplasms
Study to Evaluate the Natural History of Head and Neck Cancer Precursors in Taiwan
Background: Cancer of the mouth and throat is one of the most common cancers in Taiwan. This cancer develops over several years, beginning as white or red patches in the mouth or throat that become growths.
- Trial name
- NCT02017288
- Where
- 4 sites in Taiwan
- Volunteers
- 3,576 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Ethnic Predisposition, Risk Factors & Breast Cancer Presentation.
Breast cancer, a leading cause of mortality among females, has been the center of research for many decades. Work is in progress to further advance the research worldwide and in our region.
- Trial name
- BC (NCT05458570)
- Testing
- Breast Cancer positive patients
- Where
- Pakistan
- Volunteers
- 500 people
- Sponsor
- Bahria University
Hepatocellular Carcinoma
The Detection of Small Early Liver Cancer With Natural History Follow up
The SELINA study will recruit 200 patients with cirrhosis and small HCC and 50 patients with HCC but without cirrhosis (most of whom are expected to have FLD).
- Trial name
- SELINA (NCT05534906)
- Testing
- Blood & Urine Samples, Imaging
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Pancreas Cancer, Pancreatitis
Pancreas Registry and High Risk Registry
The purpose of this study is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas, inflammatory lesions of…
- Conditions
- Pancreas Cancer, Pancreatitis, Chronic Pancreatitis, Pancreatic Cyst
- Trial name
- NCT02775461
- Where
- 2 sites in United States
- Volunteers
- 1,368 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Papillomavirus Infections
Natural History of Human Papillomavirus (HPV) Infections in Mid-Adult Women (WHIM)
The purpose of this study is to determine rates of oral and genital human papillomavirus (HPV) infections, and look at risk factors for HPV infection in healthy mid-adult women.
- Trial name
- WHIM (NCT01295242)
- Where
- United States
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- University of Washington
Breast Cancer, Breast Cancer Recurrence
Optimal Mammography View Sequencing in Women With a History of Breast Cancer Undergoing Surveillance Mammography
This prospective, single-centre, parallel-group randomised controlled trial evaluates the optimal sequencing of mammography views in women with a history of breast cancer undergoing surveillance mammography.
- Conditions
- Breast Cancer, Breast Cancer Recurrence, Post Treatment Surveillance
- Trial name
- MammoView (NCT07443579)
- Testing
- Mammography View Sequencing
- Where
- Ireland
- Volunteers
- 400 people
- Sponsor
- Royal College of Surgeons, Ireland
Hormone Receptor Positive Breast Cancer
EVERST- Everolimus After Alpelisib in Women With Hormone Receptor-positive (HR+) Metastatic Breast Cancer (MBC)
This phase II, open-label, single-arm, study investigates the clinical benefit of everolimus combined with endocrine therapy (ET) in hormone receptor-positive (HR+), metastatic breast cancer (MBC) patients who progressed on prior…
- Trial name
- MBC (NCT07646171)
- Testing
- Everolimus (Afinitor) tablets with endocrine therapy, Blood draw for biomarker and genetic analysis
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Adenomatous Polyp, Colorectal Cancer
Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI
The purpose of this study is to find out whether METFORMIN decreases protein markers in colorectal tissue. This is a phase IIA study of the pharmacodynamics, safety and tolerability of Metformin in decreasing colorectal mucosa in…
- Conditions
- Adenomatous Polyp, Colorectal Cancer, Obesity
- Trial name
- NCT01312467
- Testing
- metformin hydrochloride
- Where
- 4 sites in United States, Canada
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Acute Ischemic Stroke, Cancer
A Prospective Study to Observe Clinical Outcomes in Patients Receiving Antiplatelet or Anticoagulant Therapy for Cancer-Associated Acute Ischemic Stroke
The goal of this observational study is to learn about the effectiveness and safety of antiplatelet and anticoagulant treatments in people with a history of cancer who have acute ischemic stroke.
- Trial name
- NCT07845903
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Mastocytosis, Monoclonal
Study of Factors Regulating Mast Cell Proliferation
This study will examine growth factors that promote and inhibit mast cell proliferation resulting in mastocytosis, a disease of excessive mast cells in the body.
- Conditions
- Mastocytosis, Monoclonal, Bone Marrow, Tryptase
- Trial name
- NCT00044122
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Female Urogenital Diseases, Breast Cancer Female
A Laser and Topical Treatment Combination in the Vulvo-vaginal Atrophy Management in Breast Cancer Patients.
The genito-urinary syndrome of menopause severely affects patients with a history of gynecological cancer, especially those diagnosed with breast cancer.
- Trial name
- NCT05585476
- Testing
- C02 microablative laser, Regenerative topical treatment
- Where
- Spain
- Volunteers
- 195 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Leukemia, Lymphoblastic, Acute, ALL, Childhood
Optimal Methods of Disease Detection in Children and Young Adults With Acute Lymphoblastic Leukemia in the Pediatric Oncology Branch
Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. It occurs when a bone marrow cell develops errors in its DNA. Certain tests are used to help detect the disease.
- Trial name
- NCT03627208
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes, Cancer
Family Genetics Health Education and Healthy Behaviors
Background: Family-based approaches to reduce disease risk and promote healthy behaviors may be better than targeting individuals.
- Conditions
- Diabetes, Cancer, Heart Disease
- Trial name
- NCT01498276
- Where
- 2 sites in United States
- Volunteers
- 310 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Colorectal Polyp, Colorectal Neoplasms
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of…
- Conditions
- Colorectal Polyp, Colorectal Neoplasms, Colorectal Adenoma, Colorectal Cancer
- Trial name
- COOP (NCT05612347)
- Testing
- FIT, Colonoscopy
- Where
- 24 sites in United States, Canada
- Volunteers
- 6,434 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer, Healthy Volunteer
An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin
Background: Blister fluid contains many of the same biomarkers (substances that can be used to determine the effects of certain kinds of treatments) as blood and urine samples, particularly regarding changes in the skin.
- Conditions
- Breast Cancer, Healthy Volunteer, Prostate Cancer
- Trial name
- NCT00923104
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- National Cancer Institute (NCI)
Current Smoker, Malignant Neoplasm
JeffQuit Group Therapy Program for Smoking Cessation in Patients With a History of Cancer
This pilot clinical trial studies how well the "JeffQuit" group therapy program works in enabling patients with a history of cancer to quit smoking.
- Trial name
- NCT02591433
- Testing
- Tobacco Cessation Counseling, Support Group Therapy, Quality-of-Life Assessment
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Neoplasms, Lymphomas
Collection of Tissue Samples for Cancer Research
Background: -Patients who are being evaluated and/or treated at the NIH Clinical Center and adult patients at participating sites will be entered onto this tissue procurement protocol for collection of tissue specimens.
- Conditions
- Neoplasms, Lymphomas, Multiple Myeloma, Myelodysplastic Syndrome
- Trial name
- NCT00900198
- Testing
- Biopsy
- Where
- 17 sites in United States, Canada
- Volunteers
- 5,000 people
- Sponsor
- National Cancer Institute (NCI)