Clinical trials: History of Cancer
Hereditary Multiple Melanoma, Melanoma (Skin)
Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma
RATIONALE: Identifying gene mutations and other risk factors in patients with melanoma and in families with a history of hereditary melanoma may help doctors identify persons at risk for melanoma and other types of cancer.
- Trial name
- NCT00450593
- Testing
- gene expression analysis, microarray analysis, molecular genetic technique
- Where
- United Kingdom
- Volunteers
- 5,000 people
- Sponsor
- Leeds Cancer Centre at St. James's University Hospital
Breast Cancer, Breast Cancer in Young Women
Interventions to Increase Screening by Breast Cancer Survivors and Their High Risk Female Relatives
The University of Michigan (UM) Schools of Nursing, Public Health, and Medicine, the Michigan Department of Community Health (MDCH) and the Michigan Cancer Consortium (MCC) are conducting a multidisciplinary academic/practice…
- Conditions
- Breast Cancer, Breast Cancer in Young Women, Breast Cancer in Women With a Strong Family History
- Trial name
- NCT01612338
- Testing
- Targeted, Enhanced Tailored
- Where
- 2 sites in United States
- Volunteers
- 1,290 people
- Sponsor
- University of Michigan
Endometrial Cancer, Gynecological Cancers
Endometrial Cancer Testing With Vaginal and Endometrial Cell Samples
Background: Endometrial cancer is one of the most common gynecologic cancers. If it is caught at an early stage, it can be treated more easily.
- Trial name
- NCT01793545
- Where
- United States
- Volunteers
- 1,932 people
- Sponsor
- National Cancer Institute (NCI)
Suspected or Known Squamous Cell Neoplasia, Prior History of Squamous Cell Dysplasia and /or Neoplasia
High Resolution Microendoscopy for the Detection of Esophageal Squamous Cell Neoplasia
The overall objective of this multicenter trial is to determine whether the use of a low-cost, high-resolution microendoscope during diagnostic upper endoscopy can improve the efficiency and accuracy of endoscopic screening for…
- Trial name
- NCT02029937
- Testing
- Proflavine, high resolution imaging
- Where
- 3 sites in United States, China
- Volunteers
- 1,300 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Breast Cancer Survivors
Combined Nutrition and Exercise Interventions in Women With Breast Cancer History
This study aims to evaluate the effects of a combined dietary-nutritional and physical exercise intervention on physical, physiological, and psychological outcomes in women who are breast cancer survivors.
- Trial name
- NCT07275957
- Testing
- Mediterranean Diet Counseling, Supervised Strength Training Program, Supervised Endurance Training Program
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Alicante
Liver Cirrhosis, Hepatocellular Carcinoma
Natural History of Liver Cirrhosis Diagnosed by Transient Elastography in HIV/HCV-coinfected Patients
Prospective multicenter cohort recruiting consecutive patients from 7 hospitals in Andalusia, southern Spain, according to following criteria: 1) HIV infection, 2) Chronic active HCV infection, 3) Older than 18 years, 4) New…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, HIV, HCV Coinfection
- Trial name
- NCT02693847
- Where
- 8 sites in Spain
- Volunteers
- 446 people
- Sponsor
- Hospital Universitario de Valme
Stage 0 Breast Carcinoma, Breast Neoplasms
Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer
The purpose of this study is to determine whether it is feasible to give a combination of Metformin and omega-3 fatty acids for one year to women with a history of early stage breast cancer.
- Conditions
- Stage 0 Breast Carcinoma, Breast Neoplasms, Stage I Breast Carcinoma, Stage II Breast Carcinoma
- Trial name
- NCT02278965
- Testing
- Metformin, Omega-3 fatty acids
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Katherine D. Crew
Early Gastric Cancer
the Train the Trainer (TTT) Plan, to Improve the Young Endoscopist's Ability to Find the Early Gastric Cancer
AIM Verified if the first stage of the Train the trainer (TTT)plan could improve the young endoscopist's ability to detect the early gastric cancer（EGC）. METHOD 1.
- Trial name
- NCT02385578
- Testing
- an educational intervention
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Brain Cancer, Brain Tumor
Natural History of and Specimen Banking for People With Tumors of the Central Nervous System
Background: Brain and spinal cord tumors are uncommon. But they contribute substantially to cancer deaths in the U.S. in children and adults. Little progress has been made in treating brain tumors.
- Conditions
- Brain Cancer, Brain Tumor, Spine Cancer, Spine Tumor
- Trial name
- NCT02851706
- Testing
- No Treatment
- Where
- United States
- Volunteers
- 1,214 people
- Sponsor
- National Cancer Institute (NCI)
Kaposi Sarcoma, KSHV Associated Multicentric Castleman Disease
Assessment of Bone Mineral Density in People Living With HIV and KSHV Associated Malignancies: A Retrospective Longitudinal Analysis
Background: Some people with human immunodeficiency virus (HIV) are on antiretroviral therapy (ART). Their cells have shown to age faster than expected.
- Conditions
- Kaposi Sarcoma, KSHV Associated Multicentric Castleman Disease, Primary Effusion Lymphoma, IL-6 Related KSHV Associated Cytokine Syndrome
- Trial name
- NCT04742387
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy
CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)
This is a multi-center, open-label study to evaluate the safety, pharmacokinetics (PK), and anti-cancer activity of oral administration of emavusertib alone or in combination with ibrutinib in adult participants with relapsed or…
- Conditions
- Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy, Relapsed Primary Central Nervous System Lymphoma, Refractory Primary Central Nervous System Lymphoma
- Trial name
- NCT03328078
- Testing
- Emavusertib, Ibrutinib
- Where
- 45 sites in United States, Czechia and 5 more
- Volunteers
- 152 people
- Sponsor
- Curis, Inc.
Cancer, Fatigue
Characterizing Fatigue Experienced by Cancer Patients Receiving Primary Treatment and Cancer Survivors
Background: Fatigue is a common side effect of cancer and its treatment. Up to 96% of patients with cancer have fatigue. The cause of fatigue in people with cancer or those receiving treatment is poorly understood, making fatigue…
- Conditions
- Cancer, Fatigue, Prostate Cancer, Breast Cancer
- Trial name
- NCT01231932
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- National Institute of Nursing Research (NINR)
Neoplasms, Cancer
Data Collection, Clinical Care and Interventions in CCR, NCI
This study provides cancer care through the National Cancer Institute's Medical Oncology Branch (MOB) to patients who are not enrolled in an active treatment research protocol.
- Trial name
- NCT00923065
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Metabolic Disorders, Cancer
A Natural History Study of Metabolic Sizing in Health and Disease
Background: Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as commonly called the metabolic rate.
- Conditions
- Metabolic Disorders, Cancer, Chronic Kidney Disease, Diabetes
- Trial name
- NCT05398783
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Prostate Cancer, Breast Cancer
Retrospective Analysis of a Drug-Metabolizing Genotype in Cancer Patients and Correlation With Pharmacokinetic and Pharmacodynamics Data
This study is a retrospective one, exploring the hypothesis that a person's genotypic makeup may be associated with a clinical response or toxic effect to a drug.
- Conditions
- Prostate Cancer, Breast Cancer, Cutaneous T-Cell Lymphoma, Lung Cancer
- Trial name
- NCT00341939
- Where
- United States
- Volunteers
- 484 people
- Sponsor
- National Cancer Institute (NCI)
Suspected or Known Squamous Cell Neoplasia, Prior History of Squamous Cell Dysplasia and /or Neoplasia
Acceptability and Performance of a Mobile Optical Biopsy Technology for Gastrointestinal Cancer Screening
The investigators have a current trial in China and the US which provides significant support for the safety, cost-effectiveness, accuracy and efficiency of a high resolution microendoscope (HRME)-guided approach in the hands of…
- Trial name
- NCT05396781
- Testing
- Proflavine, Mobile, Augmented High Resolution Microendoscope
- Where
- 2 sites in United States, Brazil
- Volunteers
- 41 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Lung Cancer
Low-dose Computed Tomography Screening for Lung Cancer in Relatives With Family History of Lung Cancer
Screening with the use of low-dose computed tomography (LDCT) reduces mortality from lung cancer. Relatives with family history of lung cancer are at increased risk of lung cancer compared to those without a family history in…
- Trial name
- NCT02519972
- Testing
- low dose computed tomography
- Volunteers
- 1,102 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Advanced Thyroid Gland Medullary Carcinoma, Stage III Thyroid Gland Medullary Carcinoma AJCC v8
Natural History of Medullary Thyroid Cancer to Inform Advanced Disease Management
This study utilizes a multi-institutional registry to describe the natural history of medullary thyroid cancer that has spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) in…
- Conditions
- Advanced Thyroid Gland Medullary Carcinoma, Stage III Thyroid Gland Medullary Carcinoma AJCC v8, Stage IV Thyroid Gland Medullary Carcinoma AJCC v8, Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8
- Trial name
- NCT04216732
- Testing
- Blood Pressure Measurement, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 2,030 people
- Sponsor
- M.D. Anderson Cancer Center
Neurofibromatosis 1, Plexiform Neurofibromas
Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)
Background: People with neurofibromatosis 1 (NF1) who have plexiform neurofibromas (pNFs) can have pain that affects their daily lives.
- Trial name
- NCT02544022
- Where
- 6 sites in United States
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Mesothelioma, Families
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1
Background: -A gene provides instructions to the body. Mutated genes can sometimes cause cancer. Germline mutations are those people are born with. These mutations in the BAP1 gene can cause mesothelioma and other cancers.
- Trial name
- NCT03830229
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)