Clinical trials: History of Cancer
Prostate Cancer, Liver Cancer
Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies
This study aims to provide long-term follow-up care of patients previously enrolled in a vaccine study that involved poxviral vectors.
- Conditions
- Prostate Cancer, Liver Cancer, Breast Cancer, Colon Cancer
- Trial name
- NCT00451022
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Mesothelioma, Families
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1
Background: -A gene provides instructions to the body. Mutated genes can sometimes cause cancer. Germline mutations are those people are born with. These mutations in the BAP1 gene can cause mesothelioma and other cancers.
- Trial name
- NCT03830229
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Lynch Syndrome, Colorectal Cancer
Family History Study on Cancer Risk
This study aims to identify the optimal method to recognize, risk stratify, and provide follow-up care for individuals at risk of hereditary cancer.
- Conditions
- Lynch Syndrome, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT04145388
- Testing
- online cancer risk assessment, Usual care
- Where
- United States
- Volunteers
- 18,623 people
- Sponsor
- Kaiser Permanente
Prostate Cancer
The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)
Prostate cancer is the most common non-skin cancer among Veterans and the second leading cause of male cancer death. Current methods of screening men for prostate cancer are inaccurate and cannot identify which men do not have…
- Trial name
- ProGRESS (NCT05926102)
- Testing
- Precision screening intervention, Usual care
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Locally Advanced or Metastatic Infantile Fibrosarcoma Harboring an NTRK Gene Fusion, Infantile Fibrosarcoma
A Study Called EPI VITRAKVI to Compare Treatment Results in Patients With Infantile Fibrosarcoma (IFS), a Type of Connective Soft Tissue Cancer, Who Received a Treatment Called Larotrectinib From a Study Called SCOUT With Patient Data From an External Database
This is an observational study in which data from the past of children and young people with a specific cancer, called NTRK gene fusion positive infantile fibrosarcoma (IFS) is studied.
- Trial name
- EPI VITRAKVI (NCT05236257)
- Testing
- Larotrectinib (Vitrakvi, BAY2757556), Standard of Care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- Bayer
Hemangioblastoma, Hippel Lindau Disease
Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease
The purpose of this study is to learn more about the growth of brain and spinal cord tumors and cysts that develop in association with them in patients with von Hippel-Lindau disease.
- Trial name
- NCT00005902
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stage 0 Breast Carcinoma, Breast Neoplasms
Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer
The purpose of this study is to determine whether it is feasible to give a combination of Metformin and omega-3 fatty acids for one year to women with a history of early stage breast cancer.
- Conditions
- Stage 0 Breast Carcinoma, Breast Neoplasms, Stage I Breast Carcinoma, Stage II Breast Carcinoma
- Trial name
- NCT02278965
- Testing
- Metformin, Omega-3 fatty acids
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Katherine D. Crew
Breast Cancer
Nipple Aspiration, Ductal Lavage, and Duct Endoscopy in Screening Women at Moderate-to-High Risk of Developing Breast Cancer
RATIONALE: Screening tests, such as nipple aspiration, ductal lavage, and breast duct endoscopy, may help doctors detect cancer cells early and plan more effective treatment for breast cancer.
- Trial name
- NCT00081003
- Testing
- gene expression analysis, protein expression analysis, cytology specimen collection procedure
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Neoplasms, Skin Neoplasms
M7824 Related Adverse Effects in Adults With Cancer
Background: Immunotherapy drugs use a person s own immune system to help fight cancer. These drugs work better for some people than others. The drug M7824 has helped some people with cancer. But it can cause side effects.
- Trial name
- NCT04267861
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- National Cancer Institute (NCI)
Polycystic Ovary Syndrome
Incretin Effect in PCOS Women
This study investigates the incretin effect in women with polycystic ovary syndrome (PCOS) before and after removal of their insulin resistance by metformin.
- Trial name
- NCT01892254
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Smoking History, Current Smoker
Increasing Lung Cancer Screening Among Emergency Department Patients - LCS R01
This randomized clinical trial evaluates the effectiveness of text messaging and facilitated referral strategies to increase lung cancer screening uptake among emergency department patients who meet lung cancer screening…
- Conditions
- Smoking History, Current Smoker, Lung Cancer Screening
- Trial name
- NCT07566221
- Testing
- Basic Referral, Facilitated Referral, Text Messaging
- Volunteers
- 1,036 people
- Sponsor
- University of Rochester
Familial Ovarian Cancer, Familial Breast Cancer
Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
Individuals and families with known or suspected syndromes that include breast, ovarian or genetically-related cancers are enrolled in this family study, which is a syndrome-specific sub-set of the long-standing DCEG Human…
- Conditions
- Familial Ovarian Cancer, Familial Breast Cancer, BRCA1-associate Malignancies, BRCA2-associated Malignancies
- Trial name
- NCT00040222
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- National Cancer Institute (NCI)
AL Amyloidosis
A Registry of AL Amyloidosis (ReAL)
The purpose of this protocol is to generate a large registry of patients with AL amyloidosis.
- Trial name
- ReAL (NCT04839003)
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cervical Carcinoma, Human Papillomavirus Infection
Evaluating the Human Papillomavirus Self-Collection Experience in Individuals Who Have Experienced Sexual Trauma
This study explores the human papillomavirus (HPV) self-collection experience among individuals with a history of sexual trauma.
- Trial name
- NCT05458869
- Testing
- HPV Self-Collection, Interview, Survey Administration
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Cockayne Syndrome, Skin Neoplasms
Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility.
- Conditions
- Cockayne Syndrome, Skin Neoplasms, Xeroderma Pigmentosum, Trichothiodystrophy Syndromes
- Trial name
- NCT00001813
- Where
- United States
- Volunteers
- 709 people
- Sponsor
- National Cancer Institute (NCI)
Appendix Cancer, Pseudomyxoma Peritonei
The Appendix Cancer PMP Research Foundation Natural History Study/Patient Registry
ACPMP's first-ever patient-powered global patient registry/natural history study collects patient and caregiver information and data to fuel clinical trials and drive breakthroughs for appendix cancer and PMP.
- Trial name
- NCT07769346
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Appendix Cancer Pseudomyxoma Peritonei Research Foundation
Recurrent Respiratory Papillomatosis, Pulmonary Neoplasm
The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)
Recurrent respiratory papillomatosis (RRP) is an orphan disease that affects approximately 20,000 people in the United States and is caused by infection with human papillomavirus (HPV) types 6 and 11.
- Trial name
- NCT06412172
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Lung Non-Small Cell Carcinoma, Thoracic Cancer
Qualitative Study on Detection & Tx of NSCLC in Pts w/ a History of Alcohol or SUD
This study will attempt to identify social facilitators and barriers to detection and treatment of non-small cell lung cancer in order to learn how a history of substance abuse or alcohol use impacts care for non-small cell lung…
- Trial name
- NCT07186699
- Testing
- Non-Interventional Study
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Southern California
Neoplastic Syndromes, Hereditary, Comparative Effectiveness Research
Family History and Cancer Risk Study
Investigators from Vanderbilt University Medical Center (VUMC), Duke University, and Meharry Medical College (MMC) are collaborating on a family health history study to deploy a family health history (FHH) platform, MeTree.
- Trial name
- FOREST (NCT05079334)
- Where
- 2 sites in United States
- Volunteers
- 1,847 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Breast Cancer, Ovarian Cancer
Guilford Genomic Medicine Initiative (GGMI)
Genomic medicine, using genetic information to improve health outcomes, is heralded as the answer to rising medical costs by focusing on prevention and tailored care.
- Conditions
- Breast Cancer, Ovarian Cancer, Colon Cancer, Thrombophilia
- Trial name
- GGMI (NCT01372553)
- Where
- United States
- Volunteers
- 1,184 people, healthy volunteers welcome
- Sponsor
- The Moses H. Cone Memorial Hospital