Clinical trials: History of Cancer
Lung Cancer, Non-Small Cell
A Study Of Oral GW572016 In Advanced Or Metastatic Non-Small Cell Lung Cancer
This study was designed to evaluate and compare the efficacy of two dose schedules of an oral investigational drug for the treatment of advanced or metastatic non-small cell lung cancer.
- Trial name
- NCT00073008
- Testing
- GW572016 (lapatinib)
- Where
- 31 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- GlaxoSmithKline
Neurofibromatosis 1, Peripheral Nerve Neoplasms, Malignant
Incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) Development in Participants With Neurofibromatosis Type 1 (NF1) Receiving and Not Receiving Medical Therapies Directed at Plexiform Neurofibromas (PN)
Background: NF1 is a genetic syndrome. Tumors appear early in life. Many people with NF1 develop PN. These tumors can become an aggressive cancer called MPNST.
- Trial name
- NCT04774289
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- National Cancer Institute (NCI)
Cancer, Breast, Cancer, Ovarian
Family History App in Personalized Medicine
A complete family history (FH) may identify persons at high risk for certain conditions. They can be offered genetic testing and life-saving screening and treatment.
- Conditions
- Cancer, Breast, Cancer, Ovarian, Cancer, Colorectal, Cancer, Prostate
- Trial name
- FHAMe (NCT04726319)
- Testing
- FHAMe Intervention
- Where
- Canada
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Bladder Cancer, Bladder Urothelial Carcinoma
Bladder Perforation Post-TURBT: Definition, Incidence and Natural HistoryStudy
In view of sparse data of precise definition, risk factors, natural history and management of bladder perforation following Transurethral resection of bladder tumour (TURBT).
- Conditions
- Bladder Cancer, Bladder Urothelial Carcinoma, Trauma, Injuries
- Trial name
- TURBT-BP (NCT04129606)
- Testing
- Computed tomographic cystography
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Abdelwahab Hashem
Current Smoker, Malignant Neoplasm
JeffQuit Group Therapy Program for Smoking Cessation in Patients With a History of Cancer
This pilot clinical trial studies how well the "JeffQuit" group therapy program works in enabling patients with a history of cancer to quit smoking.
- Trial name
- NCT02591433
- Testing
- Tobacco Cessation Counseling, Support Group Therapy, Quality-of-Life Assessment
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Prostate Cancer, Breast Cancer
Collection of Blood From Patients With Cancer
This study will collect blood from patients with cancer to study the level of cells which decrease the immune response (suppressor cells) before and after chemotherapy.
- Conditions
- Prostate Cancer, Breast Cancer, Colon Cancer, Lung Cancer
- Trial name
- NCT00034216
- Where
- United States
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Polycythemia Vera, Essential Thrombocythaemia
Prevalence Of Germline Gene Mutations In Patients With Myeloproliferative Neoplasms With Family History
Philadelphia-negative myeloproliferative neoplasms (MPNs) occur sporadically and are due to somatic mutations in the JAK2 (Janus kinase 2), CALR (calreticulin) and MPL (thrombopoietin receptor) genes.
- Conditions
- Polycythemia Vera, Essential Thrombocythaemia, Myelofibrosis
- Trial name
- NCT06923670
- Testing
- NGS testing, NGS analysis for mutations in genes involved in familial predisposition to hematological malignancies
- Volunteers
- 496 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy
CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)
This is a multi-center, open-label study to evaluate the safety, pharmacokinetics (PK), and anti-cancer activity of oral administration of emavusertib alone or in combination with ibrutinib in adult participants with relapsed or…
- Conditions
- Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy, Relapsed Primary Central Nervous System Lymphoma, Refractory Primary Central Nervous System Lymphoma
- Trial name
- NCT03328078
- Testing
- Emavusertib, Ibrutinib
- Where
- 45 sites in United States, Czechia and 5 more
- Volunteers
- 152 people
- Sponsor
- Curis, Inc.
Glioblastoma
Key Longitudinal Associations With Risk and Glioblastoma Outcomes
The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.
- Trial name
- Key LARGO (NCT06625684)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Lung Cancer, High-Risk Cancer
Taiwan Real-world LDCT Screening Behavior and Outcome Research for High Risk Subjects Based on Health Promotion Administration
Lung cancer is the leading cause of mortality in the world, and also in Taiwan.Despite the researches and availability in new therapies, it causes the highest mortality and is one of the most preventable cancers as well.
- Conditions
- Lung Cancer, High-Risk Cancer, Smoking, Pollution; Exposure
- Trial name
- TRIO (NCT05557487)
- Testing
- Low dose computed tomography
- Where
- 7 sites in Taiwan
- Volunteers
- 6,618 people, healthy volunteers welcome
- Sponsor
- Gee-Chen Chang
Plexiform Neurofibromas, NF1
Study of Plexiform Neurofibromas in Neurofibromatosis Type 1
Background: -Plexiform neurofibromas in patients with NF1 are a significant cause of morbidity but little is known about the natural history of these lesions.
- Trial name
- NCT00006435
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer Screening, Military Service-related Environmental and Occupational Exposures
Personalizing Veterans' Lung Cancer Screening and Diagnosis
Lung cancer screening with low-dose chest computed tomography (CT) is currently recommended for high-risk individuals who are 50 to 80 years old, have smoked cigarettes for at least 20 pack-years, and currently smoke or quit…
- Conditions
- Lung Cancer Screening, Military Service-related Environmental and Occupational Exposures, Cancer Survivor, Family History of Lung Cancer
- Trial name
- MAS-EXPAND (NCT07838519)
- Testing
- Low-dose computed tomography
- Where
- 7 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- VA Office of Research and Development
Stomach Neoplasms, Stomach Cancer
Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer
Background: Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers.
- Conditions
- Stomach Neoplasms, Stomach Cancer, Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), Hereditary Diffuse Gastric Cancer (HDGC)
- Trial name
- NCT03030404
- Where
- United States
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Pleural Effusion Due to Another Disorder (Disorder)
Natural History of Nonspecific Pleuritis Diagnosed After Video-assisted-thoracoscopic-surgery
The investigators want to determine the incidence of malignant disease, type of malignant disease and overall survival in patients diagnosed with NSP after VATS.
- Trial name
- NCT03270228
- Testing
- Nonspecific pleuritis after VATS thoracoscopy
- Where
- Denmark
- Volunteers
- 10,000 people
- Sponsor
- Naestved Hospital
Cancer, General Research Use
Connect for Cancer Prevention Study (Connect)
Background: The National Cancer Institute, part of the National Institutes of Health, has partnered with nine health care systems across the U.S. to establish the Connect for Cancer Prevention Study.
- Trial name
- NCT04609072
- Where
- 10 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Panhypopituitarism, Gigantism/Acromegaly
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
There is a variety of tumors affecting the pituitary gland in childhood; some of these tumors (eg craniopharyngioma) are included among the most common central nervous system tumors in childhood.
- Conditions
- Panhypopituitarism, Gigantism/Acromegaly, Prolactinoma, Cushing Disease
- Trial name
- NCT00001595
- Testing
- Tissue specimen collection, MRI
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Prostate Cancer, Breast Cancer
Retrospective Analysis of a Drug-Metabolizing Genotype in Cancer Patients and Correlation With Pharmacokinetic and Pharmacodynamics Data
This study is a retrospective one, exploring the hypothesis that a person's genotypic makeup may be associated with a clinical response or toxic effect to a drug.
- Conditions
- Prostate Cancer, Breast Cancer, Cutaneous T-Cell Lymphoma, Lung Cancer
- Trial name
- NCT00341939
- Where
- United States
- Volunteers
- 484 people
- Sponsor
- National Cancer Institute (NCI)
Breast Neoplasms, Breast Cancer
Comparison of Ultrasound and Breast MRI for Breast Cancer Detection
The goal of this randomized clinical trial is to compare diagnostic results of secondary breast cancer surveillance using breast ultrasound abbreviated MRI and full protocol MRI.
- Trial name
- NCT05797545
- Testing
- Breast MRI for Breast Cancer Detection
- Where
- 3 sites in South Korea
- Volunteers
- 1,756 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Gastric Cancer, Gastric Neoplasm
Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis
Objective: To follow people with GISTs and collect tumor tissue so that it can be studied in the lab. Eligibility: People age 6 and older who have a GIST.
- Conditions
- Gastric Cancer, Gastric Neoplasm, Gastrointestinal Stromal Sarcoma, Gastrointestinal Stromal Neoplasm
- Trial name
- NCT04557969
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Neoplasms
Adding Family History of Colorectal Cancer to the Dutch FIT-based Screening Program
The aim of this study is to identify more persons with advanced neoplasia in the current national CRC screening, by adding data on family history of CRC (using a validated online questionnaire) to FIT.
- Trial name
- NCT02698462
- Testing
- Family history questionnaire
- Volunteers
- 6,000 people
- Sponsor
- Prof. Evelien Dekker, MD, PhD