Clinical trials: Hook Worm
Amebiasis, Cryptosporidiosis
Parasitic Infections of the Gastrointestinal Tract
This protocol offers diagnosis and standard medical treatment for various parasitic gastrointestinal infections. Gastrointestinal parasites are either worms (helminths) or one-celled animals called protozoans which live in the…
- Conditions
- Amebiasis, Cryptosporidiosis, Giardiasis, Parasitic Disease
- Trial name
- NCT00001162
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Trichuriasis, Strongyloidiasis
Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in Honduras
The goal of this Phase III clinical trial is to evaluate the efficacy, safety, and acceptability of different treatment regimens for Trichuris trichiura infection in schoolchildren aged 6 to 15 years living in La Moskitia…
- Conditions
- Trichuriasis, Strongyloidiasis, Ascariasis, Hookworm Infection
- Trial name
- AIM-T (NCT07661316)
- Testing
- Albendazole 400 mg, Albendazole Plus Ivermectin, Fixed-Dose Combination Albendazole/Ivermectin (FDC)
- Where
- Honduras
- Volunteers
- 368 people
- Sponsor
- Mundo Sano Foundation
Anemia, Worm Infections
Effect of Hookworm Elimination and Vitamin A Intervention on Iron Status of Preschool Children in Sichuan, China
The present study is intended to supplement the preschool anemic children with vitamin A capsule and de-hookworm administration in poverty Sichuan province.
- Trial name
- NCT02675140
- Testing
- ZENTEL, ZENTEL and Vitamin A Soft Capsules
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Chengdu Maternal and Children's Health Care Hospital
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel Adjuvant
This study is designed to evaluate the safety, reactogenicity, and immunogenicity of Na-GST-1 adsorbed to Alhydrogel® with or without two different dose concentrations of a novel adjuvant, GLA-AF (1 µg or 5 μg) among healthy…
- Trial name
- NCT01385189
- Testing
- 10 μg Na-GST-1/Alhydrogel, 30 μg Na-GST-1/Alhydrogel, 100 μg Na-GST-1/Alhydrogel
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity Study of Na-GST-1 With or Without CpG
Na-GST-1 is a protein expressed during the adult stage of the hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02143518
- Testing
- Na-GST-1/Alhydrogel®, CpG 10104
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Necator Americanus Infection
Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections
Mebendazole tablets which are produced by most pharmaceutical manufacturers, including the State Pharmaceutical Manufacturing Corporation (SPMC) of Sri Lanka, contain a mixture of polymorphs A and C.
- Trial name
- NCT01350271
- Testing
- Mebendazole polymorph A and C 500 mg, Mebendazole polymorph C
- Where
- 2 sites in Sri Lanka
- Volunteers
- 214 people
- Sponsor
- University of Kelaniya
Helminthiasis, Ascaris Infection
Soil-transmitted Helminth Reinfection Rates After Single and Repeated School Hygiene Education
Soil-transmitted helminth (STH) infections caused by Ascaris lumbricoides, Trichuris trichiura, or hookworm, affect approximately 1.5 millions individuals primarily in tropical and subtropical regions.
- Conditions
- Helminthiasis, Ascaris Infection, Trichuris Infection, Hookworm Infections
- Trial name
- NCT04227834
- Testing
- Health hygiene education
- Where
- Indonesia
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Universitas Sumatera Utara
Soil-transmitted Helminth Infections
Community Health Education and Hygiene Promotion Added to Deworming Among Ethnic Khmer Children in Vietnam
This study evaluated whether adding community health education and household hygiene promotion to supervised deworming could improve soil-transmitted helminth (STH) outcomes and related caregiver and household factors among…
- Trial name
- NCT07855978
- Testing
- Albendazole 400 mg, Community Health Education and Hygiene Promotion
- Where
- 4 sites in Vietnam
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Trichuriasis, Ascariasis
Efficacy and Safety of MOX/ALB Co-administration
This study is a double-blind randomized controlled superiority trial aiming at providing evidence on the efficacy and safety of co-administered moxidectin and albendazole versus albendazole monotherapy (standard of care) against…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections
- Trial name
- NCT04726969
- Testing
- Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, Ivermectin 3 mg Oral Tablet
- Where
- Côte d’Ivoire
- Volunteers
- 255 people
- Sponsor
- Jennifer Keiser
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura
This study aims to provide evidence on the efficacy, safety and acceptability of the new, chewable formulation of oxantel pamoate administered as a single dose or multiple doses, compared to mebendazole in children infected with…
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- OXA-TRI (NCT06720259)
- Testing
- Oxantel Pamoate, Mebendazole
- Where
- Tanzania
- Volunteers
- 163 people
- Sponsor
- Jennifer Keiser
Hookworm Infections
Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm
The rational of this study is to provide evidence on the safety and efficacy of a new chewable tablet of mebendazole compared to the standard tablet in preschool- and school-aged children infected with hookworm.
- Trial name
- CHEW_MEB_PEMBA (NCT03995680)
- Testing
- Mebendazole
- Where
- Tanzania
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Malaria,Falciparum, Neglected Tropical Diseases
Adjunctive Ivermectin Mass Drug Administration for Malaria Control
This is a cluster-randomized placebo-controlled clinical trial to evaluate the additive benefit of Ivermectin (IVM) (or Placebo) mass drug administration (MDA) to dihydroartemisinin-piperaquine (DP) MDA for malaria control in a…
- Conditions
- Malaria,Falciparum, Neglected Tropical Diseases, Strongyloidiasis, Lymphatic Filariasis
- Trial name
- MATAMAL (NCT04844905)
- Testing
- Ivermectin, Dihydroartemisinin-piperaquine
- Where
- Guinea-Bissau
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hookworm Infections
Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection
This study evaluates the efficacy, safety and immunogenicity of different formulations of the Na-GST-1 hookworm vaccine using a controlled human hookworm infection model in healthy, hookworm-naive adults.
- Trial name
- NCT03172975
- Testing
- Na-GST-1/Alhydrogel, Na-GST-1/Alhydrogel + CPG 10104, Na-GST-1/Alhydrogel + GLA-AF
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Necator Americanus Infection
Repeated Controlled Human Hookworm Infection
Twenty-four healthy hookworm-naive volunteers will be exposed to 50 L3 Necator americanus larvae for a maximum of three times.
- Trial name
- ReCHHI1 (NCT03257072)
- Testing
- 50 Necator americanus L3 larvae, 100 Necator americanus L3 larvae, 150 Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Meta Roestenberg
Helminthiasis, Nematode Infection
Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya
The mainstay of control of soil-transmitted helminths (STH) is school-based deworming but recent modelling has highlights that in all but low very transmission settings, the treatment of school-aged children is unlikely to…
- Conditions
- Helminthiasis, Nematode Infection, Disease Transmission, Infectious
- Trial name
- TUMIKIA (NCT02397772)
- Testing
- albendazole
- Where
- Kenya
- Volunteers
- 21,761 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Intestinal Diseases, Helminthiasis
Efficacy of Albendazole to Treat Intestinal Helminths and Its Effect on Gut Microflora
Albendazole is a main anti-helminth, however there is a lack of data regarding its efficacy in the school children population. The aim of this study is to evaluate the efficacy of the albendazole one versus two and three doses…
- Trial name
- NCT01192802
- Testing
- albendazole
- Where
- Gabon
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Albert Schweitzer Hospital
Celiac Disease
Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity
The disappearance of intestinal parasites from humans in developed countries may be responsible for the upsurge in many diseases including Celiac Disease, Crohn's, ulcerative colitis, asthma and hay fever.
- Trial name
- NCT00671138
- Testing
- Necator americanus
- Where
- 3 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults
Hookworms digest hemoglobin from erythrocytes for use as an energy source via a proteolytic cascade that begins with the aspartic protease, APR-1.
- Trial name
- NCT01717950
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Gluco-Pyranosylphospho-Lipid A Aqueous Formulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm Infection
Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious.
- Trial name
- NCT01940757
- Testing
- Necator americanus Hookworm Larvae
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Necator Americanus Infection
Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center
Four healthy hookworm-naive volunteers will be exposed to 50 L3 Necator americanus larvae once and will retain infection for up to 2 years.
- Trial name
- CHHIL (NCT03126552)
- Testing
- Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center