Clinical trials: Hormone Disturbance
Type 2 Diabetes, Diabetes
Improving Self Management Skills of Older Adults With Diabetes
The study will help determine if the Better Choices Better Health Diabetes program (community-based or online, also known as the Diabetes Self-Management Program) improves the hbA1C of people with Type-II diabetes.
- Trial name
- NCT01943357
- Testing
- Diabetes Self Management Program
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Stanford University
Type 2 Diabetes
Cognitive Behavioral Intervention in Diabetes Self-Management
The proposed study is a two arm randomized controlled trial with longitudinal follow-up that compares cognitive behavioral interventions (ENHANCE) to a control group with attention.
- Trial name
- NCT01182701
- Testing
- Cognitive behavioral training
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Hawaii
Pancreatic Neoplasms
Institut Paoli-Calmettes Pancreatic Neoplasms Database
Database of Institut Paoli Calmettes diagnosed with Pancreatic neoplasms
- Trial name
- NCT02869581
- Testing
- Data collection
- Where
- France
- Volunteers
- 8,500 people
- Sponsor
- Institut Paoli-Calmettes
Diabetes Mellitus, Cellular Senescence
Effect of Sodium-glucose Cotransporter-2 Inhibitor in Cellular Senescence in Patients With Cardiovascular Diseases or Type 2 Diabetes
Patients with type 2 diabetes (T2D) are more prevalent with aging-related comorbidities and frailty, which leads to a shorter life expectancy than non-diabetic individuals and that this excess mortality is largely attributable to…
- Conditions
- Diabetes Mellitus, Cellular Senescence, Sodium-Glucose Transporter 2 Inhibitors
- Trial name
- NCT05975528
- Testing
- SGLT2 inhibitor, Glimepiride
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Diabetes Mellitus, Insulin-Dependent, Hypercholesterolemia
Statins in Children With Type 1 Diabetes and Hypercholesterolemia
Children with type1 diabetes (T1DM) have increased risk for cardiovascular disease (CVD) due to chronic increase in the blood sugars and inflammation.
- Trial name
- NCT01236365
- Testing
- Atorvastatin
- Where
- 5 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Recurrent Epithelial Ovarian Cancer
Salvage Systemic Therapy With or Without Stereotactic Ablative Radiotherapy for Recurrent Ovarian Cancer
Rationale Ovarian cancer is the 3rd most common gynecologic malignancy in Korea. The standard treatment is tumor debulking surgery with or without adjuvant chemotherapy.
- Trial name
- SABR-ROC (NCT05444270)
- Testing
- Standard salvage therapy, Standard salvage therapy + SABR
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Yonsei University
Cystoid Macular Edema, Diabetes Mellitus
Assessing Diabetes Mellitus on Cytokine Analysis and Macular Edema Following FLACS
The purpose of this study is to assess the effects of diabetes mellitus (DM) on anterior chamber cytokine production and postoperative macular edema in patients undergoing femtosecond laser-assisted cataract surgery (FLACS).
- Conditions
- Cystoid Macular Edema, Diabetes Mellitus, Cataract
- Trial name
- NCT04856670
- Testing
- Cataract surgery
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Uptown Eye Specialists
Diabete Type 2, Diabetes
The Healthy Eating and Active Living to Reverse Diabetes Pilot Study
The HEAL Diabetes Program is a multicomponent intensive plant-forward healthy eating program designed to reverse diabetes. Several recent studies, most notably the Diabetes UK-funded Diabetes Remission Clinical Trial (DiRECT) in…
- Conditions
- Diabete Type 2, Diabetes, Overweight , Obesity
- Trial name
- HEAL Diabetes (NCT07316569)
- Testing
- Intensive Multicomponent Healthy Eating and Weight Loss Intervention, Enhanced Usual Diabetes Care
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Tennessee
Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8
Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer
This phase Ib trial tests the safety, side effects, and best dose of leflunomide in combination with gemcitabine in treating patients with pancreatic cancer that may have spread from where it first started to nearby tissue, lymph…
- Conditions
- Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06454383
- Testing
- Biospecimen Collection, Cholestyramine, Computed Tomography
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- City of Hope Medical Center
Diabete Type 2
The Use of Statin in Diabetic Patients Not Known to Have Atherosclerotic Cardiovascular Disease
the use of Statin in diabetic patients and its correlation to the guidelines recommendation.
- Trial name
- NCT06676683
- Testing
- Usage of Statin in diabetic patients
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Sohag University
Obesity, Short Stature
Study of the Molecular Basis in the Pathophysiology of Food Intake and Growth in Children
Obesity, now a global epidemic, is a leading cause of illness and mortality in the developed world. To better understand the pathophysiological mechanisms that underlie weight disorders, increasing attention is being paid to…
- Trial name
- Ghrelin (NCT00830141)
- Volunteers
- 259 people
- Sponsor
- HaEmek Medical Center, Israel
Advanced Pancreatic Cancer
APG-1387 Plus Chemotherapy in Advanced Pancreatic Adenocarcinoma
This study is a two stage study consisting of a dose escalation phase Ib and a phase II study which include subjects with previously-treated, advanced pancreatic adenocarcinoma.
- Trial name
- NCT04643405
- Testing
- APG-1387 for Injection, Gemcitabine, Nab paclitaxel
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Ascentage Pharma Group Inc.
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Type 1 Diabetes Mellitus
MRI Imaging of Labeled Human Islets Transplanted Into the Liver
The purpose of the study is to determine whether human islets labeled by iron contrast agents could be imaged using magnetic resonance after transplantation into the liver of Type 1 diabetic recipients.
- Trial name
- NCT01050166
- Testing
- Transplantation of labeled islets
- Where
- Czechia
- Volunteers
- 8 people
- Sponsor
- Frantisek Saudek
Diabetes, Diabetes Mellitus, Type 2
INITIATE Plus (INITiation of Insulin to Reach A1c TargEt) Study
This trial is conducted in the United States of America (USA). The purpose of this study is to compare the effectiveness and safety of a biphasic insulin aspart standard titration regimen when coupled with dietary intervention to…
- Trial name
- INITIATE plus (NCT00101751)
- Testing
- biphasic insulin aspart, dietary regimen
- Where
- United States
- Volunteers
- 4,877 people
- Sponsor
- Novo Nordisk A/S
Turner Syndrome, Peripheral Angiopathy
AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)
Turner syndrome is a genetic condition, rare, due to the total or partial absence of one X chromosome, affecting 1/2500 newborn female. It combines almost constantly short stature and ovarian failure with infertility.
- Conditions
- Turner Syndrome, Peripheral Angiopathy, Vascular Malformation, Lymphedema
- Trial name
- AVAST (NCT02250456)
- Testing
- Echo doppler
- Where
- 6 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Strasbourg, France
Pancreatic Neoplasm, Pancreas Adenocarcinoma
Pancreatic Cancer Dietary Assessment Study
This is a prospective observational study which aims to evaluate; The prevalence of pancreatic insufficiency in patients with pancreatic malignancies (adenocarcinoma and neuroendocrine tumours).
- Conditions
- Pancreatic Neoplasm, Pancreas Adenocarcinoma, Well-Differentiated Neuroendocrine Carcinoma, Malignant Neoplasm of Pancreas
- Trial name
- PanDA (NCT03616431)
- Testing
- Pancreo-KIT breath test
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- The Christie NHS Foundation Trust
Growth Hormone Deficiency
Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD)
The aim of this study is to assess the developmental patterns of lung function in children affected by growth hormone deficiency after one year of GH therapy.The assessment by specific questionnaires of quality of life and of…
- Trial name
- GHD (NCT02507245)
- Testing
- Growth Hormone-Releasing Hormone
- Volunteers
- 48 people
- Sponsor
- Stefania La Grutta, MD
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Efficacy of HIPEC as NACT and Postoperative Chemotherapy in the Treatment of Advanced-Stage Epithelial Ovarian Cancer
This project is a multi-center, prospective, randomized controlled clinical observation the safety and efficacy of hyperthermic intraperitoneal chemotherapy as neoadjuvant chemotherapy(NACT) and postoperative chemotherapy after…
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- EHNPCTASEOC (NCT03180177)
- Testing
- Hyperthermic Intraperitoneal Chemotherapy, Interval debulking surgery, neoadjuvant chemotherapy
- Where
- China
- Volunteers
- 263 people
- Sponsor
- Shu-Zhong Cui
Sarcopenia, Hypogonadism
TOM: Testosterone in Older Men With Sarcopenia
The purpose of this study is to determine whether testosterone replacement in older men with low testosterone levels will increase muscle strength, improve physical performance and overall sense of well being, and reduce fatigue.
- Conditions
- Sarcopenia, Hypogonadism, Muscular Diseases
- Trial name
- NCT00240981
- Testing
- Topical testosterone gel 1% (active formulation)
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Boston Medical Center