Clinical trials: Hormone Replacement
Acute Renal Failure, Critical Illness
Metabolic Aspects of Citrate Anticoagulation in Renal Replacement Therapy
Citrate anticoagulation is associated with metabolic side effects which are linked to a portion of citrate reaching systemic circulation.
- Trial name
- Citrate (NCT01361581)
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
Acute Kidney Injury
Renal Replacement Therapy Plus Extracorporeal Carbon Dioxide Removal
This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows…
- Trial name
- NCT02595619
- Testing
- RRT plus ECCO2R
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Turin, Italy
Renal Insufficiency, Acute, Renal Replacement Therapy
Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure
This multicentre SHARF4 (Stuivenberg Hospital Acute Renal Failure) study aims to investigate outcome in patients with acute renal failure (ARF), stratified according to severity of disease (SHARF score) and randomised to…
- Trial name
- NCT00322933
- Testing
- renal replacement therapy (intermittent or continuous)
- Where
- Belgium
- Volunteers
- 1,628 people
- Sponsor
- Ziekenhuis Netwerk Antwerpen (ZNA)
Heart Failure Acute
Development and Validation of a Simple-to-use Nomogram for Predicting In-hospital Mortality in Acute Heart Failure Patients Undergoing Continuous Renal Replacement Therapy
Acute heart failure (AHF) is one of the most common causes of hospitalization and life-threatening medical condition around worldwide.
- Trial name
- NCT04751838
- Testing
- no intervention
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Qilu Hospital of Shandong University
Acute Kidney Injury in Pediatric Patients
Prismaflex HF20 Set and Prismaflex® System 7.10/7.20 for Acute Continuous Renal Replacement Therapy (CRRT) in Children
The primary objective of this study is to evaluate the efficacy of the Gambro Prismaflex® HF20 Set based on testing the hypothesis that it delivers sufficient renal replacement therapy to effectively treat acute kidney injury…
- Trial name
- NCT02561247
- Testing
- Prismaflex HF20 CRRT Filter, Prismaflex® System 7.10 and 7.20
- Where
- 6 sites in United States
- Volunteers
- 23 people
- Sponsor
- Vantive Health LLC
Tobacco Dependence
Varenicline for Long-term Nicotine Replacement Therapy (NRT) Users
Primary aim: Will varenicline be better than placebo to get long-term users of NRT to stop? Secondary aim: To assess in details some side effects of varenicline i.e. nausea and abnormal dreams.
- Trial name
- NCT00977249
- Testing
- support and visits, varenicline
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Nicotine Dependence
Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers
The proposed study will assess the efficacy of moclobemide, a selective, reversible MAO-A inhibitor, in facilitating smoking cessation in treatment-seeking female smokers.
- Trial name
- RIMA (NCT01926626)
- Testing
- Nicotine Patch, Moclobemide
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Jed E. Rose
Severe Burn Injury
Balanced Volume Replacement Therapy With Ringer's Acetate Solution in Burn Injury
This observational study compares the influence of Ringer's Lactate solution and Ringer's Acetate solution on organ function scores following severe burn injury.
- Trial name
- VoLTRAB (NCT00609700)
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Klinikum St. Georg gGmbH
Glaucoma
Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on Brimonidine 0.2%/Timolol 0.5% Fixed Combination Therapy (COMBIGAN®) in Latin America
The purpose of this study was to assess the efficacy and tolerability of changing to AZARGA® from prior COMBIGAN® pharmacotherapy in participants with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT01518244
- Testing
- Brinzolamide/timolol maleate fixed combination
- Volunteers
- 50 people
- Sponsor
- Alcon Research
Perimenopausal Disorder, Depression
Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"
Using neuroimaging, the investigator will study the effects of estrogen on mood and brain function in perimenopausal women with depression.
- Trial name
- Duavee (NCT03740009)
- Testing
- Bazedoxifene/Conjugated Estrogen
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes Mellitus, Obesity
The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men With Type 2 Diabetes Mellitus and Obesity
The goal of this study is to learn whether semaglutide (treatment for type 2 diabetes and obesity) can improve signs and symptoms of hypogonadism in men with type 2 diabetes, obesity and hypogonadism (a condition when levels of…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Functional Hypogonadism
- Trial name
- SEMAT (NCT06489457)
- Testing
- Semaglutide, Testosterone Undecanoate
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Smoking Cessation
Gen AI Powered Behavioral Support Plus Chewing Gum Intervention for Construction Workers Who Smoke
The goal of this pilot trial is to learn if 1-week NRT sampling, 3-week chewing gum, and 12-week chatbot-delivered instant messaging support works to help smoking cessation in construction workers who smoke.
- Trial name
- NCT07649018
- Testing
- AWARD advice, Brief leaflet on health warning and smoking cessation, Referral card
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Osteoporosis
Effects of Continuous Combined Hormone Replacement Therapy and Clodronate on Bone Mineral Density (BMD) in Osteoporotic Women
Recent studies suggest that the combination of two inhibitors of bone resorption may induce a greater increase in bone mineral density (BMD) than either agent alone.
- Trial name
- Osteo (NCT00877097)
- Testing
- Klodronate and Kliogest, Bonefos
- Volunteers
- 167 people
- Sponsor
- Kuopio University Hospital
Regional Citrate Anticoagulation, Ionized Calcium
No Monitoring of Post-filter Ionized Calcium in Regional Citrate Anticoagulation
Do no monitor of post-circuit ionized calcium affact the filter life time of continueous renal replacement therapy with regional citrate anticoagulation circuit? A randomized control trial
- Conditions
- Regional Citrate Anticoagulation, Ionized Calcium, Continuous Renal Replacement Therapy
- Trial name
- NCT04792424
- Testing
- Regional citrate anticoagulation, Vasopressor, Antibiotic
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Acute Kidney Injury
Iatrogenic Deficiencies in ICU Patients With Prolonged Continuous Renal Replacement Therapy
ICU patients are recruited after at least 5 days treatment with continuous renal replacement therapy. Blood samples are drawn at time of recruitment and then every 3-5 days until ceseation of renal replacement therapy.
- Trial name
- IBRIST (NCT06983197)
- Testing
- blood test
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Smoking Cessation
Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Students
The study is a randomized, controlled trial comparing music therapy associated to NRT versus NRT alone to evaluate the value of music therapy in improving the management of craving among 120 student smokers (18 to 25 years old).
- Trial name
- NCT05589220
- Testing
- Music Intervention, Nicotine replacement
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Poitiers University Hospital
Cystic Fibrosis, Gastrointestinal System Disease
CFTR Modulators and Gastrointestinal Complications
To elucidate the similarities and distinctions in non-pulmonary manifestations of cystic fibrosis (CF) including distal intestinal obstruction syndrome (DIOS) incidence and pancreatic enzyme replacement therapy (PERT) use between…
- Conditions
- Cystic Fibrosis, Gastrointestinal System Disease, Distal Intestinal Obstruction Syndrome, Pancreatic Enzyme Abnormality
- Trial name
- CFTR-MAGIC (NCT05253859)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 47,023 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Gaucher Disease
A Study of Enzyme Replacement Therapy (VPRIV) in People With Type 1 Gaucher Disease Who Were Previously Treated With Substrate Reduction Therapy
The study will provide information on outcomes in people with type 1 Gaucher disease when they are treated with velaglucarase alfa (also called VPRIV), under standard care.
- Trial name
- SWITCH (NCT04718779)
- Testing
- Digital Engagement Application (GD App), No Intervention
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Takeda
Chronic Kidney Disease, Cardiovascular Diseases
SEDentary Lifestyle, Mortality and Major Adverse Clinical Outcomes in Chronic KIDney Disease
The goal of this study is to learn if a simple home exercise program can benefit patients with advanced chronic kidney disease. There is also an observational part of the study without an exercise program.
- Conditions
- Chronic Kidney Disease, Cardiovascular Diseases, Frailty
- Trial name
- SEDKID (NCT06935786)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- 3 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Turku University Hospital
Chronic Kidney Diseases, Protein-Energy Malnutrition
Effect of a Specialized Oral Supplement on Nutritional Status and Quality of Life in Non-dialysis CKD
Patients whit chronic kidney disease (CKD) there is a high prevalence of nutritional disorders and negative changes in body composition, which is strongly associated with an increased risk of morbidity and mortality.
- Trial name
- NCT06576479
- Testing
- Nutritious Shake, Nutritional counseling
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- NIN Institute
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