Clinical trials: Hormone Replacement
Growth Hormone Deficiency, Chronic Heart Failure
Long-Term Efficacy and Safety of Growth Hormone Replacement Therapy in Chronic Heart Failure
After the encouraging results of 6 months of Growth Hormone Replacement Therapy in Patients With Chronic Heart Failure and Coexisting Growth Hormone Deficiency (NCT00591760) the investigators wanted to collect data about the…
- Trial name
- NCT01576861
- Testing
- Somatotropin
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Federico II University
Smoking Cessation
Smoking Reduction or Cessation With Nicotine Replacement Therapy
The purpose of this study is to test the success rate of smoking reduction or cessation with different nicotine products.
- Trial name
- NCT00840242
- Testing
- Nicotine gum, Nicotine inhaler
- Where
- 2 sites in Czechia
- Volunteers
- 314 people
- Sponsor
- McNeil AB
Chronic Kidney Diseases, Subclinical Hypothyroidism
Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR.
Study design: Phase II study, randomized, double-blind, unicentric, two-arm, placebo-controlled clinical trial. Methods and participants: Patients with Chronic Kidney Disease G2-G5 with proteinuria without renal replacement…
- Trial name
- TSHrenal (NCT03898622)
- Testing
- Levothyroxine
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Hospital Civil de Guadalajara
Hyperphosphatemia Patients With Chronic Kidney Disease on 3x/Week Replacement Therapy
Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis
This study will evaluate the efficacy of SBR759 compared to sevelamer HCl in lowering serum phosphate levels in Chronic Kidney Disease patients on hemodialysis
- Trial name
- SBR759 (NCT00704483)
- Testing
- SBR759, Sevelamer HCl
- Where
- 66 sites in United States, Australia and 11 more
- Volunteers
- 321 people
- Sponsor
- Novartis Pharmaceuticals
Cerebral Small Vessel Diseases, Postmenopausal Symptoms
Effect of Menopause Hormone Therapy In Postmenopausal Women With CSVD And MCI
The objective of this clinical trial is to explore the efficacy of menopausal hormone therapy in early menopausal women with CSVD and MCI.
- Conditions
- Cerebral Small Vessel Diseases, Postmenopausal Symptoms, Mild Cognitive Impairment, White Matter Hyperintensity
- Trial name
- MIRACLE (NCT05982470)
- Testing
- Estradiol Gel, Progesterone Soft Capsule
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Beijing Tiantan Hospital
Acute Renal Failure on Dialysis (Disorder)
Prescription-based Fluid Management Versus Usual Care in Critically Ill Patients on KRT Trial in UK
The PROBE Fluid UK randomised controlled trial compares a protocol-based fluid removal strategy with usual care in critically ill patients with acute kidney injury receiving kidney replacement therapy.
- Trial name
- PROBE Fluid UK (NCT06471777)
- Testing
- Fluid removal
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Smoking Cessation, Electronic Cigarette Use
CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes
Many people smoke cigarettes and use e-cigarettes, and have a hard time stopping. Nicotine replacement therapy medications, such as nicotine patches and lozenges, have been shown to help people quit e-cigarette use.
- Conditions
- Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- CAN-DOSE (NCT06087328)
- Testing
- Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Renal Replacement Therapy
Citrate Anticoagulation in Renal Replacement Therapy: Impact of a High Post-filter Calcium Target on Efficacy
Regional citrate anticoagulation (RCA) is the recommended method for anticoagulation in continuous renal replacement therapy (CRRT). However, the optimal post-filter ionized calcium (iCa) target level remains unclear.
- Trial name
- Ca-CIBLE (NCT05814341)
- Testing
- Citrate
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Kidney Disease Stage 5
Shared Decision Making for Choosing renAl Replacement Therapy in Chronic Kidney Disease Patients
Shared decision making (SDM) is an approach where clinicians and patients make decisions together using the best available evidence.
- Trial name
- SDM-ART (NCT04976166)
- Testing
- Education
- Where
- 19 sites in South Korea
- Volunteers
- 1,194 people
- Sponsor
- Seoul National University Hospital
Smoking, Smoking Cessation
A Novel Treatment to Boost Quit Attempts and Cessation Among Unmotivated Smokers
A sample of smokers who have no current plans to quit will be recruited for this study and randomized to one of two intervention conditions: 1. Practice Quit Attempt (PQA) aided by brief advice and self-help materials, or 2.
- Trial name
- NCT00706979
- Testing
- Practice Quit Attempt plus nicotine lozenge, Practice Quit Attempt only
- Volunteers
- 849 people
- Sponsor
- Medical University of South Carolina
Hypothyroidism
Monitoring and Evaluation of the Levothyroxin Replacement Therapy in Pregnant Women With Hypothyroidism
The aim of the study was to evaluate the clinical control program in patients with hypothyroidism during pregnancy (suggested in resent guidelines). Is it possible by monitoring the patients every 4.
- Trial name
- NCT02094079
- Testing
- biomedical outcomes
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Birte Nygaard
Gaucher Disease Type 1
Clinical Study to Evaluate the Long Term Efficacy, Safety and Tolerability of Miglustat in Patients With Stable Type 1 Gaucher Disease
Although miglustat has been approved as a treatment for mild to moderate type 1 Gaucher disease in patients who are unsuitable for enzyme replacement therapy (ERT), more data are required to establish the long term efficacy…
- Trial name
- NCT00319046
- Testing
- Miglustat
- Volunteers
- 42 people
- Sponsor
- Actelion
Thyroid Disease, Kidney Diseases, Chronic
A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients
Hypothyroidism, defined by elevated thyrotropin (TSH) levels, is a common endocrine complication of chronic kidney disease that has been associated with impaired quality of life and cardiovascular complications.
- Trial name
- NCT03191188
- Testing
- Levothyroxine Sodium
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of California, Irvine
Fabry Disease
Enzyme Replacement Therapy in Fabry Disease
Fabry disease is an X-linked rare metabolic disease, caused by a deficient activity of the hydrolase α-Galactosidase A, and characterized by a progressive and systematic deposition of glycosphingolipids in many organs.
- Trial name
- NCT00149318
- Testing
- Biochemical analyses.
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Tobacco Use Cessation
Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
The goal of this research study is to learn about 2 different interactive methods that are designed to help people with HIV/AIDS stop smoking.
- Trial name
- NCT02302859
- Testing
- Nicotine Patch, Questionnaires, Pamphlet
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Kidney Replacement Therapy
Community Health Workers in an Interdisciplinary Outpatient CKD Clinic to Optimize Social Care Navigation, Patient Engagement, and Home Dialysis Utilization
The goal of this clinical trial is to learn if this intervention (the CHOOSE Home intervention) is feasible and may lead to more home dialysis usage in a high-risk patient population.
- Trial name
- CHOOSE Home (NCT06925776)
- Testing
- CHOOSE Home Intervention, Usual Care
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Montefiore Medical Center
Uremic Pruritus, Chronic Kidney Disease-associated Pruritus
Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis
Several studies investigated the effectiveness of Gabapentin in Uremic Pruritus (UP). No previous studies investigated the use of fexofenadine in UP.
- Conditions
- Uremic Pruritus, Chronic Kidney Disease-associated Pruritus, Hemodialysis, End-stage Renal Disease
- Trial name
- NCT06466421
- Testing
- Fexofenadine, Gabapentin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Critically Ill, Acute Kidney Injury
Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill
Compared with AN69 hemofilter, AN69 ST hemofilter may prolong the time of hemofilter and decrease the quantity of heparin during continuous renal replacement therapy in critically ill.
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- NCT01823484
- Testing
- AN 69 ST hemofilter, AN 69 hemofilter
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Vaping Cessation
Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation
This research focuses on maximizing the chances of successfully quitting vaping. A large, pragmatic community-based clinical trial is planned in New Zealand to build on existing evidence from previous vaping and smoking cessation…
- Trial name
- EQUIT3 (NCT06832098)
- Testing
- Nicotine patches plus nicotine mouth spray, Nicotine Tapering Plan
- Where
- New Zealand
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Antithrombinemia
Evaluation of the Relevance of Antithrombin Prescriptions at Strasbourg University Hospitals
Antithrombin (AT) is a physiological inhibitor of the coagulation cascade. In therapeutics, its presence in sufficient quantities is necessary for the pharmacological activity of unfractionated heparin (UFH) and partially…
- Trial name
- EPPATHUS (NCT07276074)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Strasbourg, France
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