Clinical trials: Hormone Replacement
Sepsis
Cytokine Removal by CRRT in Pediatric Sepsis
This pilot study will compare the effect of diffusive versus convective Continuous Renal Replacement Therapy (CRRT) in children with sepsis who require CRRT.
- Trial name
- NCT00537693
- Testing
- Continuous Renal Replacement Therapy
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Menopausal Women, Respiratory Tract Infections (RTI)
Comparing and Predicting the Risk of Respiratory Tract Infection (RTI) Among Post-menopausal Women on or Without Hormone Replacement Therapy (HRT): an Observational Cohort Study
Background: Respiratory tract infections (RTIs) are a major public health concern. Global studies published in Lancet Infect. Dis.
- Trial name
- Meno_Flu (NCT07292857)
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Insomnia, Menopause
No More Sleepless Nights in Perimenopause
The goal of the clinical trial is to learn if Hormone Replacement Therapy (HRT) and Cognitive Behavioral Therapy (CBT-I) can treat insomnia in menopausal women.
- Trial name
- NCT06497894
- Testing
- Cognitive Behavioural Therapy for Insomnia (CBT-I), Hormone Replacement Therapy (HRT), Sleep Hygiene
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Kidney Failure
Protocol to Assess the Severity of Acute Kidney Injury
The principal objective is to safely determine if we can identify the severity of Acute Kidney Injury (AKI) early in the course of the disease. Once enrolled, we will draw blood and urine for relevant biomarkers.
- Trial name
- AKI (NCT00673244)
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- George Washington University
Betel Nut Cessation
Assessing the Use of Nicotine Gum to Decrease Betel Nut Chewing in Saipan
The study will include a prospective, randomized, double-blinded trial, with a total of 45 subjects enrolled. Research subjects will be recruited from a population of adult patients (current patients at Commonwealth Healthcare…
- Trial name
- NCT05758298
- Testing
- Non-medicated gum, NICOTINE 2MG GUM, NICOTINE 4MG GUM
- Sponsor
- University of Texas Southwestern Medical Center
Gaucher's Disease Type III
Study to Evaluate the Efficacy and Safety of Venglustat in Adult and Pediatric Patients With Gaucher Disease Type 3
This is a parallel arm, Phase 3, double-blind, double-dummy, active-comparator, 2 arm study to evaluate the efficacy and safety of daily oral venglustat versus intravenous Cerezyme infusions every two weeks for improvement or…
- Trial name
- LEAP2MONO (NCT05222906)
- Testing
- Venglustat, imiglucerase
- Where
- 22 sites in United States, Argentina and 9 more
- Volunteers
- 43 people
- Sponsor
- Sanofi
Iron Deficiency Anaemia, Iron Deficiency Anemia
Incidence of Hypophosphatemia After Treatment With Iron Isomaltoside/Ferric Derisomaltose vs Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia
The trial was designed to evaluate the incidence of unintended hypophosphatemia (low level of phosphate in the blood) in subjects with iron deficiency anaemia (IDA).
- Trial name
- NCT03238911
- Testing
- Iron isomaltoside/ferric derisomaltose, Ferric carboxymaltose
- Where
- 16 sites in United States
- Volunteers
- 123 people
- Sponsor
- Pharmacosmos A/S
Fabry Disease
Safety Study of Replagal® Therapy in Children With Fabry Disease
The purpose of this study is to assess the safety of Replagal in children with Fabry disease who who have not previously been treated with enzyme replacement therapy (ERT).
- Trial name
- NCT01363492
- Testing
- Replagal (agalsidase alfa)
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Shire
Continuous Renal Replacement Therapy, CO2 Removal
Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry
The aim of the present study is to assess the metabolic impact of Continuous Renal Replacement Therapy and overview the obstacles and important factors compromising the use of Indirect Calorimetry in CRRT and suggest a model to…
- Conditions
- Continuous Renal Replacement Therapy, CO2 Removal, Nutrition Poor, Acute Renal Failure
- Trial name
- MECCIAS (NCT03314363)
- Testing
- blood gas analysis under citrate predilution, filter replacement, IC
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Adrenal Insufficiency
Adherence in Chronic Adrenal Insufficiency
Adherence, concerns and satisfaction with information in German patients with adrenal insufficiency as well as the influence of a standardized education program will be assessed by a compared cross-sectional and longitudinal…
- Trial name
- NCT03399383
- Testing
- Patient education
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Wuerzburg University Hospital
Cerebral Small Vessel Diseases, Postmenopausal Symptoms
Effect of Menopause Hormone Therapy In Postmenopausal Women With CSVD And MCI
The objective of this clinical trial is to explore the efficacy of menopausal hormone therapy in early menopausal women with CSVD and MCI.
- Conditions
- Cerebral Small Vessel Diseases, Postmenopausal Symptoms, Mild Cognitive Impairment, White Matter Hyperintensity
- Trial name
- MIRACLE (NCT05982470)
- Testing
- Estradiol Gel, Progesterone Soft Capsule
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Beijing Tiantan Hospital
Congenital Adrenal Hyperplasia
Open-label Comparison of Chronocort® Versus Standard Glucocorticoid Replacement Therapy
This study is an open-label, randomised, titration-blinded, parallel arm, multicenter study to compare twice daily Chronocort® with standard care in participants with Congenital Adrenal Hyperplasia (CAH).
- Trial name
- RESTORE (NCT03532022)
- Testing
- Chronocort®, Standard Care
- Where
- United States
- Sponsor
- Neurocrine UK Limited
Mucopolysaccharidosis Type 7
An Open-Label Treatment Protocol With UX003 rhGUS Enzyme Replacement Therapy for an Advanced Stage MPS 7 Patient
Emergency access granted to treat a single patient with advanced Mucopolysaccharidosis Type 7 with UX003 Recombinant Human Beta-glucuronidase (rhGUS) Enzyme Replacement Therapy via IV administration every other week (QOW) for up…
- Trial name
- NCT02097251
- Testing
- UX003
- Where
- United States
- Sponsor
- Joyce Fox
Gaucher Disease
A Study of Velaglucerase Alfa (VPRIV) Given as Standard Patient Care in Young Children With Gaucher Disease
The main aim of this study is to learn if velaglucerase alfa (VPRIV) improves growth and symptoms in participants up to 5 years of age with Gaucher disease. Symptoms will be checked with blood tests.
- Trial name
- PEDS (NCT04721366)
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Takeda
Menopause
Study of the Effectiveness of Clinical Hypnosis and Self-hypnosis in Relieving Hot Flashes in Menopausal Women
The onset of menopause is accompanied by a significant drop in blood estradiol levels, the main symptom of which is hot flashes. These are present in 80% of menopausal women and are debilitating in 25% of cases.
- Trial name
- HYPNOMENO-2 (NCT07572981)
- Testing
- Hypnosis session, Group self-hypnosis, Unstructured supportive interview
- Where
- France
- Volunteers
- 94 people
- Sponsor
- University Hospital, Toulouse
Acute Kidney Injury, Citrate
Citrate Versus Heparin in Continuous Renal Replacement Therapy :
This study is a prospective, multicenter, open-label randomized trial comparing regional citrate anticoagulation (RCA) with heparin-free protocol.
- Conditions
- Acute Kidney Injury, Citrate, Cytokines, Hemodynamic Responses
- Trial name
- NCT04865510
- Testing
- Regional citrate anticoagulation
- Where
- Thailand
- Volunteers
- 41 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Acute Kidney Injury
The Effect of Standard vs. Shorter Filter Lifespan During Continuous Renal Replacement Therapy
This study aims to investigate shorter vs. standard filter lifespans in critically ill patients receiving continuous renal replacement therapy (CRRT) for acute kidney injury (AKI).
- Trial name
- SPECIAL (NCT07630220)
- Testing
- time span of filter change
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universität Münster
Renal Insufficiency / Therapy
PD Catheter Data Collection
Peritoneal Dialysis (PD) is a Renal Replacement Therapy for patients with renal insufficiency that has been used more frequently in recent years.
- Trial name
- Catheter (NCT07156123)
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Severe Native Calcific Aortic Stenosis, Symptomatic Heart Disease Due to Severe Native Calcific Aortic Stenosis
Validation Of anatomY-specific Aortic Valve Implantation Guided by Software Using EncantoR
VOYAGER CE Clinical Study using the Encantor TAVI System.
- Trial name
- VOYAGER CE (NCT07696182)
- Testing
- Prospective, single-arm, multi-center study.
- Volunteers
- 150 people
- Sponsor
- Abbott Medical Devices
Osteoporosis, Turner's Syndrome
Hormone Replacement Therapy to Treat Turner Syndrome
This study will evaluate the effects of hormone replacement therapy on patients with Turner syndrome (TS)-a genetic disorder in females in which part or all of one X chromosome is missing.
- Trial name
- NCT00013546
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
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