Clinical trials: Hormone Replacement
Menopause
Study to Compare the Effect of Hormone Replacement Therapy (HRT) on Breast and Cardiovascular Metabolic Markers in Postmenopausal Women
This study is to evaluate the effects of continuously combined 17b-estradiol/dydrogesterone in comparison with tibolone on the breast metabolic markers, in particular the total insulin-like growth factor-1 (IGF-1), in…
- Trial name
- NCT00145522
- Testing
- 17ß-Estradiol/Dydrogesterone, Tibolone
- Where
- 11 sites in Italy
- Volunteers
- 135 people
- Sponsor
- Solvay Pharmaceuticals
Tobacco Use Cessation, Smoking Cessation
Treating Low-Income Smokers in the Hospital Emergency Department
This study will test the effectiveness of an Emergency Department (ED) initiated tobacco intervention which includes counseling and medication.
- Conditions
- Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
- Trial name
- NCT01328431
- Testing
- Brief Intervention with NRT Initiation
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- Yale University
Nicotine Dependence
An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence
The transdermal nicotine patch is the most widely used form of tobacco dependence treatment in the US and Europe, but most smokers are unable to successfully quit with this form of treatment.
- Trial name
- NCT01047527
- Testing
- Transdermal nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Quality of Life, Renal Insufficiency
A One Visit Follow Up of Adults With Fabry Disease Who Started Long-term Enzyme Replacement Therapy As Children
The objective of this study is to obtain follow up data on a cohort of well-studied patients with Fabry disease who have been on ERT since childhood for a total of about 15 years.
- Conditions
- Quality of Life, Renal Insufficiency, Cardiac Event
- Trial name
- NCT04002531
- Testing
- General and Neurological examination, Vital signs, 12 lead electrocardiogram
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Baylor Research Institute
Healthy, Osteoporosis
Hormone Replacement in Young Women With Premature Ovarian Failure
The human ovary produces male sex hormones (androgen) and female sex hormones (estrogen). Currently, androgen is not included in hormone replacement therapy for women with premature ovarian failure.
- Conditions
- Healthy, Osteoporosis, Premature Ovarian Failure
- Trial name
- NCT00001951
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Thyroid Diseases
Thyroid and Glucose and Energy Metabolism
This study will examine how two thyroid preparations-levothyroxine (T4) and liothyronine (T3)-affect fat and cholesterol metabolism, blood sugar regulation, and thyrotropin secretion in patients who have had their thyroid gland…
- Trial name
- NCT00106119
- Testing
- Liothyronine and Levothyroxine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Estradiol 8 vs 12 mg for Endometrial Preparation in HRT-FET
The goal of this clinical trial is to learn whether 12 mg or 8 mg of oral estradiol valerate is better for preparing the endometrium in women undergoing hormone replacement frozen embryo transfer (HRT-FET) cycles.
- Conditions
- Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Frozen Embryo Transfer (FET), Endometrial Preparation
- Trial name
- NCT07526207
- Testing
- Progynova®
- Where
- 2 sites in Egypt
- Volunteers
- 850 people
- Sponsor
- Cairo University
Infection, Renal Failure
Pharmacokinetics of Meropenem During High-dose CRRT
Assessment of meropenem plasma concentration in critically ill patients who require CRRT (continuous renal replacement therapy). A standard dose of meropenem is administered, i.e. 1 gram every 8 hours.
- Trial name
- NCT03507751
- Testing
- Meropenem, CRRT
- Where
- Poland
- Volunteers
- 19 people
- Sponsor
- Medical University of Lublin
Smoking, COPD
Nurse Smoking Cessation of Patients With Chronic Obstructive Pulmonary Disease (COPD) With Nicotine Replacement Therapy (NRT) and Behavioral Support
This is a smoking cessation study with COPD patients where the researchers wanted to evaluate if nicotine sublingual tablets or placebo combined with low or high individual support could increase ½ and 1 year quit rates.
- Trial name
- NCT00132236
- Testing
- nicotine sublingual tablets, low and high behavior support
- Where
- 7 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Pancreatic Neoplasm, Pancreas Adenocarcinoma
Pancreatic Cancer Dietary Assessment Study
This is a prospective observational study which aims to evaluate; The prevalence of pancreatic insufficiency in patients with pancreatic malignancies (adenocarcinoma and neuroendocrine tumours).
- Conditions
- Pancreatic Neoplasm, Pancreas Adenocarcinoma, Well-Differentiated Neuroendocrine Carcinoma, Malignant Neoplasm of Pancreas
- Trial name
- PanDA (NCT03616431)
- Testing
- Pancreo-KIT breath test
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- The Christie NHS Foundation Trust
Hemophilia B
Lead-in Study of VGB-R04 Gene Therapy for Hemophilia B-- An Observational Survey Analysis Study
This is a prospective, open, multicenter, observational lead-in study，to collect prospective efficacy and safety data of current replacement therapy in adult hemophilia B patients.
- Trial name
- NCT05442528
- Volunteers
- 20 people
- Sponsor
- Shanghai Vitalgen BioPharma Co., Ltd.
Fluid Overload
Bio Electrical Impedance Analysis to Monitor Fluid Status During Deresuscitation Strategy in Continuous Renal Replacement Therapy
Fluid overload is a poor prognostic factor in patients undergoing continuous renal replacement therapy in critical care. A strategy of active fluid removal by net ultrafiltration (UFnet) is one of the means to correct it.
- Trial name
- UF BIA (NCT05160467)
- Testing
- Segmental multi-frequency bio electrical impedance analysis
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon
Hypogonadotrophic Hypogonadism
The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism
The study searched for answers to two questions 1. What is the effect of testosterone replacement therapy on endothelial dysfunction, inflammation and insulin resistance? 2.
- Trial name
- NCT01533129
- Testing
- Testogel 50 mg transdermal gel, Testosterone 250mg injection
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Gulhane School of Medicine
Turner Syndrome, Hypogonadism; Ovarian
Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome
This 14-month, phase IV, randomized controlled crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06570460
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
Septic Shock
Safety and Efficiency of Combined Extracorporeal Blood Purification in Neurosurgical ICU. Prospective RCT
To assess the efficiency and safety of combined extracorporeal blood purification in patients with septic shock in Neurosurgical ICU in comparison with the efficiency and safety of the continuous renal replacement therapy (CRRT).
- Trial name
- NEUROCOMB (NCT04152174)
- Testing
- Combined extracorporeal blood purification, CRRT
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Burdenko Neurosurgery Institute
Diabetes Mellitus, Type 2
Effect of Meal Replacement Therapy on Glucose Control and Metabolic Parameters in Patients With Uncontrolled Diabetes
To evaluate the effect of meal replacement therapy on glucose control and other metabolic parameters in patients with uncontrolled type 2 diabetes. Methodology: This is an open-label, prospective, randomized control trial study.
- Trial name
- NCT06862180
- Testing
- Meal replacement therapy
- Where
- Malaysia
- Volunteers
- 108 people
- Sponsor
- Hospital Universiti Sains Malaysia
Hypopituitarism, Pituitary Tumors
Effect of 5 Years of GH Replacement on Atherosclerosis
Adult patients with hypopituitarism under adequate conventional hormone replacement therapy have reduced life expectancy due to excess vascular events (1-4).
- Conditions
- Hypopituitarism, Pituitary Tumors, Growth Hormone Deficiency
- Trial name
- 5yrGH (NCT00462475)
- Testing
- Recombinant Growth Hormone, Genotropin (Pfizer)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Alzheimer Disease
Alzheimer's Disease: Therapeutic Potential of Estrogen
This is a 15-month study to determine the effectiveness of hormone replacement therapy in improving memory and the ability to live independently in postmenopausal women with Alzheimer's disease.
- Trial name
- NCT00066157
- Testing
- Transdermal estradiol, Medroxyprogesterone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Wisconsin, Madison
End-stage Heart Failure
Carmat TAH Early Feasibility Study
Feasibility study of the Carmat TAH as a treatment for transplant-eligible patients in severe, end-stage heart failure.
- Trial name
- NCT04117295
- Testing
- Carmat Total Artificial Heart
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Carmat SAS
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