Clinical trials: Hormone Replacement
Renal Replacement Therapies, Outcome Assessment
Outcomes of Critically Ill Patients Undergoing RRT- a Registry Based Study.
Rationale: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is a frequently occurring entity among critically ill patients.
- Trial name
- NCT06897254
- Where
- Nepal
- Volunteers
- 516 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Fabry Disease
Replagal Enzyme Replacement Therapy for Children With Fabry Disease
Primary Objective(s): To assess the safety of Replagal at a dose of 0.2 mg/kg administered over 40 (+/-10) minutes in children with Fabry disease To assess the effect of Replagal on heart rate variability in patients 7 to 17…
- Trial name
- NCT00084084
- Testing
- Agalsidase alfa
- Where
- 14 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Shire
Smoking Cessation, Electronic Cigarette Use
Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan
Smoking is prevalent in Pakistan, and a large proportion of the adult population smokes cigarettes or uses other forms of tobacco.
- Trial name
- NCT06063421
- Testing
- Electronic Cigarette (EC), Nicotine Replacement Therapy
- Where
- Pakistan
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Strategic Health Research Limited
Tobacco Use Disorder, Tobacco Dependence
Equitable Smoking Relapse Prevention
The goal of this clinical trial is to test a GPS (Global Positioning System)-enabled smartphone app (QuitBuddy) in current smokers.
- Trial name
- NCT05625685
- Testing
- Quitbuddy, Control, SDoH Augmentation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bryan W. Heckman
ARDS, Hypercapnic Respiratory Failure
Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome
The study aims to investigate the efficacy of extracorporeal CO2 removal for correction of hypercapnia in coronavirus disease 19 (COVID-19)-associated acute respiratory distress syndrome
- Conditions
- ARDS, Hypercapnic Respiratory Failure, AKI
- Trial name
- NCT04351906
- Testing
- ECCO2R
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Giessen
Men With Low Testosterone Levels
Study to Determine the Effects of Testosterone Replacement Therapy in Aging Men With Androgen Deficiency
The T-001 study is a placebo-controlled investigation of the effects of injectable testosterone replacement therapy on prostate tissues of aging men with low testosterone levels.
- Trial name
- NCT00161304
- Testing
- Testosterone Enanthate
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Leonard S. Marks, M.D.
End-stage Renal Disease
The Incidence of Extended-spectrum β-lactamase (ESBL) Klebsiella Pneumonia in Patient on Renal Replacement Therapy
The prevalence of ESBL Klebsiella pneumonia was higher in patient with renal replacement therapy.
- Trial name
- NCT01612182
- Testing
- renal replacement therapy
- Where
- South Korea
- Volunteers
- 1,289 people
- Sponsor
- Inje University
Acute Kidney Injury, Citrate
Citrate Versus Heparin in Continuous Renal Replacement Therapy :
This study is a prospective, multicenter, open-label randomized trial comparing regional citrate anticoagulation (RCA) with heparin-free protocol.
- Conditions
- Acute Kidney Injury, Citrate, Cytokines, Hemodynamic Responses
- Trial name
- NCT04865510
- Testing
- Regional citrate anticoagulation
- Where
- Thailand
- Volunteers
- 41 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Hypogonadism, Opioid-Related Disorders
Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
The purpose of this randomized controlled clinical trial is to evaluate the effects of clomiphene citrate compared to placebo (substance without active medication) in men who are taking pain medication (opioids) for chronic pain…
- Conditions
- Hypogonadism, Opioid-Related Disorders, Male Infertility
- Trial name
- NCT01880086
- Testing
- Clomiphene citrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Weill Medical College of Cornell University
Cholesterol Ester Storage Disease (CESD), Lysosomal Acid Lipase Deficiency
Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of SBC-102 (Sebelipase Alfa) in Adult Subjects With Lysosomal Acid Lipase Deficiency
This was an extension study to Study LAL-CL01 (NCT01307098). The primary objective of the study was to evaluate the long-term safety and tolerability of sebelipase alfa in participants with liver dysfunction due to lysosomal acid…
- Conditions
- Cholesterol Ester Storage Disease (CESD), Lysosomal Acid Lipase Deficiency, LAL-Deficiency
- Trial name
- NCT01488097
- Testing
- sebelipase alfa
- Where
- 10 sites in United States, Canada and 3 more
- Volunteers
- 8 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Peritoneal Dialysis (PD), Hemodialysis
Examine the Epidemiology and Outcomes of Transitions From PD-to-HD in Canada
Transitions from peritoneal dialysis to hemodialysis are common during kidney replacement therapy and may be associated with adverse outcomes.
- Conditions
- Peritoneal Dialysis (PD), Hemodialysis, Kidney Replacement Therapy
- Trial name
- UPLIFT-PD CORR (NCT07477210)
- Where
- Canada
- Volunteers
- 17,000 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Smoking Cessation, Coronary Artery Disease
Cytisine Compared to Combination NRT in Relapsed Smokers
Cigarette smoking causes cardiovascular disease (CVD) yet many smokers with CVD are unable to quit despite strong desire to do so.
- Trial name
- CYTvsNRT+ (NCT04286295)
- Testing
- Cytisine, Nicoderm C-Q Transdermal Product, Nicorette Lozenge Product
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Peritoneal Dialysis (PD), Hemodialysis
A Survey for Patients and Caregivers Aiming to Understand and Improve the Care of Patients at High Risk of Transfer From Peritoneal Dialysis to Hemodialysis:
Home dialysis is encouraged in Canada and peritoneal dialysis is the most common home dialysis method. However, many patients discontinue peritoneal dialysis, often transferring to hemodialysis.
- Conditions
- Peritoneal Dialysis (PD), Hemodialysis, Kidney Replacement Therapy, Transition
- Trial name
- ULIFT-PD (NCT07437677)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury
Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients
This is a multinational, prospective, observational study designed to characterize patient demographics, prescription parameters, and process measures of continuous renal replacement therapy (CRRT) in intensive care units (ICUs)…
- Conditions
- Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury, Renal Dialysis, Critical Illness
- Trial name
- iCRRT (NCT07365111)
- Testing
- continuous renal replacement therapy
- Where
- Canada
- Volunteers
- 100,000 people
- Sponsor
- University of Alberta
Septic Shock, Acute Kidney Injury
Use of Oxiris Filter in Septic Shock Patients Requiring Renal Replacement Therapy: A Retrospective Cohort Study
Sepsis and septic shock are major causes of mortality in critically ill patients and are frequently associated with acute kidney injury requiring renal replacement therapy.
- Trial name
- NCT07569406
- Testing
- Oxiris filter, Standard Hemofilter
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Prevention of Thromboembolic Events
Study to Assess the Safety, Tolerability, Effects on the Body, Absorption, Distribution and Elimination of 25 mg BAY2433334 in Renal Impairment Including Renal Replacement Therapy ("Dialysis")
BAY2433334 is under clinical development for prevention of complications in diseases such as heart attack, irregular heart beat or stroke which can arise by formation of blood clots elsewhere in the body and travels through the…
- Trial name
- NCT04510987
- Testing
- BAY2433334 single dose in treatment groups 1-4 and 6 as well as on the dialysis free day of treatment 5, BAY2433334 on dialysis treatment day
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Bayer
Menopause
Vascular Effect of Tibolone in the Brachial Artery
The interruption of the secretion of sex steroids occurring during menopause, causes a change in vascular pattern at various levels. As a result, several agencies have side effects that interfere with women's health.
- Trial name
- TDILA (NCT01543399)
- Testing
- Tibolone
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Selmo Geber
Hypogonadism
Effects of Replacement Therapy With Sexual Steroid Hormones on the Insulin Sensitivity of Hypogonadal Man
Sexual steroids administered to supra-physiological doses are likely to change the carbohydrate and lipid metabolism. Investigators propose to study in 12 hypogonadal men hypogonadotropic or hypergonadotropic treated with…
- Trial name
- STEROSENS (NCT02847806)
- Testing
- Estradiol (Insulin sensitivity), Testosterone (Insulin sensitivity)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Caen
Hypophosphatasia
Study of ALXN1850 in Participants With Hypophosphatasia (HPP)
This is an open-label, dose-escalating study to assess safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and immunogenicity of ALXN1850 when given intravenous (IV) and subcutaneous (SC) to adults with HPP.
- Trial name
- NCT04980248
- Testing
- ALXN1850
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Kidney Injury, Renal Insufficiency
Pharmacokinetics of Antiepileptics in Patients on CRRT
The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to…
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Renal Failure, Pharmacokinetics
- Trial name
- PADRE (NCT03632915)
- Testing
- Levetiracetam, Lacosamide, Phenytoin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Maryland, Baltimore
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