Clinical trials: Hormone Replacement
Spinal Cord Injury, Hypogonadism
Testosterone Replacement Therapy in Chronic Spinal Cord Injury
It has long been recognized that co-morbidity associated with multiple metabolic syndrome, such as adverse body composition, insulin resistance and autonomic nervous system impairment, may lead to significant increase in…
- Trial name
- NCT00266864
- Testing
- Testosterone Transdermal System (Androderm 5 mg patch)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation
Provoked Craving Relief Study by NRT
This study is designed to assess the ability of the mint nicotine mouth strip to relieve provoked cigarette craving in light smokers compared to nicotine lozenge and nicotine gum.
- Trial name
- NRT (NCT01476202)
- Testing
- nicotine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Smoking Cessation, Electronic Cigarette Use
CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes
Many people smoke cigarettes and use e-cigarettes, and have a hard time stopping. Nicotine replacement therapy medications, such as nicotine patches and lozenges, have been shown to help people quit e-cigarette use.
- Conditions
- Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- CAN-DOSE (NCT06087328)
- Testing
- Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Endometrial Cancer
Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer
RATIONALE: Estrogen replacement therapy may improve quality-of-life in postmenopausal women with endometrial cancer. It is not yet known whether estrogen replacement therapy will affect cancer recurrence.
- Trial name
- NCT00002976
- Testing
- conjugated estrogens
- Where
- 149 sites in United States
- Volunteers
- 2,108 people
- Sponsor
- Gynecologic Oncology Group
Acute Kidney Injury
Dialysis Weaning in Intensive Care Units (Dialysis STOP)
Evaluation of daily urinary urea excretion, to guide Renal Replacement Therapy weaning, in Intensive Care Units. The objective is to show that remove the dialysis catheter, once daily urinary urea excretion is greater than 1.35…
- Trial name
- D-STOP (NCT03763188)
- Testing
- Use of daily urinary urea excretion
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Dr Alexandre Gros
Hypoparathyroidism, Endocrine System Diseases
A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Adults With Hypoparathyroidism
During the first 26 weeks of the trial, participants were randomly assigned to one of two groups: one group received TransCon PTH and one group received placebo.
- Conditions
- Hypoparathyroidism, Endocrine System Diseases, Parathyroid Diseases
- Trial name
- PaTHway (NCT04701203)
- Testing
- TransCon PTH
- Where
- 21 sites in United States, Canada and 5 more
- Volunteers
- 84 people
- Sponsor
- Ascendis Pharma Bone Diseases A/S
Pineal Tumor
Melatonin Replacement Therapy in Pinealectomized Patients
This is an open-label, single-arm, single-center, proof-of-concept study to assess the effects of melatonin on cardiac autonomic activity in melatonin non-proficient pinealectomized patients.
- Trial name
- NCT03885258
- Testing
- Melatonin Replacement Therapy
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- University of Sao Paulo
Cognitive Decline, Mucopolysaccharidosis I
A Study of Intrathecal Enzyme Therapy for Cognitive Decline in MPS I
This is a 24-month study of the use of laronidase administered into the spinal fluid to treat cognitive decline in mucopolysaccharidosis I (MPS I).
- Conditions
- Cognitive Decline, Mucopolysaccharidosis I, Hurler-Scheie Syndrome, Scheie Syndrome
- Trial name
- NCT00852358
- Testing
- laronidase
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Patricia I. Dickson, M.D.
Acute Renal Failure, Dialysis Related Complication
Simplified Regional Citrate Anticoagulation Protocols for CVVH, CVVHDF and SLED: a Pilot Study
The aim of the study are: 1) To evaluate the occurrence of acid-base alterations and the incidence of hypophosphatemia during different modalities of Renal Replacement Terapy (RRT) in critically ill patients [CVVH, CVVHDF and…
- Conditions
- Acute Renal Failure, Dialysis Related Complication, Hypophosphatemia, Hypomagnesemia
- Trial name
- NCT03976440
- Testing
- Renal Replacement Therapy (RRT) start
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Parma
Cytomegalovirus Retinitis, Acute Renal Failure
Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration
Cidofovir is an acyclic nucleotide analog with broad-spectrum antiviral activity against herpesviruses. Its potency in inhibiting HCMV has been shown in conventional in vitro studies.
- Trial name
- NCT01866397
- Testing
- Cidofovir pharmacokinetics
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Medical University of Vienna
Gaucher Disease
Study of Velaglucerase Alfa Enzyme Replacement Therapy in Japanese Patients With Gaucher Disease
Gaucher disease is an inherited deficiency of the lysosomal enzyme glucocerebrosidase (GCB) that leads to progressive accumulation of glucocerebroside within macrophages and subsequent tissue and organ damage; typically of the…
- Trial name
- NCT01614574
- Testing
- velaglucerase alfa
- Where
- 3 sites in Japan
- Volunteers
- 6 people
- Sponsor
- Shire
Fabry Disease
Replagal Enzyme Replacement Therapy for Adults With Fabry Disease
This study will determine the safety and effectiveness of the drug Replagal for treating people with Fabry disease, an inherited metabolic disorder.
- Trial name
- NCT00097890
- Testing
- Replagal (Agalsidase Alfa), Replagal
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Endocrine Disease, Infertility
Evaluation of Women With Endocrine and Reproductive-Related Conditions
This study was designed to allow inpatient and outpatient evaluation of women with a variety of reproductive and endocrine-related disorders for purposes of research and physician education.
- Conditions
- Endocrine Disease, Infertility, Leiomyoma, Endometriosis
- Trial name
- NCT00001850
- Where
- United States
- Volunteers
- 833 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome in Premature Infant
Fast Assessment of Surfactant Deficiency in Preterm Infants to Speed up Treatment - Validation Study
The aim is to re-validate a FTIR spectroscopy test for measuring lung maturity/Respiratory Distress Syndrome (RDS) before conducting a RCT using this test to guide surfactant treatment of preterm infants.
- Trial name
- FAST2 (NCT05615428)
- Testing
- LS-ratio
- Where
- 3 sites in Denmark
- Volunteers
- 68 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Severe Sepsis
The Benefits of Early Initiation of Continual Renal Replacement Therapy in Patients With Severe Sepsis
The study will evaluate the benefit of early initiation of CRRT in the initial phase of severe sepsis in patients admitted to the ICU. Primary evaluated end-point is 28-day mortality.
- Trial name
- NCT03141112
- Testing
- renal replacement therapy
- Volunteers
- 200 people
- Sponsor
- Radovan Uvizl
After Cardiac Surgery, Diuretic Resistance
Evaluation of the Efficacy of rhBNP in Patients With Diuretic Resistance After Cardiac Surgery
evaluation of the efficacy of recombinant human brain natriuretic peptide in patients with diuretic resistance after cardiac surgery: a prospective single-center single-blind randomized controlled study
- Trial name
- rhBNP (NCT07086287)
- Testing
- rhBNP and standard basic treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Chronic Renal Failure
Efficacy of an Intradialysis Combined Training Program on Disability Level and Physical Performance.
The patient subjected to hemodialysis has a low physical capacity due to being advanced in years and the complexity of the process, which is encouraged by family members and caregivers who lead them to a total dependence.
- Trial name
- PTH-CKD0113 (NCT02883309)
- Testing
- intradialytic physical training program
- Sponsor
- Universidad Austral de Chile
Prostate Cancer
Testosterone in Castration-Resistant Prostate Cancer
Primary Objective: 1. To assess the prostate-specific antigen (PSA)-response (50% decline) to Testosterone Replacement Therapy (TRT) in men with "intermediate and good-risk" Castration-Resistant Prostate Cancer (CRPC).
- Trial name
- NCT00577980
- Testing
- Testosterone
- Sponsor
- M.D. Anderson Cancer Center
Cigarette Smoker, Tobacco Use Disorder
Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation
This randomized clinical trial studies how well behavioral activation therapy and nicotine replacement therapy work in increasing smoking cessation.
- Trial name
- NCT02697227
- Testing
- Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Kidney Injury, Renal Failure, Acute
Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy
Per-dialytic hypotension is common in Intensive Care Unit patients under continuous renal replacement therapy, and occurs in nearly 50% of the patients.
- Trial name
- PRELOAD-CRRT (NCT03139123)
- Testing
- Hemodynamic monitoring during passive leg raising
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
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