Clinical trials: Hormones
Hypothyroidism
Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism
Thyroid disorders, in particular hypothyroidism, are associated with gastrointestinal impairment, such as celiac disease. A study reported an increased prevalence of celiac disease in a large cohort of children affected by…
- Trial name
- NCT02917863
- Testing
- L-Thyroxine (tablet, per os), L-Thyroxine (oral drops, solution)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Meyer Children's Hospital IRCCS
Progesterone,Hormone Replacement Thawed Embryo Transfer Cycles
Serum Progesterone Level in HRT-FET：a RCT
In the window of implantation, progesterone plays an important role. Sufficient serum progesterone is basic for ongoing pregnancy. Vaginal progesterone is more and more widely used in ART. As it has no hepatic first pass effect.
- Trial name
- NCT04248309
- Testing
- intramuscular progesterone 20-40mg from D3 until pregnancy test
- Volunteers
- 423 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Human Immunodeficiency Virus, Growth Hormone Treatment
Impact of Recombinant Human Growth Hormone on HIV Persistence
Antiretroviral therapy (ART) has improved the health of more than 18 million people infected with HIV by controlling viral replication, AIDS and non-AIDS events, and by reducing the risk of transmission.
- Trial name
- NCT03091374
- Testing
- Somatotropin (Human)
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
PYY, Ghrelin
The Effect of Breakfast With Different Macronutrient Composition on PYY, Ghrelin, GLP-1,Glucose Level, VAS for Hunger, VAS for Satiety and Ad Libitum Intake 4 Hours After Breakfast in Obese Women
Gut hormones, such as PYY and ghrelin, are associated with appetite control and obesity. Protein is thought to be the most satieting nutrient and could affect production of several gut hormones.
- Conditions
- PYY, Ghrelin, Appetite, Gut Hormones
- Trial name
- NCT03697486
- Testing
- diet with different composition
- Where
- Indonesia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Hormone Receptor Positive Breast Cancer
A Global Study to Compare the Effects of Fulvestrant and Arimidex in a Subset of Patients With Breast Cancer.
The purpose of the study is to compare how treatment with Fulvestrant (FASLODEX) or Anastrozole (ARIMIDEX) effects disease progression for women with locally advanced or metastatic breast cancer who have not had prior hormonal…
- Trial name
- FALCON (NCT01602380)
- Testing
- faslodex 500mg, arimidex 1mg, faslodex dummy
- Where
- 118 sites in United States, Argentina and 18 more
- Volunteers
- 462 people
- Sponsor
- AstraZeneca
Primary Parathyroid Adenomas
Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU) Treatment Procedure
This study is a multicentre, open, uncontrolled trial for the observation of histological changes in parathyroid adenomas following high intensity focused ultrasound (HIFU).
- Trial name
- NCT01060982
- Testing
- Ultrasonic ablation device
- Where
- 2 sites in France
- Volunteers
- 5 people
- Sponsor
- Theraclion
Subfertility
Letrozole in Stimulated IVF Cycles
In-vitro fertilization (IVF) is the treatment of choice for couples with prolonged infertility. The treatment usually involves hormonal stimulation of the ovaries by follicle stimulating hormone (FSH), followed by surgical…
- Trial name
- NCT02912988
- Testing
- Letrozole
- Where
- 2 sites in China
- Volunteers
- 900 people
- Sponsor
- The University of Hong Kong
Postmenopause, Metabolism
GLYLO Supplement Pilot Trial on Glycation and Aging in Postmenopausal Women
The aim of this study is to assess the effectiveness of GLYLO, a dietary supplement, in postmenopausal women aged 45 to 65 who are overweight or obese and have elevated HbA1c levels.
- Conditions
- Postmenopause, Metabolism, Geroscience
- Trial name
- GRACE (NCT06813261)
- Testing
- GLYLO
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Buck Institute for Research on Aging
Premenstrual Syndrome
Effectiveness of Flutamide in Treating Women With Premenstrual Dysphoric Disorder
This study will evaluate the effectiveness of flutamide in reducing symptoms of premenstrual dysphoric disorder.
- Trial name
- NCT00611923
- Testing
- Flutamide
- Volunteers
- 115 people
- Sponsor
- Weill Medical College of Cornell University
Diabetes Mellitus, Type 2
The Role of Gut Hormones and Hepcidin in Type 2 Diabetes Mellitus
This study aims to investigate the potential of the gut hormones GLP-1, PP, PYY and the iron regulatory hormone hepcidin as biomarkers for progression to complications in diabetes mellitus.
- Trial name
- NCT02413762
- Testing
- No intervention
- Where
- United Arab Emirates
- Volunteers
- 1,512 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Syncope, Bradycardia
Registry of Device Implantation
The implantable device therapy for cardiac arrhythmias has been an established therapy, and one of the common standard procedures in cardiac clinical practice.
- Conditions
- Syncope, Bradycardia, Tachycardia, Sudden Cardiac Death
- Trial name
- NCT03360227
- Testing
- implantation of cardiac devices
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Prostatic Neoplasms
A Phase II Study of Degarelix in the Management of Non-Metastatic Hormone-Refractory Prostate Cancer
This study is being offered to patients who have hormone resistant prostate cancer (HRPC). This means that their prostate cancer is no longer responding to standard hormonal therapy.
- Trial name
- OTT10-06 (NCT01545882)
- Testing
- Degarelix
- Where
- 3 sites in Canada
- Volunteers
- 5 people
- Sponsor
- Ottawa Hospital Research Institute
Addison Disease
Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease
Addison's disease is a rare disease, wherein the adrenals can not produce sufficient steroid hormones (cortisol and aldosterone).
- Trial name
- NCT01271296
- Testing
- Liquorice, Grapefruit Juice
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Haukeland University Hospital
In-vitro Fertilization
Combination of Gonadotropin-releasing Hormone Agonist and Human Chorionic Gonadotropin Triggered by Normal Responder in GnRH-antagonist Cycles
Background The trigger for the final maturation of the ovum by providing integration of Human Chorionic Gonadotropin (hCG) and Gonadotropin - releasing hormone (GnRH) agonist was first introduced long ago, but clinically not…
- Trial name
- NCT02862782
- Testing
- hCG (Ovitrelle 250 mcg mcg - Merck Serono), hCG (Ovitrelle 250 mcg mcg - Merck Serono) + GnRH agonist (Decapeptyl 0.2mg - Ferring Gmgh)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Breast Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
A Study to Determine the Efficacy of a Digital Self-management Support Tool to Improve the Quality of Life During Adjuvant HOrmonal Therapy for Patients With Early Breast Cancer
Randomized trial that compares a personalized digitally-enabled pathway delivered by a mobile application in addition to standard of care vs.
- Trial name
- HOPE (NCT06781996)
- Testing
- multimodal Resilience© digital companion, Standard supportive care
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Adenomyosis
Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis
Adenomyosis is characterized by the appearance of endometrial cells in the muscular layer of the uterus. It affects about 15-20% of the female population.
- Trial name
- NAPPED II (NCT02197923)
- Testing
- Myometrial biopsy, endometrial biopsy
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Breast Neoplasms
A Study of Abemaciclib (LY2835219) Combined With Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer
The main purpose of this study is to compare progression-free survival for women with hormone receptor positive (HR+), human epidermal growth factor receptor (HER2) negative advanced breast cancer receiving either abemaciclib +…
- Trial name
- MONARCH 2 (NCT02107703)
- Testing
- Abemaciclib, Fulvestrant
- Where
- 146 sites in United States, Australia and 18 more
- Volunteers
- 669 people
- Sponsor
- Eli Lilly and Company
Nicotine Dependence
IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior
Clinical studies are proposed to analyze the interactions between nicotine, alterations in endocrine hormones, mood and cardiovascular measures.
- Trial name
- NCT01589055
- Testing
- Intravenous Nicotine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Chronic Kidney Disease (Stages 3b-5), Hemodialysis
Virtual Reality Versus Intradialytic Neuromuscular Electrical Stimulation on Renin Hormone in Chronic Kidney Patients
Worldwide accelerated advances in physical rehabilitation of chronic kidney disease; particularly whom undergoing hemodialysis. Multimodal therapeutic approaches may maximize their recovery through preliminary evidence indicating…
- Conditions
- Chronic Kidney Disease (Stages 3b-5), Hemodialysis, Shoulder Adhesive Capsulitis
- Trial name
- NCT07760285
- Testing
- Virtual Reality session, intradialytic neuromuscular electrical stimulation, Maitland Mobilization
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Adly A Adam
Inflammation, Glucose Metabolism Disorders
Endotoxin & Cytokines. Do Protein Loss and Metabolic Effects Depend on Central Nervous System (CNS) Activation of Stress Hormones or on Local Mechanisms in Muscle and Fat?
Main objective : The purpose of this study is to prove that the effects of bacterial endotoxin and cytokine TNF-α, on protein loss, fatty acid release, and glucose metabolism depend on two mechanisms: 1.
- Trial name
- NCT01452958
- Testing
- TNF-alpha, Endotoxin
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital