Clinical trials: Hospital Acquired Infection
Antibiotic, Healthcare Associated Infection
Evaluating Antibiotic Stewardship Assisted by Computer in the University Hospital of Nancy (MACABAO)
Antibiotic resistance is one of the most pressing health threats that mankind faces now and in the coming decades. Antibiotic resistance leads to longer hospital stays, higher medical costs and increased mortality.
- Trial name
- MACABAO (NCT04976829)
- Testing
- Antibiotic stewardship and healthcare-associated infections surveillance assisted by computer
- Volunteers
- 100,000 people
- Sponsor
- Central Hospital, Nancy, France
Nosocomial Infection
Administration of a Lactobacillus GG and Vitamins Containing Mixture is Effective in Preventing Nosocomial Infection in Children
Nosocomial infections are infections that occur from the time of 'entry in the hospital up to 48h after discharge. In most developed countries, the incidence of nosocomial infections in children is between 5% and 44% with the…
- Trial name
- NCT02558192
- Testing
- Lactobacillus Rhamnosus GG
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Federico II University
Pneumonia, Bacterial Pneumonia
An Effectiveness, Safety, and Microbiology Study of Doripenem in Patients With Nosocomial (Hospital-acquired) Pneumonia
The purpose of this study is to evaluate the effectiveness and safety of doripenem monohydrate in the treatment of patients with nosocomial (hospital-acquired) pneumonia.
- Conditions
- Pneumonia, Bacterial Pneumonia, Ventilator-Associated Pneumonia, Infections, Nosocomial
- Trial name
- NCT00502801
- Testing
- doripenem
- Where
- 40 sites in United States, Argentina and 7 more
- Volunteers
- 185 people
- Sponsor
- PriCara, Unit of Ortho-McNeil, Inc.
Parenteral Nutrition
Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN
Many hospitalized patients who are malnourished or not eating receive intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications.
- Trial name
- TPN2 (NCT00672854)
- Testing
- ClinOleic 20% Intravenous Emulsion, Intralipid, 20% Intravenous Emulsion
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Hospital Acquired Pneumonia
Predictors and Outcomes of Ventilated Hospital-acquired Pneumonia
Hospital-acquired pneumonia (HAP) is defined as an infection of the pulmonary parenchyma that develops in patients admitted to hospital for more than 48 hours and that was not incubating at the time of admission.
- Trial name
- NCT07667582
- Testing
- mechanical ventilation (MV)
- Where
- Egypt
- Volunteers
- 151 people
- Sponsor
- Assiut University
Hospital Infection, Multi-antibiotic Resistance
Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs.
Colistin is an antibiotic active against several classes of multi-resistant gram-negative bacteria; the drug should be used in high doses in patients on continuous renal replacement therapy, since the drug is eliminated through…
- Conditions
- Hospital Infection, Multi-antibiotic Resistance, Critically Ill
- Trial name
- NCT04995133
- Testing
- Colistin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hospital-acquired Pneumonia
Feasibility Study of Contemporary Diagnostics for Patients With Suspected Hospital-Acquired Pneumonia.
Hospital-Acquired Pneumonia (HAP) is a severe lung infection that develops while a patient is in hospital. We aim to design a trial to see if modern diagnostic investigations can safely improve outcomes for patients suspected of…
- Trial name
- HAP-FAST (NCT05483309)
- Testing
- CT scan, FilmArray Pneumonia Panel
- Where
- 3 sites in United Kingdom
- Volunteers
- 220 people
- Sponsor
- University of Liverpool
Diarrhea, Clostridium Infections
Efficacy and Safety of BIO-K + CL1285 in Prevention of Antibiotic-associated Diarrhea in Hospitalized Adult Patients
The purpose of this study is to evaluate the efficacy and safety of Bio-K + CL1285 versus placebo in the prevention of antibiotic-associated diarrhea in hospitalized adult patients.
- Trial name
- NCT00328263
- Testing
- Lactobacillus acidophilus CL1285 and Lactobacillus casei
- Where
- 8 sites in Canada
- Volunteers
- 472 people
- Sponsor
- Bio-K Plus International Inc.
Acute-On-Chronic Liver Failure
Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections.
Acute on chronic liver failure patients are at high risk for nosocomial infections due to liver dysfunction, which impairs immune responses and increases vulnerability to infections.
- Trial name
- NCT06818565
- Testing
- Meropenem Injection, Ceftazidime-avibactam, Teicoplanin
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Healthcare Associated Infection, Critically Ill
Dynamic Full-field Optical Coherence Tomography for Structural and Microbiological Characterization of Endotracheal Tube Biofilm in Critically Ill Patients
Biofilm is a microstructure organised into aggregates of microbiological species within a polymeric matrix. As early as the 2000s, the Centers for Disease Control and Prevention (CDC) recognised the possible role of the biofilm…
- Conditions
- Healthcare Associated Infection, Critically Ill, Endotracheal Tube
- Trial name
- BIOPAVIR2 (NCT06379139)
- Testing
- •Dynamic Full-Field Optical Coherence Tomography analysis of endotracheal tube
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial
Critically ill people who need a breathing machine often develop hospital-acquired lung infections. These infections are commonly treated with the antibiotics piperacillin/tazobactam or meropenem.
- Conditions
- Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP), Nosocomial Respiratory Infection, Critical Illness
- Trial name
- ROAD-RCT (NCT07820501)
- Testing
- Resistance-Optimised Precision Dosing, Standard Care Dosing
- Volunteers
- 610 people
- Sponsor
- The University of Queensland
Urinary Infections
Prevention of Catheter Associated Lower Urinary Infections Using the Oxys Indwelling Catheter
The safety and efficacy of a urinary catheter designed to prevent catheter associated urinary infections is studied.
- Trial name
- NCT02658903
- Testing
- Oxys Catheter, Covidien Mona-Therm Foley catheter
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- Oxys Medical AG
Urinary Tract Infection, Acute Pyelonephritis
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
This is an open-label, randomized, multi-center, interventional, active-controlled Phase 4 study to evaluate the efficacy and safety of CAZ-AVI versus BAT in the treatment of infected participants with selected infection types…
- Conditions
- Urinary Tract Infection, Acute Pyelonephritis, Hospital Acquired Pneumonia, Ventilator-associated Pneumonia
- Trial name
- NCT04882085
- Testing
- Zavicefta, Ceftazidime-Avibactam, Best Available Treatment
- Where
- 37 sites in China
- Volunteers
- 60 people
- Sponsor
- Pfizer
Nosocomial Infection
Healthcare-Associated Infections in Ukraine and the Activity of 4-Thiazolidinone Derivatives Against Related Pathogens
The goal of this observational study is to evaluate the species spectrum and biological properties of bacterial and fungal pathogens causing healthcare-associated infections (HAIs) and to investigate the antimicrobial activity of…
- Trial name
- HAIsUA (NCT06508398)
- Testing
- Microbiological Diagnostic Testing
- Where
- Ukraine
- Volunteers
- 250 people
- Sponsor
- Danylo Halytsky Lviv National Medical University
Infections, Hospital, Ventilator-Associated Pneumonia
Strategies To Prevent Pneumonia 2 (SToPP2)
Ventilator-associated pneumonia (VAP) is a serious complication in mechanically ventilated critically ill patients. The intervention tested in this project (swabbing the mouth with chlorhexidine before the endotracheal tube is…
- Conditions
- Infections, Hospital, Ventilator-Associated Pneumonia, Mechanical Ventilation Complication
- Trial name
- SToPP2 (NCT00893763)
- Testing
- Pre-intubation CHX, Control
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- University of South Florida
Pneumonia - Bacterial
Impact of BioFire FilmArray Pneumonia Panel vs Routine Diagnostics on Antimicrobial Outcomes (DOOR-MAT)
Multidrug-resistant bacterial infections are a growing global health concern. Hospital-acquired pneumonia is one of the most common infections occurring during hospitalization and can be associated with high mortality, reaching…
- Trial name
- NCT07585604
- Testing
- Multiplex PCR-based pneumonia panel (BIOFIRE® FILMARRAY® Pneumonia Panel)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hospital Acquired Pneumonia
Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype
Determine the efficacy of dexamethasone plus standard of care (SOC) as compared to placebo plus SOC for treating severe hospital-acquired pneumonia in critically ill patients with a proinflammatory phenotype; It's an…
- Trial name
- HAP-DEX (NCT06269900)
- Testing
- Dexamethasone
- Where
- 34 sites in France, Greece and 1 more
- Volunteers
- 450 people
- Sponsor
- Nantes University Hospital
Ventilator-Associated Pneumonia
Epidemiology of Risk Factors for Hospital-acquired Pneumonia (HAP) in Intensive Care Unit (ICU) Patients
A retrospective, observational study compiled data from all consecutively admitted patients older than 18 years at ICU University Hospital in Olomouc in the period from 1 January 2011 to 31 December 2015 who fulfilled the…
- Trial name
- NCT02779933
- Testing
- Epidemiology od HAP
- Volunteers
- 310 people
- Sponsor
- University Hospital Olomouc
Community-Acquired Pneumonia
Comparison Between Amoxycillin/Clavulanic Acid and Oxacillin/Ceftriaxone for Community Acquired-pneumonia
Objective: To compare the clinical effectiveness and hospital costs, the initial empirical treatment, Oxacillin / Ceftriaxone and Amoxicillin / Clavulanate in children with Community Acquired Pneumonia (CAP) severe.
- Trial name
- NCT01166932
- Testing
- Amoxycillin/clavulanic acid, ceftriaxone/oxacillin
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Healthcare Associated Infection
Evaluation of Healthcare Waste Management Practices and Problems Among Primary and Secondary Hospitals
Healthcare waste is defined as the total waste stream from a healthcare facility. Most of it (75-90%) is similar waste to domestic waste and is known as healthcare general waste and is made up of paper, plastic packaging, food…
- Trial name
- NCT06739863
- Testing
- healthcare waste management
- Where
- Pakistan
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Superior University