Clinical trials: Hospitalized Patients
Influenza
Assessment of Efficacy of CR8020 and CR6261, Monoclonal Antibodies, Against Influenza Infection
The purpose of this study is to evaluate the rate of decline in quantitative viral load measured in hospitalized patients with Influenza A infection
- Trial name
- NCT01992276
- Testing
- CR8020, CR6261
- Where
- 68 sites in United States, Australia and 10 more
- Sponsor
- Crucell Holland BV
Chronic Obstructive Pulmonary Disease, Respiratory Disease
A Microphone for Monitoring Coughs
Aging of the population is dramatically increasing the number of hospitalized patients, with the consequent challenges of limited medical personnel and resources in hospitals.
- Trial name
- CoughMonit (NCT05007574)
- Testing
- Microphone MI-305
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Ligue Pulmonaire Neuchâteloise
Intravenous Fluids, Fluid and Electrolyte Imbalance
SOFI: A Quality Improvement Project to Standardize Use of Intravenous Fluids in Hospitalized Pediatric Patients
Intravenous fluids (IVF) are used in hospitalized patients to replenish the fluid and electrolyte losses of patients who cannot take adequate hydration by mouth or through their gut.
- Conditions
- Intravenous Fluids, Fluid and Electrolyte Imbalance, ADH Inappropriate
- Trial name
- SOFI (NCT03924674)
- Testing
- Education, clinical decision support tools
- Where
- 89 sites in United States
- Volunteers
- 106 people
- Sponsor
- Seattle Children's Hospital
Urinary Retention
Indwelling Urinary Catheterization Versus Clean Intermittent Catheterization for the Short-term Management of Hospitalized Patients With Transient Acute Urinary Retention
Objective: Acute urinary retention (AUR) is a common problem in hospitalized patients. Either indwelling urethral catheterization or clean intermittent catheterization (CIC) can be the choice of treatment.
- Trial name
- NCT02942641
- Testing
- Indwelling urethral catheterization (Foley), Clean intermittent catheterization (CIC), Foley
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Diabetes, Diabetes Mellitus
Continuous Glucose Monitoring of Hospitalized Patients With Diabetes
Systematic continuous glucose monitoring (CGM) is commonly provided as a treatment option to patients with diabetes in ambulatory care settings yet is rarely provided during hospitalization.
- Conditions
- Diabetes, Diabetes Mellitus, Glucose, High Blood, Glucose, Low Blood
- Trial name
- NCT04230694
- Testing
- Dexcom Generation 6 CGM (Dexcom Gen6) device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor Research Institute
Hospital Undernutrition, Malnutrition
INAPEN Protocol for Impact of Breakfast Improvement
Hospital undernutrition is a common health problem [1]. As a countermeasure, French hospitals have created a system of cross-function committees for feeding and nutrition called CLANs [Comité de Liaison pour l'alimentation et la…
- Conditions
- Hospital Undernutrition, Malnutrition, Nutritional Deficiency
- Trial name
- INAPEN (NCT01342861)
- Testing
- Addition of protein (milky food in the breakfast)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Centre Hospitalier de Meaux
Malnutrition (Diagnosis), Nutrition Disorders
NRS 2002: Nutritional Screen in Cancer Patients
Diagnosing the nutritional status of cancer patients is extremely important. An appropriate nutritional status supports a better tolerance to the treatment. A working protocol is essential to start with Nutritional Screening.
- Conditions
- Malnutrition (Diagnosis), Nutrition Disorders, Nutrition Surveys, Scoring System
- Trial name
- NCT04137666
- Where
- Ecuador
- Volunteers
- 68 people
- Sponsor
- Sociedad de Lucha Contra el Cáncer del Ecuador
BPSD (Behavioral and Psycological Symptoms of Dementia)
Psychosocial Intervention for Behavioral Symptoms in Hospitalized Patients With Dementia or Delirium
Behavioral and psychological symptoms are common among older adults hospitalized with dementia or delirium and may include agitation, wandering, delusions, hallucinations, aggression, oppositional behavior, and sleep…
- Trial name
- ESSECOA (NCT07778329)
- Testing
- Sensory and General Stimulation With Caregiver Education, Standard Pharmacological Management
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Heart Failure, Rehabilitation
Prognosis Predictors for Heart Failure
This study is looking for the predictors of the survival or rehospitalization of patients with heart failure with reduced ejection fraction. Participants who are discharged from an acute heart failure hospitalization are enrolled.
- Conditions
- Heart Failure, Rehabilitation, Morality, Hospitalization
- Trial name
- NCT04838470
- Testing
- cardiac rehabilitation
- Volunteers
- 792 people
- Sponsor
- Chang Gung Memorial Hospital
Physical Activity
Activity on Prescription to Promote Physical Activity in Hospitalized Patients
This study tries to improve patient's activity by a "Prescription for Activity" led by physiotherapists in secondary health care setting. Three groups are compared in regard to their increase of physical activity.
- Trial name
- NCT01622829
- Testing
- "Prescription for Activity" and individual instructions, "Prescription for Activity", without instructions, usual physiotherapy
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Heidelberg University
Heart Failure
Home-Based Fluid Status Monitoring in Heart Failure Patients
This is a prospective, multi-center, single-arm study enrolling adult patients who have been hospitalized for heart failure and subsequently discharged.
- Trial name
- NCT04013373
- Testing
- SOZO Bioimpedance Spectroscopy Device
- Where
- 15 sites in United States
- Volunteers
- 92 people
- Sponsor
- ImpediMed Limited
Diuretic Toxicity, Acute Kidney Injury
Risk Factors and Machine Learning Model for Diuretics Related Acute Kidney Injury
Acute kidney injury (AKI) is a series of clinical syndromes in which serum creatinine (Scr) concentrations increase over a short period of time, or urine output decreases.
- Trial name
- NCT05527054
- Testing
- Diuretics
- Where
- China
- Volunteers
- 18,000 people
- Sponsor
- Qianfoshan Hospital
COVID-19
Aprepitant Injectable Emulsion in Patients With COVID-19 (GUARDS-1)
The study will evaluate the efficacy and safety of aprepitant injectable emulsion added to standard of care for hospitalized patients with COVID-19.
- Trial name
- NCT04470622
- Testing
- Aprepitant injectable emulsion
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Heron Therapeutics
Adrenal Insufficiency, Cirrhosis
Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?
The hepatoadrenal syndrome has been well described in the literature and is known to be associated with poorer outcomes in both stable and critically ill cirrhotic patients.
- Conditions
- Adrenal Insufficiency, Cirrhosis, Spur Cell Anemia, Lecithin Acyltransferase Deficiency
- Trial name
- NCT03368066
- Testing
- Cosyntropin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Aspirin Resistance
Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia
Acetylsalicylic acid (Aspirin, ASA) is the most widely prescribed drug used in primary and secondary prevention of cardiovascular disease.
- Trial name
- Aspirine (NCT01104441)
- Where
- 2 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Limoges
Acute Respiratory Distress Syndrome, ARDS
Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)
To evaluate the safety and efficacy of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles (EVs), ExoFlo, versus placebo for the treatment of hospitalized patients with…
- Trial name
- NCT05354141
- Testing
- ExoFlo, Intravenous normal saline
- Where
- 32 sites in United States
- Volunteers
- 970 people
- Sponsor
- Direct Biologics, LLC
COVID-19
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19
The primary objectives are: Pooled Phase 3 (Cohort 1) and Phase 2 (Cohort 1A) To evaluate the virologic efficacy of REGN10933+REGN10987 compared to placebo in reducing viral load of SARS-CoV-2 To evaluate the clinical efficacy of…
- Trial name
- NCT04426695
- Testing
- REGN10933+REGN10987 combination therapy
- Where
- 123 sites in United States, Brazil and 4 more
- Volunteers
- 2,252 people
- Sponsor
- Regeneron Pharmaceuticals
Venous Thromboembolism
Computerized Decision Support for Prevention of VTE in Hospitalized Medical Patients Across the Continuum of Care (DC-eALERT)
Hospitalized medical patients have an increased risk of venous thromboembolism (VTE) across the continuum of care, including after hospital discharge.
- Trial name
- DC-eALERT (NCT03728166)
- Testing
- Electronic alert
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Non-severe Pulmonary Embolism, Pulmonary Embolism
Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study
The objective of the study is to evaluate the prognostic performance of the chair lift test in the initial assessment of the severity of non-severe pulmonary embolism in hospitalized patients, in comparison with the current…
- Conditions
- Non-severe Pulmonary Embolism, Pulmonary Embolism, Non-high-risk Pulmonary Embolism, Pulmonary Embolism Acute
- Trial name
- SIT-EP (NCT06166329)
- Testing
- chair lift test
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Rouen
COVID-19 Pneumonia
Adding Colchicine to Tocilizumab in Patients With Severe COVID-19 Pneumonia.
Colchicine acts upstream in the cytokines cascade by inhibiting the NLRP3 inflammasome while IL-6 receptor antagonists (tocilizumab) block the end result of the cytokines cascade.
- Trial name
- NCT05118737
- Testing
- Colchicine
- Where
- Qatar
- Volunteers
- 230 people
- Sponsor
- Hamad Medical Corporation