Clinical trials: Household Contacts
Tuberculosis, Pulmonary, Household Contacts
Airborne Preventive Measures to Reduce New TB Infections in Household Contacts
Tuberculosis (TB) is currently one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent (ranking above HIV/AIDS).
- Conditions
- Tuberculosis, Pulmonary, Household Contacts, Tuberculosis
- Trial name
- TBMask (NCT04938596)
- Testing
- Respiratory bundle
- Where
- Chile
- Volunteers
- 432 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Tuberculosis, Pediatric ALL
Patient Centered Intervention to Prevent Tuberculosis Among Children Under Five Years Old
Isoniazid preventive therapy (IPT) reduces the risk of tuberculosis in 60%. Young children are at higher risk of developing severe forms of TB, though this can be prevented with a full course of IPT.
- Conditions
- Tuberculosis, Pediatric ALL, Behavior, Health
- Trial name
- NCT03881228
- Testing
- Increasing the completion of IPT
- Where
- Peru
- Volunteers
- 356 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Tuberculosis
Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries
The ERASE - TB study will be conducted in order to fill a critical unmet need for tuberculosis control. Persons who are in contact with an infectious TB case may become infected themselves.
- Trial name
- ERASE-TB (NCT04781257)
- Testing
- New test candidates
- Where
- 3 sites in Mozambique, Tanzania and 1 more
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Michael Hoelscher
Coronavirus Infection
Serologic Testing of Household Contacts of Confirmed Cases of COVID-19
SARS-CoV-2 has now crossed the 1 million number of cases and tens of thousands of deaths. It´s R0 has been calculated between 2 and 5.7 solely based on clinical symptoms but it is estimated to likely be higher.
- Trial name
- NCT04393142
- Where
- Mexico
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
COVID-19
Intranasal Heparin Treatment to Reduce Transmission Among Household Contacts of COVID 19 Positive Adults and Children
Coronavirus-induced disease 2019 (COVID-19) is an infection caused by a virus whose full name is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- INHERIT (NCT05204550)
- Testing
- unfractionated heparin, 0.9%sodium chloride
- Where
- Australia
- Volunteers
- 506 people
- Sponsor
- Murdoch Childrens Research Institute
COVID-19
A Study to Test Whether BI 767551 Can Prevent COVID-19 in People Who Have Been Exposed to SARS-CoV-2
This study is open to adults living with a person who has tested positive for the coronavirus SARS-CoV-2. People who do not have symptoms of COVID-19 can take part in this study.
- Trial name
- NCT04894474
- Testing
- BI 767551 intravenous, BI 767551 inhalation
- Sponsor
- Boehringer Ingelheim
Covid19, SARS-CoV-2 Infection
Efficacy and Safety of Nitazoxanide for Post Exposure Prophylaxis of COVID-19 in Household Contacts
The primary objective of this study is to evaluate the efficacy of the drug nitazoxanide 500 mg, administered three times a day, in relation to placebo in preventing the development of COVID-19 in household contacts of patients…
- Conditions
- Covid19, SARS-CoV-2 Infection, Households Contacts
- Trial name
- PENTZ (NCT04788407)
- Testing
- Nitazoxanide
- Where
- Argentina
- Volunteers
- 456 people
- Sponsor
- Fundación Huésped
Microbiome
Effect of Lactobacillus on the Microbiome of Household Contacts Exposed to COVID-19
The purpose of this study is to evaluate the effect of the probiotic Lactobacillus rhamnosus GG (LGG) and the effect of COVID-19 on the microbiome (the microorganisms that live in and on the human body) in exposed household…
- Trial name
- NCT04399252
- Testing
- Lactobacillus rhamnosus GG
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Participants
COVID-19 Study Assessing the Efficacy and Safety of Anti-Spike SARS CoV-2 Monoclonal Antibodies for Prevention of SARS CoV-2 Infection Asymptomatic in Healthy Adults and Adolescents Who Are Household Contacts to an Individual With a Positive SARS-CoV-2 RT-PCR Assay
Primary Objectives: Cohort A: To evaluate the efficacy of REGN10933+REGN10987 compared to placebo in preventing symptomatic SARS-CoV-2 infection (broad-term) confirmed by RT-qPCR Cohort A and Cohort A1: To evaluate the safety and…
- Trial name
- NCT04452318
- Testing
- REGN10933 + REGN10987
- Where
- 134 sites in United States, Moldova and 1 more
- Volunteers
- 3,303 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Tuberculosis, Pulmonary, Households
Acceptability and Feasibility of Home-based TB Testing
This study aims to evaluate the utility of home-based point-of-care TB testing for early diagnosis and linkage to care of household contacts of TB patients, addressing the need for active case finding and early detection of…
- Trial name
- NCT04973371
- Testing
- Home-based point-of-care (POC) TB testing using GeneXpert device + MTB/RIF test
- Where
- South Africa
- Volunteers
- 98 people
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Tuberculosis
Nurse-Led, Symptom-Based Screening of Household Child Contacts of Tuberculosis Index Cases
To assess implementation of a nurse-led, symptom-based screening program in local, decentralized clinics for tuberculosis (TB) screening of child contacts less than 5 years old who were exposed to tuberculosis in the home.
- Trial name
- SOAR (NCT03074799)
- Testing
- Symptom -based Screening(Child Contacts), Clinical based Decisions
- Where
- South Africa
- Volunteers
- 4,054 people
- Sponsor
- Johns Hopkins University
COVID-19
Evaluate Azvudine in Preventing SARS-Cov-2 Infection in Household Contacts of Covid-19 in China
A Phase II Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Azvudine in Preventing SARS-Cov-2 Infection in Household Contacts of Individuals Infected with SARS-CoV-2 in China
- Trial name
- NCT05682599
- Testing
- Azvudine
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai Henlius Biotech
Tuberculosis
Effectiveness of Active Case Finding of Household Contacts in a Routine Tuberculosis (TB) Control Program
The purpose of this study is to determine the effectiveness and cost-effectiveness of a new population-based active case-finding program among adult household contacts of new infectious TB cases to detect active TB cases in the…
- Trial name
- NCT02174380
- Testing
- Active Household Contact Evaluation
- Where
- Peru
- Volunteers
- 1,900 people
- Sponsor
- Lena Shah
Influenza
Feasibility of Cocooning Immunization Strategy With Influenza Vaccine
Influenza causes epidemics of respiratory infection in young children each winter. Young children, particularly those under 6 months of age are most vulnerable to suffering from complications secondary to influenza infection.
- Trial name
- Piiitch (NCT00570037)
- Testing
- Trivalent inactivated influenza vaccine
- Where
- 2 sites in United States
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- Duke University
Immunization; Infection
A Study to Assess the Carriage of Pneumococci in Children Aged ≤8 Years, and Their Household Contacts
Since the introduction of pneumococcal conjugate vaccines, this research group has conducted several carriage studies. These were at key points in the evolution of the pneumococcal immunisation schedule, with regard to the…
- Trial name
- PIN2 (NCT03407690)
- Testing
- nasal swab
- Where
- 2 sites in United Kingdom
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Public Health England
SARS-CoV-2 Infection
Phase 3 Study of S-217622 in Prevention of Symptomatic SARS-CoV-2 Infection
The purpose of this study is to measure the proportion of participants who are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (positive reverse transcription polymerase chain reaction [RT-PCR] test)…
- Trial name
- SCORPIO-PEP (NCT05897541)
- Testing
- S-217622
- Where
- 178 sites in United States, Argentina and 3 more
- Volunteers
- 3,701 people, healthy volunteers welcome
- Sponsor
- Shionogi
Covid19
Seroprevalence of IgG Antibodies to SARS-CoV-2 (COVID-19) in Primary Health Care Workers and Their Household Contacts
Many uncertainties remain regarding the epidemiological and clinical characteristics of COVID-19, including the number of people exposed to the disease, the persistence of the humoral response and its associated neutralisation…
- Trial name
- COVID-SeroPRIM (NCT04808986)
- Testing
- Serological test for the detection of IgG anti-SARS-CoV-2
- Where
- France
- Volunteers
- 2,817 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Influenza, Human, Respiratory Tract Infections
A Study to Confirm Efficacy of a Single Dose of Baloxavir Marboxil in the Post-exposure Prophylaxis (PEP) of Influenza Virus Infection in Chinese Participants
The main purpose of the study is to evaluate the efficacy of a single dose of baloxavir marboxil compared with placebo in the PEP of influenza virus infection with respect to symptomatic, laboratory-confirmed influenza in…
- Conditions
- Influenza, Human, Respiratory Tract Infections, Post-exposure Prophylaxis
- Trial name
- Pearlstone (NCT07827599)
- Testing
- Baloxavir marboxil
- Where
- 8 sites in China
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Influenza
Study to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A or B in Households
Otherwise healthy index patients (IP) are randomized to either baloxavir marboxil or placebo if their influenza symptoms onset was within 48 hours of screening.
- Trial name
- NCT03969212
- Testing
- Baloxavir Marboxil
- Where
- 142 sites in United States, Bulgaria and 14 more
- Volunteers
- 4,138 people
- Sponsor
- Hoffmann-La Roche
Influenza
A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts
This study consists of two parts: Part A Surveillance and Part B Transmission. The main purpose of Part A is to evaluate the prevalence of pre-dose and treatment-emergent amino acid substitutions in pediatric participants' <12…
- Trial name
- Pebblestone (NCT06094010)
- Testing
- Baloxavir Marboxil
- Where
- 51 sites in United States, Bulgaria and 2 more
- Volunteers
- 1,100 people
- Sponsor
- Hoffmann-La Roche