Clinical trials: Human Embryo Culture
Embryo Culture, Embryo Culture Media
Evaluation of an Undisturbed Embryo Culture System for Embryo Development in IVF/ICSI Cycles
This is a prospective, multicenter, randomized controlled clinical trial designed to evaluate whether a fully undisturbed closed embryo culture system can improve the developmental potential of embryos cultured in vitro and…
- Conditions
- Embryo Culture, Embryo Culture Media, Embryo Quality
- Trial name
- Embryos UECS (NCT07522281)
- Testing
- Gems FEM fertilization medium + Geri incubator+Gems one-step medium, Vitrolife fertilization medium+benchtop incubator + Vitrolife sequential culture media
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infertility (IVF Patients), Infertility
Standardization of Variable Conditions of Embryo Transfer Into the Uterine Cavity in the Procedure of Medically Assisted Procreation in Humans
The EFECT study is a clinical trial designed to determine whether improving the consistency of embryo transfer procedures can increase pregnancy success in patients undergoing frozen embryo transfer (cryoET).
- Conditions
- Infertility (IVF Patients), Infertility, ART
- Trial name
- EFECT (NCT07396181)
- Testing
- Embryocase, Embryopass, Embryocase+Embryopass
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Przychodnia Lekarska nOvum Katarzyna Kozioł, Piotr Lewandowski sp.k.
In Vitro Human Embryo Development
Improving Embryogenesis by Adding Growth Factors to In Vitro Human Culture Media
The investigators suppose that adding growth factors that had been found in the female tubal fluid and uterus to In Vitro single step culture media for human embryos might improve the the embryogenesis In Vitro and the clinical…
- Trial name
- GFSSSCM (NCT02426008)
- Testing
- Growth Factors and Cytokine adding to embryo culture media, No Intervention
- Where
- Egypt
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Infertility
Comparison Of The Embryoscope Time-Lapse System With Standard Embryo Culture
"Embryoscopes," allow for embryo culture to be performed in an automated incubation system under time lapse photography. Manufacturers of these systems (and investigators who have used these systems) claim that the availability…
- Trial name
- NCT02246309
- Testing
- Embryoscope Time Lapse System, Standard Embryo Culture
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility
A Comparison of Ongoing Pregnancy Rate Between Cleavage Stage and Early Compacting Embryo Transfer at 66±2 Hours After ICSI Using Single Step Culture Medium
A comparison of ongoing pregnancy rate between cleavage stage and early compacting embryo transfer at 66±2 hours after ICSI using single step culture medium
- Trial name
- NCT02987075
- Testing
- Compacting embryo transferring, Non- compacting embryo transferring
- Where
- Vietnam
- Volunteers
- 430 people
- Sponsor
- Vietnam National University
Recurrent Miscarriages
Maternal Embryo Interaction in Recurrent Miscarriages
Background of the study: The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
- Trial name
- MEER (NCT03156491)
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Embryo Quality
Group Culture May Affect Embryo Quality in Assisted Reproduction Technology
One of the vital factors in achieving pregnancies in assisted reproductive technologies (ART) is maximizing embryo quality, which is significantly influenced by embryo culture conditions.
- Trial name
- NCT04011319
- Testing
- group culture
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Culture Media, Blastocyst
Comparisons of Human Embryonic Development Using Single Medium With and Without the Addition of Antioxidants
Aim: To investigate the impact of antioxidants (acetyl-L-carnitine, N-acetyl-L-cysteine and a-lipoic acid) on embryo development and subsequently the clinical outcome.
- Conditions
- Culture Media, Blastocyst, Antioxidants, Embryo
- Trial name
- NCT02971878
- Testing
- Acetyl-L-carnitine (ALC), N-acetyl-L-cysteine (NAC) and α-lipoic acid (ALA)
- Where
- Sweden
- Volunteers
- 128 people
- Sponsor
- Fertilitetscentrum AB
Infertility, In Vitro Fertilization
Injection of Day 2 Embryo Culture Supernatant Into the Uterine Cavity Didn't Improve Implantation and Pregnancy Rates
Forty-five infertile women undergoing in vitro fertilization treatment were managed by uterine cavity injection of day 2 embryo culture supernatant before day 3 embryo transfer.
- Trial name
- NCT00730496
- Testing
- uterine cavity injection of day 2 embryo culture supernatant
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shen-Zhen City Maternity and Child Healthcare Hospital
Infertility
A Benchtop Incubator Prospective Study
The use of extended embryo culture to the blastocyst stage and preimplantation genetic testing for aneuploidy (PGT-A) has enabled identification and selection of embryos with the best developmental potential and improved in vitro…
- Trial name
- NCT04969575
- Testing
- Insemination and culture, Media refreshment Group 1, Culture media preparation and refreshment
- Where
- United Arab Emirates
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Culture Media, Blastocyst
Adding Antioxidants Into Human Sequential Culture Media System
Upon collection, human oocytes are fertilized and culture up to the blastocyst stage, followed by transfer and / or cryopreservation. Culture media systems have been developed that support each step of this process.
- Conditions
- Culture Media, Blastocyst, Antioxidants, Embryo
- Trial name
- Antioxidants (NCT02999958)
- Testing
- Antioxidants
- Where
- 2 sites in Japan
- Volunteers
- 128 people
- Sponsor
- Vitrolife
Infertility
Embryo Development in Microfluidics System of Culture
Embryo culture is a cornerstone of in vitro fertilization treatments. Usually, embryos are cultured in microdrops of culture media in incubators with controlled temperature, humidity and atmosphere.
- Trial name
- NCT01003548
- Testing
- SMART dynamic system of embryo culture, Static culture
- Where
- Brazil
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Poor Responder, Severe Male Infertility
Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
In this study the suitability of two -sequential and single step- commercially available culture media from the same brand was compared.
- Conditions
- Poor Responder, Severe Male Infertility, Embryo Development, Blastocyst
- Trial name
- NCT02575924
- Testing
- sequential medium, 1-step medium
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- European Hospital
Infertility, Reproductive Sterility
Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy?
This Clinical Study has been designed to assess and compare the impact of in vitro or in vivo culture conditions on the euploidy of sibling blastocysts.
- Trial name
- NCT02652143
- Testing
- AneVivo (Medical device for in vivo culture of embryos), comparator for embryo culture in vitro
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Anecova SA
Infertility, Genetic Diseases
Time-Lapse Incubation for Embryo Culture - Morphokinetics and Environmental Stability
Embryo culture and selection has been a continuous challenge in evolution since the birth of In Vitro Fertilization (IVF). Traditionally, embryo quality and its presumed suitability for transfer were assessed based on morphologic…
- Trial name
- NCT02657811
- Testing
- Miri, Benchtop Multi-room incubator, Miri TL, Time-Lapse incubator
- Where
- Israel
- Volunteers
- 372 people
- Sponsor
- Shaare Zedek Medical Center
Aneuploidy, Infertility
A Time-lapse Monitoring Prospective Study
While numerous types of commercially available human embryo culture media exist for human blastocyst culture, the impact of culture conditions on blastocyst development and aneuploidy formation is not fully understood.
- Trial name
- NCT04901247
- Testing
- media refreshment, embryo grading
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 50 people
- Sponsor
- ART Fertility Clinics LLC
In Vitro Maturation of Oocytes
Embryo Developmental Potential in a Novel 2-step IVM System
In vitro maturation is a valid option for PCO(S) patients in the daily ART clinic, however maturation and embryologic development are not yet matching the efficiency levels obtained by standard COS treatment.
- Trial name
- CAPA-IVM-Sib (NCT04285892)
- Testing
- CAPA-IVM
- Where
- Belgium
- Volunteers
- 23 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Influence of Post-thaw Embryo Culture Interval on Assisted Reproduction Success Rates
The transfer of frozen / thawed embryos has been routinely performed in the last 30 years as part of Assisted Reproduction treatment (ART).
- Trial name
- NCT03381001
- Testing
- embryo transfer after thaw and culture, embryo transfer with no culture
- Where
- Brazil
- Volunteers
- 268 people
- Sponsor
- Federal University of Minas Gerais
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Fertility
Evaluation of Group Culture in WOW Dishes of Human Embryos in Order to Optimize the Single Embryo Transfer (SET) Strategy.
In cattle less than 10% of the embryos develop to the blastocyst stage when embryos are cultured individually, however when bovine embryos are cultured in groups a typical 25-35% of blastocysts can be observed.
- Trial name
- WOW (NCT02010424)
- Testing
- control group, Primo Vision embryo culture dish (CE labeled, Vitrolife)
- Where
- 2 sites in Belgium
- Volunteers
- 158 people
- Sponsor
- University Hospital, Ghent