Clinical trials: Human Embryo Culture
Infertility, Reproductive Techniques, Assisted
An Alternative Culture Medium to Better Support Preimplantation Embryo Development in Vitro
The purpose of this research study is to evaluate a newly developed embryo culture media system for human clinical use in ART.
- Trial name
- NCT02457481
- Testing
- Embryo Culture medium
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Foundation for Fertility Research
Low Oxygen Tension
The Effect of Embryo Culture Under Low Oxygen Tension on Pregnancy Rates
This study will determine whether the use of low oxygen tension during "in vitro" embryo culture may increase the pregnancy rates in women undergoing egg donation.
- Trial name
- NCT01532193
- Testing
- Decreased oxygen concentration
- Where
- Spain
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Single Embryo Transfer, Fertilization in Vitro
Advantages of Early Intrauterine Transfer of "Blank" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s).
Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure.
- Trial name
- TRABLAN (NCT06177613)
- Testing
- Blank culture transfer
- Where
- 7 sites in France, Reunion
- Volunteers
- 1,154 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Embryo Development, Blastocyst IVF
Effects of Light vs. Heavy Paraffin Oil on Embryo Culture in IVF: A Prospective Study on Development and Pregnancy Rate
This prospective study aims to compare the effects of light and heavy paraffin oil in embryo culture during in vitro fertilization (IVF).
- Conditions
- Embryo Development, Blastocyst IVF, Pregnancy Rates, IVF
- Trial name
- NCT06838923
- Testing
- Light Paraffin Oil, Heavy Paraffin Oil
- Where
- Vietnam
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Infertility
Efficacy of Endocell® vs Conventional Medium in the Treatment of Infertility
The aim of this study is to demonstrate the efficacy of a single embryo transfer at blastocyst stage (Day 5) after co-culture on Autologous Endometrial Cell Culture (AECC) versus transfer of a single embryo at Day 3 after culture…
- Trial name
- NCT01058603
- Testing
- - Conventional culture medium for IVF, - Endocell®
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Laboratoires Genévrier
Infertility
The Effect of Embryo Culture Under a Continuous CO2 Setting Versus a Sequential CO2 Setting
The purpose of this study is to determine if embryo culture under a single CO2 setting improves blastocyst formation rate.
- Trial name
- NCT04693806
- Testing
- Continuous CO2 Level
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Human Embryo Culture
Effect of Protein Concentration on Human Embryo Development
Protein Concentration in Human Embryo Culture Media remains assigned to the manufacturers with no clear evidence on which concentration is ideal.
- Trial name
- PCHED (NCT03630848)
- Testing
- Effect of Protein on Blastocyst Development
- Where
- 2 sites in Egypt
- Volunteers
- 1,536 people
- Sponsor
- Ibn Sina Hospital
Infertility
Effects of Embryogen in RIF Patients
The purpose of this study was to investigate the potential effects of Granulocyte-Macrophage Stimulating-Colony Factor (GM-CSF) supplementation in embryo culture for patients with repeated implantation failure (RIF)
- Trial name
- RIF (NCT02250768)
- Testing
- GM-CSF
- Where
- 2 sites in Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vietnam National University
Infertility/Sterility
Markers in Follicular Fluid and in Embryo Culture Medium as a Marker of Oocyte and Embryo Quality
Assessment of the quality of follicular fluid and early embryo via chemical markers.
- Trial name
- NCT03350009
- Where
- Israel
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Infertility
EnMotion, Embryo's Natural Motion
The purpose of the study is to determine if a dynamic embryo microenvironment impacts embryo development and reproductive potential in comparison to static culture.
- Trial name
- EnMotion (NCT02467725)
- Testing
- Dynamic culture platform
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility
TICON-Day 3, Time Lapse Versus Conventional Method in Day 3 Embryo Culture and Assessment
The main purpose of the study was to evaluate the overall clinical value of GERI+ as an integrated embryo culture and assessment system, providing an undisturbed culture environment, continuous monitoring of embryo development…
- Trial name
- TICON (NCT03164551)
- Testing
- GERI+ incubator, Conventional incubator
- Where
- 17 sites in Canada, Denmark and 5 more
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Frozen Embryo Transfer (FET)
Cryopreserved Pre-embryo Transfer in a Cytokine-rich Medium Versus Hyaluronic Acid
This multicenter, randomized, double-blind study compares a GM-CSF-enriched embryo transfer medium with a hyaluronic acid-enriched medium in women undergoing single frozen embryo transfer.
- Trial name
- CSF-EG (NCT07869576)
- Testing
- Cytokine-rich embryo transfer medium, Hyaluronic acid-enriched embryo transfer medium
- Volunteers
- 610 people
- Sponsor
- Vida Recoletas Sevilla
to Evaluate the Feasibility and Accuracy of Using cfDNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for PGD
Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis
This study aims to evaluate the feasibility and accuracy of using cfDNA analysis of spent embryo culture media as a non-invasive approach for PGD. Specifically, the objectives of the study are: 1.
- Trial name
- NCT07076719
- Testing
- Trophectoderm (TE) Biopsy, Non-invasive Preimplantation Genetic Diagnosis
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- Sohag University
Reproductive Issues, Subfertility
A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis
During assisted reproductive technology treatment, embryo selection is an important process that may affect the clinical pregnancy rate.
- Conditions
- Reproductive Issues, Subfertility, IVF
- Trial name
- NCT05896709
- Testing
- MK-RS
- Where
- Hong Kong
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
Infertility, Implantation Failure
ISM1 Versus EmbrioGen Media for Embryo Culture With Previous Failure Implantation in ART Treatments
Recently, it has been suggested that culture of embryos in EmbryoGen medium can increase the live birth rate in IVF patients with a previous history of pregnancy loss.
- Trial name
- NCT01689454
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Biogenesi
Infertility
Blastocyst Culture Using Time-lapse in Good Prognosis IVF Patients and Elective Single Embryo Transfer
Choosing the best embryo for transfer has become the major challenge in in vitro fertilization (IVF). Morphology alone is obviously not enough and time-lapse incubation has added embryo development kinetics as another selection…
- Trial name
- NCT01773603
- Testing
- Embryoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Murat Çetinkaya
Embryo Culture
Evaluating the Influence of 3D Culture Dish Design on Preimplantation Genetic Development in Sibling Oocytes: a Randomized Trial
Evaluating the Influence of 3D Culture Dish Design on Preimplantation Genetic Development in Sibling Oocytes: A Randomized Trial
- Trial name
- NCT06850909
- Testing
- Microdrop GPS dish, 16 well BIRR dish
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ganin Fertility Center
Infertility
Optimizing the Temperature for Embryo Culture in In Vitro Fertilization
Many human and animal studies over the past 40 years have revealed that ovaries and Fallopian tubes have a lower temperature than core body temperature, especially around the time of ovulation and early embryo development.
- Trial name
- NCT01506089
- Testing
- 36 degrees Celsius
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
in Vitro Fertilization
Embryo Transfer With Self-spent Culture Medium
Embryo Transfer With Self-spent Culture Medium or new Culture Medium in Vitro Fertilization - Embryo Transfer Process, to analyze which way can improve clinical pregnancy outcomes, is there a significant difference between the…
- Trial name
- NCT03728140
- Testing
- Self-spent Culture Medium
- Where
- China
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Bin Wu
Embryo Diagnosis and Selection
Clinical Validation of Embryo Cinematography
The purpose of this study is to determine whether the multivariable model for embryo selection (Meseguer et al. 2012) together with undisturbed controlled conditions obtained by a time-lapse incubator system is effective in…
- Trial name
- NCT01549262
- Testing
- Observe embryo development with "Unisense FertiliTech A/S" (EC Certificte DGM - 673), Observe embryo development
- Where
- Spain
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA