Clinical trials: Human Embryo Culture
Infertility
Amino Acid Profiling of Spent Culture Medium
The purpose of this study is to develop an algorithm for embryo selection based on amino acid profiling (AAP) of spent culture medium.
- Trial name
- EmbryoSure (NCT01587547)
- Where
- 2 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- Origio A/S
Temperature; Extreme, Exposure
Embryo Culture At a Constant Temperature of 36.6°C or 37.1°C
On the day of oocyte retrieval, participants will be randomized to stable culture at 37.1°C or 36.6°C with the ultimate aim of finding a difference in clincial pregnancies.
- Trial name
- NCT03548532
- Testing
- G210 incubator
- Where
- Belgium
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Adding Insulin to IVF Culture Media Significantly Improve Outcome
Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In Vitro culture and detect the the effect upon embryo quality and implantation potential.
- Trial name
- NCT02420171
- Testing
- Adding insulin to In Vitro culture media
- Where
- 2 sites in Egypt
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Embryo Development
Outcome of Embryo Culture at Two Oxygen Tensions
The purpose of this study is to assess whether reduced oxygen tension in embryo culture has any effect on clinical outcome.
- Trial name
- NCT00718822
- Testing
- oxygen concentration in the culture atmosphere
- Where
- Slovenia
- Volunteers
- 647 people
- Sponsor
- University Medical Centre Maribor
Embryo Development
Culture Media and Blastocyst Development
The aim of this non-interventional study is to compare the blastulation rate per fertilized oocyte in two different single step culture media commercially available (GEMS and Irvine culture media).
- Trial name
- NCT03497052
- Testing
- In vitro culture in medium 1, In vitro culture in medium 2
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Clinica Valle Giulia
Pregnancy, Fertility
Prognostic Value of PIF Detection in Embryo Culture Media Correlation With Pregnancy Outcome
PIF: biomarker of successful implantation To overcome the poor reproductive potential of embryos generated during in vitro fertilization cycles and the lack of markers enabling the identification of the most competent ones, it is…
- Trial name
- PIF-SET1 (NCT01803893)
- Where
- 5 sites in United States, France and 1 more
- Volunteers
- 500 people
- Sponsor
- BioIncept LLC
Infertility
Comparison of Culture Media for in Vitro Embryo Development
The purpose of this study is to collect development and outcome data on human embryos which are cultured in a 2nd generation continuous single culture medium (CSCM2) with the objective to demonstrate its performance efficacy in…
- Trial name
- NXGeM (NCT02846012)
- Testing
- CSCM2
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Ovation Fertility
Fertility Issues, Blastocyst IVF
A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology
To evaluate whether there were significant differences in the effects of constant (5%) versus sequential (5%-2%) oxygen concentration protocols in embryo culture on term live birth rates.
- Conditions
- Fertility Issues, Blastocyst IVF, Embryo Culture
- Trial name
- NCT07050537
- Testing
- Constant oxygen concentration protocols in embryo culture, Sequential oxygen concentration protocols in embryo culture
- Where
- 6 sites in China
- Volunteers
- 980 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Embryo Development
Impact of Culture Conditions on the Embryo Quality
The purpose of this study is to compare different culture conditions. The effect of the type of incubator (standard versus mini-incubator) and the effect of the oxygen concentration (5% versus 20%) will be evaluated on the embryo…
- Trial name
- NCT01767805
- Testing
- Standard incubator, Mini incubator, 5% oxygen
- Where
- 2 sites in Belgium
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Infertility
Automation of Gamete Preparation, Intracytoplasmic Sperm Injection (ICSI), Embryo Culture, and Vitrification
Patients suffering from infertility may seek assisted conception treatment. In a full treatment cycle, the sperm and eggs (gametes) from the intended parents will be looked after by skilled laboratory staff (embryologists) who…
- Trial name
- NCT06074835
- Testing
- Gamete preparation, ICSI, embryo culture and vitrification robot assistant, Routine Manual ICSI Workflow
- Where
- Mexico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Conceivable Life Sciences
ART
Evaluation of a Closed Assisted Reproductive Technology (ART) Station Versus an Open Flow Cabinet
There is not yet a standardized system of human embryonic culture in vitro. In addition, technical improvements continually appear.
- Trial name
- NCT03343938
- Testing
- Embryo handling in a closed station
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Vida Recoletas Sevilla
Embryo Selection, IVF
Embryo Selection by Metabolomic Profiling of Embryo Culture Medium With Mass Spectroscopy as an Adjunct to Morphology
Identification of the embryo with the highest potential to implant and establish an ongoing pregnancy is a primary aim in human assisted reproduction.
- Conditions
- Embryo Selection, IVF, Morphology
- Trial name
- NCT02698488
- Testing
- Morphology, Morphology and Mass Spectroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Istanbul University
Other Complications Associated With Artificial Fertilization
Comparison of Individual Culture and Group Culture of Preimplantation Embryos in Human IVF Treatments
Prospective randomized comparison of two widely used in vitro culture system in human IVF treatments. In vitro fertilized oocytes and embryos are cultured in individual culture media droplets using conventional petridish or in…
- Trial name
- GroupCulture (NCT01774006)
- Testing
- individual embryo culture or group culture
- Where
- Hungary
- Volunteers
- 532 people
- Sponsor
- Semmelweis University
Embryo Culture
Impact of Human Embryo Culture System on Live Birth
Previous studies in human and different mammals have proved that the embryo group culture (in the same culture medium drop) using a reduced volume is associated with a better embryo development.
- Trial name
- AGRUPADO (NCT01904006)
- Testing
- New Culture Condition, Standard Culture Condition
- Where
- Spain
- Volunteers
- 182 people
- Sponsor
- Vida Recoletas Sevilla
Embryo Culture Media, Metabolomics
Targeted Metabolomics and Spent Embryo Culture Medium
More than 8 million babies have been born through in vitro fertilization (IVF). Non-invasive observation of embryos in vitro to better understand their development is becoming increasingly important.
- Trial name
- NCT06094439
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- gyn-medicum Göttingen
Embryo Culture
Incubator Temperature for Culturing Human Embryos
Incubator temperature is one of the most precious variables in IVF labs. When the IVF started, almost all incubator temperatures were set at 37 degrees which mimic in vivo conditions.
- Trial name
- NCT01706900
- Testing
- Incubator Temp set to 36.5 degree, Incubator Temp 37 degree
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Infertility
Validation of Addition of Uterine Fluid to Human Embryo Culture Medium
Infertility or infertility affects about 15% of couples of reproductive age. It is estimated that 80 million people around the world suffer from this problem.
- Trial name
- NCT03436758
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- IVI Murcia
Infertility
Adding Cytokines to In Vitro Human Culture Media to Improve Embryogenesis and Implantation
Assessment of the embryological benefit of in vitro adding of Cytokines (LIF 5ng/ml, HB-EGF 5ng/ml and GM-CSF 2n/ml) to the culture media and closely monitor its effect on embryogenesis and implantation outcomes.
- Trial name
- GHLCSHED (NCT02420886)
- Testing
- Adding LIF, HB-EGF and GM-CSF to Lifeglobal human IVF culture media
- Where
- 2 sites in Egypt
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Embryonic Development, Embryo Morphokinetics
Embryo Culture Under Constant 5% vs Gradient 8%, 5%, 2% Oxygen Concentration
The purpose of this study is to investigate the development of human embryos in vitro under two different oxygen concentrations; a static 5% during all five days of culture or under an oxygen gradient, starting with 8% from day-0…
- Conditions
- Embryonic Development, Embryo Morphokinetics, Embryo Morphometry
- Trial name
- NCT05898178
- Testing
- Experimental intervention: 8-5-2% oxygen gradient concentration in the incubator
- Where
- Slovenia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor