Clinical trials: Human Energy Expenditure
Healthy Volunteers
Diet-Induced-Obesity Resistant Phenotypes in Humans
Background: Obesity is the result of many factors, including genetics and lifestyle, such as over-eating high-calorie foods and not being physically active. Obesity affects approximately one third of adults in the United States.
- Trial name
- NCT00999154
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Diabetes
Differential Metabolism of Dietary Fatty Acids
Differences in how diet fats are converted to energy could explain some of the reported differences in health effects among different classes of dietary fat (e.g. monounsaturated vs. saturated).
- Conditions
- Obesity, Diabetes, Hyperlipidemia
- Trial name
- NCT00059254
- Testing
- Oleic acid (OA), Palmitic Acid (PA)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Study of the Effect of Vagus Nerve Stimulation on Human Brown Adipose Tissue Activity
To evaluate the effect of vagus nerve stimulation for refractory epilepsy on the activity of human brown adipose tissue.
- Trial name
- NCT01491282
- Testing
- Enabling and disabling VNS
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Maastricht University
Obesity, Diabetes
Raspberry Ketone Intake Upregulates Circulating FGF21 and Induces Energy Expenditure in Humans
To investigate the molecular mechanism of raspberry ketone on regulating obesity, the investigators studied the effect of raspberry ketone intake on FGF21 in plasma.
- Conditions
- Obesity, Diabetes, NAFLD (Nonalcoholic Fatty Liver Disease)
- Trial name
- NCT06681597
- Testing
- Raspberry ketone
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanchang University
Metabolic Response to Dietary Modification
The CLOCK Study - A Human Dietary Intervention Study on Peripheral Circadian Clocks and Energy Metabolism
This human dietary intervention study with a cross-over design aims to investigate the effect of two different diurnal patterns of meal composition on peripheral circadian clocks and energy metabolism in healthy men.
- Trial name
- CLOCK (NCT02487576)
- Testing
- Carbohydrate-rich (HC), Fat-rich (HF)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Overweight
Methionine and Cysteine Restriction in Humans
The aim of this study is to examine the effect of methionine and cysteine restriction on energy and macronutrient metabolism in overweight human subjects
- Trial name
- NCT03629392
- Testing
- Low met/cys diet, Moderate met/cys diet, High met/cys diet
- Where
- Norway
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Healthy
The Acute Effects of Capsiate During Exercise
Capsiate is a non-pungent analogue of capsaicin, the component of hot peppers that makes them hot or spicy. Unlike capsaicin, capsiate is not spicy or hot.
- Trial name
- NCT00692601
- Testing
- Acute consumption of Capsiate Natura
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Healthy Volunteers
Food Intake Response to Short-Term Modifications of Metabolism in Humans
One reason people gain weight is eating more calories from food than what they need for energy over 24 hours. Metabolism is the amount of energy a person uses over 24 hours.
- Trial name
- NCT02939404
- Testing
- Cold exposure, Normal temperature, Fixed diet
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy Volunteers
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Background: Changes in how a person's body burns energy or calories can affect their weight over time. The lowest level of energy the body needs to function is called basal metabolic rate.
- Trial name
- NCT01950520
- Testing
- Propranolol, Pindolol, Dantrolene
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Angiotensin-(1-7) and Energy Expenditure in Human Obesity
The objective of this study is to better define the role of the hormone angiotensin-(1-7) in energy balance. We will test the overall hypothesis that angiotensin-(1-7) increases resting energy expenditure and promotes markers of…
- Trial name
- NCT03777215
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Amy Arnold
Human Energy Expenditure
Validation of a Portable Indirect Calorimeter
This study plans to test the accuracy of a new device (the Apollo EE Device) that measures resting energy expenditure (REE) using only oxygen consumed (VO2).
- Trial name
- NCT04469452
- Testing
- Apollo Device
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Graves Disease, Thyroid Cancer
Impact of Thyroid Hormones on Human Glucose and Energy Metabolism
The goal of this clinical trial to clarify the impact of changes in thyroid hormone levels on glucose and lipid metabolism. Patients will be included in whom thyroid hormone levels are intentionally changed by treatment.
- Trial name
- NCT07410637
- Testing
- Oral Glucose Tolerance Test
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Ulm
Healthy Underweight, Normal Weight Adults
Energy Metabolism and Eating Behavior in Underweight and Normal-weight Individuals
This study evaluates eating behavior and metabolic responses following consumption of a high-fat high-energy meal in healthy underweight and normal-weight adults.
- Trial name
- PROB I (NCT07671105)
- Testing
- High-fat high-energy meal
- Where
- Chile
- Volunteers
- 59 people
- Sponsor
- Jose Galgani
Human Energy Expenditure
A New Approach to Measuring Energy Expenditure in Humans
Accurately measuring how many calories a person burns each day is difficult to do. Researchers can do this with a technique called doubly labeled water (DLW).
- Trial name
- NCT01938794
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity and Overweight
Adaptation of Human Brown Adipose Tissue to Calorie Restriction
The BATON study investigates how human brown adipose tissue (BAT) adapts to a controlled caloric restriction diet in young adults with obesity.
- Trial name
- BATON (NCT06878989)
- Testing
- Caloric restriction diet, Weight maintenance diet
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Granada
Type 2 Diabetes Mellitus, Obesity
Short Chain Fatty Acid Metabolism and Energy Metabolism
Gut microbiota is being increasingly recognized as an important factor in fat distribution, insulin sensitivity and glucose and lipid metabolism.
- Trial name
- NCT01826162
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hyperthyroidism
Effects of Hyperthyroidism on Amount and Activity of Brown Adipose Tissue
The investigators wish to evaluate the effect of thyroid hormones on brown adipose tissue in humans in an observational study on patients with thyrotoxicosis.
- Trial name
- NCT02133040
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aarhus University Hospital
Regulation of Energy Expenditure
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1
Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue…
- Trial name
- NCT07030725
- Testing
- Menthol Gel, Time control
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity, Type 2 Diabetes
Rectal Short Chain Fatty Acids Combinations and Substrate and Energy Metabolism
Gut microbiota is being increasingly recognized as an important factor in fat distribution, insulin sensitivity and glucose and lipid metabolism.
- Trial name
- NCT01983046
- Testing
- Three different mixture of acetate, butyrate and propionate and palcebo
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Energy Expenditure, Substrate Oxidation
Helichrysum Italicum Infusion Ingestion in Humans
The study evaluates the acute effects of Helichrysum italicum on resting energy expenditure and substrate oxidation in humans. The resting energy expenditure and substrate oxidation will be measured by indirect calorimetry at…
- Conditions
- Energy Expenditure, Substrate Oxidation, Blood Pressure
- Trial name
- SMILJ (NCT04818905)
- Testing
- Helichrysum italicum infusion, Hot water
- Where
- Slovenia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Primorska