Clinical trials: Human Energy Expenditure
Infant Body Composition and Metabolism, Metabolism
Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants
The purpose of this research study is to understand how infants metabolize different meals and to develop clinical tools which identify infants as having two different phenotypes.
- Conditions
- Infant Body Composition and Metabolism, Metabolism, Energy Expenditure, Infant Formula
- Trial name
- SPROUT (NCT07096011)
- Testing
- Meal Test - Human Milk, Meal Test - Infant Formula
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Healthy
Human Auto-ethanol Formation and Acetate Signaling
The HotFacets study is a randomized, controlled, cross-over meal study that investigates the acute effects of alcohol consumption on short-chain fatty acids dynamics, energy metabolism, and biomarkers.
- Trial name
- HotFacets (NCT05130619)
- Testing
- Ethanol
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diabetes
Validation of the Doubly Labelled Water Method in Subjects With Type 2 Diabetes Mellitus
The present study is an exploratory trial to establish a feasible DLW (doubly labelled water) protocol for implementation in clinical trials conducted at Profil Institut für Stoffwechselforschung, investigating treatment options…
- Trial name
- DLW (NCT02518581)
- Testing
- Doubly labelled water method
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction
Cardiac Energetics and Function in Normal Human Ageing
Normal aging is characterized by altered cardiovascular function. Our preliminary data with MR imaging and spectroscopy in normal subjects without cardiovascular disease or hypertension show that age-related cardiac dysfunction…
- Conditions
- Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction, Ageing
- Trial name
- NCT01504828
- Testing
- Ramipril
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Obesity
The Role of Tea Catechins and Caffeine in Relation to Energy Metabolism
The aim of this study is to elucidate the role of specific catechins, a mixture of catechins and caffeine in relation to weight control with particular emphasis on energy metabolism and fat oxidation.
- Trial name
- NCT00611416
- Testing
- green tea, Mix of catechins and caffeine, EGCG
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity, Insulin Resistance
Nicotinamide Riboside and Metabolic Health
This study will investigate the effects of 6 week Nicotinamide Riboside supplementation (1000 mg/day) on metabolic health in healthy (pre)obese humans. The primary objective will be hepatic and whole body insulin sensitivity.
- Trial name
- NCT02835664
- Testing
- Nicotinamide Riboside (Niagen)
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity
Impact of Black Pepper on Energy Expenditure and Substrate Utilization
As obesity rates worldwide continue to increase, there is a focus on identifying active food ingredients which increase metabolic rate which can be used as a dietary supplement in the treatment of overweight and obesity.
- Trial name
- NCT01729143
- Testing
- 24-hour energy expenditure and substrate utilization
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Volunteers
Inosine Energy Expenditure Study
Investigators want to test whether the intake of the nucleoside inosine increases the human energy expenditure. Inosine occurs as a metabolic intermediate in the human body and is sometimes taken as a dietary supplement by…
- Trial name
- InoBAT (NCT04476238)
- Testing
- Inosine
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Intranasal Glucagon and Energy Balance
People who are overweight often find it difficult to lose weight through diet and medications because weight loss reduces the amount of energy spent by the body and increases appetite.
- Trial name
- INGEB (NCT03650582)
- Testing
- Glucagon
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Healthy Volunteers
Global Positioning Satellite and Accelerometry to Assess Human Locomotion (ACTI GPS)
The aim of the study is to validate the association of the GPS and accelerometer tools in order to assess the humain locomotion during exercises. The hypotheses are: 1.
- Trial name
- ActiGPS (NCT01805219)
- Testing
- GPS and accelerometer recording (s) during exercises
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Healthy
Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study
Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance.
- Trial name
- MIBAT (NCT02682706)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Human Energy Expenditure
Measurements of Water in Breath and Saliva
This study proposes to demonstrate the feasibility of measuring 2H:1H and 18O:16O in saliva and breath by comparing the natural abundances of 2H:1H and 18O:16O in saliva and urine of un-dosed humans.
- Trial name
- NCT03233256
- Testing
- Feasibility of measuring 2H:1H and 18O:16O in saliva and breath.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures
This study will examine how body metabolism adjusts to small changes in environmental temperature and how it may be related to weight loss.
- Trial name
- NCT00521729
- Testing
- Exposure to Cold Temperature
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Basic Science
Phosphate Metabolites in Brain of Humans Aged 50+
The objective of this research project is to determine in elderly subjects (>50 year old) by 31P-MRS the brain concentration of phosphorous metabolites species and fluxes, before and after consumption of 2 commercially available…
- Trial name
- NCT03541473
- Testing
- Peptamen® 1.5 Vanilla, Boost Plus® Vanilla
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy
Chronic Cold Exposure and Energy Metabolism in Humans
Background: Researchers are studying how metabolism and hormone levels change in response to mild changes in environmental temperature. Changes in metabolism may lessen with time because of hormonal adaptations.
- Trial name
- NCT01730105
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Energy Metabolism, Hypoxia
Human Metabolic Dynamics at Rest and During Aerobic Exercise Under Normobaric Normoxic and Moderate Hypoxic Conditions
The aim is to define in detail metabolic pathways at rest and during aerobic exercise in normal and healthy men and women under normobaric normoxic and moderate hypoxic conditions, using metabolomics technologies based on…
- Conditions
- Energy Metabolism, Hypoxia, Metabolism and Nutrition Disorder
- Trial name
- NCT03121885
- Testing
- 30-minute movement activity, Hypoxia
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Benjamin Gollasch