Clinical trials: Human Immunodeficiency Virus, open to volunteers
Substance Abuse, Substance Addiction
The Trans-Led Care Study
This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery.
- Conditions
- Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol)
- Trial name
- TLC (NCT06880705)
- Testing
- The TLC Program
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Illinois Institute of Technology
HIV (Human Immunodeficiency Virus), AIDS
Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers
This study aims to investigate the disease progression trends and risk factors of common AIDS-related tumors, including Kaposi sarcoma, lymphoma, lung cancer, and et al., among people living with HIV.
- Conditions
- HIV (Human Immunodeficiency Virus), AIDS, Kaposi Sarcoma (KS), Lymphoma
- Trial name
- NCT07696169
- Volunteers
- 1,000 people
- Sponsor
- Shenzhen Third People's Hospital
Human Immunodeficiency Virus (HIV) Infection
Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)
This is a single-group, open-label, multi-site study in pediatric participants with human immunodeficiency virus type 1 (HIV-1) infection, aged 4 weeks to <12 years and weighing <45 kg, who are treatment-naive (TN) or have been…
- Trial name
- NCT04375800
- Testing
- Doravirine, 2 NRTIs, DOR/3TC/TDF
- Where
- 24 sites in United States, Colombia and 4 more
- Volunteers
- 84 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV - Human Immunodeficiency Virus, Socio-economic Status
Impact of Migration History and Social Conditions on the Immuno-virological Control of HIV in Migrants in France
Migrants living with HIV - whether the infection was diagnosed in their country of origin or in France- frequently experience vulnerabilities related to their migration trajectories and often face socioeconomic and administrative…
- Conditions
- HIV - Human Immunodeficiency Virus, Socio-economic Status, Migrants
- Trial name
- PrimoAVIH (NCT07691424)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Human Immunodeficiency Virus
Nice Human Immunodeficiency Virus (HIV) Cohort
Historically, the database on the HIV was organized within the framework of the medico-economic file of the human immunodeficiency (DMI-2), introduced jointly by the Direction of Hospitals (Mission AIDS) and the INSERM at the end…
- Trial name
- NCT03690063
- Testing
- Follow up
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
HIV - Human Immunodeficiency Virus
Coronary Artery Calcium Score in HIV Mexican Population (The CACsHIVMex Study)
The risk of atherosclerotic cardiovascular disease is increased in people with HIV infection, including young patients and those with few traditional cardiovascular risk factors.
- Trial name
- CACsHIVMex (NCT07662161)
- Testing
- Simple coronary CT scan
- Where
- Mexico
- Volunteers
- 384 people
- Sponsor
- Instituto Mexicano del Seguro Social
Human Immunodeficiency Virus (HIV), HIV Pre-exposure Prophylaxis
HIV Testing Counselor-led Care to Catalyze Integration of PrEP Delivery in Family Planning Clinics
This is a cluster randomized, stepped wedge implementation study to introduce HIV testing services (HTS) counselor-led PrEP care in public health clinics in Kenya.
- Trial name
- HTS PrEP (NCT07089966)
- Testing
- HTS counselor-led PrEP care model
- Where
- Kenya
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV (Human Immunodeficiency Virus)
Multimorbidity and Polypharmacy in People With HIV vs. the General Population in the Basque Country
People living with HIV now have a life expectancy similar to that of the general population, thanks to major advances in antiretroviral treatment.
- Trial name
- NCT07621224
- Testing
- No intervention
- Volunteers
- 12,546 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute
HIV (Human Immunodeficiency Virus)
Boosting Olfactory and Sensory Training Study (BOOST)
The goal of this study is to examine two types of olfactory interventions (conventional olfactory training vs scented marker training) in adults with HIV. The two research questions are: 1.
- Trial name
- BOOST (NCT07221123)
- Testing
- Conventional Smell Training Group, Scented Marker Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Human Immunodeficiency Virus (HIV)-1 Infection, HIV-1 Subtype A6 Infection
Long-Acting Cabotegravir and Rilpivirine in People Living With HIV-1 Subtype A6: A Real-World Retrospective Study
This study evaluates the real-world effectiveness and safety of a long-acting injectable HIV treatment consisting of cabotegravir and rilpivirine in people living with HIV-1.
- Conditions
- Human Immunodeficiency Virus (HIV)-1 Infection, HIV-1 Subtype A6 Infection, HIV-1 Subtype B Infection, Virologically Suppressed HIV-1 Infection Receiving Long-Acting Antiretroviral Therapy
- Trial name
- LACRIS (NCT07370649)
- Testing
- Cabotegravir Plus Rilpivirine Long-Acting Injectable
- Where
- 7 sites in Czechia, Germany and 1 more
- Volunteers
- 250 people
- Sponsor
- Pomeranian Medical University Szczecin
MASLD, HIV (Human Immunodeficiency Virus)
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV
Metabolic dysfunction-associated steatotic liver disease (MASLD), commonly known as fatty liver disease, is increasingly prevalent worldwide.
- Trial name
- MASLD (NCT07640880)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yinzhong Shen
HIV (Human Immunodeficiency Virus)
A Clinical Study Evaluating the Safety, Tolerability, and Effect on HIV Reservoir of Ibalizumab Combined With Chidamide (a Histone Deacetylase Inhibitor) in People Living With HIV
HIV viral reservoirs represent the major barrier to curing AIDS, and effectively reducing viral reservoirs in people living with HIV through different strategies has become a research priority in the HIV field.
- Trial name
- NCT07635992
- Testing
- Ibalizumab Combined with Chidamide
- Volunteers
- 18 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
HIV - Human Immunodeficiency Virus, HIV Antiretroviral Therapy (ART) Adherence
Improving the HIV Care Continuum With mHealth Technology
Youth living with HIV (YLHIV) face barriers to engagement and retention in HIV care, show poor medication adherence, and often fail to achieve and maintain viral suppression.
- Conditions
- HIV - Human Immunodeficiency Virus, HIV Antiretroviral Therapy (ART) Adherence, mHealth Application, mHealth Intervention
- Trial name
- NCT07631104
- Testing
- MindBodyU Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Carolina
Alcohol Use Disorder, Human Immunodeficiency Virus
Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection
Alcohol use disorder (AUD) has been associated with high prevalence of inflammation-associated co-morbidities in people living with HIV even those receiving effective antiretroviral therapy (ART).
- Trial name
- NCT06139224
- Testing
- 4 week prebiotic consumption
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
HIV, HIV - Human Immunodeficiency Virus
Intervention to Reduce HIV Related Stigma Among Pregnant and Postpartum Women
Purpose of this Study: The main purpose of this study is to adapt an existing evidence-based intervention, Project Accept Post-Test Support Services (PTSS) Module 3, specifically for pregnant and postpartum women living with HIV…
- Conditions
- HIV, HIV - Human Immunodeficiency Virus, Postpartum, Pregnancy
- Trial name
- WAT (NCT07064928)
- Testing
- Adapted Project Accept's Post-Test Support Services (PTSS) Module 3
- Where
- Ghana
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
HIV (Human Immunodeficiency Virus)
A Safety and Efficacy Trial of Chidamide Combined With NKG2D CAR-NK Cell Therapy for Reducing the HIV Viral Reservoir
This study aims to investigate the safety and preliminary efficacy of an innovative therapeutic strategy combining chidamide with NKG2D-directed chimeric antigen receptor natural killer (CAR-NK) cells in individuals living with…
- Trial name
- NCT07577986
- Testing
- Chidamide Combined with NKG2D CAR-NK Cell Therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Human Papillomavirus (HPV), HPV Associated Cancers
Testing the Feasibility of Different HPV Screening and Care Strategies for Women Living With HIV
The overall goal of this study is to inform the design and establish feasibility for a future clinical trial to determine the optimal management of women living with HIV (WLWH) with high-risk human papillomavirus (hrHPV) detected…
- Conditions
- Human Papillomavirus (HPV), HPV Associated Cancers, Cervical Cancer, Human Immunodeficiency Virus (HIV)
- Trial name
- NCT07576842
- Testing
- HPV DNA Testing (Abbott Alinity m HPV Assay), Visual Inspection with Acetic Acid, Cervical Histology (Biopsy Procedures)
- Where
- Botswana
- Volunteers
- 750 people
- Sponsor
- University of California, San Diego
Tuberculosis (TB), Human Immunodeficiency Virus (HIV) Prophylaxis
Integrating HIV Prevention With TB Household Contact Evaluation in Uganda
This household randomized implementation study assesses the implementation and effectiveness of home-based HIV self- testing and PrEP initiation versus standard clinic referral for PrEP initiation during modified standard-of-care…
- Trial name
- TB PrEP (NCT07119359)
- Testing
- Home-based HIV self-testing, Home-based initiation of PrEP
- Where
- Uganda
- Volunteers
- 2,480 people, healthy volunteers welcome
- Sponsor
- University of Washington
Syphilis, Human Immunodeficiency Virus
Cefixime Clinical Trial
This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.
- Trial name
- NCT04958122
- Testing
- Cefixime 400mg, benzathine penicillin
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Southern California
HIV (Human Immunodeficiency Virus), IRIS
Prevention of AIDS With Opportunistic Infection Paradoxical IRIS
This study was a multicenter, open-label, randomized controlled clinical trial designed to evaluate the efficacy and safety of glucocorticoids in preventing paradoxical immune reconstitution inflammatory syndrome (IRIS) in…
- Trial name
- NCT07565623
- Testing
- Prednisolone
- Volunteers
- 131 people
- Sponsor
- Shanghai Public Health Clinical Center