Clinical trials: Human Immunodeficiency Virus Transmission
HIV Infections, Hepatitis B
Project UNITY - HIV Risk Reduction and Vaccine Education Interventions
To determine the efficacy of an enhanced HIV risk reduction intervention delivered concurrently with a vaccination schedule to reduce the number of unprotected vaginal and anal sex acts among HIV-negative, high-risk non-injection…
- Trial name
- NCT00150098
- Testing
- Enhanced HIV risk reduction and HIV vaccine education
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- New York Blood Center
HIV-1, HIV Infections
Genotypic Resistant HIV Strains in Taiwan
Based on the investigators previous study, seventy-four of 786 HIV-1 isolates (9.4%), collected between 1999 to 2006, harbored one or more primary mutations associated with antiretroviral resistance to reverse-transcriptase…
- Trial name
- NCT00954863
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
HIV, Seroconversion, HIV
Accurate Staging of Immuno-virological Dynamics During Acute HIV Infection
In this prospective longitudinal study we aim to assess how immunologic and viral aspects of the human immunodeficiency virus (HIV) viral reservoir, established during early HIV infection and responsible for viral rebound at…
- Trial name
- ACS (NCT03449706)
- Testing
- Early combination anti-retroviral treatment
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
HIV Infection, Alcohol Use
Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV)
This study is a randomized controlled trial (RCT) to compare the effects of varenicline, cytisine, and nicotine replacement therapy (NRT) to reduce: 1) alcohol use and craving, 2) smoking; and 3) inflammation and risk for…
- Conditions
- HIV Infection, Alcohol Use, Smoking
- Trial name
- St PETER HIV (NCT02797587)
- Testing
- Varenicline, Cytisine, Nicotine Replacement Therapy
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Boston Medical Center
HIV Infections
CASI-Plus mHealth for Ukraine's APS Program (Aim 2)
The CASI-Plus mHealth intervention seeks to improve partner elicitation and testing as part of assisted partner services (APS) in Ukraine, through a mHealth client engagement tool using computer-assisted self-interview (CASI).
- Trial name
- NCT05826977
- Testing
- CASI-Plus
- Where
- 2 sites in Ukraine
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV, HIV Infections
Switching the Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) or Protease Inhibitor (PI) to Maraviroc in HIV Subjects
Patients with HIV-1 infection on HAART regimen including 2 NRTI/NtRTIs plus one of the following : 1 PI/ritonavir or ATV/unboosted or 1 NNRTI, will be randomized to switch from the NNRTI/PI to maraviroc (300 mg /12 h) or to…
- Trial name
- NCT00966329
- Testing
- maraviroc, control group
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Germans Trias i Pujol Hospital
HIV Infections, HCV
The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City
The goal of this pilot clinical trial is to learn if an intervention that trains Gancheros (people who provide injection services in exchange for drugs or money) to conduct risk-reduction outreach could help lower risk for human…
- Conditions
- HIV Infections, HCV, Overdose
- Trial name
- NCT06316739
- Testing
- Ganchero intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI)
HIV/AIDS
Peer-Educator-coordinated vs Nurse-coordinated ART Refill for Adolescents and Young Adults Living With HIV in Lesotho
Sub-Saharan Africa (SSA) is home to 85% of the adolescents and young people living with HIV (AYPLHIV) globally and they are heavily affected by the HIV/AIDS epidemic: AYPLHIV in SSA are the only population group for whom…
- Trial name
- PEBRA (NCT03969030)
- Testing
- PEBRA model
- Where
- 20 sites in Lesotho
- Volunteers
- 307 people
- Sponsor
- Amstutz Alain
Herpes Simplex, HIV Infections
The Pilot Study of Foscarnet Cream in the Treatment of Mucocutaneous Herpes Simplex Virus Infections in Immunocompromised Patients Unresponsive to Acyclovir Treatment
PRIMARY: To evaluate the clinical activity of foscarnet cream on the index lesion of mucocutaneous herpes simplex virus (HSV) infections in immunocompromised patients previously unresponsive to acyclovir treatment.
- Trial name
- NCT00002144
- Testing
- Foscarnet sodium
- Where
- 8 sites in United States
- Volunteers
- 12 people
- Sponsor
- Astra USA
Mycobacterium Avium-intracellulare Infection, HIV Infections
Rifabutin Therapy for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in AIDS Patients With CD4 Counts = or < 200: A Double-Blind, Placebo-Controlled Trial
The primary objectives of this trial are: To compare the safety of oral rifabutin versus placebo in the treatment of Mycobacterium avium complex (MAC) bacteremia in AIDS patients with CD4 counts less than or equal to 200…
- Trial name
- NCT00002032
- Testing
- Rifabutin
- Where
- 33 sites in United States
- Volunteers
- 750 people
- Sponsor
- Pharmacia
Inflammation, HIV Infection
Immunomodulation Using VB-201 to Reduce Arterial Inflammation in Treated HIV - VITAL HIV Trial
This study is a double blinded, placebo-controlled, randomized, parallel group study, designed to compare the efficacy and safety of VB-201 80mg taken orally once daily to placebo for anti-inflammation in HIV-infected subjects.
- Conditions
- Inflammation, HIV Infection, Cardiovascular Disease
- Trial name
- NCT04939311
- Testing
- VB-201
- Where
- United States
- Sponsor
- Priscilla Hsue, MD
Hiv
HIV Care Cascade and Linkage to Antiretroviral Therapy Among Hospitalized Adults in Lusaka, Zambia
The population of inpatients is large in Zambia; however, because of poor linkages between hospitals and community HIV care, there are few data to analyze their engagement in HIV care before and after hospitalization.
- Trial name
- COLAH (NCT03158844)
- Testing
- Standard of care
- Where
- Zambia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Anal Intraepithelial Neoplasia, High-grade Squamous Intraepithelial Lesion
Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions
This randomized phase III trial studies imiquimod or fluorouracil to see how well they work compared to observation in treating patients with high-grade anal squamous skin lesions who are human immunodeficiency virus…
- Conditions
- Anal Intraepithelial Neoplasia, High-grade Squamous Intraepithelial Lesion, HIV Infection
- Trial name
- NCT02059499
- Testing
- imiquimod, fluorouracil, questionnaire administration
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 91 people
- Sponsor
- AIDS Malignancy Consortium
HIV Infections
Raltegravir Augmentation on Persistent Central Nervous System (CNS) Immunoactivation in Treated HIV-1 Patients
This pilot study focuses on the persistence of central nervous system (CNS) immune activation that has been observed in the presence of 'effective' combination antiretroviral therapy (cART).
- Trial name
- NCT00672932
- Testing
- raltegravir
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Francisco
Depression, HIV
Implementing Depression and Adherence Treatment
The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression.
- Conditions
- Depression, HIV, Adherence, Treatment, AIDS
- Trial name
- NCT07032363
- Testing
- Core Implementation Strategies, Enhanced Implementation Strategies
- Where
- South Africa
- Volunteers
- 10 people
- Sponsor
- University of Miami
HIV/AIDS, Hypertension
A Nurse-led Intervention to Extend the HIV Treatment Cascade for Cardiovascular Disease Prevention
Strategies to improve uptake of cardiovascular disease preventive therapies among people living with HIV (PLHIV) are urgently needed.
- Conditions
- HIV/AIDS, Hypertension, Hyperlipidemias
- Trial name
- EXTRA-CVD (NCT03643705)
- Testing
- Multi-component intervention, General prevention education
- Where
- 3 sites in United States
- Volunteers
- 298 people
- Sponsor
- Case Western Reserve University
HIV Infections
Immune Function of Infants With HIV
This observational study will evaluate data from infants born to HIV infected mothers in order to better characterize disease progression in early HIV infection.
- Trial name
- NCT00073229
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Contraceptive Usage, Opioid Dependence
Improving Effective Contraceptive Use Among Opioid-maintained Women: Stage II
Nearly 9 of every 10 pregnant opioid-dependent women report that the current pregnancy was unintended and the majority of non-pregnant opioid-maintained women do not use contraception or use less effective methods like condoms.
- Trial name
- NCT02411357
- Testing
- Treatment as usual, WHO contraception protocol, Incentives
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- University of Vermont
Human Immunodeficiency Virus
Improving TelePrEP Initiation and Retention Outcomes in the US: The MISTR+ Study
This study uses a rapid randomized controlled trial (RCT) design to examine HIV pre-exposure prophylaxis (PrEP) delivered through telehealth.
- Trial name
- NCT07821671
- Testing
- No Marginal Cost Interventions, Low-Marginal Cost Interventions, Standard of Care
- Where
- United States
- Volunteers
- 223,165 people
- Sponsor
- Emory University
HIV Infections
HIV Counseling and Testing and Linkage to Care in Uganda
This study will compare the effectiveness of brief versus detailed HIV counseling sessions, paired with referrals to either HIV-specific medical care or usual care, in reducing HIV risk behavior and in increasing treatment…
- Trial name
- NCT00648232
- Testing
- Voluntary brief HIV counseling and testing, Voluntary longer, more detailed HIV counseling and testing, Enhanced linkage to care
- Where
- Uganda
- Volunteers
- 3,415 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.