Clinical trials: Human Immunodeficiency Virus Type 1
Herpes Simplex, HIV Infections
A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons
The primary objective of this research study is to assess if daily valacyclovir therapy for suppression of HSV-2 reactivation is associated with a decrease in mucosal HIV shedding in individuals co-infected with both HSV-2 and…
- Trial name
- NCT00161434
- Testing
- valacyclovir
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
AIDS Vaccines, HIV Infections
Phase 1 Safety Study of Two Experimental HIV Vaccines
This study will test whether two experimental HIV vaccines are safe and whether they cause any side effects in healthy adults. It will examine the body s immune response to the vaccines and monitor the social impact, if any, of…
- Conditions
- AIDS Vaccines, HIV Infections, HIV-1
- Trial name
- NCT00479999
- Testing
- VRC-HIVADV027-00-VP, VRC-HIVADV038-00-VP
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection
A Clinical Study Of An Investigational Regimen Including Marketed HIV Drugs In HIV-1 Pediatric Subjects Ages 2-18 Years
This is a 48-week study to collect additional information on the safety, tolerability, pharmacokinetics, and antiviral activity of an investigational regimen (course of therapy) including FDA approved HIV drugs in HIV-infected…
- Trial name
- NCT00040664
- Testing
- ritonavir, fosamprenavir
- Where
- 42 sites in United States, Canada and 5 more
- Volunteers
- 69 people
- Sponsor
- ViiV Healthcare
HIV Infections
Safety and Effectiveness of the Oral HIV Entry Inhibitor Vicriviroc in HIV Infected Patients
New treatment options are critical for treatment-experienced HIV infected patients with drug resistance. HIV entry inhibitors have been shown effective in patients with resistance to other anti-HIV drugs.
- Trial name
- NCT00082498
- Testing
- SCH-D (vicriviroc)
- Where
- 30 sites in United States
- Volunteers
- 119 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1
Trial of Maraviroc (UK-427,857) in Combination With Zidovudine/Lamivudine Versus Efavirenz in Combination With Zidovudine/Lamivudine
Maraviroc (UK-427,857), a selective and reversible CCR5 coreceptor antagonist, has been shown to be active in vitro against a wide range of clinical isolates (including those resistant to existing classes).
- Trial name
- MERIT (NCT00098293)
- Testing
- Maraviroc + Zidovudine/Lamivudine, Efavirenz + Zidovudine/Lamivudine, Maraviroc (UK-427,857) + Zidovudine/Lamivudine
- Where
- 144 sites in United States, Argentina and 12 more
- Volunteers
- 916 people
- Sponsor
- ViiV Healthcare
HIV Infections
A Comparison of Three Anti-HIV Drug Combinations in HIV-Infected Patients
The purpose of this study is to look at the effects of different anti-HIV drug combinations on body fat changes in HIV-positive patients who have never received anti-HIV therapy before.
- Trial name
- NCT00005106
- Testing
- Lamivudine/Zidovudine, Abacavir sulfate, Nelfinavir mesylate
- Where
- 39 sites in United States
- Volunteers
- 230 people
- Sponsor
- Glaxo Wellcome
HIV Infection
Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir
The objective of this study is to discover a new approach in which human immunodeficiency virus (HIV) can be eradicated from an infected individual by intensified antiretroviral treatment coupled with immunomodulation.
- Trial name
- EraMune02 (NCT00976404)
- Testing
- DNA + HIV-rAd5 vaccine, ART intensification (raltegravir), ART intensification (maraviroc)
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Robert L. Murphy
HIV Infections
Clinical Sensitivity of Clearview Rapid Tests in 12-17 y/o Pediatric Population
This study is to establish the clinical sensitivity of the Chembio Diagnostics Systems, Inc. Clearview COMPLETE HIV 1/2 Assay and Clearview HIV 1/2 Stat-Pak Assay (Clearview HIV tests) in pediatric subjects who are between 12 and…
- Trial name
- NCT00567749
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Chembio Diagnostic Systems, Inc.
HIV-1 Infection
A Proof of Concept Study to Evaluate the Antiviral Activity, Safety, and Pharmacokinetics of the CCR5 Antagonist TBR 652 in HIV 1-Infected, Antiretroviral Treatment-Experienced, CCR5 Antagonist-Naïve Patients
A double-blind, randomized, placebo-controlled, dose-escalating study to assess the antiviral activity, safety, tolerability, and pharmacokinetics (PK) of the CCR5 antagonist TBR 652 monotherapy dosed orally once daily (QD) for…
- Trial name
- NCT01092104
- Testing
- TBR-652, TBR-652 50 mg, TBR-652 75 mg
- Volunteers
- 52 people
- Sponsor
- Tobira Therapeutics, Inc.
HIV-1-infection, Sleep Deprivation
Poor Sleep and Inflammation in HIV-Infected Adults
People living with HIV (PLWH) often have poor sleep, which may put them at a higher risk for many chronic diseases, including cardiovascular disease.
- Conditions
- HIV-1-infection, Sleep Deprivation, Inflammation
- Trial name
- SASH (NCT03848325)
- Testing
- Sleep deprivation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
HIV Infections
A Study of Dementia and Neurological Problems in HIV Infected Patients Who Are Participating in ACTG A5175
The purpose of this study is to determine how often dementia and other neurological problems occur in people with HIV. Participants of ACTG A5175 will enroll in this study.
- Trial name
- NCT00096824
- Testing
- Neurological assessment
- Where
- 11 sites in Brazil, India and 3 more
- Volunteers
- 860 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
HIV Infections
Safety Study of Once a Day ART and Opiate Substitute.
This study looks at HIV-infected subjects who are on methadone treatment and medicines for HIV.
- Trial name
- 3OD (NCT00324688)
- Testing
- Viread
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Gilead Sciences
HIV Seropositivity, HIV Drug Resistance
Study of the Prevalence of Transmitted HIV-1 Resistance, Viral Diversity, and Cluster Identification in Patients at the Time of HIV-1 Diagnosis
The primary objective of the study is to determine the frequency of transmission of viruses carrying at least one antiretroviral resistance mutation in all participants newly diagnosed with HIV-1
- Conditions
- HIV Seropositivity, HIV Drug Resistance, HIV Infections
- Trial name
- PRINAVIH (NCT07146529)
- Volunteers
- 30,060 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Infection, Human Immunodeficiency Virus
Safety and Tolerability Study to Evaluate Lower Dose of GSK2248761 in Antiretroviral Treatment-Naive HIV-1 Infected Adults.
GSK has in-licensed a novel NNRTI-class candidate (GSK2248761, IDX12899) for the treatment of subjects with HIV-1 infection from Idenix Pharmaceuticals.
- Trial name
- NCT00945282
- Testing
- GSK2248761, Lopinavir/ritonavir, HAART
- Where
- Argentina
- Volunteers
- 8 people
- Sponsor
- ViiV Healthcare
HIV Infections
Comparison of Treatment Simplification by LPV/r vs Current Treatment Continuation in HIV-Infected Patients
The purpose of this study is to compare the efficacy and tolerance of a treatment simplification by a Lopinavir/ritonavir monotherapy versus continuation of current treatment in HIV-infected patients
- Trial name
- KALESOLO (NCT00140751)
- Testing
- Lopinavir/ritonavir (drug)
- Where
- 25 sites in France
- Volunteers
- 186 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Resilience, HIV-1-infection
Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging With HIV
This study will examine the mechanisms and efficacy of a resilience building intervention in older people living with HIV.
- Conditions
- Resilience, HIV-1-infection, Stress, Psychological
- Trial name
- RISE+ (NCT05314088)
- Testing
- RISE+, Stress Reduction Control
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Alabama at Birmingham
HIV Infections, Hemophilia A
Effect of Indinavir Plus Two Other Anti-HIV Drugs on Blood Clotting in HIV-Positive Males With Hemophilia
The purpose of this study is to see if indinavir plus two other anti-HIV drugs affect blood clotting in HIV-positive patients with hemophilia.
- Trial name
- NCT00002386
- Testing
- Indinavir sulfate, Lamivudine, Stavudine
- Where
- 8 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Influence of Atorvastatin on Viral Replication During Antiretroviral Treatment Interruption
To determine the influence of atorvastatin on plasma viral replication when the latter is given before and during highly active anti-retroviral therapy (HAART) in patients with HIV infection and viral suppression.
- Trial name
- NCT00355251
- Testing
- Atorvastatin 40 mg/Atorvastatin 80 mg
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Germans Trias i Pujol Hospital
HIV, HIV Infections
Study to Evaluate the Safety and Efficacy of Stribild Versus Atripla in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults
To evaluate the safety and efficacy of Stribild®, a single tablet regimen (STR) containing fixed doses of elvitegravir (EVG)/cobicistat (COBI [GS-9350])/emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) versus efavirenz…
- Trial name
- NCT01095796
- Testing
- Stribild, Atripla
- Where
- 102 sites in United States, Puerto Rico
- Volunteers
- 707 people
- Sponsor
- Gilead Sciences
HIV
A Randomized, Prospective Study of the Efficacy, Safety and Tolerability of Two Doses of GW433908Ritonavir Given With Abacavir/Lamivudine Fixed Dose Combination
The purpose of this study is to evaluate the antiretroviral efficacy, safety, and tolerability of fos-amprenavir boosted with either of two doses of ritonavir (RTV) when administered in combination with ABC/3TC…
- Trial name
- NCT00335270
- Testing
- fos-amprenavir calcium, ritonavir, abacavir/lamivudine as Epzicom
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
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