Clinical trials: Human Immunodeficiency Viruses
HIV Infection, Hepatitis C
Improving Fibrosis Outcomes With Metformin
This study will evaluate the role of Metformin on liver fibrosis in HCV-HIV co-infected and HCV mono-infected patients with insulin resistance receiving DAA HCV treatment.
- Trial name
- NCT02306070
- Testing
- Metformin, No metformin treatment
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
HIV Infections
The Role of Naive T-Cells in HIV Pathogenesis
While HIV mainly infects mature T-cells it can also infect newly produced (or naïve) T-cells. These infected naïve T cells may then act a viral reservoir even in patients with undetectable viral loads.
- Trial name
- NCT00206531
- Where
- Australia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bayside Health
HIV, Fenofibrate
The Influence of Ritonavir, Alone and in Combination With Lopinavir, on Fenofibric Acid Pharmacokinetics in Healthy Volunteers
Background: Patients infected with the human immunodeficiency virus (HIV) are often treated with protease inhibitors that help fight HIV infection.
- Conditions
- HIV, Fenofibrate, Protease Inhibitors, Hypertriglyceridemia
- Trial name
- NCT01148004
- Testing
- Fenofibrate, Ritonavir, Lopinavir/Ritonavir
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections, Circumcision
Infant Male Circumcision in Gaborone, Botswana, and Surrounding Areas: Feasibility, Safety and Acceptability
Background: Novel HIV prevention approaches are urgently needed in Botswana and elsewhere in sub-Saharan Africa. Although adult male circumcision (MC) has been shown to reduce the heterosexual acquisition of HIV by men by about…
- Trial name
- NCT00971958
- Testing
- Circumcision, Mogen Clamp, Plastibell
- Where
- Botswana
- Volunteers
- 1,235 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cognition Disorders, HIV Infections
Safety and Effectiveness of the Selegiline "Patch" for Decreased Mental Function in HIV Patients
A decrease in mental function often occurs in patients with HIV. Antiretroviral (ARV) drugs are used to treat this but are not entirely effective. Some other therapy could play a role.
- Trial name
- NCT00013585
- Testing
- Selegiline hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 127 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malnutrition, Cancer
Impact of a New Plant-based High-energy Oral Nutritional Supplement on Nutritional Outcomes in Malnourished Patients
This study aims to compare nutritional outcomes in terms of percentage of weight gain between a new planted-based high-energy ONS and a standard high-energy ONS with animal protein (cow's mil protein) in patients at malnutrition…
- Conditions
- Malnutrition, Cancer, Inflammatory Bowel Diseases, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT06055543
- Testing
- Fortimel
- Where
- 6 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Danone Specialized Nutrition
HIV Infection, Vaginal Atrophy
Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial
During menopause, there is a decrease in a hormone estrogen, which leads to aging of the vagina. Vaginal aging includes changes in the type and amount of healthy bacteria in the vagina, inflammation and a breakdown of natural…
- Conditions
- HIV Infection, Vaginal Atrophy, Menopause, Menopause Related Conditions
- Trial name
- NCT04079218
- Testing
- Estradiol Vaginal Insert
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kerry Murphy
HIV, Opioid Dependence
Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
To conduct a randomized clinical trial (RCT) of a community-friendly behavioral intervention designed to reduce HIV risk behavior among injection drug users (IDUs) in drug treatment by comparing risk-behavior outcomes of four…
- Trial name
- NCT01741350
- Testing
- Community-friendly Health Recovery Program, Time-and-Attention-Matched Control Condition
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Connecticut
HIV Infections
A Study of Tumor Necrosis Factor and Human Interferon-gamma in Patients With AIDS Related Complex
To study the tolerance and toxicity of the combination of tumor necrosis factor (TNF) and interferon gamma (IFN-G) or as single agent TNF or IFN-G in HIV infected patients.
- Trial name
- NCT00001004
- Testing
- Tumor Necrosis Factor, Interferon gamma-1b
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Candidiasis, Esophageal, HIV Infections
A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems
To compare the safety, tolerance, and effectiveness of fluconazole and ketoconazole in the treatment of candidal esophagitis in immunocompromised patients.
- Trial name
- NCT00002304
- Testing
- Ketoconazole, Fluconazole
- Where
- 42 sites in United States, Canada
- Sponsor
- Pfizer
Pre-Exposure Prophylaxis
Thailand HIV and Stigma Reduction Study
This project will develop a multi-component, technology-delivered intervention designed to reduce HIV and intersectional stigma and improve the use of HIV pre-exposure prophylaxis (PrEP) among HIV-negative Thai vulnerable…
- Trial name
- NCT06576648
- Testing
- Mobile Healthy Choices (mHC), Finding Respect and Ending Stigma around HIV (FRESH), Standard PrEP Counseling
- Where
- 3 sites in Thailand
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
HIV Infections
Evaluating the Safety and Tolerability of Ruxolitinib in Antiretroviral-Treated HIV-Infected Adults
The purpose of this study was to evaluate the safety and tolerability of ruxolitinib in HIV-positive adults who were virologically suppressed and who were on antiretroviral therapy (ART).
- Trial name
- NCT02475655
- Testing
- Ruxolitinib
- Where
- 14 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy, HIV
Safety and Pharmacokinetics (PK) of a Polyurethane Tenofovir Disoproxil Fumarate (TDF) Vaginal Ring (TDF IVR-002)
This prospective, two-site, two-arm, randomized, single-blind, placebo-controlled trial will examine the safety and pharmacokinetics (PK) of a polyurethane tenofovir disoproxil fumarate (TDF) vaginal ring when used continuously…
- Trial name
- TDF IVR-002 (NCT02762617)
- Testing
- Tenofovir disoproxil fumarate intravaginal ring
- Where
- 2 sites in United States, Kenya
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Marla Keller
HIV-infection
Clinical Trial of Safety and Pharmacokinetics of VM-1500 After Multiple Oral Administration in Healthy Volunteers
The purpose of the study to assess safety and tolerability of VM-1500 and to determine main pharmacokinetic parameters of VM-1500 after multiple oral administration in adult healthy subjects.
- Trial name
- NCT02489435
- Testing
- VM-1500
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Viriom
HIV
The Impact of Structured Exercise on Brain Health in HIV Positive Individuals
Exercise programs that combine resistance exercise with aerobic training yield optimal health benefits for people with HIV. The global aim of this study is to contribute evidence for the impact potential of a comprehensive…
- Trial name
- NCT03053817
- Testing
- Exercise group
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University
Colitis, HIV Infections
A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients
To determine the oral bioavailability of three dose levels of oral ganciclovir given with and without glutamic acid hydrochloride in patients with cytomegalovirus (CMV) GI disease, and to compare the bioavailability of these…
- Trial name
- NCT00000768
- Testing
- Glutamic acid hydrochloride, Ganciclovir
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Directly Observed Therapy for HIV Infected Adolescents
Adherence to a doctor-prescribed anti-HIV drug regimen is crucial in the management of HIV infection. In previous studies with tuberculosis patients, directly observed therapy (DOT), a strategy in which patients are observed…
- Trial name
- NCT00259389
- Testing
- Directly observed therapy (DOT)
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anal Cancer, Precancerous Condition
Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus
RATIONALE: High-grade squamous intraepithelial lesions of the skin near the anus are caused by the human papillomavirus (HPV). Antiviral drugs,, such as cidofovir, act against viruses and may stop these lesions from becoming…
- Trial name
- NCT00550589
- Testing
- cidofovir, DNA methylation analysis, gene expression analysis
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- AIDS Malignancy Consortium
Cytomegalovirus Retinitis, HIV Infections
A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir
To determine the pharmacokinetics (blood levels) of three dose treatment plans of oral ganciclovir during a 28-day dosing period.
- Trial name
- NCT00000668
- Testing
- Ganciclovir
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, HIV
DNA Sequencing of MDR TB in Eastern Siberia
This is protocol is generated in response to the exploratory R21 from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID) for US-Russia collaborative research in HIV/tuberculosis…
- Trial name
- NCT02508610
- Where
- Russia
- Volunteers
- 630 people
- Sponsor
- University of Virginia
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