Clinical trials: Human Immunodeficiency Viruses
HIV
Patient-Centered Disclosure Intervention for HIV-Infected Children
In the resource-limited settings where most HIV-infected children live, neither the most effective strategies to inform children of their HIV status, nor the impact of disclosure is well understood.
- Trial name
- HADITHI (NCT01947764)
- Testing
- HADITHI Intervention
- Where
- Kenya
- Volunteers
- 330 people
- Sponsor
- Indiana University
Healthy
The Effect of Lopinavir/Ritonavir on Endothelial Function
This study will examine how the anti-HIV protease inhibitor lopinavir/ritonavir (Kaletra® (Registered Trademark)) affects the function of the endothelium (lining of the arteries).
- Trial name
- NCT00076414
- Testing
- Acetylcholine, L-NMMA
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Unsafe Sex
Telephone-delivered Behavioral Interventions to Reduce Risky Sexual Behavior in HIV-positive Late Middle-age and Older Adults
The number of late middle-age and older adults living with HIV/AIDS in the U.S. continues to rise due largely to better clinical care and the improved efficacy of highly active antiretroviral therapy that has extended the lives…
- Trial name
- MI (NCT01499706)
- Testing
- 1-session of telephone-administered motivational interviewing, 4-session telephone-administered motivational interviewing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio University College of Osteopathic Medicine
Family Planning
Family Planning Service Delivery Integration For HIV Positive And At-Risk Women In Botswana: A Hybrid Type 2 Clinical Intervention And Implementation Strategy
The goal of this pilot study is to assess both implementation outcomes (acceptability, feasibility and adoption) and clinical efficacy (contraceptive method uptake by women wishing to avoid pregnancy) using a Hybrid Type 2 study…
- Trial name
- NCT03213028
- Testing
- WHO Decision-Making Tool for Family Planning Clients and Providers
- Where
- Botswana
- Volunteers
- 248 people
- Sponsor
- University of Pennsylvania
HIV/AIDS, Adherence
Real-Time Antiretroviral Therapy Adherence Intervention in Uganda
Development of Real-Time Antiretroviral Therapy Adherence Intervention in Uganda (The Wisepill Study).
- Trial name
- NCT01957865
- Testing
- Fixed SMS, real-time monitoring, Triggered SMS, real-time monitoring
- Where
- Uganda
- Volunteers
- 63 people
- Sponsor
- Massachusetts General Hospital
CMV
Effect of Atorvastatin on Subclinical Atherosclerosis
Statin administration is supposed to reduce subclinical atherosclerosis by decreasing LDL cholesterol levels, possibly via lipid-independent anti-inflammatory effect.
- Trial name
- NCT04101136
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
HIV-1 Infection, HIV Infections
Plasma and Intracellular Concentrations of Raltegravir and Etravirine Administered Once Daily
Hypothesis: the intracellular concentrations of raltegravir (RAL) and etravirine (ETV) administrated as 800 and 400 mg once a day, respectively, are similar to those obtained with the standard doses of 400 and 200 mg/12h…
- Trial name
- RAET (NCT01121809)
- Testing
- Raltegravir, Etravirine
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
HIV Infections
Acupuncture for Nausea in HIV
The subjects in this research study will be 159 men and women with HIV infection who have a history of chronic nausea for three months or greater and show evidence of two or more episodes of nausea and/or report a duration of two…
- Trial name
- AcuN (NCT00624793)
- Testing
- Acupuncture, Individualized Acup based on TCM diagnosis
- Volunteers
- 159 people
- Sponsor
- NYU Langone Health
HIV Associated Cognitive Motor Complex
Effect of Galantamine on Inflammation and Cognition
This study tests whether galantamine (GAL) reduces HIV-related inflammation and cognitive deficits. In this double-blind placebo-controlled crossover study, HIV-infected individuals (N=120; 60 smokers and 60 non-smokers) will be…
- Trial name
- CHI (NCT03384784)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania
HIV Infections
The Safety and Immunogenicity of a Potential HIV Vaccine
The potential HIV vaccine has two components: a protein immunogen based on the coat protein of HIV; and an adjuvant which enhances the vaccinee's response to the immunogen.
- Trial name
- NCT01966900
- Testing
- CN54gp140 mixed with GLA-AF
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Transgender Persons, Pre-Exposure Prophylaxis
The Stay Study: A Demonstration Project Advancing PrEP Delivery in the San Francisco Bay Area Transgender Community
The Stay Study is a multi-site, open-label HIV pre-exposure prophylaxis (PrEP) demonstration project for advancing PrEP delivery in the San Francisco Bay Area Transgender Community.
- Trial name
- NCT03120936
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet, PrEP support
- Where
- 5 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
HIV Infection
Effects of Facility-based Mother Support Groups on Prevention of mother-to Child Transmission Outcomes in Zimbabwe
The investigators hypothesize that a strategy of establishing facility-based mother support groups (MSGs) for HIV-positive mothers will result in increased retention rates of HIV-exposed infants in clinic-based PMTCT follow-up…
- Trial name
- EPAZ (NCT02216734)
- Testing
- Mother support groups for HIV+ mothers
- Where
- 2 sites in Zimbabwe
- Volunteers
- 300 people
- Sponsor
- Family AIDS Caring Trust
HIV Associated Neurocognitive Disorder
Study of Paroxetine and Fluconazole for the Treatment of HIV Associated Neurocognitive Disorder
The purpose of this study is to see if paroxetine and fluconazole are safe and effective as a treatment for problems with memory, concentration, thinking, and judgment in people who are infected with HIV.
- Trial name
- ParaFlu (NCT01354314)
- Testing
- Fluconazole, Paroxetine, Paroxetine and Fluconazole
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Johns Hopkins University
Behavior, Sex
Comparing the Efficacy of Enhanced and Standard HTC
Objective The objectives of the study are to evaluate the relative efficacy of an enhanced version of HIV testing and counselling (EHTC) versus standard-of-care HIV testing and counselling (SHTC) in reducing sexual risk…
- Trial name
- NCT03660709
- Testing
- Intervention, Control
- Where
- Hong Kong
- Volunteers
- 430 people
- Sponsor
- Chinese University of Hong Kong
Risk Reduction, HIV
Personalized HIV and STI Testing Tool
The PHASTT Study is focused on understanding of facilitators and barriers to mHealth use among young Black men who have sex with men (MSM), and testing a novel mobile app to increase HIV/STI testing and PrEP uptake.
- Conditions
- Risk Reduction, HIV, Sexually Transmitted Infections (Not HIV or Hepatitis)
- Trial name
- PHASTT (NCT03109899)
- Testing
- Sex Pro mobile Application
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
HIV (Human Immunodeficiency Virus), HPV
Feasibility Study Comparing One vs Two Probes for TA Among Cervical Cancer Screen Positive WLWH in C1001P-CS5 Rwanda
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general…
- Conditions
- HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer
- Trial name
- NCT07390916
- Testing
- Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
- Where
- Rwanda
- Volunteers
- 300 people
- Sponsor
- Fred Hutchinson Cancer Center
HIV Infections
A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV
This study investigates the use of VH3810109 with or without FTR to reduce the size and activity of the HIV viral reservoir in two sub-populations of people living with HIV: treatment-naïve adults (Population 1) and…
- Trial name
- ENTRANCE (NCT07053384)
- Testing
- VH3810109, Fostemsavir (FTR), SOC INSTI-based ART
- Where
- 41 sites in United States, Belgium and 4 more
- Volunteers
- 107 people
- Sponsor
- ViiV Healthcare
HIV Infections
Dolutegravir Study in HIV-1 Participants Completing IMPAACT Studies P1093 and P2019
Dolutegravir is a potent integrase strand transfer inhibitor. Abacavir/dolutegravir/lamivudine (ABC/DTG/3TC) is a fixed dose combination regimen containing two nucleoside reverse transcriptase inhibitors and dolutegravir.
- Trial name
- NCT03016533
- Testing
- Dolutegravir film-coated tablets, Dolutegravir film-coated dispersible tablets, ABC/DTG/3TC immediate release tablets
- Where
- 17 sites in United States, Botswana and 5 more
- Volunteers
- 100 people
- Sponsor
- ViiV Healthcare
HIV Infections, AIDS
L-Carnitine to Treat Fatigue in AIDS Patients
Patients with AIDS may develop a deficiency of the micronutrient carnitine and such a deficiency may contribute to fatigue in these patients.
- Trial name
- NCT00079599
- Testing
- L-carnitine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Nursing Research (NINR)
HIV Infections, HIV Seronegativity
A Study of GENEVAX-HIV, a Possible Vaccine
The purpose of this study is to see if it is safe to give GENEVAX-HIV, a potential HIV vaccine, to HIV-negative volunteers. The study also compares the effects of GENEVAX-HIV injected into the muscle to the effects of the drug…
- Trial name
- NCT00002232
- Testing
- APL 400-003
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth-Lederle Vaccines
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