Clinical trials: Human Papillomavirus Virus
Cervical Adenocarcinoma, Human Papillomavirus
HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma
This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections.
- Conditions
- Cervical Adenocarcinoma, Human Papillomavirus, Genome-wide Association Study, Whole Exome Sequencing
- Trial name
- NCT03742869
- Testing
- A multi-omics analysis
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Lei Li
HPV (Human Papillomavirus)-Associated
Parent Education About Human Papillomavirus (HPV)
Human papillomavirus (HPV) vaccination is an effective strategy for preventing HPV-related diseases; however, parental knowledge and vaccination intention may influence vaccine uptake among children and adolescents.
- Trial name
- NCT07447245
- Testing
- Behavioral: Health Belief Model-Based HPV Education
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Cervical Cancer, Anal Cancer
A Message Framing Intervention for Increasing Parental Acceptance of Human Papillomavirus Vaccination
The goal of this study is to determine the effects of message framing (gain vs. loss) on African American parents' acceptance of the HPV vaccine and how such effects are moderated by parents' salient beliefs prior to message…
- Conditions
- Cervical Cancer, Anal Cancer, Penile Cancer
- Trial name
- NCT03856437
- Testing
- HPV vaccination messages
- Where
- United States
- Volunteers
- 1,170 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Anal Cancer
HPV Genotype Attribution and Disease Burden of Anal Cancer in China
To demonstrate HPV prevalence and its genotype distributions in anal cancer in China and to describe demographic and clinical features of HPV-related anal cancer in China; To describe the epidemiological characteristics ,trends…
- Trial name
- NCT06670495
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Human Papillomavirus Infection
Clinical Trial to Assess the Safety, Tolerability, Reactogenicity, and Immunogenicity of a 10 Valent Human Papillomavirus Virus (10vHPV) Vaccine
Human papilloma virus (HPV) is the most common viral infection of the reproductive system and is spread through contact with infected genital skin, mucous membranes, or bodily fluids.
- Trial name
- NCT07888686
- Testing
- 10vHPV, Gardasil9
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Serum Institute of India Pvt. Ltd.
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC (American Joint Committee on Cancer) v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner
This phase Ib/II trial studies the side effects and how well stereotactic body radiation therapy and durvalumab with or without tremelimumab before surgery work in treating participants with human papillomavirus positive…
- Conditions
- Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC (American Joint Committee on Cancer) v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Human Papillomavirus Positive
- Trial name
- NCT03618134
- Testing
- Durvalumab, Modified Radical Neck Dissection, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Jonsson Comprehensive Cancer Center
HPV Positive Oropharyngeal Squamous Cell Carcinoma, Squamous Cell Carcinoma
Combining Neo-adjuvant ATR-inhibition With Nodal SBRT for Early-stage Resectable HPV+ OPSCCs
This research study is testing whether a new study drug (called ATRN-119) is safe and effective when combined with a single, highly targeted dose of radiation therapy (called stereotactic body radiation therapy or SBRT) to treat…
- Conditions
- HPV Positive Oropharyngeal Squamous Cell Carcinoma, Squamous Cell Carcinoma, HPV (Human Papillomavirus)-Associated Carcinoma, HPV Associated Cancers
- Trial name
- NCT07578467
- Testing
- ATRN-119, Stereotactic Body Radiation Therapy (SBRT)
- Volunteers
- 35 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cervical Intraepithelial Neoplasia
E7 TCR T Cell Immunotherapy for High-Grade Cervical Intraepithelial Neoplasia
Background: Human papillomavirus (HPV) can lead to High-Grade Cervical Intraepithelial Neoplasia (CIN 2,3). This type of lesion has a high risk of becoming cancer. T cells are part of the immune system.
- Trial name
- NCT04411134
- Testing
- E7 TCR
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
HPV Infections, Cervical Cancer Stage IIa
Immune Persistence After the Whole Vaccination Shcedule With Recombination Quadrivalent HPV Vaccine
To access the immune persistence of Chinese women aged 9-45 years after receiving quadrivalent HPV vaccine with the immunization schedule of 0, 2 and 6 months.
- Conditions
- HPV Infections, Cervical Cancer Stage IIa, Vaginal Cancer, Genital Wart
- Trial name
- NCT05371353
- Where
- 2 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Oropharyngeal Squamous Cell Carcinoma
Determination of Cetuximab Versus Cisplatin Early and Late Toxicity Events in HPV+ OPSCC
Oropharyngeal squamous cell carcinoma (OPSCC) incidence is increasing rapidly in the developed world. This has been attributed to a rise in Human Papillomavirus (HPV) infection.
- Trial name
- De-ESCALaTE (NCT01874171)
- Testing
- Cisplatin, Cetuximab
- Where
- 33 sites in Ireland, Netherlands and 1 more
- Volunteers
- 334 people
- Sponsor
- University of Warwick
HPV Infection, HPV-Related Carcinoma
A Phase I Clinical Trial to Evaluate the Safety of 15-valent HPV Vaccine in Healthy Chinese People Aged 18-45 Years
To evaluate the safety and tolerability of 15-valent HPV vaccine in 9-45year-old participants.
- Conditions
- HPV Infection, HPV-Related Carcinoma, Genital Wart, HPV-Related Intraepithelial Neoplasia
- Trial name
- NCT06454175
- Testing
- 15-valent recombinant human papillomavirus vaccine (Hansenulapolymorpha)
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Human Papillomavirus, Uterine Cervical Neoplasms
An HPV Vaccine Provider Intervention in Safety Net Clinics
The purpose of this study is to develop, deliver and evaluate a provider intervention for mothers and their children to encourage receipt of the human papillomavirus (HPV) vaccine in the children and appropriate cervical cancer…
- Trial name
- NCT02808832
- Testing
- Educational materials
- Where
- United States
- Volunteers
- 806 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Human Papillomavirus Infection, HPV
Human Papillomavirus in Young People Epidemiological Research 4
Anal cancer is overrepresented among gay, bisexual and other men who have sex with men (MSM), particularly those living with HIV.
- Conditions
- Human Papillomavirus Infection, HPV, HPV Infection, Anal Cancer
- Trial name
- HYPER4 (NCT05587738)
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- Monash University
HSIL of Cervix, HSIL, High Grade Squamous Intraepithelial Lesions
Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection.
This study evaluates the use of ABI-1968, a topical cream, in the treatment of cervical precancerous lesions in females without human immunodeficiency virus (HIV) infection.
- Conditions
- HSIL of Cervix, HSIL, High Grade Squamous Intraepithelial Lesions, High-Grade Cervical Intraepithelial Neoplasia, Human Papilloma Virus
- Trial name
- NCT03697226
- Testing
- Topical ABI-1968
- Where
- South Africa
- Volunteers
- 8 people
- Sponsor
- Antiva Biosciences
Cervical Neoplasia
Human Papillomavirus (HPV) and Risk of Cervical Precancer and Cancer
Background: In most women, HPV infection does not cause symptoms and the infection goes away on its own. In a small percentage of women, the HPV infection does not go away and sometimes can result in cervical precancer or cancer.
- Trial name
- NCT00435214
- Where
- United States
- Volunteers
- 131,110 people
- Sponsor
- National Cancer Institute (NCI)
Human Papilloma Virus, Human Papilloma Virus Vaccine
Advancing HPV Vaccination Among HIV Positive Adults: The CHAMPS Study
People living with HIV (PLWH) are 28 times more likely to be diagnosed with Human Papillomavirus (HPV) - associated anal cancer than the general population.
- Trial name
- CHAMPS (NCT05065840)
- Testing
- CDC 4 Pillars Program
- Where
- 4 sites in United States
- Volunteers
- 267 people
- Sponsor
- Emory University
Cervical Cancer
Pap Smear Research Study
The principal hypothesis of this study is that HPV testing and/or p16 testing, either alone or in combination or associated with a Pap smear, will demonstrate greater specificity for clinically significant precancerous disease…
- Trial name
- NCT00743626
- Testing
- Diagnostic cervical cancer screening tests (Pap smear, HPV and/or p16)
- Where
- Canada
- Volunteers
- 1,712 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Genital Infection Viral, HUMAN PAPILLOMA VIRUS
Phase II Study of HPV Therapeutic Vaccine in HPV Infected Women With Normal Cytology or ASCUS/LSIL
Human Papillomavirus (HPV) 16 and HPV 18 (the two virus genotypes targeted by the ProCervix vaccine) are the most common HPV genotypes associated with at least 70% of squamous cell carcinomas and 82% of adenocarcinomas of the…
- Trial name
- RHEIA-VAC (NCT01957878)
- Testing
- ProCervix
- Where
- 40 sites in Belgium, Finland and 5 more
- Volunteers
- 239 people
- Sponsor
- Genticel
Parents, Parent-Child Relations
Development and Psychometric Testing of HPV Knowledge Scale
The aim of this study is to develop and conduct psychometric testing of a new scale, the Human Papillomavirus Knowledge Scale (HPV-KS), particularly designed to assess HPV knowledge among parents of school-age children in…
- Trial name
- NCT06466252
- Testing
- Psychometric Group
- Where
- Indonesia
- Volunteers
- 673 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Human Papilloma Virus
Prevention of Cervical Cancer Using the Genotyping Screening and Same-day Self-sampling
In May 2018, the World Health Organization (WHO) launched a strategy to eliminate cervical cancer. While this strategy seeks to achieve coverage of 70% in disease testing and 90% in treatment by 2030, it is estimated that these…
- Trial name
- PROGRESS (NCT07232355)
- Where
- 4 sites in United States, El Salvador and 1 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Atila Biosystems Inc.
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