Clinical trials: Hyaluronic Acid
- Condition Hyaluronic Acid
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Skin Inflammation, Cosmetic Skin
35 kDa Hyaluronan Fragment (HA35) Reduces Chronic Inflammation of Skin
To explore the clinical effect and safety of 35 kDa hyaluronic acid fragment ( HA35 ) combined with negative pressure microneedle technology in improving skin problems.
- Trial name
- NCT06387212
- Testing
- 35 kDa hyaluronan fragment HA35 injection
- Where
- Mongolia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nakhia Impex LLC
Dry Eye Syndromes, Lubricant Allergy
Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
Phase I clinical study, to evaluate the safety and tolerability of the preservative-free ophthalmic solution PRO-087 versus Xyel Ofteno® and Systane Ultra®, on the ocular surface of ophthalmological and clinically healthy…
- Conditions
- Dry Eye Syndromes, Lubricant Allergy, Tear Disorder
- Trial name
- PRO-087/I (NCT03524157)
- Testing
- PRO-087, Systane Ultra, Xyel Ofteno
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye Syndromes
Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel
Objective: To assess the safety and tolerability of the PRO-165 formulation on the ocular surface of ophthalmologically and clinically healthy subjects.
- Trial name
- PRO-165 (NCT03697876)
- Testing
- PRO-165, Artelac
- Where
- Mexico
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Pregnancy, High Risk
Use of Dietary Supplements in Patients at Risk of Abortion Treated With Progesterone.
The trial aims to investigate the effect of supplementation with hyaluronic acid, alpha-lipoic acid, magnesium, vitamin D and vitamin B6 in progesterone-treated pregnant women with risk factors for abortion.
- Trial name
- NCT04874285
- Testing
- HA
- Where
- Italy
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Infra-orbital Hollows, Tear-trough Deformity
RHA® Redensity Eye Versus No-treatment for the Infra-Orbital Hollows
This is a multicenter, blinded evaluator, randomized, prospective, no treatment control clinical study to identify whether RHA® Redensity Eye (*) is superior to no treatment for the correction of moderate to severe tissue volume…
- Conditions
- Infra-orbital Hollows, Tear-trough Deformity, Wrinkle
- Trial name
- NCT04577898
- Testing
- RHA® Redensity Eye
- Where
- 4 sites in United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Dehydration
Study of In-line Pressure Using Various Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase (INFUSE-AT1A)
The purpose is to characterize the in-line pressure profiles associated with several infusion technique factors during subcutaneous (SC) infusion of Lactated Ringer's solution, preceded by recombinant human hyaluronidase…
- Trial name
- INFUSE-AT1A (NCT01116102)
- Testing
- Subcutaneous HYLENEX (recombinant human hyaluronidase) and Lactated Ringer's solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Aging
Evaluation of the Efficacy and Safety of an Injectable Hyaluronic Acid-based Filler, Art Filler® Volume: Comparative Single-blind Study of the Non-inferiority Versus Juvéderm® Voluma on the Midface, Temple and Jaw-line and Non-comparative Study on the Chin. (AF3)
The function of injectable fillers for the treatment of dermal contour deformities is to smooth dermal depressions formed by the loss of volume.
- Trial name
- AF3 (NCT04645576)
- Testing
- Face correction with injectable fillers
- Where
- France
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Laboratoires FILLMED
Wrinkles
Safety Study of Cosmetic Tissue Augmentation in People of Color
Elevess is intended for all skin types. However, further study of all soft tissue fillers is needed in people of color because of the increasing use of cosmetic dermal filler products.
- Trial name
- NCT01147172
- Testing
- Elevess
- Where
- 9 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Anika Therapeutics, Inc.
Safety
A Study to Evaluate the Safety Following Injection of GP0045 Compared to Restylane Lyft Lidocaine
This is a study to assess the safety of GP0045 compared to Restylane Lyft Lidocaine. There is a 12-week follow-up period. AEs will be recorded throughout the study.
- Trial name
- NCT03133325
- Testing
- GP0045, Restylane Lyft Lidocaine
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Nasolabial Folds
TEOSYAL® PureSense ULTRA DEEP Versus Restylane® Lidocaine for the Correction of Moderate to Severe Nasolabial Folds in Chinese Adults
This is a prospective, multi-center, randomized, controlled, subject- and evaluator-blinded clinical investigation to demonstrate non-inferiority of TEOSYAL® PureSense ULTRA DEEP compared to Restylane® Lidocaine for the…
- Trial name
- NCT06367634
- Testing
- injection in NLF
- Where
- China
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Wrinkle
A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction
This is a randomized, split-face, subject-blinded, comparative study. Subjects will receive initial treatment with Defyne on one of the NLFs and with RHA3 on the other based on the pre-determined randomization.
- Trial name
- NCT06351293
- Testing
- Defyne Treatment in Nasolabial Fold, RHA3 Treatment in Nasolabial Fold
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Esthetics
Effectiveness and Safety of STYLAGE® M Lidocaïne for Lips' Volume Augmentation and/or Redefinition of the Outline of the Lips (SMILE)
STYLAGE® M Lidocaine is a hyaluronic acid injectable gel CE (conformité européenne)-marketed since 2009 . It is indicated for the outline of the lips and/or for lips augmentation in lips mucosa.
- Trial name
- SMILE (NCT04813614)
- Testing
- STYLAGE M Lidocaine, Active control group
- Where
- 2 sites in France, Poland
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Healthy Japanese Subjects
The Effect of Oral Hyaluronic Acid on the Skin
This clinical trial aims to clarify the effect of hyaluronic acid on skin conditions.
- Trial name
- NCT05803083
- Testing
- Hyaluronic acid 75 mg/capsule, Hyaluronic acid 50 mg/capsule
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bloomage Biotechnology Corp., Ltd.
Volume Deficiency in the Mid-Face, Aging
Study of a Novel Hyaluronic Acid Based Gel for Volume Deficiency in the Mid-face (FaceHyal)
The primary objective of the study is to demonstrate the superiority of IPN-21-SENSE versus no treatment at 24 weeks after baseline for the creation or restoration of volume deficit in the mid-face.
- Conditions
- Volume Deficiency in the Mid-Face, Aging, Aesthetics
- Trial name
- FaceHyal (NCT05747456)
- Testing
- IPN-21-SENSE
- Where
- France
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Esthetic
Effectiveness and Safety of STYLAGE® XXL for Chin Augmentation in Chinese Adults
The aim of this trial is to demonstrate the efficacy and safety of STYLAGE® XXL in augmenting the chin volume among Chinese adults.
- Trial name
- NCT05009381
- Testing
- Stylage XXL at enrollment, Stylage XXL at Month 6
- Where
- 5 sites in China
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Aging, Aesthetic
Clinical Performance and Safety of STYLAGE® HydroMax
FHAME is a post-market clinical investigation designed to strengthen the clinical evidence supporting the effectiveness of STYLAGE® HydroMax in the treatment of superficial wrinkles, primarily on the cheeks.
- Trial name
- FHAME (NCT07153237)
- Testing
- STYLAGE® HydroMax
- Where
- 2 sites in France
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Skin Laxity, Skin Roughness
Aesthetic Performance and Tolerance of an Injective Intradermal Treatment for the Skin Roughness and Laxity of Back of the Hands
People lose collagen all over the body, not just in the face; skin roughness and laxity of the dorsum of the hands can result from chrono and photo-aging.
- Trial name
- NCT05590364
- Testing
- Profhilo® Body
- Where
- Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- IBSA Farmaceutici Italia Srl
Lips Enhancement, Nasolabial Fold Correction
Evaluation of the Safety and Performance of an Injectable Hyaluronic Acid Filler
Evaluation of the safety and performance of the investigational device in its three concentrations for cheek and lips augmentation and correction of the nasolabial folds, assuming that the performance of the product will be…
- Conditions
- Lips Enhancement, Nasolabial Fold Correction, Midface Volume Deficit
- Trial name
- NCT04971876
- Testing
- HLR-1, HLR-2, HLR-3
- Where
- 3 sites in Germany, Poland
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hallura Ltd.
Aging
Effectiveness and Safety of STYLAGE® L Lidocaïne in the Treatment of Nasolabial Folds
STYLAGE® L Lidocaine is a CE-marked hyaluronic acid gel intended to fill skin depressions on the face by dermal injection. In this study, 50 healthy subjects between the age of 30 and 65, with moderate to severe nasolabial folds…
- Trial name
- NICE (NCT04844216)
- Testing
- STYLAGE® L Lidocaine, Active control
- Where
- 2 sites in France, Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Cataract
Clinical Investigation of the Bacterially-Derived Healon5 Ophthalmic Viscosurgical Device (OVD)
Prospective, multicenter, paired-eye, randomized, masked, clinical trial of the bacterially-derived Healon5 OVD versus the currently available Healon5 OVD control.
- Trial name
- NCT02782676
- Testing
- Investigational Healon5 OVD, Healon5 OVD
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics