Clinical trials: Hyaluronic Acid
Aging
Effectiveness and Safety of STYLAGE® HYDRO in the Treatment of Face, Neckline Area and Neck
FLASH Study is a Post-Market Follow-Up PCMF designed to evaluate the tolerance and efficacy of STYLAGE Hydro by using a satisfaction questionnaire.
- Trial name
- FLASH (NCT05809739)
- Testing
- STYLAGE Hydro
- Where
- 2 sites in France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Myomas, Ovary Cysts
The Efficacy and Safety Study of a New Cross-linked Hyaluronan Hydrogel in the Reduction of Postsurgical Peritoneal Adhesions
The purpose of this study was to determine whether the new crosslinked hyaluronan hydrogel was safe to use, and was effective for the prevention/reduction of adhesion formation following gynecological surgery
- Conditions
- Myomas, Ovary Cysts, Endometriotic Cysts, Adhesions
- Trial name
- BAP (NCT02166554)
- Testing
- Saline, Cross-linked Hyaluronan Hydrogel
- Where
- 7 sites in China
- Volunteers
- 216 people
- Sponsor
- BioRegen Biomedical (Changzhou) Co., Ltd
Ocular Redness
A Study Comparing the Efficacy and Safety of Brimonidine Tartrate Ophthalmic Solution 0.025% With Sodium Hyaluronate Relative to Lumify in Adult Subjects With Ocular Redness
To demonstrate the efficacy of BTOS-HA as non inferior to Lumify for treating ocular redness in a population of adult subjects.
- Trial name
- NCT06803654
- Testing
- BTOS-HA, Lumify®
- Where
- 11 sites in United States
- Volunteers
- 578 people
- Sponsor
- Bausch & Lomb Incorporated
Vaginal Disease
Clinical Trial Study To Evaluate The Performance And Safety Of Ainara®
This study evaluates treatment with the medical device Ainara® compared to a HA-based gel (Hyalogin) on the improvement of vaginal dryness
- Trial name
- NCT04245293
- Testing
- Ainara, HyaloGin
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- Italfarmaco
Vulvar Atrophy
Autologous Platelet Concentrate Combined to Hyaluronic Acid Obtained With Cellular Matrix® BCT-HA Kit and Vulvovaginal Dryness
Vulvovaginal irritation is a frequent complaint among postmenopausal women. Common symptoms of vaginal atrophy include dryness, itching, burning and dyspareunia.
- Trial name
- NCT02966925
- Testing
- Cellular Matrix BCT-HA Kit
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Regen Lab SA
Bilateral Cataract, Unilateral Cataract
Comparison of the Safety and Efficacy of Ophtesis Bio 3% With a Similar 3% Sodium Hyaluronate OVD
Prospective, randomized, subject/evaluator-masked post market clinical study at up to 2 sites at Gemini eye clinic in Czech Republic. Randomization will be done by the eye surgeon.
- Trial name
- NCT05832749
- Testing
- Ophtesis Bio 3% ophthalmic viscosurgical device, Healon Endocoat 3% ophthalmic viscosurgical device
- Where
- 3 sites in Czechia
- Volunteers
- 296 people
- Sponsor
- Gemini Eye Clinic
Chronic Wounds
Freshly Manufactured 35kDa Hyaluronan Fragment HA35 for the Treatment of Chronic Wounds
In this research, the patients with chronic wounds accompanied by pain were treated by injecting freshly manufactured tissue permeable hyaluronan fragment HA35 into the tissue under the heath skin immediately surrounding the…
- Trial name
- NCT05764226
- Testing
- HA35(L20200708MP07707, Ministry of Health, Mongolia)was freshly manufactured by mixing hyaluronidase PH20 injectable solution (H31022111) and high-molecular-weight HA injectable solution (H20174089)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nakhia Impex LLC
Symptomatic Hip Osteoarthritis
The Efficacy Study of Sodium Hyaluronate to Treat Symptomatic Hip Osteoarthritis
To demonstrate the difference in terms of symptomatic efficacy between ADANT® sodium hyaluronate and placebo following an intra-articular injection in patients with symptomatic osteoarthritis of the hip.
- Trial name
- NCT00330135
- Testing
- Sodium hyaluronate
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Daiichi Sankyo
Osteoarthritis, Knee
Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE)
This study evaluates the safety and efficacy of investigational products in the treatment of knee Osteoarthritis. Half of participants will receive medical chitosan, while the other half will receive sodium hyaluronate.
- Trial name
- NCT02323451
- Testing
- Medical Chitosan, Sodium Hyaluronate Injection
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Shanghai Qisheng Biological Preparation Co., Ltd.
Correction of Nasolabial Folds
Observational Study to Evaluate Long-term Safety and Biodegradability of YVOIRE Volume s
To evaluate long-term safety of YVOIRE volume s by incidence of adverse events including injection site local reactions and biodegradability.
- Trial name
- NCT02661737
- Testing
- YVOIRE volume s
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Bladder Carcinoma in Situ (CIS)
Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID)
This is a phase III, single-arm, multicenter, international study to assess the efficacy and safety of ONCOFID-P-B following intravesical instillation in adult patients with histologically and cytologically confirmed CIS, with or…
- Trial name
- NCT05024773
- Testing
- ONCOFID P-B (PACLITAXEL-HYALURONIC ACID)
- Where
- 47 sites in United States, France and 4 more
- Volunteers
- 130 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Facial Aging, Skin Rejuvenation
Performance and Safety of Semical Dermal Fillers in Facial Rejuvenation
The aim of the study is to verify safety and performance of Semical dermal fillers according to real-world data.
- Conditions
- Facial Aging, Skin Rejuvenation, Volume Defects in the Mid-face, Lip Augmentation and Correction of Perioral Rhytids
- Trial name
- SEMDERMA (NCT07160777)
- Testing
- cross-linked hyaluronic acid, Mesolifter
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Semikal Technology
Osteoarthritis of the Knee
Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
Subjects with chronic osteoarthritis of the knee will be assigned to receive an injection of either 1.2% sodium hyaluronate or buffered saline to evaluate its effectiveness and safety for 26 weeks.
- Trial name
- NCT00988091
- Testing
- 1.2% Sodium Hyaluronate, Buffered Saline
- Where
- 34 sites in United States
- Volunteers
- 596 people
- Sponsor
- Ferring Pharmaceuticals
Lip Abnormality
THIODERM ELATE for Augmentation of Very Thin, Thin, and Moderately Thick Lips
This mono-center clinical investigation is intended to assess the safety and effectiveness of THIODERM ELATE for augmentation of very thin and thin lips in comparison with Juvéderm® Ultra 3.
- Trial name
- TILI (NCT06135337)
- Testing
- Thioderm Elate, Juvéderm Ultra 3
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Croma-Pharma GmbH
Gastro Esophageal Reflux
Effect of a Combination Oral Formulation of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate in Patients With Gastro-Esophageal Reflux Disease Not Fully Satisfied With Their Treatment
This is a post-market, multi-center, double-blind, placebo-controlled, randomized, cross-over study with GERDOff Plus added on top of the current PPI treatment in patients with GERD.
- Trial name
- NCT04202692
- Testing
- Hyaluronic acid with chondroitin sulphate and magnesium trisilicate, 1100 mg melt in mouth tablet
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- SOFAR S.p.A.
Aging, Chin Retrusion
Safety and Effectiveness Evaluation of TEOSYAL® TPVM Versus COMPARATOR for the Remodeling of the Lower Face
The clinical study is designed to prospectively evaluate the safety and effectiveness of TEOSYAL® TPVM when compared to COMPARATOR for the remodeling of the lower face
- Trial name
- LIFTUP (NCT05986630)
- Testing
- TEOSYAL® TPVM, COMPARATOR
- Where
- Switzerland
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Aesthetic, Aesthetic Rejuvenation
Clinical Investigation of the Medical Device "Alexa Volume" for Correction of Midface Volume Loss
This is a post-marketing, open-label, non-comparative, multi-center clinical investigation to evaluate the effectiveness and safety of the medical device "Alexa Volume" (DIACO BIOFARMACEUTICI S.r.l., Italy), based on cross-linked…
- Conditions
- Aesthetic, Aesthetic Rejuvenation, Midface Volumization, Age-related Volume Deficit in the Mid-face
- Trial name
- NCT06984419
- Testing
- Cross-linked hyaluronic acid dermal filler
- Where
- 4 sites in Poland, Ukraine
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Institute Hyalual GmbH
Aging
Effectiveness and Safety of STYLAGE® L Lidocaïne in the Treatment of Nasolabial Folds
STYLAGE® L Lidocaine is a CE-marked hyaluronic acid gel intended to fill skin depressions on the face by dermal injection. In this study, 50 healthy subjects between the age of 30 and 65, with moderate to severe nasolabial folds…
- Trial name
- NICE (NCT04844216)
- Testing
- STYLAGE® L Lidocaine, Active control
- Where
- 2 sites in France, Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Osteoarthritis, Knee
Evaluation of Safety and Efficacy of Wharton's Jelly Compared to Hyaluronic Acid and Saline for Knee Osteoarthritis.
The purpose of this study is to determine the safety and efficacy of intraarticular injection of umbilical cord derived Wharton's Jelly compared to hyaluronic acid and saline for treatment of knee osteoarthritis symptoms.
- Trial name
- NCT04711304
- Testing
- Umbilical Cord-derived Wharton's Jelly, Hyaluronic acid, Saline
- Volunteers
- 168 people
- Sponsor
- BioIntegrate
Osteoarthritis of the Knee
Repeat Injection of Cingal® for Osteoarthritis of the Knee
The objective of this study is to evaluate the safety of an injection of Cingal® in subjects with Osteoarthritis (OA) of the knee who participated in Cingal 13-01, and who received either a Cingal, Monovisc, or saline injection…
- Trial name
- NCT02381652
- Testing
- Cingal
- Where
- 10 sites in Czechia, Hungary and 1 more
- Volunteers
- 242 people
- Sponsor
- Anika Therapeutics, Inc.