Clinical trials: Hyaluronic Acid
Knee Osteoarthritis
Retrospective Evaluation of the Long-term Effectiveness of the CR500™ SINGLE-DOSE GEL Medical Device in Patients With Knee Osteoarthritis (KOA)
Evaluate the long-term efficacy of the CR500™ therapy in patients with knee OA.
- Trial name
- NCT07322770
- Testing
- CR 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Infraorbital Hollows
TEOSYAL RHA® 1 for the Correction of Moderate to Severe Tissue Volume Deficiency in the Infraorbital Region in Chinese Adults
This is a prospective, multi-center, randomized, no-treatment controlled, evaluator-blinded clinical investigation to identify whether TEOSYAL RHA® 1 is superior to no treatment for the correction of moderate to severe tissue…
- Trial name
- NCT06749587
- Testing
- TEOSYAL RHA® 1
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Knee Osteoarthritis
Safety and Effectiveness Study of a Non-Crosslinked HA Alkylamide HYADD(TM) 4 Hydrogel for Osteoarthritis of the Knee
The purpose of this study is to determine whether intra-articular hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.
- Trial name
- NCT02187549
- Testing
- HYMOVIS
- Where
- 21 sites in United States
- Volunteers
- 332 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Wound Healing Disorder
Study to Evaluate the Effectiveness of a Medical Device Based on Hyaluronic Acid in Wounds
The primary objective of the study is to evaluate the safety and performance of a Class IIB medical device based on linear hyaluronic acid used in the treatment of post-surgical wounds.
- Trial name
- WOUND-H (NCT06284538)
- Testing
- NOVA.EMOSTOP RE-EPITHELIZING
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- Nova Argentia S.r.l.
Dry Eye
Study of DE-089 Ophthalmic Solution in Patients With Dry Eye
Safety and efficacy of DE-089 ophthalmic solution in patients with dry eye will be evaluated in comparison with sodium hyaluronate ophthalmic solution.
- Trial name
- NCT01101984
- Testing
- diquafosol ophthalmic solution, 0.1% sodium hyaluronate ophthalmic solution.
- Where
- 2 sites in China, Singapore
- Volunteers
- 400 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Atrophic Vaginitis, Atrophic Vulvovaginitis
F-GYN for Vaginal Dryness and Vulvovaginal Atrophy
This clinical study will evaluate the efficacy and safety of F-GYN, a sterile injectable medical device containing non-crosslinked hyaluronic acid, in adult women with moderate to severe vaginal dryness and symptoms related to…
- Conditions
- Atrophic Vaginitis, Atrophic Vulvovaginitis, Vaginal Atrophy, Dyspareunia
- Trial name
- F-GYN (NCT07701863)
- Testing
- F-GYN Non-Crosslinked Hyaluronic Acid Injectable Gel, Standard Non-Hormonal Symptomatic Care
- Where
- 3 sites in Poland
- Volunteers
- 130 people
- Sponsor
- Biovico Sp. z o.o.
Knee Osteoarthritis
Pilot, Prospective, Comparative Multicentric Study Evaluating the Effects on the Arthrosis Biomarkers, the Clinical Effectiveness, the Tolerance of an Intra-articular Injection of Hyaluronic Acid KARTILAGE CROSS Versus Placebo in Patients Suffering From Knee Osteoarthritis
Intra-articular hyaluronic acid injections, also known as viscosupplementation, are a treatment option for knee osteoarthritis that serves to restore the decreasing rheological properties of synovial fluid.
- Trial name
- EPIKART (NCT02951585)
- Testing
- KARTILAGE CROSS
- Volunteers
- 81 people
- Sponsor
- Laboratoires Vivacy
Age-related Cataract, Phacoemulsification
Study to Evaluate the Safety of the Viscoelastic Substance PRO-149, Compared to Healon® EndoCoat.
Pilot, controlled, parallel group, open, randomized clinical trial to evaluate the safety of the viscoelastic substance PRO-149 (sodium hyaluronate 3%) after trans-surgical administration as a device in performing…
- Trial name
- PRO-149 (NCT04702802)
- Testing
- Sodium hyaluronate 3%
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Defect of Articular Cartilage, Knee Osteoarthritis
Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects
The purpose of this study is to evaluate the effectiveness of ReJoinTM for the Knee Osteoarthritis patients with Cartilage Defects comparing to Sodium Hyaluronate Injection.
- Trial name
- NCT02855073
- Testing
- ReJoinTM, Sodium Hyaluronate
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai AbelZeta Ltd.
Lip Abnormality
THIODERM ELATE for Augmentation of Very Thin, Thin, and Moderately Thick Lips
This mono-center clinical investigation is intended to assess the safety and effectiveness of THIODERM ELATE for augmentation of very thin and thin lips in comparison with Juvéderm® Ultra 3.
- Trial name
- TILI (NCT06135337)
- Testing
- Thioderm Elate, Juvéderm Ultra 3
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Croma-Pharma GmbH
Ocular Redness
A Study Comparing the Efficacy and Safety of Brimonidine Tartrate Ophthalmic Solution 0.025% With Sodium Hyaluronate Relative to Lumify in Adult Subjects With Ocular Redness
To demonstrate the efficacy of BTOS-HA as non inferior to Lumify for treating ocular redness in a population of adult subjects.
- Trial name
- NCT06803654
- Testing
- BTOS-HA, Lumify®
- Where
- 11 sites in United States
- Volunteers
- 578 people
- Sponsor
- Bausch & Lomb Incorporated
Meniscus Tears
Evaluation of the Performance and Safety of a Single-dose Hyaluronic Acid (Promovia Hydro Balance) in the Treatment of Non-traumatic Degenerative Meniscus Tears
Evaluation of the performance and safety of a single-dose hyaluronic acid (Promovia hydro balance) in the treatment of non-traumatic degenerative meniscus tears
- Trial name
- NCT07539194
- Testing
- Promovia Hydro Balance 100 mg, Hyaluronic acid sodium salt and trehalose
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Innate srl
Aging, Premature
Safety and Performance of DKL Crosslinked Sodium Hyaluronate 23 Dermal Filler for Improvement of NLF Appearance
This is a pivotal, prospective active-controlled, randomized, double blinded (blinded evaluator and subject), intra-individual split-face comparison, non-inferiority study of DKL crosslinked sodium hyaluronate 23 versus Juvederm…
- Trial name
- NCT05021913
- Testing
- DKL crosslinked sodium hyaluronate 23, Juvéderm Volift™ with lidocaine (Allergan, Inc)
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr. Korman Laboratories Ltd.
Dermal Fillers, Cheek Augmentation
Evaluation of Performance and Safety of Injectable KIO017 Device Range for Facial Tissue Filling
The goal of this clinical trial is to primarily evaluate the performance of KIO017 in filling/volumizing after injection in different areas in healthy women or men, older than 18 years and seeking an improvement of her/his face…
- Conditions
- Dermal Fillers, Cheek Augmentation, Lip Augmentation, Perioral Rhytids
- Trial name
- LITCHEE (NCT06872359)
- Testing
- KIO017-1, KIO017-2, KIO017-3
- Where
- 3 sites in France, Poland
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Kiomed Pharma
Osteoarthritis, Knee
Comparative Study of Two Hyaluronic Acid Formulation in the Management of Knee Osteoarthritis
The objective of this randomized, double-blind, active-controlled, non-inferiority study is to compare the effectiveness and safety of a single injection of Hymovis ONE®, a sodium hyaluronate formulation, to Monovisc™, another…
- Trial name
- NCT06528600
- Testing
- Hymovis ONE, Monovisc
- Where
- 19 sites in Italy
- Volunteers
- 350 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Dry Mouth, Xerostomia
"Hyaluronan" Formulation for Dry Mouth in Sleep Apnea Patients
During routine clinical practice, it is observed that patients with suspected obstructive sleep apnea (OSA) often reported waking up with a dry mouth during the night or in the morning.
- Conditions
- Dry Mouth, Xerostomia, OSA, Sleep Apnea
- Trial name
- NCT03295019
- Testing
- Test Oral Spray
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- You First Services
Ocular Dryness
Clinical Investigation on the Use of Ophthalmic Solution Based on Sodium Hyaluronate in Treatment of Eye Discomfort
The purpose of this study is to assess the performance and safety resulting from the treatment of an ophthalmic solution for the ocular discomfort and in particular in presence of ocular dryness.
- Trial name
- NCT05777798
- Testing
- Hyalistil Bio PF
- Where
- 2 sites in Italy
- Volunteers
- 28 people
- Sponsor
- SIFI SpA
Eye Dryness
Clinical Trial for the Evaluation of Safety and Efficacy of Drop 0.4%
The aim of the trial is to compare the safety and efficacy of the moisturizing solution DROP 0.4% with the moisturizing solution AVIZOR EYE DROPS 0.2% PRESERVED in relieving the symptoms of dry eye over one month of use.
- Trial name
- DROP04 (NCT06985875)
- Testing
- Multidose mosturizing solution DROP 0.4%, Multidose mosturizing solution Avizor Eye Drops 0.2% Preserved
- Volunteers
- 79 people
- Sponsor
- Avizor SA
Knee Osteoarthritis
Hymovis™ Versus Placebo in Knee Osteoarthritis
Purpose: The purpose of this study is to demonstrate if the intra-articular injection of a new viscoelastic Hydrogel (Hymovis) is superior to Placebo (phosphate buffered saline [PBS] in subjects with symptomatic osteoarthritis of…
- Trial name
- Hymovis (NCT01372475)
- Testing
- Hymovis Intra-articular Injection, Phosphate Buffered Saline Injection
- Where
- 33 sites in United States, Puerto Rico
- Volunteers
- 800 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Dermal Filler, Hyaluronic Acid
The Evaluation of the Safety and Effectiveness of ANIMERS Chiara LA and JUVÉDERM VOLUMA® for Aging Mid-Face
This study is to evaluate the safety and effectiveness for the correction of aging mid-face of treatment group compared with the active control group.
- Conditions
- Dermal Filler, Hyaluronic Acid, Lidocaine, Aging Mid-Face
- Trial name
- NCT04622085
- Testing
- ANIMERS Chiara LA, JUVÉDERM VOLUMA®
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SciVision Biotech Inc.