Clinical trials: Hyaluronic Acid
Blepharitis, Blepharoconjunctivitis
Performance and Safety of IRIDIUM GARZE in Blepharitis or Blepharconjunctivitis Adjuvant Treatment
The study will evaluate the clinical improvement in ocular symptoms using IRIDIUM GARZE as adjuvant treatment in patients suffering of blepharitis or blepharoconjunctivitis as primary objective.
- Trial name
- NCT07431385
- Testing
- IRIDIUM GARZE
- Where
- 5 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Chronic Ulcers
Efficacy and Safety of ZKARE® Gel and Its Accessory ZKAPI® in the Treatment of Chronic Ulcers.
This prospective, randomized, single-blind, controlled clinical investigation evaluates the efficacy and safety of ZKARE®, a topical polymeric gel dressing, and its accessory applicator ZKAPI®, for the treatment of chronic…
- Trial name
- NCT07406152
- Testing
- ZKARE®, Standard Wound Care
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- i+Med S.Coop.
Metastatic Breast Cancer
Study of Eribulin Mesylate in Combination With PEGylated Recombinant Human Hyaluronidase (PEGPH20) Versus Eribulin Mesylate Alone in Subjects With Human Epidermal Growth Factor Receptor 2 (HER2)-Negative, High-Hyaluronan (HA) Metastatic Breast Cancer (MBC)
The primary objective for the study is as follows: For the Phase 1b - to determine safety tolerability and recommended Phase 2 dose (RP2D) of eribulin mesylate in combination with PEGylated recombinant human hyaluronidase…
- Trial name
- NCT02753595
- Testing
- Eribulin mesylate, Biologic: PEGylated recombinant human hyaluronidase (PEGPH20), Biologic: PEGylated recombinant human hyaluronidase
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Eisai Inc.
Healthy Japanese Subjects
The Effect of Oral Hyaluronic Acid on the Skin
This clinical trial aims to clarify the effect of hyaluronic acid on skin conditions.
- Trial name
- NCT05803083
- Testing
- Hyaluronic acid 75 mg/capsule, Hyaluronic acid 50 mg/capsule
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bloomage Biotechnology Corp., Ltd.
Aging, Aesthetic
Clinical Performance and Safety of STYLAGE® HydroMax
FHAME is a post-market clinical investigation designed to strengthen the clinical evidence supporting the effectiveness of STYLAGE® HydroMax in the treatment of superficial wrinkles, primarily on the cheeks.
- Trial name
- FHAME (NCT07153237)
- Testing
- STYLAGE® HydroMax
- Where
- 2 sites in France
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Temporomandibular Joint Disorders, TMD
Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD Pain
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nighttime occlusive application of 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with temporomandibular…
- Conditions
- Temporomandibular Joint Disorders, TMD, Temporomandibular Joint Pain, Jaw Muscle Over-Tension
- Trial name
- HA35-TMJ (NCT07584642)
- Testing
- 10% High-Concentration 35 kDa Hyaluronan (HA35) Topical Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
Dry Eye
Phase III Confirmatory Study of DE-089 Ophthalmic Solution in Patients With Dry Eye
To investigate that the efficacy of 3% DE-089 ophthalmic solution (one drop at a time, 6 times daily, 4 weeks topical administration), in comparison to 0.1% sodium hyaluronate ophthalmic solution (0.1% HA) (one drop at a time, 6…
- Trial name
- NCT01240382
- Testing
- 3% DE-089 ophthalmic solution, 0.1% sodium hyaluronate ophthalmic solution
- Where
- Japan
- Volunteers
- 332 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Male Factor Infertility
Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI)
The purpose of this study is to determine if using microdots of hyaluronan (PICSI) to select sperm for ICSI will result in increased pregnancies especially with men that have a low hyaluronan binding score (HBA).
- Trial name
- NCT00741494
- Testing
- PICSI dish
- Where
- 9 sites in United States
- Volunteers
- 801 people
- Sponsor
- Biocoat
Correction of Nasolabial Folds
A Clinical Investigation of the Decoria® Aesthetic Group (DAG) for Correction of Nasolabial Folds (NLF)
Decoria intense is a class III medical device and is CE-marked and has been on the market since 2014. Decoria intense is a hyaluronic acid filler that will be used according to intended use for correction of nasolabial folds.
- Trial name
- Decorate01 (NCT05235126)
- Testing
- Decoria intense
- Where
- 2 sites in Sweden
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Bohus Biotech AB
Osteoarthritis, Knee
Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain
This is a multi-center, randomized, double-blind, parallel group, placebo controlled trial to compare the safety and effectiveness of a single injection of Cingal® to a single injection of Triamcinolone Hexacetonide (TH) to…
- Trial name
- NCT04231318
- Testing
- Cingal, Triamcinolone Hexacetonide (TH)
- Where
- 26 sites in United States
- Volunteers
- 231 people
- Sponsor
- Anika Therapeutics, Inc.
Intrauterine Adhesion
Efficacy and Safety of Crosslinked Hyaluronan Gel for Preventing Intrauterine Adhesion
Intrauterine adhesion (IUA) is the adhesion of intrauterine tissues due to the exposure of myometrial tissues caused by the endometrial basal injury.
- Trial name
- NCT02220621
- Testing
- Crosslinked hyaluronic acid gel, Foleys balloon catheter
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Xiaozheng Shu
Dermal Filler
Safety and Efficacy of the HA-based Dermal Fillers HYAPROF® SOFT and HYAPROF® BALANCE
Purpose of this study is the demonstration of safety and efficacy of the dermal fillers HYAPROF® SOFT and HYAPROF® BALANCE for restoration of the facial volume and contour.
- Trial name
- PMCF_HYAPROF (NCT04546152)
- Testing
- HYAPROF® SOFT and HYAPROF® BALANCE
- Where
- 2 sites in Germany
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- BioSCIENCE GmbH
Nasolabial Folds, Wrinkles
TEOSYAL® RHA Ultra Deep and Perlane-L® for the Correction of Nasolabial Folds
The purpose of this study is to compare the effectiveness and safety of TEOSYAL® RHA Ultra Deep versus Perlane-L® in the treatment of moderate to severe nasolabial folds.
- Trial name
- NCT02253147
- Testing
- TEOSYAL® RHA Ultra Deep
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Teoxane SA
Opthalomology/Dry Eye
A Post-market Study to Evaluate the Effects of Sodium Hyaluronate Based Eye Drops in Patients Affected by Dry Eye Disease
Dry eye disease (DED), also called keratoconjunctivitis sicca, is a multifactorial disease of the ocular surface characterized by loss of homeostasis of the tear film and accompanied by symptoms such as ocular discomfort and…
- Trial name
- M-DED-2020 (NCT05773963)
- Testing
- Irilens; Iridina; Afomill Lubricating Eye Drops
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Montefarmaco OTC SpA
Vulvovaginal Atrophy
Efficacy and Safety of HYDEAL-D Vaginal Pessaries Application on the Treatment of Vaginal Atrophy in Post-menopause Women
This study evaluates the efficacy and safety of hyaluronic acid derivative based vaginal pessaries for the treatment of symptoms of vulvo-vaginal atrophy in post-menopausal women.
- Trial name
- NCT03557398
- Testing
- Hydeal-D vaginal pessaries
- Where
- 2 sites in Slovakia
- Volunteers
- 40 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Knee Osteoarthritis
Post-market Study on TrHCROSS® in Knee Osteoarthritis After a Single Injection
Double-blind study assessing the safety and efficacy of TrHCROSS® in knee osteoarthritis, compared to Hyalone®, using scales such as WOMAC, VAS, and KOOS.
- Trial name
- NCT06975631
- Testing
- TrHCROSS®, Hyalone®
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- i+Med S.Coop.
Lips Enhancement, Nasolabial Fold Correction
Evaluation of the Safety and Performance of an Injectable Hyaluronic Acid Filler
Evaluation of the safety and performance of the investigational device in its three concentrations for cheek and lips augmentation and correction of the nasolabial folds, assuming that the performance of the product will be…
- Conditions
- Lips Enhancement, Nasolabial Fold Correction, Midface Volume Deficit
- Trial name
- NCT04971876
- Testing
- HLR-1, HLR-2, HLR-3
- Where
- 3 sites in Germany, Poland
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hallura Ltd.
Dry Eye, Dry Eye Disease
PMCF Study to Evaluate Performance and Safety of "Hyaluronic Acid (HA)-Based Eyedrops" Used to Relieve Dry Eye Symptoms
Dry eye disease (DED), also called keratoconjunctivitis sicca, is a common ocular condition characterized by a loss of homeostasis of the tear film and inflammation of the ocular surface.
- Conditions
- Dry Eye, Dry Eye Disease, Kerato Conjunctivitis Sicca
- Trial name
- NCT05807360
- Testing
- Hyaluronic acid eye drops
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- C.O.C. Farmaceutici S.r.l.
Glenohumeral Osteoarthritis
ORTHOVISC Shoulder Osteoarthritis Study
A comparison of Orthovisc to corticosteroid injections in the shoulder for pain due to osteoarthritis.
- Trial name
- NCT00436969
- Testing
- Orthovisc, Control
- Where
- 13 sites in United States
- Volunteers
- 274 people
- Sponsor
- DePuy Mitek
Volume Deficiency in the Mid-Face, Aging
Study of a Novel Hyaluronic Acid Based Gel for Volume Deficiency in the Mid-face (FaceHyal)
The primary objective of the study is to demonstrate the superiority of IPN-21-SENSE versus no treatment at 24 weeks after baseline for the creation or restoration of volume deficit in the mid-face.
- Conditions
- Volume Deficiency in the Mid-Face, Aging, Aesthetics
- Trial name
- FaceHyal (NCT05747456)
- Testing
- IPN-21-SENSE
- Where
- France
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy