Clinical trials: Hyaluronic Acid
Aging, Pain
RHA® Redensity With New Anesthetic Agent - Perioral Rhytids
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® Redensity with new anesthetic agent is non-inferior to RHA® Redensity with lidocaine in…
- Trial name
- NCT04069585
- Testing
- RHA® Redensity with new anesthetic agent, RHA® Redensity with lidocaine
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Nasolabial Fold, Safety
A Study to Evaluate the Performance and Safety of GP0045 for Correction of Moderate to Severe Nasolabial Folds
This is a study to assess the performance and safety of GP0045 when injected in the nasolabial folds. There is an 18 months follow up period.
- Trial name
- NCT03300466
- Testing
- GP0045, Comparator
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Cheek Augmentation, Correction of Age-related Midface Contour Deficiencies
RHA®4 for Midface Volume Deficiency
This is a prospective, randomized, controlled, blinded evaluator, multicenter, between subjects clinical study to identify whether RHA4 is non-inferior to a comparator device for treatment of midface volume deficiency 8 weeks…
- Trial name
- NCT05133739
- Testing
- injection of RHA®4 in Midface, injection of Comparator Product in Midface
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Infra-orbital Hollows, Tear-trough Deformity
RHA® Redensity Eye Versus No-treatment for the Infra-Orbital Hollows
This is a multicenter, blinded evaluator, randomized, prospective, no treatment control clinical study to identify whether RHA® Redensity Eye (*) is superior to no treatment for the correction of moderate to severe tissue volume…
- Conditions
- Infra-orbital Hollows, Tear-trough Deformity, Wrinkle
- Trial name
- NCT04577898
- Testing
- RHA® Redensity Eye
- Where
- 4 sites in United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Osteo Arthritis Shoulders
MONOVISC for Shoulder Joint Pain Relief Due to Osteoarthritis
Obtain real world, post market data to confirm the clinical improvement and safety in patients treated with a single injection of MONOVISC for the symptomatic relief of osteoarthritis in the shoulder joint.
- Trial name
- NCT04204265
- Testing
- Monovisc
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
Glenohumeral Osteoarthritis
ORTHOVISC Shoulder Osteoarthritis Study
A comparison of Orthovisc to corticosteroid injections in the shoulder for pain due to osteoarthritis.
- Trial name
- NCT00436969
- Testing
- Orthovisc, Control
- Where
- 13 sites in United States
- Volunteers
- 274 people
- Sponsor
- DePuy Mitek
Osteoarthritis
Safety and Effectiveness of Monovisc® Injection for Osteoarthritis of the Knee
The purpose of this study is to determine whether intra-articular injection of Monovisc® hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.
- Trial name
- NCT00653432
- Testing
- Monovisc®, Saline
- Where
- 31 sites in United States, Canada
- Volunteers
- 369 people
- Sponsor
- Anika Therapeutics, Inc.
Gingivitis
A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis
The aim of this study is to develop a daily use toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride with the intention of providing improved/ fast gum healing.
- Trial name
- NCT04737538
- Testing
- Experimental Dentrifrice, Positive control dentifrice, Negative control dentifrice
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Aging, Pain
RHA® 4 With New Anesthetic - Nasolabial Folds
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® 4 with New Anesthetic Agent is non-inferior to RHA® 4 (with lidocaine) in terms of…
- Trial name
- NCT04087395
- Testing
- RHA®4 with new anesthetic agent, RHA®4-Lidocaine
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Pancreatic Ductal Carcinoma
A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma
The purpose of this study is to compare the efficacy and safety of PEGylated Recombinant Human Hyaluronidase (PEGPH20) combined with nab-paclitaxel plus gemcitabine (PAG treatment), compared with placebo combined with…
- Trial name
- NCT02715804
- Testing
- Biological: PEGylated Recombinant Human Hyaluronidase (PEGPH20), nab-Paclitaxel, Gemcitabine
- Where
- 217 sites in United States, Australia and 20 more
- Volunteers
- 492 people
- Sponsor
- Halozyme Therapeutics
Nasolabial Folds, Wrinkles
TEOSYAL® RHA Ultra Deep and Perlane-L® for the Correction of Nasolabial Folds
The purpose of this study is to compare the effectiveness and safety of TEOSYAL® RHA Ultra Deep versus Perlane-L® in the treatment of moderate to severe nasolabial folds.
- Trial name
- NCT02253147
- Testing
- TEOSYAL® RHA Ultra Deep
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Teoxane SA
Ocular Discomfort
Safety and Efficacy of 2 Concentrations of Lubricin vs Sodium Hyaluronate in Ocular Discomfort After Refractive Surgery.
The objective of this study was to evaluate tolerability, safety, permanence on the ocular surface and efficacy of Lubricin (20 and 50 μg/mL) eye drops vs Sodium Hyaluronate (Vismed®) 0.18% eye drops in patients with ocular…
- Trial name
- NCT03031327
- Testing
- Lubricin 20µg/ml, Lubricin 50µg/ml, Sodium hyaluronate 0.18%
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Dompé Farmaceutici S.p.A
Dry Eye Syndromes
Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel
Objective: To assess the safety and tolerability of the PRO-165 formulation on the ocular surface of ophthalmologically and clinically healthy subjects.
- Trial name
- PRO-165 (NCT03697876)
- Testing
- PRO-165, Artelac
- Where
- Mexico
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Osteoarthritis
Non-Inferiority Study Comparing 3 Weekly Injections of SUPARTZ® vs 3 Weekly Injections of Euflexxa® for Knee OA
The purpose of this study is to demonstrate non-inferiority of three weekly intra-articular injections of SUPARTZ to three weekly intra-articular injections of Euflexxa for the relief of knee OA.
- Trial name
- NCT02110238
- Testing
- Supartz, Euflexxa
- Where
- United States
- Volunteers
- 421 people
- Sponsor
- Bioventus LLC
Degenerative Disc Disease
Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain
This is a prospective, multicenter, randomized, double-blind, placebo-controlled Phase 3 study designed to evaluate the safety and efficacy of Mesoblast's rexlemestrocel-L alone or combined with hyaluronic acid (HA) in…
- Trial name
- MSB-DR003 (NCT02412735)
- Testing
- Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture
- Where
- 48 sites in United States, Australia
- Volunteers
- 404 people
- Sponsor
- Mesoblast, Ltd.
Knee Osteoarthritis
Cingal Study for Knee Osteoarthritis
The purpose of this study is to see if a single injection of Cingal into the knee provides safe relief of pain caused by osteoarthritis.
- Trial name
- NCT01891396
- Testing
- Hyaluronic Acid and TH (Cingal®), Hyaluronic Acid (Monovisc®), Saline
- Where
- 27 sites in Bulgaria, Canada and 3 more
- Volunteers
- 368 people
- Sponsor
- Anika Therapeutics, Inc.
Cataracts
Clinical Investigation of Healon EndoCoat Ophthalmic Viscosurgical Device (OVD)
Prospective, multicenter, paired-eye, randomized, subject/evaluator-masked clinical investigation of the experimental EndoCoat OVD versus the control EndoCoat OVD.
- Trial name
- NCT05575063
- Testing
- Investigational Healon Endocoat, Control Healon EndoCoat
- Where
- 8 sites in United States
- Volunteers
- 165 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Osteoarthritis Ankle
MONOVISC for Ankle Joint Pain Relief Due to Osteoarthritis
The goal of this study is to demonstrate the clinical improvement and safety in patients treated with MONOVISC for ankle osteoarthritis.
- Trial name
- NCT04204278
- Testing
- Monovisc
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
Facial Wrinkles
Global Management of Facial Rejuvenation With a New Range of Hyaluronic Acid Dermal Fillers
The aim of this study is to assess performance and tolerance as well as investigator and subject satisfaction linked to the global management of facial rejuvenation with a new range of hyaluronic acid dermal fillers.
- Trial name
- FRESH (NCT01151436)
- Testing
- hyaluronic acid dermal fillers
- Where
- 5 sites in France, Germany
- Volunteers
- 77 people
- Sponsor
- Galderma R&D
Correction of Volume Loss in the Infraorbital Hollow Area
A Pilot Study to Assess the Effectiveness and Safety of Belotero Balance® Injection for Volume Augmentation of the Infraorbital Hollow
The pilot study aims to define safety, effectiveness, and patient-reported outcomes for Belotero Balance® use in the infraorbital hollows.
- Trial name
- NCT03777917
- Testing
- Belotero Balance®
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Merz North America, Inc.