Clinical trials: Hydrocephalus, Normal Pressure
Normal Pressure Hydrocephalus
Acetazolamide for Treating NPH in Shunt-candidates Patients
Normal pressure hydrocephalus (NPH) consists of a triad of gait disturbance, cognitive deterioration, and urinary incontinence and is characterized by enlarged cerebral ventricles.
- Trial name
- NCT03779594
- Testing
- Acetazolamide
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Rabin Medical Center
Normal Pressure Hydrocephalus
Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus
An endoscopic third ventriculostomy is considered to be successful in idiopathic normal pressure hydrocephalus (iNPH) in some literature reports, but there is a lack of high quality data.
- Trial name
- NCT03245138
- Testing
- Endoscopic Third Ventriculostomy, Ventriculo-Peritoneal Shunting
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- University Medicine Greifswald
Normal Pressure Hydrocephalus
A Randomized Cross-over Study for Normal Pressure Hydrocephalus
The goal of our study is to verify the effectiveness of the shunt and to identify the most sensitive criteria to select patients for surgery.
- Trial name
- ARCS NPH (NCT01798641)
- Testing
- MIETHKE proGAV® / MIETHKE proSA®
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Johns Hopkins University
Normal Pressure Hydrocephalus
Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)
This study aims to provide class 1 evidence supporting or refuting the existence of normal pressure hydrocephalus.
- Trial name
- NCT00727142
- Testing
- Surgical treatment
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College London Hospitals
Normal Pressure Hydrocephalus
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus
- Trial name
- NCT00600795
- Testing
- CSF collection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Normal Pressure Hydrocephalus
The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients
With the advent of the aging society, dementia becomes the focus of common people. As for the neurodegeneration dementia, no disease modifying treatments have been discovered.
- Trial name
- NCT03092804
- Testing
- ventriculo-peritoneal shunting
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Idiopathic Normal Pressure Hydrocephalus
A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus
In treating idiopathic normal pressure hydrocephalus with a shunt there is always a risk of underdrainage or overdrainage. The hypothesis is tested whether treatment of patients with an adjustable valve preset at the highest…
- Trial name
- NCT01570257
- Testing
- lowering of the performance level of an adjustable Strata valve in a ventriculoperitoneal (VP) shunt for treating idiopathic normal pressure hydrocephalus
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Erasmus Medical Center
Hydrocephalus, Normal Pressure
A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus
The main purpose of this study is to compare two types of treatment of hydrocephalus: placement of a ventriculoperitoneal (VP) shunt versus an endoscopic third ventriculostomy (ETV).
- Trial name
- NCT01115270
- Testing
- Non-invasive measures
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of California, Los Angeles
Hydrocephalus
ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients
The purpose of this study is to compare the accuracy of ShuntCheck (SC) and ShuntCheck plus Micro-Pumper (SC+MP) to radionuclide shunt patency testing (SPS) in evaluating shunt function in patients with adult hydrocephalus (AH)…
- Trial name
- SCNPH (NCT01323764)
- Testing
- ShuntCheck test
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NeuroDx Development
Normal Pressure Hydrocephalus
Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
To determine the level of association between the quantitative estimates of brain uptake of [18F]flutemetamol and the quantitative immunohistochemical and histochemistry estimates of amyloid levels in frontal lobe biopsy samples…
- Trial name
- NCT01092546
- Testing
- [18F]Flutemetamol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- GE Healthcare
Normal Pressure Hydrocephalus
ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients
The purpose of this study is to examine the role of ShuntCheck and MR Imaging in evaluating the presence or absence of Shunt Obstruction in the patients of Hydrocephalus or Idiopathic Intracranial Hypertension (IIH) undergoing…
- Trial name
- NCT00793416
- Testing
- Shunt flow detection
- Where
- United States
- Sponsor
- NeuroDx Development
Hydrocephalus, Normal Pressure, Vascular Diseases
Vascular Risk Factors in INPH-patients
Idiopathic normal pressure hydrocephalus (INPH) is a treatable and a common disease of the elderly. The overall objective of this work is to describe cardio- and cerebrovascular risk factors and vascular disease in shunted…
- Conditions
- Hydrocephalus, Normal Pressure, Vascular Diseases, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT01850914
- Where
- Sweden
- Volunteers
- 860 people
- Sponsor
- Umeå University
Hydrocephalus
ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus
The purpose of this study is to test and compare the efficacy of Endoscopic Third Ventriculostomy with shunting of Cerebrospinal fluid (CSF)for treatment for patients of Normal pressure Hydrocephalus.
- Trial name
- NCT00946127
- Testing
- Ventriculoperitoneal Shunt Placement, Endoscopic Third Ventriculostomy(ETV)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Johns Hopkins University
Normal Pressure Hydrocephalus
Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus
A novel computerised neuropsychological test battery for normal pressure hydrocephalus (NPH) has been developed. The aim is to provide the clinician with a free of charge, standardized tool, assessing the cognitive decline or…
- Trial name
- NCT01618500
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Normal Pressure Hydrocephalus
PET Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
This study will determine the level of association between the quantitative estimates of brain uptake of [18F]flutemetamol and the quantitative immunohistochemical estimates of amyloid levels in biopsy samples previously obtained…
- Trial name
- NCT01053312
- Testing
- [18F] Flutemetamol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- GE Healthcare
Hydrocephalus, Normal Pressure Hydrocephalus
A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.
The purpose of this study is to determine the agreement rate between the CODMAN Valve Position Verification (VPV) adjustment outcome (reprogramming) and X-ray verification in order to support an alternative to X-ray confirmation…
- Trial name
- NCT00196196
- Testing
- Codman VPV System
- Where
- 8 sites in United States
- Volunteers
- 274 people
- Sponsor
- Codman & Shurtleff
Idiopathic Normal Pressure Hydrocephalus
Intracranial Pressure Waves Via Lumbar Puncture
Patients are subjected to simultaneous intracranial and lumbar puncture pressure measurements. This study focus on intracranial pulse amplitude.
- Trial name
- NCT01374048
- Volunteers
- 10 people
- Sponsor
- Umeå University
Idiopathic Normal Pressure Hydrocephalus
Improved Analysis Methods for Infusion Tests
Objective: Patients with Idiopathic Normal Pressure Hydrocephalus are improved with shunt surgery. To increase the accuracy of the diagnosis, supplementary tests that characterize the cerebrospinal fluid (CSF) dynamics are used.
- Trial name
- NCT01319136
- Where
- 2 sites in Sweden
- Volunteers
- 48 people
- Sponsor
- Umeå University
Normal Pressure Hydrocephalus
Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)
A computerised neuropsychological test battery to be used as a standardised tool assessing the cognitive domains affected by idiopathic normal pressure hydrocephalus INPH was developed.
- Trial name
- NCT01265251
- Testing
- Computerized neuropsychological test, Conventional neuropsychological test
- Where
- Sweden
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Umeå University
Normal Pressure Hydrocephalus
Anterior Pituitary Function in Patients With Hydrocephalus
Hydrocephalus (secondary or idiopathic) is a condition characterized by dilatation of the lateral and third ventricles, and often associated with increased intracranial pressure (ICP).
- Trial name
- NCT00149721
- Testing
- Ventriculo-peritonal shunting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University