Clinical trials: Hydrocephalus.
Hydrocephalus
Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasound Before and After Drainage of Cerebrospinal Fluid in Patient With Hydrocephalus
Studies in patients with intracranial hypertension have shown a good relationship between optic nerve sheath diameter measured by retrobulbar ultrasound and invasively measured intracranial pressure.
- Trial name
- NCT01863329
- Testing
- retrobulbar ultrasound
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Yonsei University
Normal Pressure Hydrocephalus
Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH
Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. Urinary symptoms in normal pressure hydrocephalus are mainly represented by overactive bladder, which…
- Trial name
- PLHPN (NCT03877107)
- Testing
- Urinary symptoms profile questionnaire, Micturition calendar
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- EssaiClinique_PL-HPN
Hydrocephalus, Hydrocephalus in Children
A Study Evaluate Aqueduct's Smart External Drain
To evaluate the performance characteristics of the Smart External Drain (SED) compared with standard EVD drains in the hospital setting, specifically: Number, type and duration of staff interactions.
- Conditions
- Hydrocephalus, Hydrocephalus in Children, Tumor, Brain
- Trial name
- SED (NCT03113799)
- Testing
- Smart External Drain - SED
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Aqueduct Critical Care
Hydrocephalus
Comparison of Optic Nerve Sheath Diameter Measured by Ultrasonography Before and After Ventriculoperitoneal Shunt Surgery in Adult Patients With Hydrocephalus
Hydrocephalus is a disturbance of cerebrospinal fluid production, flow and absorption leading to intracranial hypertension. Assessment of the change in intracranial pressure after ventriculoperitoneal shunt surgery is important…
- Trial name
- NCT02663947
- Testing
- ultrasonographic measurement of optic nerve sheath diameter
- Where
- South Korea
- Sponsor
- Yonsei University
Normal Pressure Hydrocephalus
Acetazolamide for Treating NPH in Shunt-candidates Patients
Normal pressure hydrocephalus (NPH) consists of a triad of gait disturbance, cognitive deterioration, and urinary incontinence and is characterized by enlarged cerebral ventricles.
- Trial name
- NCT03779594
- Testing
- Acetazolamide
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Rabin Medical Center
Toxicity, Hydrocephalus
Isoflurane-induced Neuroinflammation in Children With Hydrocephalus
The investigators will quantify inflammatory biomarkers in cerebrospinal fluid (CSF) and serum of children with hydrocephalus who are undergoing ventriculoperitoneal shunt placement under isoflurane anesthesia.
- Trial name
- NCT02512809
- Testing
- Isoflurane, Dexmedetomidine
- Volunteers
- 25 people
- Sponsor
- Nationwide Children's Hospital
Normal Pressure Hydrocephalus
Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus
An endoscopic third ventriculostomy is considered to be successful in idiopathic normal pressure hydrocephalus (iNPH) in some literature reports, but there is a lack of high quality data.
- Trial name
- NCT03245138
- Testing
- Endoscopic Third Ventriculostomy, Ventriculo-Peritoneal Shunting
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- University Medicine Greifswald
Normal Pressure Hydrocephalus
A Randomized Cross-over Study for Normal Pressure Hydrocephalus
The goal of our study is to verify the effectiveness of the shunt and to identify the most sensitive criteria to select patients for surgery.
- Trial name
- ARCS NPH (NCT01798641)
- Testing
- MIETHKE proGAV® / MIETHKE proSA®
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Johns Hopkins University
Hydrocephalus
A Study Comparing Two Treatments for Infants With Hydrocephalus
The purpose of this study is to study whether infants with triventricular hydrocephalus (TVH) have a better long-term outcome at 5 years when they are treated with a new procedure, endoscopic third ventriculostomy (ETV), than…
- Trial name
- NCT00652470
- Testing
- Endoscopic Third Ventriculostomy, CSF Shunt Insertion
- Where
- 22 sites in United States, Argentina and 14 more
- Volunteers
- 182 people
- Sponsor
- The Hospital for Sick Children
Hydrocephalus, Intracranial Hypertension
Brain Ultrasound in the Weaning of External Ventricular Leads
External Ventricular Deviation (EDV) is a medical device that provides transient and controlled external drainage of cerebrospinal fluid (CSF). This device can also monitor intracranial pressure (ICP).
- Trial name
- ECHO-SD (NCT03531723)
- Testing
- Measuring the size of the 3rd ventricle by ultrasound
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Normal Pressure Hydrocephalus
Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)
This study aims to provide class 1 evidence supporting or refuting the existence of normal pressure hydrocephalus.
- Trial name
- NCT00727142
- Testing
- Surgical treatment
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College London Hospitals
Neurocysticercosis
People Presenting With Neurocysticercosis in North America
Background: Neurocysticercosis (NCC) is caused by tapeworms that infect people. NCC can lead to serious brain problems such as seizures, sevre headaches and difficulties with movements or sensation in the limbs.
- Trial name
- NCT02233855
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neonatal Post-Hemorrhagic Hydrocephalus
Contrast Enhanced Ultrasound Evaluation of Brain Perfusion in Neonatal Post-Hemorrhagic Hydrocephalus
The aim of the proposed project is therefore to utilize the CEUS technique to assess cerebral perfusion changes before and after ventricular shunting in neonatal cases of PHH.
- Trial name
- NCT03061045
- Testing
- Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Intravenous Powder for Suspension [LUMASON]
- Sponsor
- Johns Hopkins University
Post-Hemorrhagic Hydrocephalus
Shunt Outcomes of Post-Hemorrhagic Hydrocephalus
This multicenter, prospective pilot study will compare the effectiveness of two established procedures used in the treatment of post-hemorrhagic hydrocephalus in very low birth weight infants, specifically ventricular reservoirs…
- Trial name
- SOPHH (NCT01480349)
- Where
- 7 sites in United States, Canada
- Volunteers
- 146 people
- Sponsor
- University of Utah
Intraventricular Hemorrhage, Hydrocephalus
Optimizing Treatment of Post-hemorrhagic Ventricular Dilation in Preterm Infants
Intraventricular hemorrhage remains the most frequent, severe neurological complication of prematurity, occurring in 25-30% of preterm infants.
- Trial name
- LETAP (NCT00875758)
- Testing
- Removal of CSF through ventricular access device, Removal of CSF through a ventricular access device
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Washington University School of Medicine
Neural Tube Defects, Spina Bifida, Open
Fetal Endoscopic Surgery for Spina Bifida
This study aims to assess the feasibility to perform a fetoscopic prenatal repair of an open neural tube defect, and secondly to assess the maternal, fetal and neonatal outcomes.
- Conditions
- Neural Tube Defects, Spina Bifida, Open, Myelomeningocele, Fetal Disease
- Trial name
- FESSB (NCT03315637)
- Testing
- Fetoscopic repair of spina bifida
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hydrocephalus, Idiopathic Intracranial Hypertension
Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement
This research is being done to determine the accuracy of two noninvasive methods of measuring the pressure of the cerebrospinal fluid (CSF), also known as intracranial pressure or ICP.
- Conditions
- Hydrocephalus, Idiopathic Intracranial Hypertension, Pseudotumor Cerebri
- Trial name
- NCT01863381
- Testing
- Tympanic membrane displacement (TMD), DPOAE
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- LifeBridge Health
Hydrocephalus, Shunt Malfunction
Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotocol
This research is being done to determine the accuracy of two noninvasive methods of measuring the pressure of the spinal fluid, also known as intracranial pressure (ICP).
- Trial name
- NCT01976559
- Testing
- Tympanic Membrane Displacement (TMD), DPOAE
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- LifeBridge Health
Arnold Chiari Deformity, Hydrocephalus
Establishing the Physiology of Syringomyelia
The brain and spinal cord are surrounded by fluid called cerebrospinal fluid (CSF). The CSF flows through channels in the brain and around the spinal cord. Occasionally, people are born with malformations of these channels.
- Conditions
- Arnold Chiari Deformity, Hydrocephalus, Syringomyelia
- Trial name
- NCT00001327
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Normal Pressure Hydrocephalus
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus
- Trial name
- NCT00600795
- Testing
- CSF collection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center