Clinical trials: Hydrocephalus.
Hydrocephalus in Children
The Effect of Education Given to Parents of Children With Ventriculoperitoneal Shunt on Their Anxiety and Self-efficacy
This study aims to evaluate the effect of tele-education given to parents of children with ventriculoperitoneal shunt on their anxiety and self-efficacy.
- Trial name
- NCT06313879
- Testing
- Tele-education and Counseling Program
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Pamukkale University
Normal Pressure Hydrocephalus
Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
To determine the level of association between the quantitative estimates of brain uptake of [18F]flutemetamol and the quantitative immunohistochemical and histochemistry estimates of amyloid levels in frontal lobe biopsy samples…
- Trial name
- NCT01092546
- Testing
- [18F]Flutemetamol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- GE Healthcare
Idiopathic Normal Pressure Hydrocephalus
Study to Evaluate Efficacy of Shunt Operation for Idiopathic Normal Pressure Hydrocephalus
This study evaluates the efficacy of shunt operation for idiopathic normal pressure hydrocephalus, and determines the diagnostic value of noninvasive procedures commonly practiced in the clinic.
- Trial name
- NCT00221091
- Testing
- ventriculo-peritoneal shunt
- Where
- Japan
- Volunteers
- 110 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Hydrocephalus, Normal Pressure Hydrocephalus
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
The goal of this observational study is to evaluate the role of DTI-ALPS in the diagnostic and therapeutic management of NPH The main questions it aims to answer are: Whether the glymphatic system (GS) is actually impaired in NPH…
- Trial name
- GLINFANPH_2021 (NCT06857136)
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Hydrocephalus, Hydrocephalus in Children
A Study Evaluate Aqueduct's Smart External Drain
To evaluate the performance characteristics of the Smart External Drain (SED) compared with standard EVD drains in the hospital setting, specifically: Number, type and duration of staff interactions.
- Conditions
- Hydrocephalus, Hydrocephalus in Children, Tumor, Brain
- Trial name
- SED (NCT03113799)
- Testing
- Smart External Drain - SED
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Aqueduct Critical Care
Toxicity, Hydrocephalus
Isoflurane-induced Neuroinflammation in Children With Hydrocephalus
The investigators will quantify inflammatory biomarkers in cerebrospinal fluid (CSF) and serum of children with hydrocephalus who are undergoing ventriculoperitoneal shunt placement under isoflurane anesthesia.
- Trial name
- NCT02512809
- Testing
- Isoflurane, Dexmedetomidine
- Volunteers
- 25 people
- Sponsor
- Nationwide Children's Hospital
Chronic Adult Hydrocephalus
Multimodal Investigation in the Diagnosis and Treatment of Chronic Adult Hydrocephalus
Idiopathic chronic adult hydrocephalus (ICAH) is due to expansion of the fluid-filled cavities in the brain. The clinical symptoms are gait disturbance, mental decline and incontinence.
- Trial name
- Multimod'HCA (NCT02278848)
- Testing
- Diagnosis of ICAH using new investigative techniques (computerised gait analysis, ultrasound, MRI flow, urinary incontinence scale)
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Tours
Hydrocephalus, Nervous System Diseases
Study of Shunt Flow Sensor Accuracy in Extra-ventricular Drains.
The study hypothesis is that an ultrasonic flow sensor can accurately measure flow in hydrocephalic shunts. The ultrasonic sensor will measure cerebrospinal fluid drainage in hydrocephalus patients with external ventriculostomies…
- Conditions
- Hydrocephalus, Nervous System Diseases, Infant, Newborn Diseases
- Trial name
- NCT01108965
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Transonic Systems Inc.
Post-Hemorrhagic Hydrocephalus
Cerebral Perfusion, Oxygenation, Electrical Activity
The specific aim of the research proposal in preterm infants with IVH and PHH who require placement of an Omaya reservoir or a shunt is to determine if decreasing ventricular volume improves, middle cerebral artery flow, cerebral…
- Trial name
- NCT00747682
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Acute Brain Injury, Hydrocephalus
VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site
This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to: 1.
- Conditions
- Acute Brain Injury, Hydrocephalus, External Ventricular Drain, External Ventricular Drainage Associated Infection
- Trial name
- LACTIC (NCT07380477)
- Testing
- Sampling of blood and cerebrospinal fluid
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pediatric Critical Illness, Brain Injuries, Traumatic
Tissue Penetration of Paracetamol in Pediatric Intensive Care Patients
TIPPIC was a single-centre, prospective, observational pharmacokinetic study in critically ill children aged 1 month to 15 years who were admitted to the paediatric intensive care unit (PICU) of Ghent University Hospital with an…
- Conditions
- Pediatric Critical Illness, Brain Injuries, Traumatic, Brain Neoplasms, Intracranial Hypertension
- Trial name
- TIPPIC (NCT07916831)
- Testing
- Paracetamol, Pharmacokinetic sampling (blood and CSF microsampling)
- Where
- Belgium
- Volunteers
- 31 people
- Sponsor
- University Hospital, Ghent
Hydrocephalus, Neurological Disorder
Hyperfine Portable MRI in Hydrocephalus and Other Conditions Prompting Outpatient Brain Imaging
Participants with known or suspected hydrocephalus will receive brain scans using the Hyperfine, low field strength, portable, magnetic resonance imaging (MRI) system in addition to their scheduled outpatient standard of care…
- Trial name
- NCT04436068
- Testing
- Hyperfine MRI scan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation, The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change
CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with…
- Trial name
- NCT06005363
- Testing
- Dexmedetomidine, anesthesia depth monitoring
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Normal Pressure Hydrocephalus
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus
- Trial name
- NCT00600795
- Testing
- CSF collection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Communicating Hydrocephalus
Third Ventriculostomy Versus Shunt for Children With Hydrocephalus
Ventriculoperitoneal shunts are the standard of care for patients with communicating hydrocephalus, but they have a high failure rate - up to 40% fail within 1 year and 50% fail within 2 years.
- Trial name
- NCT01801267
- Testing
- Endoscopic third ventriculostomy (ETV), Ventricular shunt
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Intracranial Pressure
New Reference Values for Intracranial Pressure
Intracranial pressure is a cornerstone in neurosurgical care used in a variety of diseases. However currently, doubts regarding normal intracranial pressure exist.
- Trial name
- NCT03594136
- Testing
- Raumedic Neurovent-P-tel
- Where
- 3 sites in Czechia, Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Hydrocephalus
A Study Comparing Two Treatments for Infants With Hydrocephalus
The purpose of this study is to study whether infants with triventricular hydrocephalus (TVH) have a better long-term outcome at 5 years when they are treated with a new procedure, endoscopic third ventriculostomy (ETV), than…
- Trial name
- NCT00652470
- Testing
- Endoscopic Third Ventriculostomy, CSF Shunt Insertion
- Where
- 22 sites in United States, Argentina and 14 more
- Volunteers
- 182 people
- Sponsor
- The Hospital for Sick Children
Intracranial Hemorrhages, Acute Ischemic Stroke
AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Intracranial Hemorrhages, Acute Ischemic Stroke, Hydrocephalus, Cerebral Infarction
- Trial name
- AI-REACT (NCT06018545)
- Testing
- Ground truthing, Reading
- Where
- 4 sites in United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Suspected CSF Shunt Obstruction
ShuntCheck-Micro-Pumper Pediatric Clinical Outcomes Study
Primary objective is to demonstrate that data collected from ShuntCheck-Micro-Pumper (SCMP) testing results can be used in conjunction with imaging to diagnose shunt patency or obstruction in pediatric/adolescent subjects…
- Trial name
- NCT01881711
- Testing
- ShuntCheck-Micro-Pumper (SCMP), Imaging
- Where
- 11 sites in United States
- Volunteers
- 400 people
- Sponsor
- NeuroDx Development