Clinical trials: Hydrocephalus.
Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus
Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus
The goal of this RCT is to test whether volumetric assessment of magnetic resonance imaging (MRI) could diagnose shunt obstruction in Adult Hydrocephalus patients, and in addition to explore correlations of blood biomarkers…
- Trial name
- NCT07172841
- Testing
- Intervention group "Virtual OFF", Control group (no change in shunt setting)
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Hydrocephalus, Communicating
A Prospective Observational Study of Perioperative Lumbar Puncture Pressure and Shunt Valve Pressure Management in Patients with Communicating Hydrocephalus Undergoing Lumboperitoneal Shunt Surgery
Target population: patients 18 years of age or older who require surgical treatment with lumboperitoneal shunt surgery for traffic hydrocephalus Estimated sample size: 30 cases.
- Trial name
- LPP-LPS (NCT06642129)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines
- Where
- China
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Intraventricular Hemorrhage, Spina Bifida
Micro Ribonucleic Acid (miRNA) Markers of Hydrocephalus in Intraventricular Hemorrhage (IVH)
A collection of biological samples (cerebrospinal fluid [CSF] and blood) from patients under 6 years of age who are diagnosed with intraventricular hemorrhage or spina bifida.
- Trial name
- NCT02386228
- Testing
- collection of CSF and blood
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Idiopathic Normal Pressure Hydrocephalus
Integrated Multimodal Assessment to Optimize Diagnosis and Surgical Selection in Idiopathic Normal Pressure Hydrocephalus
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition that can cause walking difficulties, cognitive impairment, and urinary incontinence.
- Trial name
- NPH-OPTIMIZE (NCT07427836)
- Where
- 2 sites in Italy
- Volunteers
- 116 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Freezing of Gait, Parkinson's Disease
Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related…
- Conditions
- Freezing of Gait, Parkinson's Disease, Parkinsonism, Vascular Parkinsonism
- Trial name
- NCT07386015
- Testing
- Observational Data Collection
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin Huanhu Hospital
Idiopathic Normal Pressure Hydrocephalus (INPH)
A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial
The Placebo-Controlled Effectiveness in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt…
- Trial name
- PENS (NCT03350750)
- Testing
- programmable CSF shunt valve
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Hydrocephaly
Quantitative Characterization of Safe Irrigation for Ventricular Shunt Catheters
The objective of this pilot study is to perform a set of pressure and flow rate measurements in order to quantitatively characterize safe irrigation or "flushing" of a ventricular shunt catheter, a routine maneuver performed by a…
- Trial name
- NCT02651337
- Testing
- Cerebrospinal Fluid (CSF) Drainage
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Alcyone Therapeutics, Inc
Normal Pressure Hydrocephalus
Normal Pressure Hydrocephalus (NPH) Registry
The overall aim of the registry is to develop a longitudinal, observational database that is focused on adult patients with Normal Pressure Hydrocephalus (NPH) that can be used as a source of clinical information for individual…
- Trial name
- NCT00233701
- Where
- 28 sites in United States
- Volunteers
- 343 people
- Sponsor
- Codman & Shurtleff
Hydrocephalus
A Registry for Comparing Catheter-Related Infection Rates Among Various Shunt Systems in the Treatment of Hydrocephalus
The purpose of this Registry is to compare shunt/catheter-related infection rates among various shunt systems when used according to hospital standard of care to treat hydrocephalus.
- Trial name
- NCT00280904
- Testing
- Shunt catheter
- Where
- 8 sites in United States, Canada and 4 more
- Volunteers
- 433 people
- Sponsor
- Codman & Shurtleff
Normal Pressure Hydrocephalus
Anterior Pituitary Function in Patients With Hydrocephalus
Hydrocephalus (secondary or idiopathic) is a condition characterized by dilatation of the lateral and third ventricles, and often associated with increased intracranial pressure (ICP).
- Trial name
- NCT00149721
- Testing
- Ventriculo-peritonal shunting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Hydrocephalus, Normal Pressure
Diagnostic Accuracy of ShuntCheck Compared to Radionuclide Shunt: Patency in Patients With Normal Pressure Hydrocephalus
The purpose of this study is to assess the diagnostic accuracy of ShuntCheck compared with radionuclide shunt patency testing (SPS) to detect CSF shunt flow of NPH patients with suspected shunt obstruction.
- Trial name
- NCT04309487
- Testing
- ShuntCheck
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of South Florida
Normal Pressure Hydrocephalus
ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients
The purpose of this study is to examine the role of ShuntCheck and MR Imaging in evaluating the presence or absence of Shunt Obstruction in the patients of Hydrocephalus or Idiopathic Intracranial Hypertension (IIH) undergoing…
- Trial name
- NCT00793416
- Testing
- Shunt flow detection
- Where
- United States
- Sponsor
- NeuroDx Development
Hydrocephalus
Sonographic Monitoring of Weaning of Cerebrospinal Fluid Drainages
As elaborated above only one study reported ultrasonographic changes of the width of the lateral ventricle during clamping of EVD/LD and indicated that ultrasound monitoring might be suitable.
- Trial name
- NCT02408757
- Testing
- Sonographic monitoring
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Normal Pressure Hydrocephalus
Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus
This study aims to evaluate whether phase-contrast magnetic resonance imaging (MRI)-based cerebrospinal fluid (CSF) flow dynamics can improve the diagnosis and prognostic assessment of normal pressure hydrocephalus (NPH).
- Trial name
- NCT07831044
- Testing
- Cerebrospinal fluid drainge
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Chungnam National University Hospital
Hydrocephalus, Intracranial Hypertension
Intraventricular Drain Insertion: Comparison of Ultrasound-guided and Landmark-based Puncture of the Ventricular System
Puncture of the ventricular system is one of the most frequently performed neurosurgical interventions. This procedure is commonly performed in order to treat and/or measure pathologically elevated intracranial pressure.Therefore…
- Trial name
- In-Vent (NCT01973764)
- Testing
- Ultrasound guided ventricular drain insertion, landmark-based ventricular drain insertion
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Normal Pressure Hydrocephalus
Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus
Prospective, multi-center, randomized, controlled trial of the eShunt System in the treatment of patients with normal pressure hydrocephalus.
- Trial name
- STRIDE (NCT06498960)
- Testing
- CereVasc eShunt System, VP Shunt
- Where
- 32 sites in United States, Argentina and 1 more
- Volunteers
- 230 people
- Sponsor
- CereVasc Inc
Hydrocephalus, Shunt Malfunction
Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotocol
This research is being done to determine the accuracy of two noninvasive methods of measuring the pressure of the spinal fluid, also known as intracranial pressure (ICP).
- Trial name
- NCT01976559
- Testing
- Tympanic Membrane Displacement (TMD), DPOAE
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- LifeBridge Health
Hydrocephalus in Infants
Non-Invasive Pressure Monitor for Neonates & Infants at Risk of Developing Hydrocephalus
The goal of this clinical trial is to test a modified smart soft contact lens in neonates and infants at risk of developing hydrocephalus.
- Trial name
- NCT06310213
- Testing
- Non-Invasive Pressure Monitor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Indiana University
Hydrocephalus
Bench Study of Transcutaneous Hydrocephalic Shunt Flow Sensor Alignment Accuracy and Repeatability
The study hypothesis is that nurses and doctors can use a transcutaneously powered ultrasonic flow sensor to make repeatable and accurate hydrocephalic shunt flow measurements.
- Trial name
- NCT00651950
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Transonic Systems Inc.
Hydrocephalus
Assessment of CSF Shunt Flow With Thermal Measurements A
This study evaluates the performance of a non-invasive thermal measurement device for assessing CSF shunt flow. Patients with an existing implanted shunt and symptoms of shunt malfunction will be evaluated with the study device.
- Trial name
- NCT05015751
- Testing
- Thermal Anisotropy Measurement Device
- Where
- 4 sites in United States
- Volunteers
- 44 people
- Sponsor
- Rhaeos, Inc.