Clinical trials: Hydrocephalus.
Hydrocephalus
Ventricular Size Involvement in Neuropsychological Outcomes in Pediatric Hydrocephalus
This multicenter, prospective study of children with hydrocephalus will examine whether or not ventricle size is associated with poor cognitive outcomes.
- Trial name
- VINOH (NCT01797627)
- Where
- 8 sites in United States, Canada
- Volunteers
- 78 people
- Sponsor
- University of Utah
Normal Pressure Hydrocephalus
CPT-3 in Normal Pressure Hydrocephalus
The study will collect prospective cohort data of individuals that are undergoing routine clinical care for suspected idiopathic Normal Pressure Hydrocephalus (NPH).
- Trial name
- NCT03521518
- Testing
- Conner's Continuous Performance Test-3
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University Medical Center
Hydrocephalus
EVD Drainage Data and Intracranial Pressure (ICP) Measurements
Rhaeos, Inc. is initially targeting hydrocephalus, a life threatening condition caused by an abnormal accumulation of cerebrospinal fluid (CSF).
- Trial name
- RHAEOS (NCT05546996)
- Testing
- FlowSense
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Hydrocephalus.
Tablet-guided Versus Freehand (Tab-Guide) Ventriculostomy : Study Protocol to the Test Accuracy of Ventriculostomy in a Randomized Controlled Trial
Background: Despite the widespread use of external ventricular drainage, revision rates and associated complications are reported between 10-40%.
- Trial name
- Tab-Guide (NCT02048553)
- Testing
- Tablet-guided ventriculostomy, Freehand
- Where
- Switzerland
- Volunteers
- 320 people
- Sponsor
- University Hospital, Geneva
Hydrocephalus
Measurements of CSF Shunts and Off-Shunt Locations With Wireless Thermal Anisotropy Measurement Devices
This study collects data using non-invasive devices for assessing CSF shunt flow using thermal anisotropy measurements in a prospective study setting.
- Trial name
- NCT06513572
- Testing
- FlowSense
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Rhaeos, Inc.
Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic
Unsteady Gait in Older People May be a Common and Treatable Neurological Disease Associated With Increased Mortality
We live in an aging population and a third of the older population has a gait disorder that may cause institutionalization, and increased mortality.
- Conditions
- Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic, Gait Disorders in Old Age
- Trial name
- VESPR2 (NCT07137403)
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Umeå University
Subarachnoid Hemorrhage, Cerebral Vasospasm
Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage
The purpose of this study is to determine the role of Proteomics and Metallomics in Cerebral Vasospasm following Subarachnoid Hemorrhage
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hydrocephalus
- Trial name
- NCT01799018
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- State University of New York - Upstate Medical University
Hydrocephalus
Bactiseal Catheter Safety Registry Study
Research Purpose: This study aims to continuously evaluate the safety of subjects implanted with a catheter (trade name: Bactiseal) produced by Integra LifeSciences Production Corporation.
- Trial name
- NCT06276543
- Testing
- antibiotic-impregnated catheter
- Where
- 8 sites in China
- Volunteers
- 200 people
- Sponsor
- Integra LifeSciences Corporation
Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including, Sickle Cell Disease
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Cell-free fetal DNA (cffDNA) is present in the maternal blood from the early first trimester of gestation and makes up 5%-20% of the total circulating cell-free DNA (cfDNA) in maternal plasma.
- Conditions
- Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including, Sickle Cell Disease, Cystic Fibrosis, Fragile X Syndrome
- Trial name
- DANNIgene (NCT06147414)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Idiopathic Normal Pressure Hydrocephalus (INPH)
Acetazolamide Trial in Normal Pressure Hydrocephalus
A pharmacological treatment to patients with normal pressure hydrocephalus (NPH) is missing. The aim is to investigate if acetazolamide given to patients with NPH improves gait function and study the pathophysiological mechanisms…
- Trial name
- DRAIN (NCT04975269)
- Testing
- Acetazolamide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University Hospital
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Danish RAndomized Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage
The DRAIN trial is an international multi-centre, 1:1 randomised, parallel-group, superiority clinical trial investigating gradual weaning vs.
- Trial name
- DRAIN (NCT03948256)
- Testing
- Control intervention, Experimental intervention
- Where
- 4 sites in Denmark, Norway
- Volunteers
- 245 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Post-hemorrhagic Hydrocephalus (PHH)
Assessing CSF Flow Dynamics in Pediatric Hemorrhagic Hydrocephalus
The purpose of this study is to evaluate the safety and efficacy of ventricular microdosing of indocyanine green (ICG) in order to assess cerebrospinal fluid (CSF) ventricular dynamics and extracranial CSF outflow using…
- Trial name
- NCT06994949
- Testing
- fCTOT cap, NIRF planar imaging, ICG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eva Sevick
Idiopathic Normal Pressure Hydrocephalus
Gait Pattern and Experienced Global Change After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus
Part 1 Patients with idiopathic Normal Pressure Hydrocephalus (iNPH) have variable disabilities regarding gait, balance, cognition and continence.
- Trial name
- NCT04795089
- Testing
- Shunt surgery
- Where
- Sweden
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Hydrocephalus in Infants, Hydrocephalus Acquired
CEUS Evaluation of Hydrocephalus in Neonates and Infants
Hydrocephalus affects up to 2 out of every 500 births and results in long-term disability in up to 78% of those affected. The standard treatment of hydrocephalus is cerebrospinal fluid (CSF) diversion via placement of an invasive…
- Trial name
- NCT06693752
- Testing
- Sulfur Hexafluoride Lipid Type A Microspheres 25 mg Injection Powder for Suspension [LUMASON]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
Hydrocephaly, CSF Shunts
Cefazolin Antibiotic Prophylaxis in Ventricular Shunt Surgery: Determination of Cerebrospinal Fluid Concentration During Valve Implantation
The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin.
- Conditions
- Hydrocephaly, CSF Shunts, Antibiotic Prophylaxis
- Trial name
- CC -PIV (NCT07067736)
- Testing
- Cefazolin antibiotic prophylaxis
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Strasbourg, France
Hydrocephalus
Guided Application of Ventricular Catheters
Failure of ventricular catheters remains a significant problem in patients with hydrocephalus. The purpose of this study is to determine whether the use of a simple instrument assisted by a smart phone application software can…
- Trial name
- GAVCA (NCT01811589)
- Testing
- Thomale-Guide, Free-hand
- Where
- 9 sites in Germany
- Volunteers
- 144 people
- Sponsor
- Aesculap AG
Walking, Cognitive Function
Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia
The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia…
- Trial name
- NCT00494689
- Where
- 2 sites in Singapore
- Volunteers
- 30 people
- Sponsor
- Devathasan Neurology Practice Pte Ltd
Normal Pressure Hydrocephalus, Sleep Apnea
Normal Pressure Hydrocephalus and Sleep Apnea
Normal-pressure hydrocephalus is associated with increases in the intracranial pressure during the night sleep. Sleep apnea also increases the intracranial pressure during the apneic spells.
- Conditions
- Normal Pressure Hydrocephalus, Sleep Apnea, Cerebrospinal Fluid Shunt Occlusion
- Trial name
- NPH/OSA (NCT04471740)
- Testing
- CSF shunt diversion
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Valencia
Normal Pressure Hydrocephalus
Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery
The idea is to assess the predictive value of flow magnetic resonance imaging (flow MRI) for patient suffering normal pressure hydrocephalus (NPH) planned for surgery.
- Trial name
- NCT01815775
- Testing
- clinical and imaging examinations
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Beta-amiloid and Phospho-tau Proteins in CSF, Ventricular Size After CSF Shunt
CSF Protein Markers as Prognostic Indicators of the Response to CSF Shunt in Normotensive Hydrocephalus
In all published series of adult chronic hydrocephalus, there is a percentage between twenty and twenty-five percent of patients who present poor results after implantation of a cerebrospinal fluid shunt,1-11 usually…
- Conditions
- Beta-amiloid and Phospho-tau Proteins in CSF, Ventricular Size After CSF Shunt, Cognitive Impairment and CSF Shunt, Motor Impairment Evolution After CSF Shunt
- Trial name
- NCT05915000
- Testing
- Lumbar CSF protein marker determination
- Where
- 2 sites in Spain
- Volunteers
- 150 people
- Sponsor
- University of Valencia